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Protein
Submitted name:

Paired box protein Pax-6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi157 – 216HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental proteinSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-6Imported
Gene namesi
Name:PAX6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000007372.20
HGNCiHGNC:8620 PAX6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000007372

PTM / Processingi

Proteomic databases

PeptideAtlasiB1B1I9

Expressioni

Gene expression databases

BgeeiENSG00000007372
ExpressionAtlasiB1B1I9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB1B1I9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 144PairedInterPro annotationAdd BLAST141
Domaini155 – 215HomeoboxInterPro annotationAdd BLAST61

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili155 – 175Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotation, Paired boxPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230939

Family and domain databases

CDDicd00086 homeodomain, 1 hit
Gene3Di1.10.10.101 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS51057 PAIRED_2, 1 hit

Sequencei

Sequence statusi: Fragment.

B1B1I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA
60 70 80 90 100
DAKVQVLDNQ NVSNGCVSSI NRVLRNLASE KQQMGADGMY DKLRMLNGQT
110 120 130 140 150
GSWGTRPGWY PGTSVPGQPT QDGCQQQEGG GENTNSISSN GEDSDEAQMR
160 170 180 190 200
LQLKRKLQRN RTSFTQEQIE ALEKEFERTH YPDVFARERL AAKIDLPEAR
210 220 230 240 250
IQVWFSNRRA KWRREEKLRN QRRQASNTPS HIPISSSFST SVYQPIPQPT
260 270 280 290 300
TPVSSFTSGS MLGRTDTALT NTYSALPPMP SFTMANNLPM QPPVPSQTSS
310 320 330 340 350
YSCMLPTSPS VNGRSYDTYT PPHMQTHMNS QPMGTSGTTS TGLISPGVSV
360
PVQVPGSEPD MSQYWPR
Length:367
Mass (Da):40,514
Last modified:June 7, 2017 - v10
Checksum:i63E6AB9AF71E87E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei367Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83307 Genomic DNA No translation available.
Z95332 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000423822; ENSP00000388132; ENSG00000007372
UCSCiuc058acj.1 human

Similar proteinsi

Entry informationi

Entry nameiB1B1I9_HUMAN
AccessioniPrimary (citable) accession number: B1B1I9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: June 7, 2017
Last modified: April 25, 2018
This is version 95 of the entry and version 10 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported