B1GP90 (B1GP90_BACAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase HAMAP MF_01511
EC=1.7.1.7 HAMAP MF_01511

Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase HAMAP MF_01511

Gene names

Name:	guaC HAMAP MF_01511 EMBL EDT17613.1
ORF Names:	BAM_5768 EMBL EDT17613.1

Organism

Bacillus anthracis str. A0465 EMBL EDT17613.1

Taxonomic identifier

486620 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	327 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511 SAAS SAAS005994
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511 SAAS SAAS005994
Sequence similarities	Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. HAMAP MF_01511

Ontologies

Keywords
Ligand	NADP HAMAP MF_01511 SAAS SAAS005994
Molecular function	Oxidoreductase HAMAP MF_01511 SAAS SAAS005994 EMBL EDT17613.1
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: HAMAP dihydroorotate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	204 – 227	24	NADP By similarity HAMAP MF_01511
Sites
	Active site	175	1	Thioimidate intermediate By similarity HAMAP MF_01511

Sequences

	Sequence		Length	Mass (Da)
	B1GP90 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 02AD48048B6224AE	FASTA	327	36,148
	10 20 30 40 50 60 MENVFDYEDI QLIPAKCIVN SRSECDTTVT LGKHKFKLPV VPANMQTIID ERIATYLAEN 70 80 90 100 110 120 NYFYIMHRFQ PEKRISFIRD MQSRGLIASI SVGVKEDEYE FVQQLAAEHL TPEYITIDIA 130 140 150 160 170 180 HGHSNAVINM IQHIKKHLPE SFVIAGNVGT PEAVRELENA GADATKVGIG PGKVCITKIK 190 200 210 220 230 240 TGFGTGGWQL AALRWCAKAA SKPIIADGGI RTNGDVAKSI RFGATMVMIG SLFAGHEESP 250 260 270 280 290 300 GETIEKDGKL YKEYFGSASE FQKGEKKNVE GKKMFVEHKG SLEDTLIEME QDLQSSISYA 310 320 GGTKLDSIRT VDYVVVKNSI FNGDKVY

References

[1]	"Genome sequence of Bacillus anthracis A0465." Dodson R.J., Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Sutton G., Brettin T.S. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A0465 EMBL EDT17613.1.
[2]	Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A0465 EMBL EDT17613.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABLH01000029 Genomic DNA. Translation: EDT17613.1.
3D structure databases
ProteinModelPortal	B1GP90.
SMR	B1GP90. Positions 1-321.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	24636068. VBIBacAnt29655_5006.
Family and domain databases
HAMAP	MF_01511. GMP_reduct_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001295. Dihydroorotate_DH_CS. IPR005994. GMP_reduct2. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR11911:SF30. PTHR11911:SF30. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMs	TIGR01306. GMP_reduct_2. 1 hit.
PROSITE	PS00912. DHODEHASE_2. 1 hit. PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1GP90_BACAN

Accession

Primary (citable) accession number: B1GP90

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)