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B1AZ99

- OTUD3_MOUSE

UniProt

B1AZ99 - OTUD3_MOUSE

Protein

OTU domain-containing protein 3

Gene

Otud3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei72 – 721By similarity
    Active sitei75 – 751NucleophileBy similarity
    Active sitei181 – 1811By similarity

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB

    GO - Biological processi

    1. protein K11-linked deubiquitination Source: UniProtKB
    2. protein K6-linked deubiquitination Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 3 (EC:3.4.19.12)
    Gene namesi
    Name:Otud3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1920412. Otud3.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396OTU domain-containing protein 3PRO_0000424025Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000095441.

    Structurei

    3D structure databases

    ProteinModelPortaliB1AZ99.
    SMRiB1AZ99. Positions 51-189.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 188125OTUPROSITE-ProRule annotationAdd
    BLAST
    Domaini229 – 26941UBA-likeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni69 – 757Cys-loopBy similarity
    Regioni126 – 13611Variable-loopBy similarityAdd
    BLAST
    Regioni176 – 1816His-loopBy similarity

    Domaini

    The UBA-like domain has no influence on ubiquitin hydrolysis.By similarity
    Specificity is given by the S1' ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops.By similarity

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation
    Contains 1 UBA-like domain.Curated

    Phylogenomic databases

    eggNOGiNOG136081.
    GeneTreeiENSGT00390000016392.
    HOGENOMiHOG000049263.
    HOVERGENiHBG056738.
    InParanoidiB1AZ99.
    KOiK13717.
    OMAiANKNQLP.
    OrthoDBiEOG70ZZNW.
    PhylomeDBiB1AZ99.
    TreeFamiTF329594.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1AZ99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRKQAAKSR PGSGGRRAEA ERKRDERAAR RALAKERRNR PDPGGSGCEE    50
    EFVSFANQLQ ALGLKLREVP GDGNCLFRAL GDQLEGHSRN HLKHRQETVD 100
    YMIRQREDFE PFVEDDIPFE KHVASLSKPG TFAGNDAIVA FARNHQLNVV 150
    IHQLNAPLWQ IRGTDKGSTR ELHIAYRYGE HYDSVRRIND NSEAPAHLLT 200
    DFQMLHQDGA NKKEKMKTKG VDVKDGLRDD VEDAVHKVGS ATGCTDFNLI 250
    VQNLEAENYN IKSAITALLQ VNQGTGNDAE ENHEPGDRVK QRGPSREEAG 300
    SGRRLSGNQG RNEGRMETSE ARASPAEESK AHKSQLPKVT NKQRREQQRL 350
    EKKKRQEERH RLKALENRNG SRDTGRSEAD MNTQVTLVKT FAALNI 396
    Length:396
    Mass (Da):44,576
    Last modified:April 8, 2008 - v1
    Checksum:i605943E424F79A47
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL929473 Genomic DNA. No translation available.
    CH466615 Genomic DNA. Translation: EDL13286.1.
    CCDSiCCDS51337.1.
    RefSeqiNP_082729.1. NM_028453.1.
    UniGeneiMm.238081.
    Mm.307701.

    Genome annotation databases

    EnsembliENSMUST00000097830; ENSMUSP00000095441; ENSMUSG00000041161.
    GeneIDi73162.
    KEGGimmu:73162.
    UCSCiuc008vln.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL929473 Genomic DNA. No translation available.
    CH466615 Genomic DNA. Translation: EDL13286.1 .
    CCDSi CCDS51337.1.
    RefSeqi NP_082729.1. NM_028453.1.
    UniGenei Mm.238081.
    Mm.307701.

    3D structure databases

    ProteinModelPortali B1AZ99.
    SMRi B1AZ99. Positions 51-189.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000095441.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000097830 ; ENSMUSP00000095441 ; ENSMUSG00000041161 .
    GeneIDi 73162.
    KEGGi mmu:73162.
    UCSCi uc008vln.2. mouse.

    Organism-specific databases

    CTDi 23252.
    MGIi MGI:1920412. Otud3.

    Phylogenomic databases

    eggNOGi NOG136081.
    GeneTreei ENSGT00390000016392.
    HOGENOMi HOG000049263.
    HOVERGENi HBG056738.
    InParanoidi B1AZ99.
    KOi K13717.
    OMAi ANKNQLP.
    OrthoDBi EOG70ZZNW.
    PhylomeDBi B1AZ99.
    TreeFami TF329594.

    Miscellaneous databases

    NextBioi 337577.
    PROi B1AZ99.
    SOURCEi Search...

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiOTUD3_MOUSE
    AccessioniPrimary (citable) accession number: B1AZ99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 16, 2013
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3