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B1AZ99 (OTUD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
OTU domain-containing protein 3

EC=3.4.19.12
Gene names
Name:Otud3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Domain

The UBA-like domain has no influence on ubiquitin hydrolysis By similarity.

Specificity is given by the S1' ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops By similarity.

Sequence similarities

Contains 1 OTU domain.

Contains 1 UBA-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396OTU domain-containing protein 3
PRO_0000424025

Regions

Domain64 – 188125OTU
Domain229 – 26941UBA-like
Region69 – 757Cys-loop By similarity
Region126 – 13611Variable-loop By similarity
Region176 – 1816His-loop By similarity

Sites

Active site721 By similarity
Active site751Nucleophile By similarity
Active site1811 By similarity

Sequences

Sequence LengthMass (Da)Tools
B1AZ99 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 605943E424F79A47

FASTA39644,576
        10         20         30         40         50         60 
MSRKQAAKSR PGSGGRRAEA ERKRDERAAR RALAKERRNR PDPGGSGCEE EFVSFANQLQ 

        70         80         90        100        110        120 
ALGLKLREVP GDGNCLFRAL GDQLEGHSRN HLKHRQETVD YMIRQREDFE PFVEDDIPFE 

       130        140        150        160        170        180 
KHVASLSKPG TFAGNDAIVA FARNHQLNVV IHQLNAPLWQ IRGTDKGSTR ELHIAYRYGE 

       190        200        210        220        230        240 
HYDSVRRIND NSEAPAHLLT DFQMLHQDGA NKKEKMKTKG VDVKDGLRDD VEDAVHKVGS 

       250        260        270        280        290        300 
ATGCTDFNLI VQNLEAENYN IKSAITALLQ VNQGTGNDAE ENHEPGDRVK QRGPSREEAG 

       310        320        330        340        350        360 
SGRRLSGNQG RNEGRMETSE ARASPAEESK AHKSQLPKVT NKQRREQQRL EKKKRQEERH 

       370        380        390 
RLKALENRNG SRDTGRSEAD MNTQVTLVKT FAALNI 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL929473 Genomic DNA. No translation available.
CH466615 Genomic DNA. Translation: EDL13286.1.
RefSeqNP_082729.1. NM_028453.1.
UniGeneMm.238081.
Mm.307701.

3D structure databases

ProteinModelPortalB1AZ99.
SMRB1AZ99. Positions 51-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000095441.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000097830; ENSMUSP00000095441; ENSMUSG00000041161.
GeneID73162.
KEGGmmu:73162.
UCSCuc008vln.2. mouse.

Organism-specific databases

CTD23252.
MGIMGI:1920412. Otud3.

Phylogenomic databases

eggNOGNOG136081.
GeneTreeENSGT00390000016392.
HOGENOMHOG000049263.
HOVERGENHBG056738.
InParanoidB1AZ99.
KOK13717.
OMAANKNQLP.
OrthoDBEOG70ZZNW.
PhylomeDBB1AZ99.
TreeFamTF329594.

Family and domain databases

InterProIPR003323. OTU.
[Graphical view]
PfamPF02338. OTU. 1 hit.
[Graphical view]
PROSITEPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio337577.
PROB1AZ99.
SOURCESearch...

Entry information

Entry nameOTUD3_MOUSE
AccessionPrimary (citable) accession number: B1AZ99
Entry history
Integrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot