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B1H1P9

- PPAL_XENLA

UniProt

B1H1P9 - PPAL_XENLA

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Protein

Lysosomal acid phosphatase

Gene

acp2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441NucleophileBy similarity
Active sitei290 – 2901Proton donorBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal acid phosphatase (EC:3.1.3.2)
Short name:
LAP
Gene namesi
Name:acp2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6253082. acp2.

Subcellular locationi

Lysosome membrane By similarity; Single-pass membrane protein By similarity; Lumenal side By similarity. Lysosome lumen By similarity
Note: The soluble form arises by proteolytic processing of the membrane-bound form.By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232Sequence AnalysisAdd
BLAST
Chaini33 – 432400Lysosomal acid phosphatasePRO_0000356291Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi161 ↔ 373By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi214 ↔ 313By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi348 ↔ 352By similarity

Post-translational modificationi

The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB1H1P9.
SMRiB1H1P9. Positions 33-375.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 384352LumenalSequence AnalysisAdd
BLAST
Topological domaini406 – 43227CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the histidine acid phosphatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002203.
KOiK14410.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1H1P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADGSCLGSG PQLGLIALLV VLLFSAVPLA QSRELRFVTL VYRHGDRSPV
60 70 80 90 100
HGYPTDVHKE SVWPQGYGQL TQVGMKQHWD LGQELRARYK GFLNESYNRH
110 120 130 140 150
EIYVRSTDVD RTLMSAEANL AGLYPPEGPQ IFNPNITWQP IPIHTIPESE
160 170 180 190 200
DQLLKFPISP CPAYVKLQEE TRQSAEYINM TTTYKAFLQM VANKTGLSDC
210 220 230 240 250
TLESVWSVYD TLFCEKTHNF SLPTWATADV LSKLNKLKDF SFVFLFGVHE
260 270 280 290 300
RVKKARLQGG VLVDQILKNM TAAANNASNG LKLLAYSAHD STLGALQLAL
310 320 330 340 350
DVYNGKQAPY ASCHIFELYK EDSGNFTVQM YFRNESGKTP YPVSLPGCAH
360 370 380 390 400
ACPLQDFQSL LQPILAQDWE EECQTTSFIM TEETIIGLTI GAIALFIIIV
410 420 430
VLMLLSCNEP KDDGYQHVSD EGDDHETKGL AM
Length:432
Mass (Da):48,243
Last modified:April 29, 2008 - v1
Checksum:i7EB42A5E3837E245
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC160691 mRNA. Translation: AAI60691.1.
RefSeqiNP_001121203.1. NM_001127731.1.
UniGeneiXl.71198.

Genome annotation databases

GeneIDi100158274.
KEGGixla:100158274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC160691 mRNA. Translation: AAI60691.1 .
RefSeqi NP_001121203.1. NM_001127731.1.
UniGenei Xl.71198.

3D structure databases

ProteinModelPortali B1H1P9.
SMRi B1H1P9. Positions 33-375.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100158274.
KEGGi xla:100158274.

Organism-specific databases

CTDi 53.
Xenbasei XB-GENE-6253082. acp2.

Phylogenomic databases

HOVERGENi HBG002203.
KOi K14410.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiPPAL_XENLA
AccessioniPrimary (citable) accession number: B1H1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: April 29, 2008
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3