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B1AYL0

- B1AYL0_MOUSE

UniProt

B1AYL0 - B1AYL0_MOUSE

Protein

Sodium channel protein

Gene

Scn9a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: RefGenome

    GO - Biological processi

    1. behavioral response to pain Source: MGI
    2. inflammatory response Source: MGI
    3. membrane depolarization during action potential Source: RefGenome
    4. neuronal action potential Source: RefGenome
    5. post-embryonic development Source: MGI
    6. response to toxic substance Source: MGI
    7. sodium ion transmembrane transport Source: RefGenome

    Keywords - Molecular functioni

    Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel proteinUniRule annotation
    Gene namesi
    Name:Scn9aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:107636. Scn9a.

    Subcellular locationi

    Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: RefGenome
    2. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Structurei

    3D structure databases

    ProteinModelPortaliB1AYL0.
    SMRiB1AYL0. Positions 1748-1900.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00560000076721.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    KOiK04841.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    IPR028803. SCN9A.
    [Graphical view]
    PANTHERiPTHR10037:SF28. PTHR10037:SF28. 1 hit.
    PfamiPF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1AYL0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKGHKDEKK DDEEEGPKPS     50
    SDLEAGKQLP FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF 100
    NATPALYMLS PFSPLRRISI KILVHSLFSM LIMCTILTNC IFMTMSNPPD 150
    WTKNVEYTFT GIYTFESLIK ILARGFCVGE FTFLRDPWNW LDFVVIVFAY 200
    LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ SVKKLSDVMI 250
    LTVFCLSVFA LIGLQLFMGN LKHKCFRKDL EQNETLESIM STAESEEELK 300
    RYFYYLEGSK DALLCGFSTD SGQCPEGYEC VTAGRNPDYG YTSFDTFGWA 350
    FLALFRLMTQ DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV 400
    VAMAYEEQNQ ANIEEAKQKE LEFQQMLDRL KKEQEEAEAI AAAAAEYTSL 450
    GRSRIMGLSE SSSETSRLSS KSAKERRNRR KKKKQKLSSG EEKGDDEKLS 500
    KSGSEESIRK KSFHLGVEGH HRAREKRLST PNQSPLSIRG SLFSARRSSR 550
    TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 600
    ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEGTTN 650
    QMRKKRLSSS YFLSEDMLND PHLRQRAMSR ASILTNTVEE LEESRQKCPP 700
    WWYRFAHTFL IWNCSPYWIK FKKFIYFIVM DPFVDLAITI CIVLNTLFMA 750
    MEHHPMTDEF KNVLAVGNLV FTGIFAAEMV LKLIAMDPYE YFQVGWNIFD 800
    SLIVTLSLVE LFLADVEGLS VLRSFRLLRV FKLAKSWPTL NMLIKIIGNS 850
    VGALGNLTLV LAIIVFIFAV VGMQLFGKSY KECVCKINEN CKLPRWHMND 900
    FFHSFLIVFR VLCGEWIETM WDCMEVAGQT MCLIVYMMVM VIGNLVVLNL 950
    FLALLLSSFS SDNLTAIEED TDANNLQIAV ARIKRGINYV KQTLREFILK 1000
    SFSKKPKGSK DTKRTADPNN KRENYISNRT LAEISKDHNF LKEKDKISGF 1050
    SSSLDKSFMD ENDYQSFIHN PSLTVTVPIA PGESDLENMN TEELSSDSDS 1100
    DYSKERRNRS SSSECSTVDN PLPGEEEAEA EPINADEPEA CFTDGCVRRF 1150
    PCCQVNIDSG KGKVWWTIRK TCYRIVEHSW FESFIVLMIL LSSGALAFED 1200
    IYIEKKKTIK IILEYADKIF TYIFILEMLL KWVAYGYKTY FTNAWCWLDF 1250
    LIVDVSLVTL VANTLGYSDL GPIKSLRTLR ALRPLRALSR FEGMRVVVNA 1300
    LIGAIPSIMN VLLVCLIFWL IFSIMGVNLF AGKFYECVNT TDGSRFSVSQ 1350
    VANRSECFAL MNVSGNVRWK NLKVNFDNVG LGYLSLLQVA TFKGWMDIMY 1400
    AAVDSVNVNA QPIYEYNLYM YIYFVIFIIF GSFFTLNLFI GVIIDNFNQQ 1450
    KKKLGGQDIF MTEEQKKYYN AMKKLGSKKP QKPIPRPGNK FQGCIFDLVT 1500
    NQAFDITIMV LICLNMVTMM VEKEGQTDYM SFVLYWINVV FIILFTGECV 1550
    LKLISLRHYY FTVGWNIFDF VVVILSIVGM FLAEMIEKYF VSPTLFRVIR 1600
    LARIGRILRL IKGAKGIRTL LFALMMSLPA LFNIGLLLFL VMFIYAIFGM 1650
    SNFAYVKKEA GINDMFNFET FGNSMICLFQ ITTSAGWDGL LAPILNSAPP 1700
    DCDPKKVHPG SSVEGDCGNP SVGIFYFVSY IIISFLVVVN MYIAVILENF 1750
    SVATEESTEP LSEDDFEMFY EVWEKFDPDA TQFIEFCKLS DFAAALDPPL 1800
    LIAKPNKVQL IAMDLPMVSG DRIHCLDILF AFTKRVLGES GEMDSLRSQM 1850
    EERFMSANPS KVSYEPITTT LKRKQEDVSA TIIQRAYRRY RLRQNVKNIS 1900
    SIYIKDGDRD DDLPNKEDIV FDNVNENSSP EKTDATASTI SPPSYDSVTK 1950
    PDQEKYETDK TEKEDKEKDE SRK 1973
    Length:1,973
    Mass (Da):224,667
    Last modified:April 8, 2008 - v1
    Checksum:i2317EF807F7A2C9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928623 Genomic DNA. No translation available.
    AL928726 Genomic DNA. No translation available.
    RefSeqiXP_006499098.1. XM_006499035.1.
    UniGeneiMm.440889.

    Genome annotation databases

    EnsembliENSMUST00000112354; ENSMUSP00000107973; ENSMUSG00000075316.
    GeneIDi20274.
    KEGGimmu:20274.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL928623 Genomic DNA. No translation available.
    AL928726 Genomic DNA. No translation available.
    RefSeqi XP_006499098.1. XM_006499035.1.
    UniGenei Mm.440889.

    3D structure databases

    ProteinModelPortali B1AYL0.
    SMRi B1AYL0. Positions 1748-1900.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000112354 ; ENSMUSP00000107973 ; ENSMUSG00000075316 .
    GeneIDi 20274.
    KEGGi mmu:20274.

    Organism-specific databases

    CTDi 6335.
    MGIi MGI:107636. Scn9a.

    Phylogenomic databases

    GeneTreei ENSGT00560000076721.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    KOi K04841.

    Miscellaneous databases

    NextBioi 35546306.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR024583. DUF3451.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    IPR028803. SCN9A.
    [Graphical view ]
    PANTHERi PTHR10037:SF28. PTHR10037:SF28. 1 hit.
    Pfami PF11933. DUF3451. 1 hit.
    PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB1AYL0_MOUSE
    AccessioniPrimary (citable) accession number: B1AYL0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3