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B1GYV8

- GCSPB_UNCTG

UniProt

B1GYV8 - GCSPB_UNCTG

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciUTER471821:GJAD-764-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:TGRD_718
OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
Taxonomic identifieri471821 [NCBI]
Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
ProteomesiUP000001691: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 478478Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000148003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei264 – 2641N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi471821.TGRD_718.

Structurei

3D structure databases

ProteinModelPortaliB1GYV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B1GYV8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLLNELSS ENRPAYSVDS DVEIDAQIPE NLKRSSGLGL PSITENDLSR
60 70 80 90 100
HFTNLSRKNY ALSTSFYPLG SCTMKYNPLI NERVAKNEAF NFIHPYQPGK
110 120 130 140 150
SMQGVLKIMY ELEKDLCEIS GMDCFSLQQA AGAHGEFTGL LIIAKYFKSI
160 170 180 190 200
KQKRTKIIIP DTAHGTNPAS AALAGFGTVS LKSESDGSIL PEKLKKILTP
210 220 230 240 250
EIAAVMLTVP NTLGAFEKNI PEISRIVHEN GSLLYYDGAN LNAVMGIVRP
260 270 280 290 300
GDMGFDVMHI NLHKTFSTPH GGGGPGSGPV GVKEFLEPFL PVPKIESRKS
310 320 330 340 350
KFVLNYKKPK SIGKLKAFLG NFPVILKAYV YIKSLGAEGL KNVSEWAVLN
360 370 380 390 400
ANYMLARFKD KIDVPAGSRC MHEFVLSPKS LFKNNVKTLD VAKRLLDYGY
410 420 430 440 450
YAPTIYFPLI VEEAVMLEPT ETESKETMDA FIDTLIKIIY EEATQEPQKL
460 470
KEAPFNTSVR RLNEVEAARN PVLKWKKA
Length:478
Mass (Da):53,051
Last modified:April 29, 2008 - v1
Checksum:iF9DC789C4F244D66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG14201.1.
RefSeqiWP_015423722.1. NC_020419.1.
YP_001956662.1. NC_020419.1.

Genome annotation databases

GeneIDi6373373.
KEGGirsd:TGRD_718.
PATRICi38572110. VBIUncTer52152_1230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009510 Genomic DNA. Translation: BAG14201.1 .
RefSeqi WP_015423722.1. NC_020419.1.
YP_001956662.1. NC_020419.1.

3D structure databases

ProteinModelPortali B1GYV8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 471821.TGRD_718.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6373373.
KEGGi rsd:TGRD_718.
PATRICi 38572110. VBIUncTer52152_1230.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci UTER471821:GJAD-764-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
    Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
    Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiGCSPB_UNCTG
AccessioniPrimary (citable) accession number: B1GYV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: April 29, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3