B1EWX2 (B1EWX2_BACAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543 EMBL EDS97855.1
ORF Names:	BAK_2189 EMBL EDS97855.1

Organism

Bacillus anthracis str. A0389 EMBL EDS97855.1

Taxonomic identifier

486623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL EDS97855.1
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	71 – 78	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B1EWX2 [UniParc]. Last modified April 29, 2008. Version 1. Checksum: 39136D9134276E69	FASTA	562	60,489
	10 20 30 40 50 60 MTTTTTVKSD IEIAQEANMK KIQEIAADLN ILEDELEPYG HYKGKLSLDI FKRLQNEKDG 70 80 90 100 110 120 KVVLVTAINP TPAGEGKSTV TVGLGQAFNK IGKKTVIALR EPSLGPTMGL KGGAAGGGFS 130 140 150 160 170 180 QVVPMEDINL HFTGDIHAIT TANNALAAFI DNHIQQGNTL GIDTRKIVWK RCVDLNDRAL 190 200 210 220 230 240 RNVVIGLGGP VQGVPREDGF DITVASEIMA VFCLATDIQD LKARLSRIVV AYNFANQPVT 250 260 270 280 290 300 VKDLGVEGAL TLLLKDALKP NLVQTLENTP AIIHGGPFAN IAHGCNSVIA TTMAAKLGDY 310 320 330 340 350 360 VITEAGFGAD LGAEKFLDIK ARAAGIKPEA VVIVATIRAL KMHGGVAKDQ LKEENVDALA 370 380 390 400 410 420 KGMENLQKHV ETIQSFGVPF VIAINKFITD TDAEVAYLQE WCNERGYAVS LTEVWEKGGQ 430 440 450 460 470 480 GGVDLAEKVL KEIEKGENNY APLYELELPL EEKIRTIAQK VYGAKDIEFA PKARKQLAQY 490 500 510 520 530 540 EGEGWSNLPI CMAKTQYSLS DDATKLGRPS DFIVTIRELK PSIGAGFIVA LTGTMLTMPG 550 560 LPKQPAALQM DVNEDGKAVG LF

References

[1]	"Genome sequence of Bacillus anthracis A0389." Dodson R.J., Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Sutton G., Brettin T.S. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A0389 EMBL EDS97855.1.
[2]	Munk A.C., Tapia R., Green L., Rogers Y., Detter J.C., Bruce D., Brettin T.S. Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: A0389 EMBL EDS97855.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	ABLB01000005 Genomic DNA. Translation: EDS97855.1.
3D structure databases
ProteinModelPortal	B1EWX2.
SMR	B1EWX2. Positions 10-560.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	24605141. VBIBacAnt25810_1774.
Phylogenomic databases
OMA	EIMAVLC.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. PS00722. FTHFS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B1EWX2_BACAN

Accession

Primary (citable) accession number: B1EWX2

Entry history

Integrated into UniProtKB/TrEMBL:	April 29, 2008
Last sequence update:	April 29, 2008
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)