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B1GYV8

- GCSPB_UNCTG

UniProt

B1GYV8 - GCSPB_UNCTG

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene
gcvPB, TGRD_718
Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciUTER471821:GJAD-764-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:TGRD_718
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
ProteomesiUP000001691: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotationPRO_1000148003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi471821.TGRD_718.

Structurei

3D structure databases

ProteinModelPortaliB1GYV8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1GYV8-1 [UniParc]FASTAAdd to Basket

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MEKLLNELSS ENRPAYSVDS DVEIDAQIPE NLKRSSGLGL PSITENDLSR    50
HFTNLSRKNY ALSTSFYPLG SCTMKYNPLI NERVAKNEAF NFIHPYQPGK 100
SMQGVLKIMY ELEKDLCEIS GMDCFSLQQA AGAHGEFTGL LIIAKYFKSI 150
KQKRTKIIIP DTAHGTNPAS AALAGFGTVS LKSESDGSIL PEKLKKILTP 200
EIAAVMLTVP NTLGAFEKNI PEISRIVHEN GSLLYYDGAN LNAVMGIVRP 250
GDMGFDVMHI NLHKTFSTPH GGGGPGSGPV GVKEFLEPFL PVPKIESRKS 300
KFVLNYKKPK SIGKLKAFLG NFPVILKAYV YIKSLGAEGL KNVSEWAVLN 350
ANYMLARFKD KIDVPAGSRC MHEFVLSPKS LFKNNVKTLD VAKRLLDYGY 400
YAPTIYFPLI VEEAVMLEPT ETESKETMDA FIDTLIKIIY EEATQEPQKL 450
KEAPFNTSVR RLNEVEAARN PVLKWKKA 478
Length:478
Mass (Da):53,051
Last modified:April 29, 2008 - v1
Checksum:iF9DC789C4F244D66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009510 Genomic DNA. Translation: BAG14201.1.
RefSeqiYP_001956662.1. NC_020419.1.

Genome annotation databases

GeneIDi6373373.
KEGGirsd:TGRD_718.
PATRICi38572110. VBIUncTer52152_1230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009510 Genomic DNA. Translation: BAG14201.1 .
RefSeqi YP_001956662.1. NC_020419.1.

3D structure databases

ProteinModelPortali B1GYV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471821.TGRD_718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6373373.
KEGGi rsd:TGRD_718.
PATRICi 38572110. VBIUncTer52152_1230.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci UTER471821:GJAD-764-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
    Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
    Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGCSPB_UNCTG
AccessioniPrimary (citable) accession number: B1GYV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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