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Protein
Submitted name:

ADAMTS-like protein 2

Gene

ADAMTSL2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ADAMTS-like protein 2Imported
Gene namesi
Name:ADAMTSL2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:14631. ADAMTSL2.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB1B0D4.

Expressioni

Gene expression databases

BgeeiB1B0D4.
ExpressionAtlasiB1B0D4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB1B0D4.
SMRiB1B0D4. Positions 159-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00760000118885.
HOGENOMiHOG000116076.
OMAiNRTCTGT.
PhylomeDBiB1B0D4.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 7 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1B0D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFEVGEGGG AGEEGKGRGR PGRSLCTHAA PARTAHLAPS ALRSARPFLW
60 70 80 90 100
EDNLLTRSQG LPDNHDQLVP DNLEAWALAG PRGLFPKRTL VIWKRIGAGL
110 120 130 140 150
VVTVALLPRM DGRWQCSCWA WFLLVLAVVA GDTVSTGSTD NSPTSNSLEG
160 170 180 190 200
GTDATAFWWG EWTKWTACSR SCGGGVTSQE RHCLQQRRKS VPGPGNRTCT
210 220 230 240 250
GTSKRYQLCR VQECPPDGRS FREEQCVSFN SHVYNGRTHQ WKPLYPDDYV
260 270 280 290 300
HISSKPCDLH CTTVDGQRQL MVPARDGTSC KLTDLRGVCV SGKCEPIGCD
310 320 330 340 350
GVLFSTHTLD KCGICQGDGS SCTHVTGNYR KGNAHLGYSL VTHIPAGARD
360 370 380 390 400
IQIVERKKSA DVLALADEAG YYFFNGNYKV DSPKNFNIAG TVVKYRRPMD
410 420 430 440 450
VYETGIEYIV AQGPTNQGLN VMVWNQNGKS PSITFEYTLL QPPHESRPQP
460 470 480 490 500
IYYGFSESAE SQGLDGAGLM GFVPHNGSLY GQASSERLGL DNRLFGHPGL
510 520 530 540 550
DMELGPSQGQ ETNEVCEQAG GGACEGPPRG KGFRDRNVTG TPLTGDKDDE
560 570 580 590 600
EVDTHFASQE FFSANAISDQ LLGAGSDLKD FTLNETVNSI FAQGAPRSSL
610 620 630 640 650
AESFFVDYEE NEGAGPYLLN GSYLELSSDR VANSSSEAPF PNVSTSLLTS
660 670 680 690 700
AGNRTHKART RPKARKQGVS PADMYRWKLS SHEPCSATCT TGVMSAYAMC
710 720 730 740 750
VRYDGVEVDD SYCDALTRPE PVHEFCAGRE CQPRWETSSW SECSRTCGEG
760 770 780 790 800
YQFRVVRCWK MLSPGFDSSV YSDLCEAAEA VRPEERKTCR NPACGPQWEM
810 820 830 840 850
SEWSECTAKC GERSVVTRDI RCSEDEKLCD PNTRPVGEKN CTGPPCDRQW
860 870 880 890 900
TVSDWGPCSG SCGQGRTIRH VYCKTSDGRV VPESQCQMET KPLAIHPCGD
910 920 930 940 950
KNCPAHWLAQ DWERCNTTCG RGVKKRLVLC MELANGKPQT RSGPECGLAK
960 970 980 990 1000
KPPEESTCFE RPCFKWYTSP WSECTKTCGV GVRMRDVKCY QGTDIVRGCD
1010 1020 1030 1040 1050
PLVKPVGRQA CDLQPCPTEP PDDSCQDQPG TNCALAIKVN LCGHWYYSKA
1060
CCRSCRPPHS
Length:1,060
Mass (Da):116,285
Last modified:April 8, 2008 - v1
Checksum:i341D2A3CEB1C5427
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX324209 Genomic DNA. No translation available.
BX629352 Genomic DNA. No translation available.
BX649571 Genomic DNA. No translation available.
RefSeqiXP_005272294.1. XM_005272237.2.
UniGeneiHs.522543.

Genome annotation databases

EnsembliENST00000393061; ENSP00000376781; ENSG00000197859.
GeneIDi9719.
KEGGihsa:9719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX324209 Genomic DNA. No translation available.
BX629352 Genomic DNA. No translation available.
BX649571 Genomic DNA. No translation available.
RefSeqiXP_005272294.1. XM_005272237.2.
UniGeneiHs.522543.

3D structure databases

ProteinModelPortaliB1B0D4.
SMRiB1B0D4. Positions 159-345.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB1B0D4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393061; ENSP00000376781; ENSG00000197859.
GeneIDi9719.
KEGGihsa:9719.

Organism-specific databases

CTDi9719.
HGNCiHGNC:14631. ADAMTSL2.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118885.
HOGENOMiHOG000116076.
OMAiNRTCTGT.
PhylomeDBiB1B0D4.

Miscellaneous databases

ChiTaRSiADAMTSL2. human.
GenomeRNAii9719.
NextBioi35466988.

Gene expression databases

BgeeiB1B0D4.
ExpressionAtlasiB1B0D4. baseline and differential.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 7 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (AUG-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB1B0D4_HUMAN
AccessioniPrimary (citable) accession number: B1B0D4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 29, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.