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B1GYV7

- GCSPA_UNCTG

UniProt

B1GYV7 - GCSPA_UNCTG

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Uncultured termite group 1 bacterium phylotype Rs-D17
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (29 Apr 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciUTER471821:GJAD-763-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:TGRD_717
    OrganismiUncultured termite group 1 bacterium phylotype Rs-D17
    Taxonomic identifieri471821 [NCBI]
    Taxonomic lineageiBacteriaElusimicrobiaenvironmental samples
    ProteomesiUP000001691: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147994Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi471821.TGRD_717.

    Structurei

    3D structure databases

    ProteinModelPortaliB1GYV7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiRLVGQTE.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B1GYV7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDYTPQNQKD KKKMLETIGI DDVSELFDTI PKDLRAKKLN ISGGKTEQEL    50
    LNYFSDIASE NKVLISFRGA GIYDHYIPSL VGEVIGRSEF WTAYTPYQAE 100
    ASQGTLQSIF EYQSLICALT GLDTSNASLY DGATATAEAV LLALRASGKN 150
    KILISQGLHP EYMQTVKTYL ENSKAEIVTL NISENGVIEK DAVDASVDDD 200
    TAAVIIQSPN FFGVVEDMQA LSTVIKSRNS LFVAVLNPLS LGVFMSPGEY 250
    KADIAVGEGQ VLGSAMRAGG ATFGFMAVKK ALEWKMPGRI AGQTTDKNGN 300
    RGFVLTLQSR EQHIRREKAT SNICTSASLN ALAGCVFLSG WGNDGFKNLA 350
    EINISKARYA FNKIKSLKGF KSKFENKVFF NEFVIETSKN IKKIQNILLK 400
    NGILGPLDLS CINENFKNCL LFCVTEQRTK AEINRLTEIL AEA 443
    Length:443
    Mass (Da):48,595
    Last modified:April 29, 2008 - v1
    Checksum:iB78DAE46504BF191
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009510 Genomic DNA. Translation: BAG14200.1.
    RefSeqiWP_015423721.1. NC_020419.1.
    YP_001956661.1. NC_020419.1.

    Genome annotation databases

    GeneIDi6373369.
    KEGGirsd:TGRD_717.
    PATRICi38572096. VBIUncTer52152_1223.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009510 Genomic DNA. Translation: BAG14200.1 .
    RefSeqi WP_015423721.1. NC_020419.1.
    YP_001956661.1. NC_020419.1.

    3D structure databases

    ProteinModelPortali B1GYV7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 471821.TGRD_717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6373369.
    KEGGi rsd:TGRD_717.
    PATRICi 38572096. VBIUncTer52152_1223.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi RLVGQTE.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci UTER471821:GJAD-763-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome of the uncultured termite group 1 bacteria in a single host protist cell."
      Hongoh Y., Sharma V.K., Prakash T., Noda S., Taylor T.D., Kudo T., Sakaki Y., Toyoda A., Hattori M., Ohkuma M.
      Proc. Natl. Acad. Sci. U.S.A. 105:5555-5560(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGCSPA_UNCTG
    AccessioniPrimary (citable) accession number: B1GYV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: April 29, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3