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Protein

Mannonate dehydratase

Gene

uxuA

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dehydration of D-mannonate.UniRule annotation

Catalytic activityi

D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O.UniRule annotation

Cofactori

Fe2+UniRule annotation, Mn2+UniRule annotation

Pathwayi: pentose and glucuronate interconversion

This protein is involved in the pathway pentose and glucuronate interconversion, which is part of Carbohydrate metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway pentose and glucuronate interconversion and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Iron, Manganese

Enzyme and pathway databases

BioCyciUTER471821:GJAD-74-MONOMER.
UniPathwayiUPA00246.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannonate dehydrataseUniRule annotation (EC:4.2.1.8UniRule annotation)
Alternative name(s):
D-mannonate hydro-lyaseUniRule annotation
Gene namesi
Name:uxuAUniRule annotation
Ordered Locus Names:TGRD_069
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
Proteomesi
  • UP000001691 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Mannonate dehydratasePRO_1000094228Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi471821.TGRD_069.

Structurei

3D structure databases

ProteinModelPortaliB1GZ70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mannonate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiGRHLWGE.
OrthoDBiEOG6ZSP6Z.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.

Sequencei

Sequence statusi: Complete.

B1GZ70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTFRWYGE NVDPIPLRYI RQIPGVEGIV WALHDIPAGE CWTVERIEEV
60 70 80 90 100
KAQAAKYNFN TDVVESVNVH EDIKLGLPSR KKYIENYKNT LKNLGRAGVK
110 120 130 140 150
VVCYNFMPVF DWTRTDLYKP QSDGSTALFY EKAKVDNINP VKFLEQMSKQ
160 170 180 190 200
EGLLTMPGWE PERLSKIKEL FEAYKEIKDD DLWENLKYFL QEIIPVAQES
210 220 230 240 250
GIKMAIHPDD PPWSIFGLSR IITCRDNIKK FLSLVDNPSN GLTLCSGSLG
260 270 280 290 300
SCTKNNIAAI VREFGDRIYF AHIRNIRHFK NGDFTETSHK TSDGSLDITE
310 320 330 340 350
IVKAYHDINY KYYVRPDHGR HIWDEKCRPG YGLYDRSLGI MYIFGLWDAF
360
EKISASKRGQ YGVE
Length:364
Mass (Da):42,121
Last modified:April 29, 2008 - v1
Checksum:i539CCD6FFF36EABB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG13552.1.
RefSeqiWP_015423081.1. NC_020419.1.
YP_001956013.1. NC_020419.1.

Genome annotation databases

EnsemblBacteriaiBAG13552; BAG13552; TGRD_069.
KEGGirsd:TGRD_069.
PATRICi38569788. VBIUncTer52152_0110.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG13552.1.
RefSeqiWP_015423081.1. NC_020419.1.
YP_001956013.1. NC_020419.1.

3D structure databases

ProteinModelPortaliB1GZ70.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi471821.TGRD_069.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAG13552; BAG13552; TGRD_069.
KEGGirsd:TGRD_069.
PATRICi38569788. VBIUncTer52152_0110.

Phylogenomic databases

eggNOGiENOG4105CHZ. Bacteria.
COG1312. LUCA.
HOGENOMiHOG000195381.
KOiK01686.
OMAiGRHLWGE.
OrthoDBiEOG6ZSP6Z.

Enzyme and pathway databases

UniPathwayiUPA00246.
BioCyciUTER471821:GJAD-74-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00106. UxuA.
InterProiIPR004628. Man_deHydtase.
IPR013022. Xyl_isomerase-like_TIM-brl.
[Graphical view]
PfamiPF03786. UxuA. 1 hit.
[Graphical view]
PIRSFiPIRSF016049. Man_dehyd. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00695. uxuA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
    Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
    Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiUXUA_UNCTG
AccessioniPrimary (citable) accession number: B1GZ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 29, 2008
Last modified: February 17, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.