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B1F6N9 (B1F6N9_BACAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein translocase subunit SecY HAMAP-Rule MF_01465
Gene names
Name:secY1 EMBL EDS94559.1
Synonyms:secY HAMAP-Rule MF_01465
ORF Names:BAK_0152 EMBL EDS94559.1
OrganismBacillus anthracis str. A0389 EMBL EDS94559.1
Taxonomic identifier486623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group ›

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently By similarity. HAMAP-Rule MF_01465 RuleBase RU000537

Subunit structure

Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA By similarity. HAMAP-Rule MF_01465

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01465.

Membrane; Multi-pass membrane protein By similarity RuleBase RU003484.

Sequence similarities

Belongs to the SecY/SEC61-alpha family. HAMAP-Rule MF_01465 RuleBase RU004349

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Transmembrane18 – 3821Helical; By similarity HAMAP-Rule MF_01465
Transmembrane67 – 8721Helical; By similarity HAMAP-Rule MF_01465
Transmembrane116 – 13621Helical; By similarity HAMAP-Rule MF_01465
Transmembrane146 – 16621Helical; By similarity HAMAP-Rule MF_01465
Transmembrane175 – 19521Helical; By similarity HAMAP-Rule MF_01465
Transmembrane214 – 23421Helical; By similarity HAMAP-Rule MF_01465
Transmembrane273 – 29321Helical; By similarity HAMAP-Rule MF_01465
Transmembrane311 – 33121Helical; By similarity HAMAP-Rule MF_01465
Transmembrane371 – 39121Helical; By similarity HAMAP-Rule MF_01465
Transmembrane393 – 41321Helical; By similarity HAMAP-Rule MF_01465

Sequences

Sequence LengthMass (Da)Tools
B1F6N9 [UniParc].

Last modified April 29, 2008. Version 1.
Checksum: A756DCDFB9EB83A6

FASTA43347,514
        10         20         30         40         50         60 
MFRTISNFMR VAEIRRKILF TLAMLIVFRI GTFIPVPFTN GDVLKAQDQL NALGILNTFG 

        70         80         90        100        110        120 
GGALKNFSIF AMGIMPYITA SIIVQLLQMD VVPKFSEWAK QGEMGRRKLT QFTRYFTIVL 

       130        140        150        160        170        180 
AFIQGFGMSI GFNGMVGGQL ILNPGWSTYL YIATVLTAGT AFLMWLGEQI TAKGVGNGIS 

       190        200        210        220        230        240 
ILIFGGIAAA IPSVISQVYQ QQFQNIGDQL FMSIVKVALI LLAVLAVIVG VIFIQQAVRK 

       250        260        270        280        290        300 
IPIQYAKRVT GGNGGYAGAQ NTHLPLKVNS AGVIPVIFAV SFLITPPTIA QFFPKHDVSQ 

       310        320        330        340        350        360 
WIIANFNYSH PVGMIIYVAL IVAFTYFYAF VQVNPEQMSE NLNKQGGYVP GIRPGKNTEQ 

       370        380        390        400        410        420 
YLTKILYRLT FVGSIFLAAI AILPVIFTKL GNLPPSAQIG GTSMLIVVGV ALETMKQLES 

       430 
QLVKRHYKGF IKQ

« Hide

References

[1]"Genome sequence of Bacillus anthracis A0389."
Dodson R.J., Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Sutton G., Brettin T.S.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A0389 EMBL EDS94559.1.
[2]Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S.
Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: A0389 EMBL EDS94559.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ABLB01000062 Genomic DNA. Translation: EDS94559.1.

3D structure databases

ProteinModelPortalB1F6N9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEDS94559; EDS94559; BAK_0152.
PATRIC24613063. VBIBacAnt25810_5601.

Phylogenomic databases

OMAFIMWLGE.

Family and domain databases

Gene3D1.10.3370.10. 1 hit.
HAMAPMF_01465. SecY.
InterProIPR026593. SecY.
IPR002208. SecY/SEC61-alpha.
IPR023201. SecY_su_dom.
[Graphical view]
PANTHERPTHR10906. PTHR10906. 1 hit.
PfamPF00344. SecY. 1 hit.
[Graphical view]
PIRSFPIRSF004557. SecY. 1 hit.
SUPFAMSSF103491. SecY. 1 hit.
TIGRFAMsTIGR00967. 3a0501s007. 1 hit.
PROSITEPS00755. SECY_1. 1 hit.
PS00756. SECY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB1F6N9_BACAN
AccessionPrimary (citable) accession number: B1F6N9
Entry history
Integrated into UniProtKB/TrEMBL: April 29, 2008
Last sequence update: April 29, 2008
Last modified: April 3, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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