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B1B1A8 (B1B1A8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Myosin, light polypeptide kinase EMBL AAI45280.1
Gene names
Name:Mylk EMBL AAI45280.1 Ensembl ENSMUSP00000023538 MGI 894806
OrganismMus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000023538
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1950 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   DomainRepeat SAAS SAAS013098
   LigandATP-binding SAAS SAAS013098
Nucleotide-binding
   Molecular functionKinase SAAS SAAS013098 EMBL AAI45280.1
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactin filament organization

Inferred from Biological aspect of Ancestor. Source: RefGenome

aorta smooth muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

bleb assembly

Inferred from electronic annotation. Source: Ensembl

cellular hypotonic response

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion transport

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from Biological aspect of Ancestor. Source: RefGenome

positive regulation of wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcell-cell junction

Inferred from direct assay PubMed 23793062. Source: MGI

cleavage furrow

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

lamellipodium

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: Ensembl

stress fiber

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

calmodulin-dependent protein kinase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

myosin light chain kinase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B1B1A8 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: C6FA116BCD821661

FASTA1,950213,609
        10         20         30         40         50         60 
MSGQLPGKTM GDVKLFASSH MSKTSHSVDP SKVSSMPLTE APAFILPPRN LCVKEGATAK 

        70         80         90        100        110        120 
FEGRVRGYPE PQVTWHRKGQ AITNGGRFLL DCGVRGTFSL VIHTVREEDK GKYTCEASNG 

       130        140        150        160        170        180 
SGARQVTVEL TVEGNSMKKR DQPVLSKASG FPGETRPSIW GECPPKFATK LGRAVVKEGQ 

       190        200        210        220        230        240 
MGRFSCKITG RPPPQVTWLK GNVPLQPSAR VSMSEKNGMQ ILEIRGVTRD DLGVYTCMVV 

       250        260        270        280        290        300 
NGSGKASMSA ELSIPGLDNA ARLAVRGTKA PSPDIRKEVT NGVSKDPETV AESKNCPSPQ 

       310        320        330        340        350        360 
RSGSSARATN SHLKSPQEPK PKLCEDAPRK VPQSSILQKS TSTITLQALK VQPEARVPAI 

       370        380        390        400        410        420 
GSFSPGEDRK SLAAPQQATL PTRQSSLGGS VGNKFVTGNI PRESQRESTF PRFESQPQSQ 

       430        440        450        460        470        480 
EVTEGQTVKF ICEVSGIPKP DVGWFLEGIP VRRREGITEV YEDGVSHHLC LLRARTRDSG 

       490        500        510        520        530        540 
RYSCTASNSL GQVSCSWSLL VDRPNLAQTA PSFSSVLKDS VVIEGQDFVL RCSVQGTPAP 

       550        560        570        580        590        600 
RVTWLLNGQP IQFAHSICEA GVAELHIQDA LPEDRGTYTC LAENAMGQVS CSATVTVQEK 

       610        620        630        640        650        660 
KGEGEREHRL SPARSKPIAP IFLQGLSDLK VMDGSQVTMT VQVSGNPPPE VIWLHDGNEI 

       670        680        690        700        710        720 
QESEDFHFEQ KGGWHSLCIQ EVFPEDTGTY TCEAWNSAGE VRTRAVLTVQ EPHDGTQPWF 

       730        740        750        760        770        780 
ISKPRSVTAT LGQSVLISCA IAGDPFPTVH WLRDGRALSK DSGHFELLQN EDVFTLVLKN 

       790        800        810        820        830        840 
VQPWHAGQYE ILLKNRVGEC SCQVSLMLHN SPSRAPPRGR EPASCEGLCG GGGVGAHGDG 

       850        860        870        880        890        900 
DRHGTLRPCW PARGQGWPEE EDGEDVRGLL KRRVETRLHT EEAIRQQEVG QLDFRDLLGK 

       910        920        930        940        950        960 
KVSTKTVSED DLKDIPAEQM DFRANLQRQV KPKTISEEER KVHSPQQVDF RSVLAKKGTP 

       970        980        990       1000       1010       1020 
KTPVPEKAPP KAATPDFRSV LGGKKKSPSE NGGNSAEVLN VKAGESPTPA GDAQAIGALK 

      1030       1040       1050       1060       1070       1080 
PVGNAKPAET PKPIGNAKPT ETLKPVGNTK PAETLKPIAN AQPSGSLKPV TNAQPAEPQK 

      1090       1100       1110       1120       1130       1140 
PVGNAKSAET SKPAGKEEVK EVKNDVNCKK GQVGATGNEK RPESQGSAPV FKEKLQDVHV 

      1150       1160       1170       1180       1190       1200 
AEGEKLLLQC QVISDPPATV TWSLNGKTLK TTKFIVLAQE GSRFSVSIEK ALPEDRGLYK 

      1210       1220       1230       1240       1250       1260 
CVAKNSAGQA ECSCQVTVDD AQTSENTKAP EMKSRRPKSS LPPVLGTESD ATVKKKPAPK 

      1270       1280       1290       1300       1310       1320 
TPTKAAMPPQ IIQFPEDQKV RAGEPVELFG KVAGTQPITC KWMKFRKQIQ ESEHIKVENG 

      1330       1340       1350       1360       1370       1380 
ESGSKLTILA ARQEHCGCYT LVVENKLGSR QAQVNLTVVD KPDPPAGTPC ASDIRSSSLT 

      1390       1400       1410       1420       1430       1440 
LSWYGSSYDG GSAVQSYNVE IWDTEDKVWK ELATCRSTSF NVQDLLPDRE YKFRVRAVNV 

      1450       1460       1470       1480       1490       1500 
YGTSEPSQES ELTAVGEKPE EPKDEVEVSD DDEKEPEVDY RTVTVNTEQK VSDVYDIEER 

      1510       1520       1530       1540       1550       1560 
LGSGKFGQVF RLVEKKTGKI WAGKFFKAYS AKEKDNIRQE ISIMNCLHHP KLVQCVDAFE 

      1570       1580       1590       1600       1610       1620 
EKANIVMVLE IVSGGELFER IIDEDFELTE RECIKYMRQI SEGVEYIHKQ GIVHLDLKPE 

      1630       1640       1650       1660       1670       1680 
NIMCVNKTGT RIKLIDFGLA RRLENAGSLK VLFGTPEFVA PEVINYEPIG YATDMWSIGV 

      1690       1700       1710       1720       1730       1740 
ICYILVSGLS PFMGDNDNET LANVTSATWD FDDEAFDEIS DDAKDFISNL LKKDMKNRLD 

      1750       1760       1770       1780       1790       1800 
CTQCLQHPWL MKDTKNMEAK KLSKDRMKKY MARRKWQKTG NAVRAIGRLS SMAMISGLSG 

      1810       1820       1830       1840       1850       1860 
RKSSTGSPTS PINAEKLESE DDVSQAFLEA VAEEKPHVKP YFSKTIRDLE VVEGSAARFD 

      1870       1880       1890       1900       1910       1920 
CKIEGYPDPE VVWFKDDQSI RESRHFQIDY DEDGNCSLII SDVCGDDDAK YTCKAVNSLG 

      1930       1940       1950 
EATCTAELIV ETMEEGEGEE GGEEEEEEEE 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain EMBL AAI45280.1.
[2]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000023538.
[4]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000023538.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC110166 Genomic DNA. No translation available.
AC154813 Genomic DNA. No translation available.
CT010574 Genomic DNA. No translation available.
BC145279 mRNA. Translation: AAI45280.1.
BC150749 mRNA. Translation: AAI50750.1.
RefSeqNP_647461.3. NM_139300.3.
UniGeneMm.33360.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023538; ENSMUSP00000023538; ENSMUSG00000022836.
GeneID107589.
KEGGmmu:107589.
UCSCuc007zbd.1. mouse.

Organism-specific databases

CTD4638.
MGIMGI:894806. Mylk.

Phylogenomic databases

GeneTreeENSGT00740000114993.
HOGENOMHOG000049287.
HOVERGENHBG052551.
InParanoidB1B1A8.
KOK00907.
OMAKFIILSQ.
OrthoDBEOG7WQ7RC.
TreeFamTF314166.

Gene expression databases

GenevestigatorB1B1A8.

Family and domain databases

Gene3D2.60.40.10. 10 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR020675. Myosin_light_ch_kinase-rel.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015725. Telokin/Myosin_light_ch_kin.
[Graphical view]
PANTHERPTHR22964. PTHR22964. 1 hit.
PTHR22964:SF44. PTHR22964:SF44. 1 hit.
PfamPF00041. fn3. 1 hit.
PF07679. I-set. 9 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMYLK. mouse.
NextBio359102.
SOURCESearch...

Entry information

Entry nameB1B1A8_MOUSE
AccessionPrimary (citable) accession number: B1B1A8
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)