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B1H1P9

- PPAL_XENLA

UniProt

B1H1P9 - PPAL_XENLA

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Protein

Lysosomal acid phosphatase

Gene
acp2
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei44 – 441Nucleophile By similarity
Active sitei290 – 2901Proton donor By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal acid phosphatase (EC:3.1.3.2)
Short name:
LAP
Gene namesi
Name:acp2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6253082. acp2.

Subcellular locationi

Lysosome membrane; Single-pass membrane protein; Lumenal side By similarity. Lysosome lumen By similarity
Note: The soluble form arises by proteolytic processing of the membrane-bound form By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini33 – 384352Lumenal Reviewed predictionAdd
BLAST
Transmembranei385 – 40521Helical; Reviewed predictionAdd
BLAST
Topological domaini406 – 43227Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal lumen Source: UniProtKB-SubCell
  3. lysosomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 Reviewed predictionAdd
BLAST
Chaini33 – 432400Lysosomal acid phosphatasePRO_0000356291Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 373 By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi193 – 1931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi214 ↔ 313 By similarity
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi348 ↔ 352 By similarity

Post-translational modificationi

The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliB1H1P9.
SMRiB1H1P9. Positions 33-375.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG002203.
KOiK14410.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00328. His_Phos_2. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
PROSITEiPS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1H1P9-1 [UniParc]FASTAAdd to Basket

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MADGSCLGSG PQLGLIALLV VLLFSAVPLA QSRELRFVTL VYRHGDRSPV    50
HGYPTDVHKE SVWPQGYGQL TQVGMKQHWD LGQELRARYK GFLNESYNRH 100
EIYVRSTDVD RTLMSAEANL AGLYPPEGPQ IFNPNITWQP IPIHTIPESE 150
DQLLKFPISP CPAYVKLQEE TRQSAEYINM TTTYKAFLQM VANKTGLSDC 200
TLESVWSVYD TLFCEKTHNF SLPTWATADV LSKLNKLKDF SFVFLFGVHE 250
RVKKARLQGG VLVDQILKNM TAAANNASNG LKLLAYSAHD STLGALQLAL 300
DVYNGKQAPY ASCHIFELYK EDSGNFTVQM YFRNESGKTP YPVSLPGCAH 350
ACPLQDFQSL LQPILAQDWE EECQTTSFIM TEETIIGLTI GAIALFIIIV 400
VLMLLSCNEP KDDGYQHVSD EGDDHETKGL AM 432
Length:432
Mass (Da):48,243
Last modified:April 29, 2008 - v1
Checksum:i7EB42A5E3837E245
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC160691 mRNA. Translation: AAI60691.1.
RefSeqiNP_001121203.1. NM_001127731.1.
UniGeneiXl.71198.

Genome annotation databases

GeneIDi100158274.
KEGGixla:100158274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC160691 mRNA. Translation: AAI60691.1 .
RefSeqi NP_001121203.1. NM_001127731.1.
UniGenei Xl.71198.

3D structure databases

ProteinModelPortali B1H1P9.
SMRi B1H1P9. Positions 33-375.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100158274.
KEGGi xla:100158274.

Organism-specific databases

CTDi 53.
Xenbasei XB-GENE-6253082. acp2.

Phylogenomic databases

HOVERGENi HBG002203.
KOi K14410.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR000560. His_Pase_superF_clade-2.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00328. His_Phos_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
PROSITEi PS00616. HIS_ACID_PHOSPHAT_1. 1 hit.
PS00778. HIS_ACID_PHOSPHAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiPPAL_XENLA
AccessioniPrimary (citable) accession number: B1H1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: April 29, 2008
Last modified: June 11, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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