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Protein

Lethal(3)malignant brain tumor-like protein 4

Gene

L3mbtl4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri370 – 414CCHHC-typePROSITE-ProRule annotationAdd BLAST45

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(3)malignant brain tumor-like protein 4
Short name:
L(3)mbt-like protein 4
Gene namesi
Name:L3mbtl4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2444889 L3mbtl4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003370781 – 621Lethal(3)malignant brain tumor-like protein 4Add BLAST621

Proteomic databases

PaxDbiB1B1A0
PRIDEiB1B1A0

PTM databases

PhosphoSitePlusiB1B1A0

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094892

Structurei

3D structure databases

ProteinModelPortaliB1B1A0
SMRiB1B1A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 152MBT 1Add BLAST101
Repeati160 – 260MBT 2Add BLAST101
Repeati269 – 364MBT 3Add BLAST96
Domaini543 – 607SAMPROSITE-ProRule annotationAdd BLAST65

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri370 – 414CCHHC-typePROSITE-ProRule annotationAdd BLAST45

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG3766 Eukaryota
ENOG410Y4AQ LUCA
HOGENOMiHOG000231019
HOVERGENiHBG071375
InParanoidiB1B1A0

Family and domain databases

InterProiView protein in InterPro
IPR004092 Mbt
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR002515 Znf_C2HC
PfamiView protein in Pfam
PF02820 MBT, 3 hits
PF00536 SAM_1, 1 hit
PF01530 zf-C2HC, 1 hit
SMARTiView protein in SMART
SM00561 MBT, 3 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51079 MBT, 3 hits
PS50105 SAM_DOMAIN, 1 hit
PS51802 ZF_CCHHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1B1A0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRQPNRKRKL SLESTERMNQ DRCTGQTEEE KKPGEVTTPS KRESSVTTAE
60 70 80 90 100
TWSWEQYLRE GNAVAAPVEL FSKDQSFPEH ENGFQVGMRL EGIDARRPSV
110 120 130 140 150
FCVLSVAEVC GYRLRLHFDG YLSCYDFWTN AGSPDIHPVG WCQKTKHELH
160 170 180 190 200
IPRDYRKDKF VWMDYLKACR LQNAPKKLFR NRSSNGPVPR EFQVGMKLEA
210 220 230 240 250
VDRRNPCLMC VATIADIVED RVRVHFDSLD DSFDYWCDVN SPYIQPVGWC
260 270 280 290 300
QENGRTLVAP QGYPHPDKFS WTDYLRASQS KAVPAKAFGM RTPHGFLPNM
310 320 330 340 350
KLEAVDKRNP QLIRVATIAD VDDYRVKIHF DGWDHKYDYW VDADSQDIHP
360 370 380 390 400
IGWCDVTGHP LEVPYGSKHV KILPGQPACP TPGCRGIGHI RGPRYAGHHS
410 420 430 440 450
AFGCPYSDVN LKREAALQDR LREQTQANLE LDPSHSKSEN PCNLNVNGKC
460 470 480 490 500
ENANSQCRLV QQAKCLKIKG KEDIDLDNLF RVLVFHPRRL EYSAAQVQQM
510 520 530 540 550
LHQPLSMTST SAHPFRDIPL SREQHCKLLP GVADIQASQV ARWTVDEVAE
560 570 580 590 600
FVQSLLGCEE HAKCFKKEQI DGKAFLLLTQ ADIVKVMRIK LGPALKIYNS
610 620
ILMFRNSQDV TEDASSQEDK R
Length:621
Mass (Da):70,898
Last modified:May 20, 2008 - v2
Checksum:i2F448B5D96E6738F
GO
Isoform 2 (identifier: B1B1A0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     154-173: DYRKDKFVWMDYLKACRLQN → GKPGHIYHLQGGVLVIPALF
     174-621: Missing.

Show »
Length:173
Mass (Da):19,732
Checksum:i07EC63FB75396F7F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033865154 – 173DYRKD…CRLQN → GKPGHIYHLQGGVLVIPALF in isoform 2. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_033866174 – 621Missing in isoform 2. 2 PublicationsAdd BLAST448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039470 mRNA Translation: BAC30360.1
AC154493 Genomic DNA No translation available.
AC191933 Genomic DNA No translation available.
CT010483, AC117803, AC154758 Genomic DNA Translation: CAP19271.1
BC147118 mRNA Translation: AAI47119.1
BC147119 mRNA Translation: AAI47120.1
RefSeqiNP_796252.2, NM_177278.5 [B1B1A0-1]
UniGeneiMm.137356

Genome annotation databases

GeneIDi320858
KEGGimmu:320858
UCSCiuc008dkk.2 mouse [B1B1A0-2]
uc008dkm.2 mouse [B1B1A0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLMBL4_MOUSE
AccessioniPrimary (citable) accession number: B1B1A0
Secondary accession number(s): B2RVB2, Q8BHZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: April 25, 2018
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health