ID   B1B0D4_HUMAN            Unreviewed;      1060 AA.
AC   B1B0D4;
DT   08-APR-2008, integrated into UniProtKB/TrEMBL.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 105.
DE   SubName: Full=ADAMTS like 2 {ECO:0000313|Ensembl:ENSP00000376781.3};
GN   Name=ADAMTSL2 {ECO:0000313|Ensembl:ENSP00000376781.3};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376781.3, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376781.3, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376781.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; BX324209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX629352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX649571; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005272294.1; XM_005272237.3.
DR   AlphaFoldDB; B1B0D4; -.
DR   SMR; B1B0D4; -.
DR   MassIVE; B1B0D4; -.
DR   PeptideAtlas; B1B0D4; -.
DR   Antibodypedia; 45302; 99 antibodies from 24 providers.
DR   Ensembl; ENST00000393061.7; ENSP00000376781.3; ENSG00000197859.11.
DR   UCSC; uc004cei.4; human.
DR   HGNC; HGNC:14631; ADAMTSL2.
DR   VEuPathDB; HostDB:ENSG00000197859; -.
DR   GeneTree; ENSGT00940000159447; -.
DR   PhylomeDB; B1B0D4; -.
DR   BioGRID-ORCS; 9719; 14 hits in 1142 CRISPR screens.
DR   ChiTaRS; ADAMTSL2; human.
DR   GenomeRNAi; 9719; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000197859; Expressed in right atrium auricular region and 93 other cell types or tissues.
DR   ExpressionAtlas; B1B0D4; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR   Gene3D; 2.60.120.830; -; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR045371; ADAMTS_CR_3.
DR   InterPro; IPR010294; ADAMTS_spacer1.
DR   InterPro; IPR010909; PLAC.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR13723:SF41; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8; 1.
DR   PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR   Pfam; PF19236; ADAMTS_CR_3; 1.
DR   Pfam; PF05986; ADAMTS_spacer1; 1.
DR   Pfam; PF08686; PLAC; 1.
DR   Pfam; PF19030; TSP1_ADAMTS; 4.
DR   Pfam; PF00090; TSP_1; 1.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00209; TSP1; 7.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 7.
DR   PROSITE; PS50900; PLAC; 1.
DR   PROSITE; PS50092; TSP1; 5.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR613273-3};
KW   Proteomics identification {ECO:0007829|MaxQB:B1B0D4,
KW   ECO:0007829|PeptideAtlas:B1B0D4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          1021..1059
FT                   /note="PLAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50900"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          523..549
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          643..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        168..209
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        172..214
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT   DISULFID        183..199
FT                   /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ   SEQUENCE   1060 AA;  116285 MW;  341D2A3CEB1C5427 CRC64;
     MLFEVGEGGG AGEEGKGRGR PGRSLCTHAA PARTAHLAPS ALRSARPFLW EDNLLTRSQG
     LPDNHDQLVP DNLEAWALAG PRGLFPKRTL VIWKRIGAGL VVTVALLPRM DGRWQCSCWA
     WFLLVLAVVA GDTVSTGSTD NSPTSNSLEG GTDATAFWWG EWTKWTACSR SCGGGVTSQE
     RHCLQQRRKS VPGPGNRTCT GTSKRYQLCR VQECPPDGRS FREEQCVSFN SHVYNGRTHQ
     WKPLYPDDYV HISSKPCDLH CTTVDGQRQL MVPARDGTSC KLTDLRGVCV SGKCEPIGCD
     GVLFSTHTLD KCGICQGDGS SCTHVTGNYR KGNAHLGYSL VTHIPAGARD IQIVERKKSA
     DVLALADEAG YYFFNGNYKV DSPKNFNIAG TVVKYRRPMD VYETGIEYIV AQGPTNQGLN
     VMVWNQNGKS PSITFEYTLL QPPHESRPQP IYYGFSESAE SQGLDGAGLM GFVPHNGSLY
     GQASSERLGL DNRLFGHPGL DMELGPSQGQ ETNEVCEQAG GGACEGPPRG KGFRDRNVTG
     TPLTGDKDDE EVDTHFASQE FFSANAISDQ LLGAGSDLKD FTLNETVNSI FAQGAPRSSL
     AESFFVDYEE NEGAGPYLLN GSYLELSSDR VANSSSEAPF PNVSTSLLTS AGNRTHKART
     RPKARKQGVS PADMYRWKLS SHEPCSATCT TGVMSAYAMC VRYDGVEVDD SYCDALTRPE
     PVHEFCAGRE CQPRWETSSW SECSRTCGEG YQFRVVRCWK MLSPGFDSSV YSDLCEAAEA
     VRPEERKTCR NPACGPQWEM SEWSECTAKC GERSVVTRDI RCSEDEKLCD PNTRPVGEKN
     CTGPPCDRQW TVSDWGPCSG SCGQGRTIRH VYCKTSDGRV VPESQCQMET KPLAIHPCGD
     KNCPAHWLAQ DWERCNTTCG RGVKKRLVLC MELANGKPQT RSGPECGLAK KPPEESTCFE
     RPCFKWYTSP WSECTKTCGV GVRMRDVKCY QGTDIVRGCD PLVKPVGRQA CDLQPCPTEP
     PDDSCQDQPG TNCALAIKVN LCGHWYYSKA CCRSCRPPHS
//