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B1H1P9

- PPAL_XENLA

UniProt

B1H1P9 - PPAL_XENLA

Protein

Lysosomal acid phosphatase

Gene

acp2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441NucleophileBy similarity
    Active sitei290 – 2901Proton donorBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosomal acid phosphatase (EC:3.1.3.2)
    Short name:
    LAP
    Gene namesi
    Name:acp2
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6253082. acp2.

    Subcellular locationi

    Lysosome membrane By similarity; Single-pass membrane protein By similarity; Lumenal side By similarity. Lysosome lumen By similarity
    Note: The soluble form arises by proteolytic processing of the membrane-bound form.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal lumen Source: UniProtKB-SubCell
    3. lysosomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 432400Lysosomal acid phosphatasePRO_0000356291Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi161 ↔ 373By similarity
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi214 ↔ 313By similarity
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi348 ↔ 352By similarity

    Post-translational modificationi

    The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliB1H1P9.
    SMRiB1H1P9. Positions 33-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 384352LumenalSequence AnalysisAdd
    BLAST
    Topological domaini406 – 43227CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidine acid phosphatase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG002203.
    KOiK14410.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00328. His_Phos_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B1H1P9-1 [UniParc]FASTAAdd to Basket

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    MADGSCLGSG PQLGLIALLV VLLFSAVPLA QSRELRFVTL VYRHGDRSPV    50
    HGYPTDVHKE SVWPQGYGQL TQVGMKQHWD LGQELRARYK GFLNESYNRH 100
    EIYVRSTDVD RTLMSAEANL AGLYPPEGPQ IFNPNITWQP IPIHTIPESE 150
    DQLLKFPISP CPAYVKLQEE TRQSAEYINM TTTYKAFLQM VANKTGLSDC 200
    TLESVWSVYD TLFCEKTHNF SLPTWATADV LSKLNKLKDF SFVFLFGVHE 250
    RVKKARLQGG VLVDQILKNM TAAANNASNG LKLLAYSAHD STLGALQLAL 300
    DVYNGKQAPY ASCHIFELYK EDSGNFTVQM YFRNESGKTP YPVSLPGCAH 350
    ACPLQDFQSL LQPILAQDWE EECQTTSFIM TEETIIGLTI GAIALFIIIV 400
    VLMLLSCNEP KDDGYQHVSD EGDDHETKGL AM 432
    Length:432
    Mass (Da):48,243
    Last modified:April 29, 2008 - v1
    Checksum:i7EB42A5E3837E245
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC160691 mRNA. Translation: AAI60691.1.
    RefSeqiNP_001121203.1. NM_001127731.1.
    UniGeneiXl.71198.

    Genome annotation databases

    GeneIDi100158274.
    KEGGixla:100158274.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC160691 mRNA. Translation: AAI60691.1 .
    RefSeqi NP_001121203.1. NM_001127731.1.
    UniGenei Xl.71198.

    3D structure databases

    ProteinModelPortali B1H1P9.
    SMRi B1H1P9. Positions 33-375.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100158274.
    KEGGi xla:100158274.

    Organism-specific databases

    CTDi 53.
    Xenbasei XB-GENE-6253082. acp2.

    Phylogenomic databases

    HOVERGENi HBG002203.
    KOi K14410.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR000560. His_Pase_superF_clade-2.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00328. His_Phos_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
    PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiPPAL_XENLA
    AccessioniPrimary (citable) accession number: B1H1P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3