Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B1GZW3 (TPIS_UNCTG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Triosephosphate isomerase

Short name=TIM
EC=5.3.1.1
Alternative name(s):
Triose-phosphate isomerase
Gene names
Name:tpiA
Ordered Locus Names:TGRD_312
OrganismUncultured termite group 1 bacterium phylotype Rs-D17 [Complete proteome] [HAMAP]
Taxonomic identifier471821 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaenvironmental samples

Protein attributes

Sequence length250 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate = glycerone phosphate. HAMAP-Rule MF_00147

Pathway

Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00147

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. HAMAP-Rule MF_00147

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00147

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00147.

Sequence similarities

Belongs to the triosephosphate isomerase family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
Pentose shunt
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pentose-phosphate shunt

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functiontriose-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Triosephosphate isomerase HAMAP-Rule MF_00147
PRO_1000096546

Sites

Active site951Electrophile By similarity
Active site1671Proton acceptor By similarity
Binding site91Substrate By similarity
Binding site111Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
B1GZW3 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: 5CFEDA283AAD4BB8

FASTA25027,025
        10         20         30         40         50         60 
MRKPLMAGNW KMNKTVSEAV SFVKALKGAV TGVSNVEILV CPAFTVLYEV NNEIKGSNIN 

        70         80         90        100        110        120 
LGAQNLFGEA KGAFTGEIST AMIRDTGCSY VIVGHSERRQ YFGETDEAVN KKTKAALAAD 

       130        140        150        160        170        180 
ITPIVCVGET LKERENNVTF SVIEKQVRNG LADLTLQQAS LTVIAYEPVW AIGTGKTATP 

       190        200        210        220        230        240 
DQAQEVHSFI RKIYAQMYEE SAEKVRILYG GSVNPGNVSD LMKKSDIDGG LVGGASLEAE 

       250 
SFTKLVKYSK 

« Hide

References

[1]"Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009510 Genomic DNA. Translation: BAG13795.1.
RefSeqYP_001956256.1. NC_020419.1.

3D structure databases

ProteinModelPortalB1GZW3.
SMRB1GZW3. Positions 1-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471821.TGRD_312.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6372753.
KEGGrsd:TGRD_312.
PATRIC38570602. VBIUncTer52152_0496.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0149.
HOGENOMHOG000226412.
KOK01803.
OMAAKLGCTF.
OrthoDBEOG66QM23.

Enzyme and pathway databases

BioCycUTER471821:GJAD-338-MONOMER.
UniPathwayUPA00109; UER00189.
UPA00138.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00147_B. TIM_B.
InterProIPR013785. Aldolase_TIM.
IPR022896. TrioseP_Isoase_bac/euk.
IPR000652. Triosephosphate_isomerase.
IPR020861. Triosephosphate_isomerase_AS.
[Graphical view]
PANTHERPTHR21139. PTHR21139. 1 hit.
PfamPF00121. TIM. 1 hit.
[Graphical view]
SUPFAMSSF51351. SSF51351. 1 hit.
TIGRFAMsTIGR00419. tim. 1 hit.
PROSITEPS00171. TIM_1. 1 hit.
PS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPIS_UNCTG
AccessionPrimary (citable) accession number: B1GZW3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: February 19, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways