B1AYL0 (B1AYL0_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Sodium channel protein type 9 subunit alpha Ensembl ENSMUSP00000107973

Gene names

Name:

Scn9a Ensembl ENSMUSP00000107973 MGI 107636

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000107973

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1973 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003809.
Sequence similarities	Belongs to the sodium channel family. RuleBase RU003809
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000107973

Ontologies

Keywords
Biological process	Ion transport Sodium transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378
Ligand	Sodium
Molecular function	Ion channel Sodium channel RuleBase RU003809 Voltage-gated channel RuleBase RU003809
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavioral response to pain Inferred from mutant phenotype PubMed 15314237. Source: MGI inflammatory response Inferred from mutant phenotype PubMed 15314237. Source: MGI post-embryonic development Inferred from mutant phenotype PubMed 15314237. Source: MGI response to toxin Inferred from direct assay PubMed 16029194. Source: MGI sodium ion transmembrane transport Inferred from electronic annotation. Source: GOC
Cellular_component	voltage-gated sodium channel complex Inferred from electronic annotation. Source: InterPro
Molecular_function	voltage-gated sodium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1AYL0 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 2317EF807F7A2C9C	FASTA	1,973	224,667
	10 20 30 40 50 60 MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS SDLEAGKQLP 70 80 90 100 110 120 FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF NATPALYMLS PFSPLRRISI 130 140 150 160 170 180 KILVHSLFSM LIMCTILTNC IFMTMSNPPD WTKNVEYTFT GIYTFESLIK ILARGFCVGE 190 200 210 220 230 240 FTFLRDPWNW LDFVVIVFAY LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ 250 260 270 280 290 300 SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK 310 320 330 340 350 360 RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA FLALFRLMTQ 370 380 390 400 410 420 DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE 430 440 450 460 470 480 LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL GRSRIMGLSE SSSETSRLSS KSAKERRNRR 490 500 510 520 530 540 KKKKQKLSSG EEKGDDEKLS KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG 550 560 570 580 590 600 SLFSARRSSR TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 610 620 630 640 650 660 ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEGTTN QMRKKRLSSS 670 680 690 700 710 720 YFLSEDMLND PHLRQRAMSR ASILTNTVEE LEESRQKCPP WWYRFAHTFL IWNCSPYWIK 730 740 750 760 770 780 FKKFIYFIVM DPFVDLAITI CIVLNTLFMA MEHHPMTDEF KNVLAVGNLV FTGIFAAEMV 790 800 810 820 830 840 LKLIAMDPYE YFQVGWNIFD SLIVTLSLVE LFLADVEGLS VLRSFRLLRV FKLAKSWPTL 850 860 870 880 890 900 NMLIKIIGNS VGALGNLTLV LAIIVFIFAV VGMQLFGKSY KECVCKINEN CKLPRWHMND 910 920 930 940 950 960 FFHSFLIVFR VLCGEWIETM WDCMEVAGQT MCLIVYMMVM VIGNLVVLNL FLALLLSSFS 970 980 990 1000 1010 1020 SDNLTAIEED TDANNLQIAV ARIKRGINYV KQTLREFILK SFSKKPKGSK DTKRTADPNN 1030 1040 1050 1060 1070 1080 KRENYISNRT LAEISKDHNF LKEKDKISGF SSSLDKSFMD ENDYQSFIHN PSLTVTVPIA 1090 1100 1110 1120 1130 1140 PGESDLENMN TEELSSDSDS DYSKERRNRS SSSECSTVDN PLPGEEEAEA EPINADEPEA 1150 1160 1170 1180 1190 1200 CFTDGCVRRF PCCQVNIDSG KGKVWWTIRK TCYRIVEHSW FESFIVLMIL LSSGALAFED 1210 1220 1230 1240 1250 1260 IYIEKKKTIK IILEYADKIF TYIFILEMLL KWVAYGYKTY FTNAWCWLDF LIVDVSLVTL 1270 1280 1290 1300 1310 1320 VANTLGYSDL GPIKSLRTLR ALRPLRALSR FEGMRVVVNA LIGAIPSIMN VLLVCLIFWL 1330 1340 1350 1360 1370 1380 IFSIMGVNLF AGKFYECVNT TDGSRFSVSQ VANRSECFAL MNVSGNVRWK NLKVNFDNVG 1390 1400 1410 1420 1430 1440 LGYLSLLQVA TFKGWMDIMY AAVDSVNVNA QPIYEYNLYM YIYFVIFIIF GSFFTLNLFI 1450 1460 1470 1480 1490 1500 GVIIDNFNQQ KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPGNK FQGCIFDLVT 1510 1520 1530 1540 1550 1560 NQAFDITIMV LICLNMVTMM VEKEGQTDYM SFVLYWINVV FIILFTGECV LKLISLRHYY 1570 1580 1590 1600 1610 1620 FTVGWNIFDF VVVILSIVGM FLAEMIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL 1630 1640 1650 1660 1670 1680 LFALMMSLPA LFNIGLLLFL VMFIYAIFGM SNFAYVKKEA GINDMFNFET FGNSMICLFQ 1690 1700 1710 1720 1730 1740 ITTSAGWDGL LAPILNSAPP DCDPKKVHPG SSVEGDCGNP SVGIFYFVSY IIISFLVVVN 1750 1760 1770 1780 1790 1800 MYIAVILENF SVATEESTEP LSEDDFEMFY EVWEKFDPDA TQFIEFCKLS DFAAALDPPL 1810 1820 1830 1840 1850 1860 LIAKPNKVQL IAMDLPMVSG DRIHCLDILF AFTKRVLGES GEMDSLRSQM EERFMSANPS 1870 1880 1890 1900 1910 1920 KVSYEPITTT LKRKQEDVSA TIIQRAYRRY RLRQNVKNIS SIYIKDGDRD DDLPNKEDIV 1930 1940 1950 1960 1970 FDNVNENSSP EKTDATASTI SPPSYDSVTK PDQEKYETDK TEKEDKEKDE SRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000107973.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000107973.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL928623 Genomic DNA. No translation available. AL928726 Genomic DNA. No translation available.
IPI	IPI00671181.
UniGene	Mm.440889.
3D structure databases
ProteinModelPortal	B1AYL0.
SMR	B1AYL0. Positions 1748-1903.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112354; ENSMUSP00000107973; ENSMUSG00000075316.
UCSC	uc008jxd.1. mouse.
Organism-specific databases
MGI	MGI:107636. Scn9a.
Phylogenomic databases
GeneTree	ENSGT00560000076721.
HOGENOM	HOG000231755.
HOVERGEN	HBG053100.
Gene expression databases
ArrayExpress	B1AYL0.
Family and domain databases
InterPro	IPR024583. DUF3451. IPR005821. Ion_trans_dom. IPR000048. IQ_motif_EF-hand-BS. IPR001696. Na_channel_asu. IPR010526. Na_trans_assoc. [Graphical view]
Pfam	PF11933. DUF3451. 1 hit. PF00520. Ion_trans. 4 hits. PF06512. Na_trans_assoc. 1 hit. [Graphical view]
PRINTS	PR00170. NACHANNEL.
SMART	SM00015. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35546306.
SOURCE	Search...

Entry information

Entry name

B1AYL0_MOUSE

Accession

Primary (citable) accession number: B1AYL0

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	April 3, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)