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B1B1A8

- B1B1A8_MOUSE

UniProt

B1B1A8 - B1B1A8_MOUSE

Protein
Submitted name:

Myosin light chain kinase, smooth muscle

Gene

Mylk

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calmodulin-dependent protein kinase activity Source: RefGenome
    3. myosin light chain kinase activity Source: RefGenome

    GO - Biological processi

    1. actin filament organization Source: RefGenome
    2. aorta smooth muscle tissue morphogenesis Source: Ensembl
    3. bleb assembly Source: Ensembl
    4. cellular hypotonic response Source: Ensembl
    5. positive regulation of calcium ion transport Source: Ensembl
    6. positive regulation of cell migration Source: RefGenome
    7. positive regulation of wound healing Source: Ensembl

    Keywords - Molecular functioni

    KinaseSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Myosin light chain kinase, smooth muscleImported
    Submitted name:
    Myosin, light polypeptide kinaseImported
    Gene namesi
    Name:MylkImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:894806. Mylk.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. cleavage furrow Source: Ensembl
    3. cytoplasm Source: Ensembl
    4. lamellipodium Source: Ensembl
    5. plasma membrane Source: Ensembl
    6. stress fiber Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriB1B1A8.

    Family & Domainsi

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000114993.
    HOGENOMiHOG000049287.
    HOVERGENiHBG052551.
    InParanoidiB1B1A8.
    KOiK00907.
    OMAiKFIILSQ.
    OrthoDBiEOG7WQ7RC.
    TreeFamiTF314166.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR020675. Myosin_light_ch_kinase-rel.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015725. Telokin/Myosin_light_ch_kin.
    [Graphical view]
    PANTHERiPTHR22964. PTHR22964. 1 hit.
    PTHR22964:SF44. PTHR22964:SF44. 1 hit.
    PfamiPF00041. fn3. 1 hit.
    PF07679. I-set. 9 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 8 hits.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50853. FN3. 1 hit.
    PS50835. IG_LIKE. 9 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1B1A8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGQLPGKTM GDVKLFASSH MSKTSHSVDP SKVSSMPLTE APAFILPPRN     50
    LCVKEGATAK FEGRVRGYPE PQVTWHRKGQ AITNGGRFLL DCGVRGTFSL 100
    VIHTVREEDK GKYTCEASNG SGARQVTVEL TVEGNSMKKR DQPVLSKASG 150
    FPGETRPSIW GECPPKFATK LGRAVVKEGQ MGRFSCKITG RPPPQVTWLK 200
    GNVPLQPSAR VSMSEKNGMQ ILEIRGVTRD DLGVYTCMVV NGSGKASMSA 250
    ELSIPGLDNA ARLAVRGTKA PSPDIRKEVT NGVSKDPETV AESKNCPSPQ 300
    RSGSSARATN SHLKSPQEPK PKLCEDAPRK VPQSSILQKS TSTITLQALK 350
    VQPEARVPAI GSFSPGEDRK SLAAPQQATL PTRQSSLGGS VGNKFVTGNI 400
    PRESQRESTF PRFESQPQSQ EVTEGQTVKF ICEVSGIPKP DVGWFLEGIP 450
    VRRREGITEV YEDGVSHHLC LLRARTRDSG RYSCTASNSL GQVSCSWSLL 500
    VDRPNLAQTA PSFSSVLKDS VVIEGQDFVL RCSVQGTPAP RVTWLLNGQP 550
    IQFAHSICEA GVAELHIQDA LPEDRGTYTC LAENAMGQVS CSATVTVQEK 600
    KGEGEREHRL SPARSKPIAP IFLQGLSDLK VMDGSQVTMT VQVSGNPPPE 650
    VIWLHDGNEI QESEDFHFEQ KGGWHSLCIQ EVFPEDTGTY TCEAWNSAGE 700
    VRTRAVLTVQ EPHDGTQPWF ISKPRSVTAT LGQSVLISCA IAGDPFPTVH 750
    WLRDGRALSK DSGHFELLQN EDVFTLVLKN VQPWHAGQYE ILLKNRVGEC 800
    SCQVSLMLHN SPSRAPPRGR EPASCEGLCG GGGVGAHGDG DRHGTLRPCW 850
    PARGQGWPEE EDGEDVRGLL KRRVETRLHT EEAIRQQEVG QLDFRDLLGK 900
    KVSTKTVSED DLKDIPAEQM DFRANLQRQV KPKTISEEER KVHSPQQVDF 950
    RSVLAKKGTP KTPVPEKAPP KAATPDFRSV LGGKKKSPSE NGGNSAEVLN 1000
    VKAGESPTPA GDAQAIGALK PVGNAKPAET PKPIGNAKPT ETLKPVGNTK 1050
    PAETLKPIAN AQPSGSLKPV TNAQPAEPQK PVGNAKSAET SKPAGKEEVK 1100
    EVKNDVNCKK GQVGATGNEK RPESQGSAPV FKEKLQDVHV AEGEKLLLQC 1150
    QVISDPPATV TWSLNGKTLK TTKFIVLAQE GSRFSVSIEK ALPEDRGLYK 1200
    CVAKNSAGQA ECSCQVTVDD AQTSENTKAP EMKSRRPKSS LPPVLGTESD 1250
    ATVKKKPAPK TPTKAAMPPQ IIQFPEDQKV RAGEPVELFG KVAGTQPITC 1300
    KWMKFRKQIQ ESEHIKVENG ESGSKLTILA ARQEHCGCYT LVVENKLGSR 1350
    QAQVNLTVVD KPDPPAGTPC ASDIRSSSLT LSWYGSSYDG GSAVQSYNVE 1400
    IWDTEDKVWK ELATCRSTSF NVQDLLPDRE YKFRVRAVNV YGTSEPSQES 1450
    ELTAVGEKPE EPKDEVEVSD DDEKEPEVDY RTVTVNTEQK VSDVYDIEER 1500
    LGSGKFGQVF RLVEKKTGKI WAGKFFKAYS AKEKDNIRQE ISIMNCLHHP 1550
    KLVQCVDAFE EKANIVMVLE IVSGGELFER IIDEDFELTE RECIKYMRQI 1600
    SEGVEYIHKQ GIVHLDLKPE NIMCVNKTGT RIKLIDFGLA RRLENAGSLK 1650
    VLFGTPEFVA PEVINYEPIG YATDMWSIGV ICYILVSGLS PFMGDNDNET 1700
    LANVTSATWD FDDEAFDEIS DDAKDFISNL LKKDMKNRLD CTQCLQHPWL 1750
    MKDTKNMEAK KLSKDRMKKY MARRKWQKTG NAVRAIGRLS SMAMISGLSG 1800
    RKSSTGSPTS PINAEKLESE DDVSQAFLEA VAEEKPHVKP YFSKTIRDLE 1850
    VVEGSAARFD CKIEGYPDPE VVWFKDDQSI RESRHFQIDY DEDGNCSLII 1900
    SDVCGDDDAK YTCKAVNSLG EATCTAELIV ETMEEGEGEE GGEEEEEEEE 1950
    Length:1,950
    Mass (Da):213,609
    Last modified:April 8, 2008 - v1
    Checksum:iC6FA116BCD821661
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC110166 Genomic DNA. No translation available.
    AC154813 Genomic DNA. No translation available.
    CT010574 Genomic DNA. No translation available.
    BC145279 mRNA. Translation: AAI45280.1.
    BC150749 mRNA. Translation: AAI50750.1.
    RefSeqiNP_647461.3. NM_139300.3.
    UniGeneiMm.33360.

    Genome annotation databases

    EnsembliENSMUST00000023538; ENSMUSP00000023538; ENSMUSG00000022836.
    GeneIDi107589.
    KEGGimmu:107589.
    UCSCiuc007zbd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC110166 Genomic DNA. No translation available.
    AC154813 Genomic DNA. No translation available.
    CT010574 Genomic DNA. No translation available.
    BC145279 mRNA. Translation: AAI45280.1 .
    BC150749 mRNA. Translation: AAI50750.1 .
    RefSeqi NP_647461.3. NM_139300.3.
    UniGenei Mm.33360.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023538 ; ENSMUSP00000023538 ; ENSMUSG00000022836 .
    GeneIDi 107589.
    KEGGi mmu:107589.
    UCSCi uc007zbd.1. mouse.

    Organism-specific databases

    CTDi 4638.
    MGIi MGI:894806. Mylk.

    Phylogenomic databases

    GeneTreei ENSGT00740000114993.
    HOGENOMi HOG000049287.
    HOVERGENi HBG052551.
    InParanoidi B1B1A8.
    KOi K00907.
    OMAi KFIILSQ.
    OrthoDBi EOG7WQ7RC.
    TreeFami TF314166.

    Miscellaneous databases

    ChiTaRSi MYLK. mouse.
    NextBioi 359102.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori B1B1A8.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR011009. Kinase-like_dom.
    IPR020675. Myosin_light_ch_kinase-rel.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR015725. Telokin/Myosin_light_ch_kin.
    [Graphical view ]
    PANTHERi PTHR22964. PTHR22964. 1 hit.
    PTHR22964:SF44. PTHR22964:SF44. 1 hit.
    Pfami PF00041. fn3. 1 hit.
    PF07679. I-set. 9 hits.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 8 hits.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50853. FN3. 1 hit.
    PS50835. IG_LIKE. 9 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: BrainImported.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB1B1A8_MOUSE
    AccessioniPrimary (citable) accession number: B1B1A8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3