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B1AZ99

- OTUD3_MOUSE

UniProt

B1AZ99 - OTUD3_MOUSE

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Protein

OTU domain-containing protein 3

Gene

Otud3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei72 – 721By similarity
Active sitei75 – 751NucleophileBy similarity
Active sitei181 – 1811By similarity

GO - Molecular functioni

  1. ubiquitin-specific protease activity Source: UniProtKB

GO - Biological processi

  1. protein K11-linked deubiquitination Source: UniProtKB
  2. protein K6-linked deubiquitination Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 3 (EC:3.4.19.12)
Gene namesi
Name:Otud3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1920412. Otud3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396OTU domain-containing protein 3PRO_0000424025Add
BLAST

Proteomic databases

MaxQBiB1AZ99.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095441.

Structurei

3D structure databases

ProteinModelPortaliB1AZ99.
SMRiB1AZ99. Positions 51-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 188125OTUPROSITE-ProRule annotationAdd
BLAST
Domaini229 – 26941UBA-likeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni69 – 757Cys-loopBy similarity
Regioni126 – 13611Variable-loopBy similarityAdd
BLAST
Regioni176 – 1816His-loopBy similarity

Domaini

The UBA-like domain has no influence on ubiquitin hydrolysis.By similarity
Specificity is given by the S1' ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops.By similarity

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation
Contains 1 UBA-like domain.Curated

Phylogenomic databases

eggNOGiNOG136081.
GeneTreeiENSGT00390000016392.
HOGENOMiHOG000049263.
HOVERGENiHBG056738.
InParanoidiB1AZ99.
KOiK13717.
OMAiANKNQLP.
OrthoDBiEOG70ZZNW.
PhylomeDBiB1AZ99.
TreeFamiTF329594.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AZ99-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRKQAAKSR PGSGGRRAEA ERKRDERAAR RALAKERRNR PDPGGSGCEE
60 70 80 90 100
EFVSFANQLQ ALGLKLREVP GDGNCLFRAL GDQLEGHSRN HLKHRQETVD
110 120 130 140 150
YMIRQREDFE PFVEDDIPFE KHVASLSKPG TFAGNDAIVA FARNHQLNVV
160 170 180 190 200
IHQLNAPLWQ IRGTDKGSTR ELHIAYRYGE HYDSVRRIND NSEAPAHLLT
210 220 230 240 250
DFQMLHQDGA NKKEKMKTKG VDVKDGLRDD VEDAVHKVGS ATGCTDFNLI
260 270 280 290 300
VQNLEAENYN IKSAITALLQ VNQGTGNDAE ENHEPGDRVK QRGPSREEAG
310 320 330 340 350
SGRRLSGNQG RNEGRMETSE ARASPAEESK AHKSQLPKVT NKQRREQQRL
360 370 380 390
EKKKRQEERH RLKALENRNG SRDTGRSEAD MNTQVTLVKT FAALNI
Length:396
Mass (Da):44,576
Last modified:April 8, 2008 - v1
Checksum:i605943E424F79A47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929473 Genomic DNA. No translation available.
CH466615 Genomic DNA. Translation: EDL13286.1.
CCDSiCCDS51337.1.
RefSeqiNP_082729.1. NM_028453.1.
UniGeneiMm.238081.
Mm.307701.

Genome annotation databases

EnsembliENSMUST00000097830; ENSMUSP00000095441; ENSMUSG00000041161.
GeneIDi73162.
KEGGimmu:73162.
UCSCiuc008vln.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929473 Genomic DNA. No translation available.
CH466615 Genomic DNA. Translation: EDL13286.1 .
CCDSi CCDS51337.1.
RefSeqi NP_082729.1. NM_028453.1.
UniGenei Mm.238081.
Mm.307701.

3D structure databases

ProteinModelPortali B1AZ99.
SMRi B1AZ99. Positions 51-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000095441.

Proteomic databases

MaxQBi B1AZ99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000097830 ; ENSMUSP00000095441 ; ENSMUSG00000041161 .
GeneIDi 73162.
KEGGi mmu:73162.
UCSCi uc008vln.2. mouse.

Organism-specific databases

CTDi 23252.
MGIi MGI:1920412. Otud3.

Phylogenomic databases

eggNOGi NOG136081.
GeneTreei ENSGT00390000016392.
HOGENOMi HOG000049263.
HOVERGENi HBG056738.
InParanoidi B1AZ99.
KOi K13717.
OMAi ANKNQLP.
OrthoDBi EOG70ZZNW.
PhylomeDBi B1AZ99.
TreeFami TF329594.

Miscellaneous databases

NextBioi 337577.
PROi B1AZ99.
SOURCEi Search...

Family and domain databases

InterProi IPR003323. OTU.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
PROSITEi PS50802. OTU. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOTUD3_MOUSE
AccessioniPrimary (citable) accession number: B1AZ99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3