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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi110ZincUniRule annotation1
Metal bindingi112ZincUniRule annotation1
Metal bindingi137ZincUniRule annotation1
Metal bindingi139ZincUniRule annotation1
Binding sitei257ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:TGRD_542
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
Proteomesi
  • UP000001691 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000901181 – 494Glutamate--tRNA ligaseAdd BLAST494

Proteomic databases

PRIDEiB1H0J3

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi471821.TGRD_542

Structurei

3D structure databases

ProteinModelPortaliB1H0J3
SMRiB1H0J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 20"HIGH" regionUniRule annotationAdd BLAST11
Motifi254 – 258"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiAYYAFDT

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B1H0J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIRVRFAP SPTGDLHIGG VRTALFNWLF AKNKGGKFIL RIEDTDETRS
60 70 80 90 100
TGESAKVILD AMKWLELEWN EGPGNENLKY SPYSQMKRKE RGIYRKYADE
110 120 130 140 150
LVAKELAYPC YCTPEEIDVM RKKAKADKLP PKYDGKCRHL TPGQRKQKEI
160 170 180 190 200
EGKKAVVRFK MFGSGTTVLN DIIRGRVKFD NSLLDDFVIM KASGVPAYNF
210 220 230 240 250
ACVVDDYLME ITHVLRGDDH ISNAPRQMHI YNALGWEMPE FAHMSMILGA
260 270 280 290 300
GGARLSKRHG HTSVLEYRKE GYLREALINY LALLGWSTED SQQIFTIEEL
310 320 330 340 350
KQKFSVERCG ISPSIFDPAK LLWLNGEKIR SKTPQQVYEL FIDWLKYTGN
360 370 380 390 400
EKLTETWDVE LLKKALILEH DKIKLLKDIP SLVDFFFTKN VDYKEEAVKK
410 420 430 440 450
TLLSEKSKDI AKLVLIESAA RLPNQLDFSA ISLEQYARNL AAEKNIKTGQ
460 470 480 490
VFHPIRVAIS GRMQGPGLFQ MMEVMGKEDV VRRINVAINK FFQK
Length:494
Mass (Da):56,547
Last modified:April 29, 2008 - v1
Checksum:iE1A64E5136CA754A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA Translation: BAG14025.1
RefSeqiWP_015423550.1, NC_020419.1
YP_001956486.1, NC_020419.1

Genome annotation databases

EnsemblBacteriaiBAG14025; BAG14025; TGRD_542
KEGGirsd:TGRD_542
PATRICifig|471821.5.peg.883

Similar proteinsi

Entry informationi

Entry nameiSYE_UNCTG
AccessioniPrimary (citable) accession number: B1H0J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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