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B1H0L3 (ASSY_UNCTG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:TGRD_562
OrganismUncultured termite group 1 bacterium phylotype Rs-D17 [Complete proteome] [HAMAP]
Taxonomic identifier471821 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaenvironmental samples

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_1000116194

Regions

Nucleotide binding22 – 309ATP By similarity

Sites

Binding site1001Citrulline By similarity
Binding site1051Citrulline By similarity
Binding site1301ATP; via amide nitrogen By similarity
Binding site1321Aspartate By similarity
Binding site1361Aspartate By similarity
Binding site1361Citrulline By similarity
Binding site1371Aspartate By similarity
Binding site1401Citrulline By similarity
Binding site1891Citrulline By similarity
Binding site1981Citrulline By similarity
Binding site2741Citrulline By similarity
Binding site2861Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
B1H0L3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 4D6FFBA9ECAE48EF

FASTA41346,249
        10         20         30         40         50         60 
MAINKVSSKP VCRDGVKKVV VAYSGGLDTS IILSWVKENY GCEVVACCVD VGQGKELEGL 

        70         80         90        100        110        120 
DEKAKKTGAS KSYIIDAKKE FVTNYIYPTI KVNALYENKY YLGTSLARPI IAEKIADVVK 

       130        140        150        160        170        180 
KEKADAVCHG ATGKGNDQVR FELAFKSLMP NVKIIAPWRE WDIKSREDAI DYAKKRDISV 

       190        200        210        220        230        240 
PVTKAKPYSS DANLWHISYE GGVLEDLENE YDESMFKMTV SPEKAPDKPM YLAIAFEQGI 

       250        260        270        280        290        300 
PVSIDGNKFT PVELITKLNE IAGANSIGRA DIVENRLVGM KSRGVYESPA AAVLYAAHEE 

       310        320        330        340        350        360 
LESISIDRDT LHFKQLLAHK YAEIAYYGLW FSPLREALDA FINETQKYVT GSIKLKLYKG 

       370        380        390        400        410 
NIIIVARQAK YSLYSEKLAT FEKDEIYNHK DAEGFINLWG LPTKMQAMLR KSE 

« Hide

References

[1]"Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009510 Genomic DNA. Translation: BAG14045.1.
RefSeqYP_001956506.1. NC_020419.1.

3D structure databases

ProteinModelPortalB1H0L3.
SMRB1H0L3. Positions 18-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471821.TGRD_562.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6373334.
KEGGrsd:TGRD_562.
PATRIC38571456. VBIUncTer52152_0908.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMAIYNGYWW.
OrthoDBEOG6K9QCV.

Enzyme and pathway databases

BioCycUTER471821:GJAD-603-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_UNCTG
AccessionPrimary (citable) accession number: B1H0L3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways