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B1B1A8

- B1B1A8_MOUSE

UniProt

B1B1A8 - B1B1A8_MOUSE

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Protein
Submitted name: Myosin light chain kinase, smooth muscle
Gene
Mylk
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calmodulin-dependent protein kinase activity Source: RefGenome
  3. myosin light chain kinase activity Source: RefGenome

GO - Biological processi

  1. actin filament organization Source: RefGenome
  2. aorta smooth muscle tissue morphogenesis Source: Ensembl
  3. bleb assembly Source: Ensembl
  4. cellular hypotonic response Source: Ensembl
  5. positive regulation of calcium ion transport Source: Ensembl
  6. positive regulation of cell migration Source: RefGenome
  7. positive regulation of wound healing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationsImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin light chain kinase, smooth muscleImported
Submitted name:
Myosin, light polypeptide kinaseImported
Gene namesi
Name:MylkImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:894806. Mylk.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cleavage furrow Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. lamellipodium Source: Ensembl
  5. plasma membrane Source: Ensembl
  6. stress fiber Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriB1B1A8.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00740000114993.
HOGENOMiHOG000049287.
HOVERGENiHBG052551.
InParanoidiB1B1A8.
KOiK00907.
OMAiKFIILSQ.
OrthoDBiEOG7WQ7RC.
TreeFamiTF314166.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR020675. Myosin_light_ch_kinase-rel.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015725. Telokin/Myosin_light_ch_kin.
[Graphical view]
PANTHERiPTHR22964. PTHR22964. 1 hit.
PTHR22964:SF44. PTHR22964:SF44. 1 hit.
PfamiPF00041. fn3. 1 hit.
PF07679. I-set. 9 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50853. FN3. 1 hit.
PS50835. IG_LIKE. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1B1A8-1 [UniParc]FASTAAdd to Basket

« Hide

MSGQLPGKTM GDVKLFASSH MSKTSHSVDP SKVSSMPLTE APAFILPPRN     50
LCVKEGATAK FEGRVRGYPE PQVTWHRKGQ AITNGGRFLL DCGVRGTFSL 100
VIHTVREEDK GKYTCEASNG SGARQVTVEL TVEGNSMKKR DQPVLSKASG 150
FPGETRPSIW GECPPKFATK LGRAVVKEGQ MGRFSCKITG RPPPQVTWLK 200
GNVPLQPSAR VSMSEKNGMQ ILEIRGVTRD DLGVYTCMVV NGSGKASMSA 250
ELSIPGLDNA ARLAVRGTKA PSPDIRKEVT NGVSKDPETV AESKNCPSPQ 300
RSGSSARATN SHLKSPQEPK PKLCEDAPRK VPQSSILQKS TSTITLQALK 350
VQPEARVPAI GSFSPGEDRK SLAAPQQATL PTRQSSLGGS VGNKFVTGNI 400
PRESQRESTF PRFESQPQSQ EVTEGQTVKF ICEVSGIPKP DVGWFLEGIP 450
VRRREGITEV YEDGVSHHLC LLRARTRDSG RYSCTASNSL GQVSCSWSLL 500
VDRPNLAQTA PSFSSVLKDS VVIEGQDFVL RCSVQGTPAP RVTWLLNGQP 550
IQFAHSICEA GVAELHIQDA LPEDRGTYTC LAENAMGQVS CSATVTVQEK 600
KGEGEREHRL SPARSKPIAP IFLQGLSDLK VMDGSQVTMT VQVSGNPPPE 650
VIWLHDGNEI QESEDFHFEQ KGGWHSLCIQ EVFPEDTGTY TCEAWNSAGE 700
VRTRAVLTVQ EPHDGTQPWF ISKPRSVTAT LGQSVLISCA IAGDPFPTVH 750
WLRDGRALSK DSGHFELLQN EDVFTLVLKN VQPWHAGQYE ILLKNRVGEC 800
SCQVSLMLHN SPSRAPPRGR EPASCEGLCG GGGVGAHGDG DRHGTLRPCW 850
PARGQGWPEE EDGEDVRGLL KRRVETRLHT EEAIRQQEVG QLDFRDLLGK 900
KVSTKTVSED DLKDIPAEQM DFRANLQRQV KPKTISEEER KVHSPQQVDF 950
RSVLAKKGTP KTPVPEKAPP KAATPDFRSV LGGKKKSPSE NGGNSAEVLN 1000
VKAGESPTPA GDAQAIGALK PVGNAKPAET PKPIGNAKPT ETLKPVGNTK 1050
PAETLKPIAN AQPSGSLKPV TNAQPAEPQK PVGNAKSAET SKPAGKEEVK 1100
EVKNDVNCKK GQVGATGNEK RPESQGSAPV FKEKLQDVHV AEGEKLLLQC 1150
QVISDPPATV TWSLNGKTLK TTKFIVLAQE GSRFSVSIEK ALPEDRGLYK 1200
CVAKNSAGQA ECSCQVTVDD AQTSENTKAP EMKSRRPKSS LPPVLGTESD 1250
ATVKKKPAPK TPTKAAMPPQ IIQFPEDQKV RAGEPVELFG KVAGTQPITC 1300
KWMKFRKQIQ ESEHIKVENG ESGSKLTILA ARQEHCGCYT LVVENKLGSR 1350
QAQVNLTVVD KPDPPAGTPC ASDIRSSSLT LSWYGSSYDG GSAVQSYNVE 1400
IWDTEDKVWK ELATCRSTSF NVQDLLPDRE YKFRVRAVNV YGTSEPSQES 1450
ELTAVGEKPE EPKDEVEVSD DDEKEPEVDY RTVTVNTEQK VSDVYDIEER 1500
LGSGKFGQVF RLVEKKTGKI WAGKFFKAYS AKEKDNIRQE ISIMNCLHHP 1550
KLVQCVDAFE EKANIVMVLE IVSGGELFER IIDEDFELTE RECIKYMRQI 1600
SEGVEYIHKQ GIVHLDLKPE NIMCVNKTGT RIKLIDFGLA RRLENAGSLK 1650
VLFGTPEFVA PEVINYEPIG YATDMWSIGV ICYILVSGLS PFMGDNDNET 1700
LANVTSATWD FDDEAFDEIS DDAKDFISNL LKKDMKNRLD CTQCLQHPWL 1750
MKDTKNMEAK KLSKDRMKKY MARRKWQKTG NAVRAIGRLS SMAMISGLSG 1800
RKSSTGSPTS PINAEKLESE DDVSQAFLEA VAEEKPHVKP YFSKTIRDLE 1850
VVEGSAARFD CKIEGYPDPE VVWFKDDQSI RESRHFQIDY DEDGNCSLII 1900
SDVCGDDDAK YTCKAVNSLG EATCTAELIV ETMEEGEGEE GGEEEEEEEE 1950
Length:1,950
Mass (Da):213,609
Last modified:April 8, 2008 - v1
Checksum:iC6FA116BCD821661
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110166 Genomic DNA. No translation available.
AC154813 Genomic DNA. No translation available.
CT010574 Genomic DNA. No translation available.
BC145279 mRNA. Translation: AAI45280.1.
BC150749 mRNA. Translation: AAI50750.1.
RefSeqiNP_647461.3. NM_139300.3.
UniGeneiMm.33360.

Genome annotation databases

EnsembliENSMUST00000023538; ENSMUSP00000023538; ENSMUSG00000022836.
GeneIDi107589.
KEGGimmu:107589.
UCSCiuc007zbd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC110166 Genomic DNA. No translation available.
AC154813 Genomic DNA. No translation available.
CT010574 Genomic DNA. No translation available.
BC145279 mRNA. Translation: AAI45280.1 .
BC150749 mRNA. Translation: AAI50750.1 .
RefSeqi NP_647461.3. NM_139300.3.
UniGenei Mm.33360.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023538 ; ENSMUSP00000023538 ; ENSMUSG00000022836 .
GeneIDi 107589.
KEGGi mmu:107589.
UCSCi uc007zbd.1. mouse.

Organism-specific databases

CTDi 4638.
MGIi MGI:894806. Mylk.

Phylogenomic databases

GeneTreei ENSGT00740000114993.
HOGENOMi HOG000049287.
HOVERGENi HBG052551.
InParanoidi B1B1A8.
KOi K00907.
OMAi KFIILSQ.
OrthoDBi EOG7WQ7RC.
TreeFami TF314166.

Miscellaneous databases

ChiTaRSi MYLK. mouse.
NextBioi 359102.
SOURCEi Search...

Gene expression databases

Genevestigatori B1B1A8.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR020675. Myosin_light_ch_kinase-rel.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015725. Telokin/Myosin_light_ch_kin.
[Graphical view ]
PANTHERi PTHR22964. PTHR22964. 1 hit.
PTHR22964:SF44. PTHR22964:SF44. 1 hit.
Pfami PF00041. fn3. 1 hit.
PF07679. I-set. 9 hits.
PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
SM00409. IG. 1 hit.
SM00408. IGc2. 8 hits.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 9 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1B1A8_MOUSE
AccessioniPrimary (citable) accession number: B1B1A8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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