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B1GF22 (B1GF22_BACAN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable cytosol aminopeptidase HAMAP MF_00181
EC=3.4.11.1 HAMAP MF_00181
Alternative name(s):
Leucine aminopeptidase HAMAP MF_00181
Leucyl aminopeptidase HAMAP MF_00181
Gene names
Name:pepA HAMAP MF_00181 EMBL EDT20900.1
ORF Names:BAM_5234 EMBL EDT20900.1
OrganismBacillus anthracis str. A0465 EMBL EDT20900.1
Taxonomic identifier486620 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides By similarity. HAMAP MF_00181 SAAS SAAS023042

Catalytic activity

Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low. HAMAP MF_00181 SAAS SAAS023042

Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids. HAMAP MF_00181

Cofactor

Binds 2 manganese ions per subunit By similarity. HAMAP MF_00181

Subcellular location

Cytoplasm By similarity HAMAP MF_00181 SAAS SAAS011356.

Sequence similarities

Belongs to the peptidase M17 family. HAMAP MF_00181

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2721 By similarity HAMAP MF_00181
Active site3461 By similarity HAMAP MF_00181
Metal binding2601Manganese 2 By similarity HAMAP MF_00181
Metal binding2651Manganese 1 By similarity HAMAP MF_00181
Metal binding2651Manganese 2 By similarity HAMAP MF_00181
Metal binding2831Manganese 2 By similarity HAMAP MF_00181
Metal binding3421Manganese 1 By similarity HAMAP MF_00181
Metal binding3441Manganese 1 By similarity HAMAP MF_00181
Metal binding3441Manganese 2 By similarity HAMAP MF_00181

Sequences

Sequence LengthMass (Da)Tools
B1GF22 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: D400D6CC81FA31DF

FASTA49453,514
        10         20         30         40         50         60 
MFQVQKELAS HEAVVVALFE EEKTSSFVQE LDKAFEGQLQ VLLEEKELST KKKAISKVHS 

        70         80         90        100        110        120 
LGKTDVKRYY FVGLGKKESY TTETLRSALG KTFKTLQAAK VQDAAILLDS FVTEKLDAID 

       130        140        150        160        170        180 
VAHIAAEVQG LGTYELQTYK SDKKDRVELE KFTAITAEDA QEIEAALTVG YVHGRATNSA 

       190        200        210        220        230        240 
RTLVNMPPNV LTATKLAEYA VELAEKYDMD YKVLEKEEME ELGMGALLAV NQGSVEPPKM 

       250        260        270        280        290        300 
IALIYKGKEE WTDVIGFVGK GITYDTGGYS LKPREGMVGM KGDMGGAAAV LGAMEIIGEL 

       310        320        330        340        350        360 
RPEQNVIAVI PSTDNVVSGT AFKPDDVITS MSGKTIEVLN TDAEGRLALA DGITYAKKLG 

       370        380        390        400        410        420 
ANYLIDVATL TGGVIVALGN HTTGAMTNNE ELFEQVLEAS METDESIWQL PIFDRDKERV 

       430        440        450        460        470        480 
RNSKFADLNN SPGREGHAVM AGTFIGEFAE DTPWVHLDIA GTSESSGAHD LGPAGATGAM 

       490 
VRTLATLVER FGEE

« Hide

References

[1]"Genome sequence of Bacillus anthracis A0465."
Dodson R.J., Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Sutton G., Brettin T.S.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A0465 EMBL EDT20900.1.
[2]Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A0465 EMBL EDT20900.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ABLH01000003 Genomic DNA. Translation: EDT20900.1.

3D structure databases

ProteinModelPortalB1GF22.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

PATRIC24628588. VBIBacAnt29655_1360.

Phylogenomic databases

OMAFMINLAT.

Family and domain databases

HAMAPMF_00181. Cytosol_peptidase_M17.
[Tree]
InterProIPR011356. Peptidase_M17.
IPR000819. Peptidase_M17_C.
IPR023042. Peptidase_M17_cytosol_amino.
IPR008283. Peptidase_M17_N.
[Graphical view]
PANTHERPTHR11963:SF3. Peptidase_M17. 1 hit.
PfamPF00883. Peptidase_M17. 1 hit.
PF02789. Peptidase_M17_N. 1 hit.
[Graphical view]
PRINTSPR00481. LAMNOPPTDASE.
PROSITEPS00631. CYTOSOL_AP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1GF22_BACAN
AccessionPrimary (citable) accession number: B1GF22
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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