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Protein
Submitted name:

Protein Scn7a

Gene

Scn7a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • sodium channel activity Source: MGI
  • voltage-gated sodium channel activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Scn7aImported
Gene namesi
Name:Scn7aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102965. Scn7a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei238 – 26124HelicalSequence analysisAdd
BLAST
Transmembranei370 – 39425HelicalSequence analysisAdd
BLAST
Transmembranei507 – 52519HelicalSequence analysisAdd
BLAST
Transmembranei537 – 55519HelicalSequence analysisAdd
BLAST
Transmembranei576 – 60429HelicalSequence analysisAdd
BLAST
Transmembranei624 – 64421HelicalSequence analysisAdd
BLAST
Transmembranei708 – 73427HelicalSequence analysisAdd
BLAST
Transmembranei934 – 95320HelicalSequence analysisAdd
BLAST
Transmembranei974 – 99320HelicalSequence analysisAdd
BLAST
Transmembranei1059 – 108123HelicalSequence analysisAdd
BLAST
Transmembranei1169 – 119325HelicalSequence analysisAdd
BLAST
Transmembranei1252 – 127019HelicalSequence analysisAdd
BLAST
Transmembranei1282 – 130019HelicalSequence analysisAdd
BLAST
Transmembranei1312 – 133322HelicalSequence analysisAdd
BLAST
Transmembranei1369 – 139729HelicalSequence analysisAdd
BLAST
Transmembranei1476 – 149924HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • glial cell projection Source: MGI
  • plasma membrane Source: MGI
  • voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiB1AYL1.
PaxDbiB1AYL1.
PeptideAtlasiB1AYL1.
PRIDEiB1AYL1.

PTM databases

SwissPalmiB1AYL1.

Expressioni

Gene expression databases

BgeeiB1AYL1.
GenevisibleiB1AYL1. MM.

Interactioni

Protein-protein interaction databases

IntActiB1AYL1. 10 interactions.
MINTiMINT-8392826.
STRINGi10090.ENSMUSP00000042405.

Structurei

3D structure databases

ProteinModelPortaliB1AYL1.
SMRiB1AYL1. Positions 1510-1649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 404287Ion_transInterPro annotationAdd
BLAST
Domaini505 – 729225Ion_transInterPro annotationAdd
BLAST
Domaini743 – 927185Na_trans_assocInterPro annotationAdd
BLAST
Domaini933 – 1200268Ion_transInterPro annotationAdd
BLAST
Domaini1250 – 1497248Ion_transInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF4. Eukaryota.
ENOG410Y1Z2. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiB1AYL1.
KOiK04839.
OMAiLEYADMI.
OrthoDBiEOG7DJSK9.
PhylomeDBiB1AYL1.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028812. Na_channel_a7su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF14. PTHR10037:SF14. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

B1AYL1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSPEPKGL VPFTTESLEL IENHIAKKCN EDPEEEEGLK PSRNLEAGKR
60 70 80 90 100
LPIPYGTLPR GTVSEPLEDV DPYYYVKRNT FMVLNRSRVI FRFNAVSIFC
110 120 130 140 150
TLSPLNSLRR AAIKALVHPL FRLLILISVL TDSILMCMSN LPEWILAIEN
160 170 180 190 200
TLLGIYAFEI LVKVIARGIW AGSFSFLGDL WNWLDFSVTL FELITRFSPL
210 220 230 240 250
SSFLMLKTIR TFRILKIIPL NHGLQSIVMT LAQCLKKLFG AIALALFFLA
260 270 280 290 300
VFSLLGMGLF MGNLKHKCLR WPEENENETL HNRTGSLNYS PERINFYYME
310 320 330 340 350
GAKYALLCGN RTDAGQCPEG YVCVKEGTNP DNGFTSFDNF GWSLLAMFRL
360 370 380 390 400
MTQDYPELLY HQILYASGKV YMIFFVMISF WFAFYLTSLF LGILTMTYEK
410 420 430 440 450
EKQRACEESG GLDPKCQQTV KELDEENDAA EMETTQIEMK KRSPTSINTT
460 470 480 490 500
LDILEDTTLG HREEPETSRK KCPICWHKFI KTCFIWKCSP CWVKLNEFAD
510 520 530 540 550
RVITHPLADL FLVICIVLNI CFLALEHFPM SEELRSLLHV GNLVFIGIYT
560 570 580 590 600
IEMILKIIAM HPYGYFQISW NIFDSILVVL ELTEILLADV EGLAVLITVP
610 620 630 640 650
LIFIKLGKYG PPFKSLMRIL GSSLMALKDL VLLLCIFVYF SAVFGMKLFG
660 670 680 690 700
RSYKDCVCHI KEDCQPQRWH MSDFLHAYMT VFRILCGEWI ETLWECMEVA
710 720 730 740 750
GQAWCIPFYM MVILIGNLLI LYLFVTLVSS FSYYDATSEV NKEAKNLQLA
760 770 780 790 800
MARIKSGINS MLLKLMCTER SVPTEATDQI CDPSVKENIS GHTLSELSNT
810 820 830 840 850
QTFLRYKDQS SSTEKTPVTE SESQSLIASP SASETVPIAS GESDIENLDN
860 870 880 890 900
KETRSKSGNG GSKEKMKQSS SSECSTVDIA ISEEEEMVYE HEKSKLHKNG
910 920 930 940 950
YERKSSTGQI SRESRNGKIW KNIRKTCCKI VENSWFECFI GLVTLLCTGT
960 970 980 990 1000
LALEDIYIDQ RKTTKILLEY ADMIFAYIFI LEMLLKWVAY GFKAFFSNNW
1010 1020 1030 1040 1050
YKLDFMVVIV FCLSLIGKTR EDLNPLTSIK FLRALRVLSQ FERMKVVLRA
1060 1070 1080 1090 1100
LIKTTLPTVS VFLVCLMIWL LFSVIGVQLF AGKFYECIDP TKGERFPVFE
1110 1120 1130 1140 1150
VMNKSQCEKL LFNESMPWEN AKLNFDNVGN GFLSLLQVAT FNGWISIMNS
1160 1170 1180 1190 1200
AIDSVGVNMQ PSFEYNLYMY SYFIIFVIFG LFLPLCMLIG VIIRNFNKQK
1210 1220 1230 1240 1250
IKQGGSNIFI TVKQKKQYRA LKKLLYADVQ KPTPRPRNKF QGFLFDLVTH
1260 1270 1280 1290 1300
RVFNVIIILL ICFQATTIMI QKDEQSPQME TAIFWMNSIF VMLFTLECIL
1310 1320 1330 1340 1350
KLTAFRCHYF TSAWNVHDFM VVIFSITGLL LPLTIGQYFV PPSLVQLILL
1360 1370 1380 1390 1400
SRVIHILRPG KGPKVFHDLM LPLILALPAL LNISLLIFLV MFIYAIFGMY
1410 1420 1430 1440 1450
NFAYVKKEAG INDVSNFETF GSSMLCLFQV TTFSGWDGML DAIFNSQWSD
1460 1470 1480 1490 1500
CDPDKINPGT QVKGDCGSPS VGISYFVSYI LISWLIIVNM YIVLIMEFLS
1510 1520 1530 1540 1550
IPSQKKSRTL SEDDFRRFFR VWNRFDPDRT QYIDSSKLSD FAAALDPPLF
1560 1570 1580 1590 1600
MAKPNKGQLV AMDLPMAAGD RIHCLDILLA FTKRVMGKDE RVEKILSEIE
1610 1620 1630 1640 1650
SGFMLANPFK ITYEPITTTL KRKQEAVSAT IIQRAYKSYR LRQNDKNVSD
1660 1670 1680
TPAIDDRRDD LTSKGAHSGK IEEKASIQTQ I
Length:1,681
Mass (Da):192,177
Last modified:April 8, 2008 - v1
Checksum:iBD0E0A17FAFBC39C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928623 Genomic DNA. No translation available.
AL928720 Genomic DNA. No translation available.
RefSeqiNP_033161.2. NM_009135.2.
UniGeneiMm.38127.

Genome annotation databases

EnsembliENSMUST00000042792; ENSMUSP00000042405; ENSMUSG00000034810.
GeneIDi20272.
KEGGimmu:20272.
UCSCiuc008jxf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL928623 Genomic DNA. No translation available.
AL928720 Genomic DNA. No translation available.
RefSeqiNP_033161.2. NM_009135.2.
UniGeneiMm.38127.

3D structure databases

ProteinModelPortaliB1AYL1.
SMRiB1AYL1. Positions 1510-1649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB1AYL1. 10 interactions.
MINTiMINT-8392826.
STRINGi10090.ENSMUSP00000042405.

PTM databases

SwissPalmiB1AYL1.

Proteomic databases

MaxQBiB1AYL1.
PaxDbiB1AYL1.
PeptideAtlasiB1AYL1.
PRIDEiB1AYL1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042792; ENSMUSP00000042405; ENSMUSG00000034810.
GeneIDi20272.
KEGGimmu:20272.
UCSCiuc008jxf.2. mouse.

Organism-specific databases

CTDi6332.
MGIiMGI:102965. Scn7a.

Phylogenomic databases

eggNOGiENOG410INF4. Eukaryota.
ENOG410Y1Z2. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiB1AYL1.
KOiK04839.
OMAiLEYADMI.
OrthoDBiEOG7DJSK9.
PhylomeDBiB1AYL1.
TreeFamiTF323985.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiB1AYL1.
GenevisibleiB1AYL1. MM.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028812. Na_channel_a7su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF14. PTHR10037:SF14. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AYL1_MOUSE
AccessioniPrimary (citable) accession number: B1AYL1
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.