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B1GYV8 (GCSPB_UNCTG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:TGRD_718
OrganismUncultured termite group 1 bacterium phylotype Rs-D17 [Complete proteome] [HAMAP]
Taxonomic identifier471821 [NCBI]
Taxonomic lineageBacteriaElusimicrobiaenvironmental samples

Protein attributes

Sequence length478 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 478478Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_1000148003

Amino acid modifications

Modified residue2641N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B1GYV8 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: F9DC789C4F244D66

FASTA47853,051
        10         20         30         40         50         60 
MEKLLNELSS ENRPAYSVDS DVEIDAQIPE NLKRSSGLGL PSITENDLSR HFTNLSRKNY 

        70         80         90        100        110        120 
ALSTSFYPLG SCTMKYNPLI NERVAKNEAF NFIHPYQPGK SMQGVLKIMY ELEKDLCEIS 

       130        140        150        160        170        180 
GMDCFSLQQA AGAHGEFTGL LIIAKYFKSI KQKRTKIIIP DTAHGTNPAS AALAGFGTVS 

       190        200        210        220        230        240 
LKSESDGSIL PEKLKKILTP EIAAVMLTVP NTLGAFEKNI PEISRIVHEN GSLLYYDGAN 

       250        260        270        280        290        300 
LNAVMGIVRP GDMGFDVMHI NLHKTFSTPH GGGGPGSGPV GVKEFLEPFL PVPKIESRKS 

       310        320        330        340        350        360 
KFVLNYKKPK SIGKLKAFLG NFPVILKAYV YIKSLGAEGL KNVSEWAVLN ANYMLARFKD 

       370        380        390        400        410        420 
KIDVPAGSRC MHEFVLSPKS LFKNNVKTLD VAKRLLDYGY YAPTIYFPLI VEEAVMLEPT 

       430        440        450        460        470 
ETESKETMDA FIDTLIKIIY EEATQEPQKL KEAPFNTSVR RLNEVEAARN PVLKWKKA 

« Hide

References

[1]"Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009510 Genomic DNA. Translation: BAG14201.1.
RefSeqYP_001956662.1. NC_020419.1.

3D structure databases

ProteinModelPortalB1GYV8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING471821.TGRD_718.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6373373.
KEGGrsd:TGRD_718.
PATRIC38572110. VBIUncTer52152_1230.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMAWTGLMMI.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycUTER471821:GJAD-764-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_UNCTG
AccessionPrimary (citable) accession number: B1GYV8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 29, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families