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B1B1I8

- B1B1I8_HUMAN

UniProt

B1B1I8 - B1B1I8_HUMAN

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Protein
Submitted name: Paired box protein Pax-6
Gene
PAX6
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. AT DNA binding Source: Ensembl
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  3. double-stranded DNA binding Source: Ensembl
  4. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: Ensembl

GO - Biological processi

  1. astrocyte differentiation Source: Ensembl
  2. axon guidance Source: Ensembl
  3. cell fate determination Source: Ensembl
  4. cerebral cortex regionalization Source: Ensembl
  5. commitment of neuronal cell to specific neuron type in forebrain Source: Ensembl
  6. dorsal/ventral axis specification Source: Ensembl
  7. embryonic camera-type eye morphogenesis Source: Ensembl
  8. eye photoreceptor cell development Source: Ensembl
  9. forebrain anterior/posterior pattern specification Source: Ensembl
  10. forebrain dorsal/ventral pattern formation Source: Ensembl
  11. forebrain-midbrain boundary formation Source: Ensembl
  12. hindbrain development Source: Ensembl
  13. keratinocyte differentiation Source: Ensembl
  14. lacrimal gland development Source: Ensembl
  15. lens development in camera-type eye Source: Ensembl
  16. negative regulation of epithelial cell proliferation Source: Ensembl
  17. negative regulation of neuron differentiation Source: Ensembl
  18. neuron migration Source: Ensembl
  19. oligodendrocyte cell fate specification Source: Ensembl
  20. pancreatic A cell development Source: Ensembl
  21. pituitary gland development Source: Ensembl
  22. positive regulation of cell fate specification Source: Ensembl
  23. positive regulation of epithelial cell differentiation Source: Ensembl
  24. positive regulation of neuroblast proliferation Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  26. protein localization to organelle Source: Ensembl
  27. regulation of cell migration Source: Ensembl
  28. regulation of timing of cell differentiation Source: Ensembl
  29. regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment Source: Ensembl
  30. regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification Source: Ensembl
  31. regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification Source: Ensembl
  32. salivary gland morphogenesis Source: Ensembl
  33. signal transduction involved in regulation of gene expression Source: Ensembl
  34. smoothened signaling pathway Source: Ensembl
  35. type B pancreatic cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Paired box protein Pax-6Imported
Gene namesi
Name:PAX6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8620. PAX6.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nuclear chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiB1B1I8.

Expressioni

Gene expression databases

ArrayExpressiB1B1I8.

Structurei

3D structure databases

ProteinModelPortaliB1B1I8.

Family & Domainsi

Sequence similaritiesi

Contains 1 paired domain.UniRule annotation

Keywords - Domaini

Paired boxUniRule annotation

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00292. PAX. 1 hit.
[Graphical view]
PRINTSiPR00027. PAIREDBOX.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51057. PAIRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1B1I8-1 [UniParc]FASTAAdd to Basket

« Hide

MQNSHSGVNQ LGGVFVNGRP LPDSTRQKIV ELAHSGAR                38
Length:38
Mass (Da):4,059
Last modified:May 14, 2014 - v2
Checksum:i88A9798F17EE24F3
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei38 – 381Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z83307 Genomic DNA. No translation available.
Z95332 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000438681; ENSP00000404356; ENSG00000007372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z83307 Genomic DNA. No translation available.
Z95332 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali B1B1I8.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B1B1I8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000438681 ; ENSP00000404356 ; ENSG00000007372 .

Organism-specific databases

HGNCi HGNC:8620. PAX6.
GenAtlasi Search...

Miscellaneous databases

NextBioi 35467029.

Gene expression databases

ArrayExpressi B1B1I8.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00292. PAX. 1 hit.
[Graphical view ]
PRINTSi PR00027. PAIREDBOX.
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS51057. PAIRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB1B1I8_HUMAN
AccessioniPrimary (citable) accession number: B1B1I8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: May 14, 2014
Last modified: July 9, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi