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Protein
Submitted name:

Paired box protein Pax-6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-6Imported
Gene namesi
Name:PAX6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8620. PAX6.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007372.

PTM / Processingi

Proteomic databases

PaxDbiB1B1I9.

Expressioni

Gene expression databases

BgeeiENSG00000007372.
ExpressionAtlasiB1B1I9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368401.

Structurei

3D structure databases

ProteinModelPortaliB1B1I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Paired boxPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00292. PAX. 1 hit.
PRINTSiPR00027. PAIREDBOX.
SMARTiView protein in SMART
SM00351. PAX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51057. PAIRED_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

B1B1I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA
60 70 80 90 100
DAKVQVLDNQ NVSNGCVSSI NRVLRNLASE KQQMGADGMY DKLRMLNGQT
110 120 130 140 150
GSWGTRPGWY PGTSVPGQPT QDGCQQQEGG GENTNSISSN GEDSDEAQMR
160 170 180 190 200
LQLKRKLQRN RTSFTQEQIE ALEKEFERTH YPDVFARERL AAKIDLPEAR
210 220 230 240 250
IQVWFSNRRA KWRREEKLRN QRRQASNTPS HIPISSSFST SVYQPIPQPT
260 270 280 290 300
TPVSSFTSGS MLGRTDTALT NTYSALPPMP SFTMANNLPM QPPVPSQTSS
310 320 330 340 350
YSCMLPTSPS VNGRSYDTYT PPHMQTHMNS QPMGTSGTTS TGLISPGVSV
360
PVQVPGSEPD MSQYWPR
Length:367
Mass (Da):40,514
Last modified:June 7, 2017 - v10
Checksum:i63E6AB9AF71E87E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei367Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83307 Genomic DNA. No translation available.
Z95332 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000423822; ENSP00000388132; ENSG00000007372.
UCSCiuc058acj.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83307 Genomic DNA. No translation available.
Z95332 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1B1I9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368401.

Proteomic databases

PaxDbiB1B1I9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000423822; ENSP00000388132; ENSG00000007372.
UCSCiuc058acj.1. human.

Organism-specific databases

HGNCiHGNC:8620. PAX6.
OpenTargetsiENSG00000007372.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00680000099553.
HOGENOMiHOG000230939.

Miscellaneous databases

ChiTaRSiPAX6. human.

Gene expression databases

BgeeiENSG00000007372.
ExpressionAtlasiB1B1I9. baseline and differential.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00292. PAX. 1 hit.
PRINTSiPR00027. PAIREDBOX.
SMARTiView protein in SMART
SM00351. PAX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51057. PAIRED_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB1B1I9_HUMAN
AccessioniPrimary (citable) accession number: B1B1I9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: June 7, 2017
Last modified: June 7, 2017
This is version 85 of the entry and version 10 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.