SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B1AYL0

- B1AYL0_MOUSE

UniProt

B1AYL0 - B1AYL0_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium channel protein

Gene
Scn9a
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes By similarity.UniRule annotation

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: RefGenome

GO - Biological processi

  1. behavioral response to pain Source: MGI
  2. inflammatory response Source: MGI
  3. membrane depolarization during action potential Source: RefGenome
  4. neuronal action potential Source: RefGenome
  5. post-embryonic development Source: MGI
  6. response to toxic substance Source: MGI
  7. sodium ion transmembrane transport Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotations

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn9aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:107636. Scn9a.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity UniRule annotation

GO - Cellular componenti

  1. plasma membrane Source: RefGenome
  2. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliB1AYL0.
SMRiB1AYL0. Positions 1748-1903.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00560000076721.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04841.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view]
PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
PfamiPF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AYL0-1 [UniParc]FASTAAdd to Basket

« Hide

MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS     50
SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF 100
NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD 150
WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY 200
LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI 250
LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK 300
RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA 350
FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV 400
VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL 450
GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKLSSG EEKGDDEKLS 500
KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG SLFSARRSSR 550
TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 600
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEGTTN 650
QMRKKRLSSS YFLSEDMLND PHLRQRAMSR ASILTNTVEE LEESRQKCPP 700
WWYRFAHTFL IWNCSPYWIK FKKFIYFIVM DPFVDLAITI CIVLNTLFMA 750
MEHHPMTDEF KNVLAVGNLV FTGIFAAEMV LKLIAMDPYE YFQVGWNIFD 800
SLIVTLSLVE LFLADVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS 850
VGALGNLTLV LAIIVFIFAV VGMQLFGKSY KECVCKINEN CKLPRWHMND 900
FFHSFLIVFR VLCGEWIETM WDCMEVAGQT MCLIVYMMVM VIGNLVVLNL 950
FLALLLSSFS SDNLTAIEED TDANNLQIAV ARIKRGINYV KQTLREFILK 1000
SFSKKPKGSK DTKRTADPNN KRENYISNRT LAEISKDHNF LKEKDKISGF 1050
SSSLDKSFMD ENDYQSFIHN PSLTVTVPIA PGESDLENMN TEELSSDSDS 1100
DYSKERRNRS SSSECSTVDN PLPGEEEAEA EPINADEPEA CFTDGCVRRF 1150
PCCQVNIDSG KGKVWWTIRK TCYRIVEHSW FESFIVLMIL LSSGALAFED 1200
IYIEKKKTIK IILEYADKIF TYIFILEMLL KWVAYGYKTY FTNAWCWLDF 1250
LIVDVSLVTL VANTLGYSDL GPIKSLRTLR ALRPLRALSR FEGMRVVVNA 1300
LIGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFYECVNT TDGSRFSVSQ 1350
VANRSECFAL MNVSGNVRWK NLKVNFDNVG LGYLSLLQVA TFKGWMDIMY 1400
AAVDSVNVNA QPIYEYNLYM YIYFVIFIIF GSFFTLNLFI GVIIDNFNQQ 1450
KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPGNK FQGCIFDLVT 1500
NQAFDITIMV LICLNMVTMM VEKEGQTDYM SFVLYWINVV FIILFTGECV 1550
LKLISLRHYY FTVGWNIFDF VVVILSIVGM FLAEMIEKYF VSPTLFRVIR 1600
LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM 1650
SNFAYVKKEA GINDMFNFET FGNSMICLFQ ITTSAGWDGL LAPILNSAPP 1700
DCDPKKVHPG SSVEGDCGNP SVGIFYFVSY IIISFLVVVN MYIAVILENF 1750
SVATEESTEP LSEDDFEMFY EVWEKFDPDA TQFIEFCKLS DFAAALDPPL 1800
LIAKPNKVQL IAMDLPMVSG DRIHCLDILF AFTKRVLGES GEMDSLRSQM 1850
EERFMSANPS KVSYEPITTT LKRKQEDVSA TIIQRAYRRY RLRQNVKNIS 1900
SIYIKDGDRD DDLPNKEDIV FDNVNENSSP EKTDATASTI SPPSYDSVTK 1950
PDQEKYETDK TEKEDKEKDE SRK 1973
Length:1,973
Mass (Da):224,667
Last modified:April 8, 2008 - v1
Checksum:i2317EF807F7A2C9C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqiXP_006499098.1. XM_006499035.1.
UniGeneiMm.440889.

Genome annotation databases

EnsembliENSMUST00000112354; ENSMUSP00000107973; ENSMUSG00000075316.
GeneIDi20274.
KEGGimmu:20274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL928623 Genomic DNA. No translation available.
AL928726 Genomic DNA. No translation available.
RefSeqi XP_006499098.1. XM_006499035.1.
UniGenei Mm.440889.

3D structure databases

ProteinModelPortali B1AYL0.
SMRi B1AYL0. Positions 1748-1903.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000112354 ; ENSMUSP00000107973 ; ENSMUSG00000075316 .
GeneIDi 20274.
KEGGi mmu:20274.

Organism-specific databases

CTDi 6335.
MGIi MGI:107636. Scn9a.

Phylogenomic databases

GeneTreei ENSGT00560000076721.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
KOi K04841.

Miscellaneous databases

NextBioi 35546306.
SOURCEi Search...

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR024583. DUF3451.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR028803. SCN9A.
[Graphical view ]
PANTHERi PTHR10037:SF28. PTHR10037:SF28. 1 hit.
Pfami PF11933. DUF3451. 1 hit.
PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AYL0_MOUSE
AccessioniPrimary (citable) accession number: B1AYL0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 9, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi