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Protein
Submitted name:

Myosin light chain kinase, smooth muscle

Gene

Mylk

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin-dependent protein kinase activity Source: GO_Central
  3. myosin light chain kinase activity Source: MGI

GO - Biological processi

  1. actin filament organization Source: GO_Central
  2. aorta smooth muscle tissue morphogenesis Source: MGI
  3. bleb assembly Source: MGI
  4. cellular hypotonic response Source: MGI
  5. positive regulation of calcium ion transport Source: MGI
  6. positive regulation of cell migration Source: MGI
  7. positive regulation of wound healing Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_324232. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin light chain kinase, smooth muscleImported
Submitted name:
Myosin, light polypeptide kinaseImported
Gene namesi
Name:MylkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:894806. Mylk.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cleavage furrow Source: MGI
  3. cytoplasm Source: MGI
  4. extracellular vesicular exosome Source: MGI
  5. lamellipodium Source: MGI
  6. stress fiber Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiB1B1A8.
PRIDEiB1B1A8.

Expressioni

Gene expression databases

BgeeiB1B1A8.
ExpressionAtlasiB1B1A8. baseline and differential.
GenevestigatoriB1B1A8.

Structurei

3D structure databases

ProteinModelPortaliB1B1A8.
SMRiB1B1A8. Positions 508-598, 1269-1369, 1832-1933.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118877.
HOGENOMiHOG000049287.
HOVERGENiHBG052551.
KOiK00907.
OMAiKFIILSQ.
OrthoDBiEOG7WQ7RC.
PhylomeDBiB1B1A8.
TreeFamiTF314166.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR020675. Myosin_light_ch_kinase-rel.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR015725. Telokin/Myosin_light_ch_kin.
[Graphical view]
PANTHERiPTHR22964. PTHR22964. 1 hit.
PTHR22964:SF44. PTHR22964:SF44. 1 hit.
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 9 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1B1A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGQLPGKTM GDVKLFASSH MSKTSHSVDP SKVSSMPLTE APAFILPPRN
60 70 80 90 100
LCVKEGATAK FEGRVRGYPE PQVTWHRKGQ AITNGGRFLL DCGVRGTFSL
110 120 130 140 150
VIHTVREEDK GKYTCEASNG SGARQVTVEL TVEGNSMKKR DQPVLSKASG
160 170 180 190 200
FPGETRPSIW GECPPKFATK LGRAVVKEGQ MGRFSCKITG RPPPQVTWLK
210 220 230 240 250
GNVPLQPSAR VSMSEKNGMQ ILEIRGVTRD DLGVYTCMVV NGSGKASMSA
260 270 280 290 300
ELSIPGLDNA ARLAVRGTKA PSPDIRKEVT NGVSKDPETV AESKNCPSPQ
310 320 330 340 350
RSGSSARATN SHLKSPQEPK PKLCEDAPRK VPQSSILQKS TSTITLQALK
360 370 380 390 400
VQPEARVPAI GSFSPGEDRK SLAAPQQATL PTRQSSLGGS VGNKFVTGNI
410 420 430 440 450
PRESQRESTF PRFESQPQSQ EVTEGQTVKF ICEVSGIPKP DVGWFLEGIP
460 470 480 490 500
VRRREGITEV YEDGVSHHLC LLRARTRDSG RYSCTASNSL GQVSCSWSLL
510 520 530 540 550
VDRPNLAQTA PSFSSVLKDS VVIEGQDFVL RCSVQGTPAP RVTWLLNGQP
560 570 580 590 600
IQFAHSICEA GVAELHIQDA LPEDRGTYTC LAENAMGQVS CSATVTVQEK
610 620 630 640 650
KGEGEREHRL SPARSKPIAP IFLQGLSDLK VMDGSQVTMT VQVSGNPPPE
660 670 680 690 700
VIWLHDGNEI QESEDFHFEQ KGGWHSLCIQ EVFPEDTGTY TCEAWNSAGE
710 720 730 740 750
VRTRAVLTVQ EPHDGTQPWF ISKPRSVTAT LGQSVLISCA IAGDPFPTVH
760 770 780 790 800
WLRDGRALSK DSGHFELLQN EDVFTLVLKN VQPWHAGQYE ILLKNRVGEC
810 820 830 840 850
SCQVSLMLHN SPSRAPPRGR EPASCEGLCG GGGVGAHGDG DRHGTLRPCW
860 870 880 890 900
PARGQGWPEE EDGEDVRGLL KRRVETRLHT EEAIRQQEVG QLDFRDLLGK
910 920 930 940 950
KVSTKTVSED DLKDIPAEQM DFRANLQRQV KPKTISEEER KVHSPQQVDF
960 970 980 990 1000
RSVLAKKGTP KTPVPEKAPP KAATPDFRSV LGGKKKSPSE NGGNSAEVLN
1010 1020 1030 1040 1050
VKAGESPTPA GDAQAIGALK PVGNAKPAET PKPIGNAKPT ETLKPVGNTK
1060 1070 1080 1090 1100
PAETLKPIAN AQPSGSLKPV TNAQPAEPQK PVGNAKSAET SKPAGKEEVK
1110 1120 1130 1140 1150
EVKNDVNCKK GQVGATGNEK RPESQGSAPV FKEKLQDVHV AEGEKLLLQC
1160 1170 1180 1190 1200
QVISDPPATV TWSLNGKTLK TTKFIVLAQE GSRFSVSIEK ALPEDRGLYK
1210 1220 1230 1240 1250
CVAKNSAGQA ECSCQVTVDD AQTSENTKAP EMKSRRPKSS LPPVLGTESD
1260 1270 1280 1290 1300
ATVKKKPAPK TPTKAAMPPQ IIQFPEDQKV RAGEPVELFG KVAGTQPITC
1310 1320 1330 1340 1350
KWMKFRKQIQ ESEHIKVENG ESGSKLTILA ARQEHCGCYT LVVENKLGSR
1360 1370 1380 1390 1400
QAQVNLTVVD KPDPPAGTPC ASDIRSSSLT LSWYGSSYDG GSAVQSYNVE
1410 1420 1430 1440 1450
IWDTEDKVWK ELATCRSTSF NVQDLLPDRE YKFRVRAVNV YGTSEPSQES
1460 1470 1480 1490 1500
ELTAVGEKPE EPKDEVEVSD DDEKEPEVDY RTVTVNTEQK VSDVYDIEER
1510 1520 1530 1540 1550
LGSGKFGQVF RLVEKKTGKI WAGKFFKAYS AKEKDNIRQE ISIMNCLHHP
1560 1570 1580 1590 1600
KLVQCVDAFE EKANIVMVLE IVSGGELFER IIDEDFELTE RECIKYMRQI
1610 1620 1630 1640 1650
SEGVEYIHKQ GIVHLDLKPE NIMCVNKTGT RIKLIDFGLA RRLENAGSLK
1660 1670 1680 1690 1700
VLFGTPEFVA PEVINYEPIG YATDMWSIGV ICYILVSGLS PFMGDNDNET
1710 1720 1730 1740 1750
LANVTSATWD FDDEAFDEIS DDAKDFISNL LKKDMKNRLD CTQCLQHPWL
1760 1770 1780 1790 1800
MKDTKNMEAK KLSKDRMKKY MARRKWQKTG NAVRAIGRLS SMAMISGLSG
1810 1820 1830 1840 1850
RKSSTGSPTS PINAEKLESE DDVSQAFLEA VAEEKPHVKP YFSKTIRDLE
1860 1870 1880 1890 1900
VVEGSAARFD CKIEGYPDPE VVWFKDDQSI RESRHFQIDY DEDGNCSLII
1910 1920 1930 1940 1950
SDVCGDDDAK YTCKAVNSLG EATCTAELIV ETMEEGEGEE GGEEEEEEEE
Length:1,950
Mass (Da):213,609
Last modified:April 7, 2008 - v1
Checksum:iC6FA116BCD821661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110166 Genomic DNA. No translation available.
AC154813 Genomic DNA. No translation available.
CT010574 Genomic DNA. No translation available.
BC145279 mRNA. Translation: AAI45280.1.
BC150749 mRNA. Translation: AAI50750.1.
RefSeqiNP_647461.3. NM_139300.3.
UniGeneiMm.33360.

Genome annotation databases

EnsembliENSMUST00000023538; ENSMUSP00000023538; ENSMUSG00000022836.
GeneIDi107589.
KEGGimmu:107589.
UCSCiuc007zbd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110166 Genomic DNA. No translation available.
AC154813 Genomic DNA. No translation available.
CT010574 Genomic DNA. No translation available.
BC145279 mRNA. Translation: AAI45280.1.
BC150749 mRNA. Translation: AAI50750.1.
RefSeqiNP_647461.3. NM_139300.3.
UniGeneiMm.33360.

3D structure databases

ProteinModelPortaliB1B1A8.
SMRiB1B1A8. Positions 508-598, 1269-1369, 1832-1933.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiB1B1A8.
PRIDEiB1B1A8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023538; ENSMUSP00000023538; ENSMUSG00000022836.
GeneIDi107589.
KEGGimmu:107589.
UCSCiuc007zbd.1. mouse.

Organism-specific databases

CTDi4638.
MGIiMGI:894806. Mylk.

Phylogenomic databases

GeneTreeiENSGT00760000118877.
HOGENOMiHOG000049287.
HOVERGENiHBG052551.
KOiK00907.
OMAiKFIILSQ.
OrthoDBiEOG7WQ7RC.
PhylomeDBiB1B1A8.
TreeFamiTF314166.

Enzyme and pathway databases

ReactomeiREACT_324232. Smooth Muscle Contraction.

Miscellaneous databases

ChiTaRSiMylk. mouse.
NextBioi359102.
SOURCEiSearch...

Gene expression databases

BgeeiB1B1A8.
ExpressionAtlasiB1B1A8. baseline and differential.
GenevestigatoriB1B1A8.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR020675. Myosin_light_ch_kinase-rel.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR015725. Telokin/Myosin_light_ch_kin.
[Graphical view]
PANTHERiPTHR22964. PTHR22964. 1 hit.
PTHR22964:SF44. PTHR22964:SF44. 1 hit.
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 9 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1B1A8_MOUSE
AccessioniPrimary (citable) accession number: B1B1A8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 7, 2008
Last sequence update: April 7, 2008
Last modified: March 31, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.