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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi482MagnesiumUniRule annotation1
Metal bindingi488MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:TGRD_167
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
Proteomesi
  • UP000001691 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001925031 – 689Polyribonucleotide nucleotidyltransferaseAdd BLAST689

Interactioni

Protein-protein interaction databases

STRINGi471821.TGRD_167.

Structurei

3D structure databases

ProteinModelPortaliB1GZG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini549 – 608KHUniRule annotationAdd BLAST60
Domaini618 – 686S1 motifUniRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1GZG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYFKKEVDV AGKKFIVESG KVAKQAGGSC TVRIGETVVL VTVVSLKEPK
60 70 80 90 100
VGIDFMPLTV DYRERTYAAG KIPGGFFKRE TRPRDGEVLV SRLIDRSIRP
110 120 130 140 150
LFPEYYRNDT QISAVVLSHD GENDSEMAAI LGASIALYTS DLPFTTPIAS
160 170 180 190 200
VRIGKINGQL IINPLIAEQK LSDLDLVVSG TEEALTMVEA GARELSEAEM
210 220 230 240 250
LEALNLAGKT LKGICLFQKT LPAKTKIVVE QPQHNSLLKA DIEAEAVSKA
260 270 280 290 300
EMSVVIKEKC EREFFWDSFK KDISSRLLEK YPEELPSTID AILEDIFYQK
310 320 330 340 350
ARDLVLNKKI RTDGRGFEEI RPITCETGVL PRVHGSSLFT RGQTQALVTV
360 370 380 390 400
TLGSPCDMQV IDELIVEYKE RFMLHYNFPG FATGEPKRDR AVSRREIGHG
410 420 430 440 450
NLAKKALKHI MPDGEDFGYA VRIVSDILES NGSSSMASVC GGSLALFNAG
460 470 480 490 500
VPVKSSCAGV SMGLMKEGGS YVILTDITGM EDHLGDMDFK VAGTRKGITA
510 520 530 540 550
LQMDIKILGL TTEIVAQALE QAKRGRFFIL DQMDAVVSAP KNDLSNYAPR
560 570 580 590 600
MITLTIPQNK IGELIGPGGK NIRKIQEDNN VKIDIEETGR VFISGVESDG
610 620 630 640 650
VKSAKEYVEC LTVEAEVGKI YKSRVTKIMA FGAFAEILPG KEGLIHISQL
660 670 680
SNRHTKRVED VVKEGDEVKV KVIEIDKQGR INLSIKAAL
Length:689
Mass (Da):75,686
Last modified:April 29, 2008 - v1
Checksum:iAFE131BE7491AD83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG13650.1.
RefSeqiWP_015423178.1. NC_020419.1.
YP_001956111.1. NC_020419.1.

Genome annotation databases

EnsemblBacteriaiBAG13650; BAG13650; TGRD_167.
KEGGirsd:TGRD_167.
PATRICi38570078. VBIUncTer52152_0245.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG13650.1.
RefSeqiWP_015423178.1. NC_020419.1.
YP_001956111.1. NC_020419.1.

3D structure databases

ProteinModelPortaliB1GZG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471821.TGRD_167.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG13650; BAG13650; TGRD_167.
KEGGirsd:TGRD_167.
PATRICi38570078. VBIUncTer52152_0245.

Phylogenomic databases

eggNOGiENOG4105C62. Bacteria.
COG1185. LUCA.
HOGENOMiHOG000218326.
KOiK00962.
OMAiRFMFHYN.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPNP_UNCTG
AccessioniPrimary (citable) accession number: B1GZG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.