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Protein

Lethal(3)malignant brain tumor-like protein 4

Gene

L3mbtl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 4
Short name:
L(3)mbt-like protein 4
Gene namesi
Name:L3mbtl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444889. L3mbtl4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Lethal(3)malignant brain tumor-like protein 4PRO_0000337078Add
BLAST

Proteomic databases

PaxDbiB1B1A0.
PRIDEiB1B1A0.

PTM databases

PhosphoSiteiB1B1A0.

Expressioni

Gene expression databases

BgeeiB1B1A0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094892.

Structurei

3D structure databases

ProteinModelPortaliB1B1A0.
SMRiB1B1A0. Positions 52-364, 543-597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati52 – 152101MBT 1Add
BLAST
Repeati160 – 260101MBT 2Add
BLAST
Repeati269 – 36496MBT 3Add
BLAST
Domaini543 – 60765SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 MBT repeats.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
HOGENOMiHOG000231019.
HOVERGENiHBG071375.
InParanoidiB1B1A0.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF02820. MBT. 3 hits.
PF00536. SAM_1. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 3 hits.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1B1A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQPNRKRKL SLESTERMNQ DRCTGQTEEE KKPGEVTTPS KRESSVTTAE
60 70 80 90 100
TWSWEQYLRE GNAVAAPVEL FSKDQSFPEH ENGFQVGMRL EGIDARRPSV
110 120 130 140 150
FCVLSVAEVC GYRLRLHFDG YLSCYDFWTN AGSPDIHPVG WCQKTKHELH
160 170 180 190 200
IPRDYRKDKF VWMDYLKACR LQNAPKKLFR NRSSNGPVPR EFQVGMKLEA
210 220 230 240 250
VDRRNPCLMC VATIADIVED RVRVHFDSLD DSFDYWCDVN SPYIQPVGWC
260 270 280 290 300
QENGRTLVAP QGYPHPDKFS WTDYLRASQS KAVPAKAFGM RTPHGFLPNM
310 320 330 340 350
KLEAVDKRNP QLIRVATIAD VDDYRVKIHF DGWDHKYDYW VDADSQDIHP
360 370 380 390 400
IGWCDVTGHP LEVPYGSKHV KILPGQPACP TPGCRGIGHI RGPRYAGHHS
410 420 430 440 450
AFGCPYSDVN LKREAALQDR LREQTQANLE LDPSHSKSEN PCNLNVNGKC
460 470 480 490 500
ENANSQCRLV QQAKCLKIKG KEDIDLDNLF RVLVFHPRRL EYSAAQVQQM
510 520 530 540 550
LHQPLSMTST SAHPFRDIPL SREQHCKLLP GVADIQASQV ARWTVDEVAE
560 570 580 590 600
FVQSLLGCEE HAKCFKKEQI DGKAFLLLTQ ADIVKVMRIK LGPALKIYNS
610 620
ILMFRNSQDV TEDASSQEDK R
Length:621
Mass (Da):70,898
Last modified:May 20, 2008 - v2
Checksum:i2F448B5D96E6738F
GO
Isoform 2 (identifier: B1B1A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-173: DYRKDKFVWMDYLKACRLQN → GKPGHIYHLQGGVLVIPALF
     174-621: Missing.

Show »
Length:173
Mass (Da):19,732
Checksum:i07EC63FB75396F7F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei154 – 17320DYRKD…CRLQN → GKPGHIYHLQGGVLVIPALF in isoform 2. 2 PublicationsVSP_033865Add
BLAST
Alternative sequencei174 – 621448Missing in isoform 2. 2 PublicationsVSP_033866Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039470 mRNA. Translation: BAC30360.1.
AC154493 Genomic DNA. No translation available.
AC191933 Genomic DNA. No translation available.
CT010483, AC117803, AC154758 Genomic DNA. Translation: CAP19271.1.
BC147118 mRNA. Translation: AAI47119.1.
BC147119 mRNA. Translation: AAI47120.1.
RefSeqiNP_796252.2. NM_177278.5. [B1B1A0-1]
UniGeneiMm.137356.

Genome annotation databases

GeneIDi320858.
KEGGimmu:320858.
UCSCiuc008dkk.2. mouse. [B1B1A0-2]
uc008dkm.2. mouse. [B1B1A0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039470 mRNA. Translation: BAC30360.1.
AC154493 Genomic DNA. No translation available.
AC191933 Genomic DNA. No translation available.
CT010483, AC117803, AC154758 Genomic DNA. Translation: CAP19271.1.
BC147118 mRNA. Translation: AAI47119.1.
BC147119 mRNA. Translation: AAI47120.1.
RefSeqiNP_796252.2. NM_177278.5. [B1B1A0-1]
UniGeneiMm.137356.

3D structure databases

ProteinModelPortaliB1B1A0.
SMRiB1B1A0. Positions 52-364, 543-597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094892.

PTM databases

PhosphoSiteiB1B1A0.

Proteomic databases

PaxDbiB1B1A0.
PRIDEiB1B1A0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi320858.
KEGGimmu:320858.
UCSCiuc008dkk.2. mouse. [B1B1A0-2]
uc008dkm.2. mouse. [B1B1A0-1]

Organism-specific databases

CTDi91133.
MGIiMGI:2444889. L3mbtl4.

Phylogenomic databases

eggNOGiKOG3766. Eukaryota.
ENOG410Y4AQ. LUCA.
HOGENOMiHOG000231019.
HOVERGENiHBG071375.
InParanoidiB1B1A0.

Miscellaneous databases

NextBioi397573.
PROiB1B1A0.
SOURCEiSearch...

Gene expression databases

BgeeiB1B1A0.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
InterProiIPR004092. Mbt.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR002515. Znf_C2HC.
[Graphical view]
PfamiPF02820. MBT. 3 hits.
PF00536. SAM_1. 1 hit.
PF01530. zf-C2HC. 1 hit.
[Graphical view]
SMARTiSM00561. MBT. 3 hits.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS51079. MBT. 3 hits.
PS50105. SAM_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.

Entry informationi

Entry nameiLMBL4_MOUSE
AccessioniPrimary (citable) accession number: B1B1A0
Secondary accession number(s): B2RVB2, Q8BHZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 11, 2015
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.