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B1B1I9

- B1B1I9_HUMAN

UniProt

B1B1I9 - B1B1I9_HUMAN

Protein
Submitted name:

Paired box protein Pax-6

Gene

PAX6

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. AT DNA binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

    GO - Biological processi

    1. astrocyte differentiation Source: Ensembl
    2. axon guidance Source: Ensembl
    3. cell fate determination Source: Ensembl
    4. cerebral cortex regionalization Source: Ensembl
    5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
    6. dorsal/ventral axis specification Source: Ensembl
    7. embryonic camera-type eye morphogenesis Source: Ensembl
    8. eye photoreceptor cell development Source: Ensembl
    9. forebrain anterior/posterior pattern specification Source: Ensembl
    10. forebrain dorsal/ventral pattern formation Source: Ensembl
    11. forebrain-midbrain boundary formation Source: Ensembl
    12. hindbrain development Source: Ensembl
    13. keratinocyte differentiation Source: Ensembl
    14. lacrimal gland development Source: Ensembl
    15. lens development in camera-type eye Source: Ensembl
    16. negative regulation of epithelial cell proliferation Source: Ensembl
    17. negative regulation of neuron differentiation Source: Ensembl
    18. neuron migration Source: Ensembl
    19. oligodendrocyte cell fate specification Source: Ensembl
    20. pancreatic A cell development Source: Ensembl
    21. pituitary gland development Source: Ensembl
    22. positive regulation of cell fate specification Source: Ensembl
    23. positive regulation of epithelial cell differentiation Source: Ensembl
    24. positive regulation of neuroblast proliferation Source: Ensembl
    25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    26. protein localization to organelle Source: Ensembl
    27. regulation of cell migration Source: Ensembl
    28. regulation of timing of cell differentiation Source: Ensembl
    29. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
    30. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
    31. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
    32. salivary gland morphogenesis Source: Ensembl
    33. signal transduction involved in regulation of gene expression Source: Ensembl
    34. smoothened signaling pathway Source: Ensembl
    35. type B pancreatic cell differentiation Source: Ensembl

    Keywords - Molecular functioni

    Developmental proteinUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Paired box protein Pax-6Imported
    Gene namesi
    Name:PAX6Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8620. PAX6.

    Subcellular locationi

    Nucleus UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiB1B1I9.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 paired domain.UniRule annotation
    Contains paired domain.SAAS annotation

    Keywords - Domaini

    Paired boxUniRule annotationSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000230939.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B1B1I9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGARPC DISRILQTHA   50
    DAKVQVLDNQ N 61
    Length:61
    Mass (Da):6,619
    Last modified:May 14, 2014 - v3
    Checksum:i185CD25A0949908A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei61 – 611Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z83307 Genomic DNA. No translation available.
    Z95332 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000423822; ENSP00000388132; ENSG00000007372.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z83307 Genomic DNA. No translation available.
    Z95332 Genomic DNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000423822 ; ENSP00000388132 ; ENSG00000007372 .

    Organism-specific databases

    HGNCi HGNC:8620. PAX6.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000230939.

    Miscellaneous databases

    NextBioi 35467030.

    Gene expression databases

    ArrayExpressi B1B1I9.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (SEP-2013) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiB1B1I9_HUMAN
    AccessioniPrimary (citable) accession number: B1B1I9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: May 14, 2014
    Last modified: October 1, 2014
    This is version 60 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3