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B1H0L3

- ASSY_UNCTG

UniProt

B1H0L3 - ASSY_UNCTG

Protein

Argininosuccinate synthase

Gene

argG

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001CitrullineUniRule annotation
    Binding sitei105 – 1051CitrullineUniRule annotation
    Binding sitei130 – 1301ATP; via amide nitrogenUniRule annotation
    Binding sitei132 – 1321AspartateUniRule annotation
    Binding sitei136 – 1361AspartateUniRule annotation
    Binding sitei136 – 1361CitrullineUniRule annotation
    Binding sitei137 – 1371AspartateUniRule annotation
    Binding sitei140 – 1401CitrullineUniRule annotation
    Binding sitei189 – 1891CitrullineUniRule annotation
    Binding sitei198 – 1981CitrullineUniRule annotation
    Binding sitei274 – 2741CitrullineUniRule annotation
    Binding sitei286 – 2861CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi22 – 309ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciUTER471821:GJAD-603-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:TGRD_562
    OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
    Taxonomic identifieri471821 [NCBI]
    Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
    ProteomesiUP000001691: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Argininosuccinate synthasePRO_1000116194Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi471821.TGRD_562.

    Structurei

    3D structure databases

    ProteinModelPortaliB1H0L3.
    SMRiB1H0L3. Positions 18-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1H0L3-1 [UniParc]FASTAAdd to Basket

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    MAINKVSSKP VCRDGVKKVV VAYSGGLDTS IILSWVKENY GCEVVACCVD    50
    VGQGKELEGL DEKAKKTGAS KSYIIDAKKE FVTNYIYPTI KVNALYENKY 100
    YLGTSLARPI IAEKIADVVK KEKADAVCHG ATGKGNDQVR FELAFKSLMP 150
    NVKIIAPWRE WDIKSREDAI DYAKKRDISV PVTKAKPYSS DANLWHISYE 200
    GGVLEDLENE YDESMFKMTV SPEKAPDKPM YLAIAFEQGI PVSIDGNKFT 250
    PVELITKLNE IAGANSIGRA DIVENRLVGM KSRGVYESPA AAVLYAAHEE 300
    LESISIDRDT LHFKQLLAHK YAEIAYYGLW FSPLREALDA FINETQKYVT 350
    GSIKLKLYKG NIIIVARQAK YSLYSEKLAT FEKDEIYNHK DAEGFINLWG 400
    LPTKMQAMLR KSE 413
    Length:413
    Mass (Da):46,249
    Last modified:April 29, 2008 - v1
    Checksum:i4D6FFBA9ECAE48EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009510 Genomic DNA. Translation: BAG14045.1.
    RefSeqiWP_015423570.1. NC_020419.1.
    YP_001956506.1. NC_020419.1.

    Genome annotation databases

    GeneIDi6373334.
    KEGGirsd:TGRD_562.
    PATRICi38571456. VBIUncTer52152_0908.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009510 Genomic DNA. Translation: BAG14045.1 .
    RefSeqi WP_015423570.1. NC_020419.1.
    YP_001956506.1. NC_020419.1.

    3D structure databases

    ProteinModelPortali B1H0L3.
    SMRi B1H0L3. Positions 18-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471821.TGRD_562.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6373334.
    KEGGi rsd:TGRD_562.
    PATRICi 38571456. VBIUncTer52152_0908.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci UTER471821:GJAD-603-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
      Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
      Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiASSY_UNCTG
    AccessioniPrimary (citable) accession number: B1H0L3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3