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B1AY13

- UBP24_MOUSE

UniProt

B1AY13 - UBP24_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 24

Gene
Usp24
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1695 – 16951Nucleophile By similarity
Active sitei1967 – 19671Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 24
Ubiquitin thioesterase 24
Ubiquitin-specific-processing protease 24
Gene namesi
Name:Usp24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1919936. Usp24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26172617Ubiquitin carboxyl-terminal hydrolase 24PRO_0000353213Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621Phosphoserine By similarity
Modified residuei939 – 9391Phosphotyrosine1 Publication
Modified residuei1138 – 11381Phosphoserine By similarity
Modified residuei2044 – 20441Phosphoserine2 Publications
Modified residuei2074 – 20741Phosphoserine1 Publication
Modified residuei2558 – 25581Phosphoserine By similarity
Modified residuei2562 – 25621Phosphothreonine By similarity
Modified residuei2601 – 26011Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiB1AY13.
PaxDbiB1AY13.
PRIDEiB1AY13.

PTM databases

PhosphoSiteiB1AY13.

Expressioni

Gene expression databases

ArrayExpressiB1AY13.
BgeeiB1AY13.
GenevestigatoriB1AY13.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092538.

Structurei

3D structure databases

ProteinModelPortaliB1AY13.
SMRiB1AY13. Positions 1648-2040.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 4442UBAAdd
BLAST
Domaini1686 – 2039354USPAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi47 – 9145Gly-richAdd
BLAST
Compositional biasi1032 – 105928Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 UBA domain.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5077.
GeneTreeiENSGT00740000115055.
HOGENOMiHOG000068011.
HOVERGENiHBG105784.
InParanoidiB1AY13.
KOiK11840.
OrthoDBiEOG712TV9.
PhylomeDBiB1AY13.
TreeFamiTF323966.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B1AY13-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY     50
GGYEPMDSGG PSPGPGGGPR GDSGSDGSGP SRGGSTGGGG GFDPPPAYHE 100
VVDAEKNDEN GNCSGEGIEF PTTNLYELES RVLTDHWSIP YKREESLGKC 150
LLASTYLARL GLSESDENCK RFMERCMPEA FKKLLTSSAV HKWGTEIHEG 200
IYNMLMLLIE LVAERMKQDP IPIGLLGVLT MAFNPDNEYH FKNRMKVSQR 250
NWAEVFGEGN MFAISPVSTF QKEPHGWVVD LVNKFGELGG FAAIQAKLHS 300
EDIELGAVSA LVQPLGVCAE YLNSSVVQPM LDPVILTTIQ DVRSVEEKDL 350
KDKRLVSIPE LLSAIKLLCM RFQPALVTTV DALRLDILLR MLKSPHFSAK 400
MNSLKEVTKL IEDSTLSKSV KNAIDTDRLL DWLVENSVLS IALEGNIDQA 450
QYCDRIKGII ELLGSKLSLD ELTKIWKIQS GQSSTVIENI HTIIAAAAVK 500
FNADQLNHLF VLIQKSWETE SDRVRQKLLS LIGRIGREAR FEATSGKVLD 550
VLWELAHLPT LPSSLIQQAL EEHLTILSDA YAVKEAVKRS YIIKCIEDIK 600
RPGEWSSLEK NKKDGFKSSQ LNNPQFVWVV PALRQLHEIT RSFIKQTYQK 650
QDKSIIQDLK KNFEIVKLVT GSLLACHRLA AAVAGPGGLT GLTLVDGRYT 700
YREYLEAHLK FLAFFLQEAT LYLGWNRAKE IWECLVTGQD VCELDREMCF 750
EWFTKGQHDL ESDVQQQLFK EKILKLESYE ITMNGFNLFK TFFENVNLCD 800
HRLKRQGAQL YVEKLELVGM DFIWKIAMES PDEEIANEAI QLIINYSYIN 850
LNPRLKKDSV SLHKKFIADC YTRLEAASSA LGGPTLTHAV TRATKMLTAT 900
AMPTVATSVQ SPYRSTKLVI IERLLLLAER YVITIEDFYS VPRTILPHGA 950
SFHGHLLTLN VTYESTKDTF TVEAHSNETI GSVRWKIAKQ LCSPVDNIQI 1000
FTNDSLLTVN KDQKLLHQLG FSDEQVLTVK TSGSGTPSGS SADSSTSSSS 1050
SSSGAFSSSY AMEQEKSLPG VVMALVCNVF DMLYQLANLE EPRITLRVRK 1100
LLLLIPTDPA IQEALDQLDS LGRKKTLLSE TSSQSSKSPS LSSKQQHQPS 1150
ASSILESLFR SFAPGMSTFR VLYNLEVLSS KLMPTADDDM ARSCAKSFCE 1200
NFLKAGGLSL VVNVMQRDSI PSEVDYETRQ GVYSICLQLA RFLLVGQTMP 1250
TSLDEDLTKD GIEALSSRPF RNVSRQTSRQ MSLCGTPEKS SYRQLSVSDR 1300
SSIRVEEIIP AARVAIQTME ASDFTATVAC FMRLSWAAAA GRLDLVGSSQ 1350
PIKESNSLFP AGIRSRLSSS GSNCSSSSEG EPAALHAGIC VRQQSVSTKD 1400
ALIAGEALSL LVTCLQLRSQ QLASFYSLPC VADFIIDILL GSPSAEIRRV 1450
ACDQLYTLSQ TDTSAHPEVQ KPNQFLLGVI LTAQLPLWSP TSIMRGVNQR 1500
LLSQCMEYFD LRCQLLDDLT TSEMDQLRIS PATMLEDEIT WLDNFEPNRT 1550
ADCETSEADN ILLAGHLRLI KTLLSLCGAE KEMLGSSLIK PLLDDFLFRA 1600
SRIIVNSHSP ASSAAISQQD FHPKCSTVNS RLAAYEVLVM LADSSPSNLQ 1650
IITKELLSMH HQPDPALTKE FDYLPPVDSR SSSGFVGLRN GGATCYMNAV 1700
FQQLYMQPGL PESLLSVDDD TDNPDDSVFY QVQSLFGHLM ESKLQYYVPE 1750
NFWKIFKMWN KELYVREQQD AYEFFTSLID QMDEYLKKMG REQIFKNTFQ 1800
GIYSDQKICK DCPHRYEREE AFMALNLGVT SCQSLEISLD QFVRGEVLEG 1850
SNAYYCEKCK EKRITVKRTC IKSLPSVLVI HLMRFGFDWE SGRSIKYDEQ 1900
IRFPWMLNME PYTVAGMARQ DSSSEVGENG RNMDQGGGGS PRKKVALTEN 1950
YELVGVIVHS GQAHAGHYYS FIKDRRGCGK GKWYKFNDTV IEEFDLNDET 2000
LEYECFGGEY RPKVYDQTNP YTDVRRRYWN AYMLFYQRVS DQNSPVLPKK 2050
SRVSVVRQEA EDLSLSAPSS PEISPQSSPR PHRPNNDRLS ILTKLVKKGE 2100
KKGLFVEKMP ARIYQMVRDE NLKFMKNRDV YSSDYFSFVL SLASLNATKL 2150
KHPYYPCMAK VSLQLAIQFL FQTYLRTKKK LRVDTEEWIA TIEALLSKSL 2200
DACQWLVEYF ISSEGRELVK VFLLECSVRE VRVAVATILE KTLDSALFYQ 2250
DKLKSLHQLL EVLLALLDKD VPENCKNCAQ YFSLFNTFVQ KQGIRAGDLL 2300
LRHSALRHMI SFLLGVSRQN SQIRRWSSAQ AREFGNLHNT VALLVLHSDV 2350
SSQRNVAPGI FKQRPPISVA PSSPLLPLHE EVEALLFLSE GKPYLLEVMF 2400
ALRELTGSLL ALMEMVVYCC FCNEHFSFTM LHFIKNQLET APPHELKNTF 2450
QLLHEVLVIE DPIQVERVKF VFETENGLLA LMHHSNHVDS SRCYQCVKFL 2500
VTLAQKCPAA KEYFKENSHH WSWAVQWLQK KMSEHYWTPQ SNVSNETSTG 2550
KTFQRTISAQ DTLAYATALL NEKEQSGSSN GSESSPANEN GERHLQQGSE 2600
SPMMIGELRS DLDDVDP 2617
Length:2,617
Mass (Da):294,001
Last modified:April 8, 2008 - v1
Checksum:i802DFE22143B2C94
GO
Isoform 2 (identifier: B1AY13-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     408-418: TKLIEDSTLSK → SVHLSHMWPLM
     419-2617: Missing.

Show »
Length:418
Mass (Da):45,968
Checksum:i21F4B4F0BAA3737F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei408 – 41811TKLIEDSTLSK → SVHLSHMWPLM in isoform 2. VSP_035661Add
BLAST
Alternative sequencei419 – 26172199Missing in isoform 2. VSP_035662Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045043 mRNA. Translation: BAC32195.1.
AL954352, AL840623 Genomic DNA. Translation: CAM15750.1.
AL840623, AL954352 Genomic DNA. Translation: CAM19818.1.
AL840623 Genomic DNA. Translation: CAM19819.1.
BC029165 mRNA. No translation available.
CCDSiCCDS51251.1. [B1AY13-1]
RefSeqiNP_899048.2. NM_183225.2. [B1AY13-1]
UniGeneiMm.234544.

Genome annotation databases

EnsembliENSMUST00000094933; ENSMUSP00000092538; ENSMUSG00000028514. [B1AY13-1]
ENSMUST00000106798; ENSMUSP00000102410; ENSMUSG00000028514. [B1AY13-2]
GeneIDi329908.
KEGGimmu:329908.
UCSCiuc008tyf.2. mouse. [B1AY13-2]
uc008tyh.2. mouse. [B1AY13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK045043 mRNA. Translation: BAC32195.1 .
AL954352 , AL840623 Genomic DNA. Translation: CAM15750.1 .
AL840623 , AL954352 Genomic DNA. Translation: CAM19818.1 .
AL840623 Genomic DNA. Translation: CAM19819.1 .
BC029165 mRNA. No translation available.
CCDSi CCDS51251.1. [B1AY13-1 ]
RefSeqi NP_899048.2. NM_183225.2. [B1AY13-1 ]
UniGenei Mm.234544.

3D structure databases

ProteinModelPortali B1AY13.
SMRi B1AY13. Positions 1648-2040.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000092538.

PTM databases

PhosphoSitei B1AY13.

Proteomic databases

MaxQBi B1AY13.
PaxDbi B1AY13.
PRIDEi B1AY13.

Protocols and materials databases

DNASUi 329908.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000094933 ; ENSMUSP00000092538 ; ENSMUSG00000028514 . [B1AY13-1 ]
ENSMUST00000106798 ; ENSMUSP00000102410 ; ENSMUSG00000028514 . [B1AY13-2 ]
GeneIDi 329908.
KEGGi mmu:329908.
UCSCi uc008tyf.2. mouse. [B1AY13-2 ]
uc008tyh.2. mouse. [B1AY13-1 ]

Organism-specific databases

CTDi 23358.
MGIi MGI:1919936. Usp24.

Phylogenomic databases

eggNOGi COG5077.
GeneTreei ENSGT00740000115055.
HOGENOMi HOG000068011.
HOVERGENi HBG105784.
InParanoidi B1AY13.
KOi K11840.
OrthoDBi EOG712TV9.
PhylomeDBi B1AY13.
TreeFami TF323966.

Miscellaneous databases

ChiTaRSi USP24. mouse.
NextBioi 399031.
PROi B1AY13.
SOURCEi Search...

Gene expression databases

ArrayExpressi B1AY13.
Bgeei B1AY13.
Genevestigatori B1AY13.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR009060. UBA-like.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR029071. Ubiquitin-rel_dom.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
SUPFAMi SSF46934. SSF46934. 1 hit.
SSF48371. SSF48371. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50030. UBA. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2384-2617 (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-939, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2044 AND SER-2074, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2044, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUBP24_MOUSE
AccessioniPrimary (citable) accession number: B1AY13
Secondary accession number(s): Q8BLI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 4, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi