Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate synthase

Gene

argG

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei100CitrullineUniRule annotation1
Binding sitei105CitrullineUniRule annotation1
Binding sitei130ATP; via amide nitrogenUniRule annotation1
Binding sitei132AspartateUniRule annotation1
Binding sitei136AspartateUniRule annotation1
Binding sitei136CitrullineUniRule annotation1
Binding sitei137AspartateUniRule annotation1
Binding sitei140CitrullineUniRule annotation1
Binding sitei189CitrullineUniRule annotation1
Binding sitei198CitrullineUniRule annotation1
Binding sitei274CitrullineUniRule annotation1
Binding sitei286CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 30ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:TGRD_562
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
Proteomesi
  • UP000001691 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001161941 – 413Argininosuccinate synthaseAdd BLAST413

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi471821.TGRD_562.

Structurei

3D structure databases

ProteinModelPortaliB1H0L3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDH. Bacteria.
COG0137. LUCA.
HOGENOMiHOG000230093.
KOiK01940.
OMAiQCEVVTF.

Family and domain databases

CDDicd01999. Argininosuccinate_Synthase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1. 1 hit.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1H0L3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAINKVSSKP VCRDGVKKVV VAYSGGLDTS IILSWVKENY GCEVVACCVD
60 70 80 90 100
VGQGKELEGL DEKAKKTGAS KSYIIDAKKE FVTNYIYPTI KVNALYENKY
110 120 130 140 150
YLGTSLARPI IAEKIADVVK KEKADAVCHG ATGKGNDQVR FELAFKSLMP
160 170 180 190 200
NVKIIAPWRE WDIKSREDAI DYAKKRDISV PVTKAKPYSS DANLWHISYE
210 220 230 240 250
GGVLEDLENE YDESMFKMTV SPEKAPDKPM YLAIAFEQGI PVSIDGNKFT
260 270 280 290 300
PVELITKLNE IAGANSIGRA DIVENRLVGM KSRGVYESPA AAVLYAAHEE
310 320 330 340 350
LESISIDRDT LHFKQLLAHK YAEIAYYGLW FSPLREALDA FINETQKYVT
360 370 380 390 400
GSIKLKLYKG NIIIVARQAK YSLYSEKLAT FEKDEIYNHK DAEGFINLWG
410
LPTKMQAMLR KSE
Length:413
Mass (Da):46,249
Last modified:April 29, 2008 - v1
Checksum:i4D6FFBA9ECAE48EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG14045.1.
RefSeqiWP_015423570.1. NC_020419.1.
YP_001956506.1. NC_020419.1.

Genome annotation databases

EnsemblBacteriaiBAG14045; BAG14045; TGRD_562.
KEGGirsd:TGRD_562.
PATRICi38571456. VBIUncTer52152_0908.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG14045.1.
RefSeqiWP_015423570.1. NC_020419.1.
YP_001956506.1. NC_020419.1.

3D structure databases

ProteinModelPortaliB1H0L3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471821.TGRD_562.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG14045; BAG14045; TGRD_562.
KEGGirsd:TGRD_562.
PATRICi38571456. VBIUncTer52152_0908.

Phylogenomic databases

eggNOGiENOG4105CDH. Bacteria.
COG0137. LUCA.
HOGENOMiHOG000230093.
KOiK01940.
OMAiQCEVVTF.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.

Family and domain databases

CDDicd01999. Argininosuccinate_Synthase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1. 1 hit.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiASSY_UNCTG
AccessioniPrimary (citable) accession number: B1H0L3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.