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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Metal bindingi68MagnesiumUniRule annotation1
Metal bindingi141MagnesiumUniRule annotation1
Metal bindingi144MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
Ordered Locus Names:TGRD_461
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
Proteomesi
  • UP000001691 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000905711 – 190Crossover junction endodeoxyribonuclease RuvCAdd BLAST190

Proteomic databases

PRIDEiB1H0B2

Interactioni

Protein-protein interaction databases

STRINGi471821.TGRD_461

Structurei

3D structure databases

ProteinModelPortaliB1H0B2
SMRiB1H0B2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105NHU Bacteria
COG0817 LUCA
HOGENOMiHOG000012182
KOiK01159
OMAiGLTRCGI

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

B1H0B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILGIDPGL SLTGWGVVEA FSRDKVNPLQ YGCIKTMPSV PLIQRLQTIN
60 70 80 90 100
TKLQSVIDKY KPEVASIEEL FFFKATKSIA AVGQTRGAII LTASLNKIPL
110 120 130 140 150
FEYNPKSVKT ALTGYGSADK YQMQRIVKTF LRLKEIPKPD DAADALAIAV
160 170 180 190
CHVNTINWNA NNNNNASVFL KNKVFKESAK PNLLKKLFSL
Length:190
Mass (Da):21,029
Last modified:April 29, 2008 - v1
Checksum:iAED9A0F2C673B7A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA Translation: BAG13944.1
RefSeqiWP_015423470.1, NC_020419.1
YP_001956405.1, NC_020419.1

Genome annotation databases

EnsemblBacteriaiBAG13944; BAG13944; TGRD_461
KEGGirsd:TGRD_461
PATRICifig|471821.5.peg.748

Similar proteinsi

Entry informationi

Entry nameiRUVC_UNCTG
AccessioniPrimary (citable) accession number: B1H0B2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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