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Protein
Submitted name:

Ribosomal protein S6 kinase alpha-3

Gene

Rps6ka3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ribosomal protein S6 kinase alpha-3Imported
Gene namesi
Name:Rps6ka3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:104557. Rps6ka3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiB1AXN9.
PaxDbiB1AXN9.
PRIDEiB1AXN9.

Expressioni

Gene expression databases

BgeeiB1AXN9.
ExpressionAtlasiB1AXN9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033671.

Chemistry

BindingDBiB1AXN9.

Structurei

3D structure databases

ProteinModelPortaliB1AXN9.
SMRiB1AXN9. Positions 23-686.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 299260Protein kinaseInterPro annotationAdd
BLAST
Domaini300 – 36970AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini394 – 651258Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
OrthoDBiEOG7B8S38.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AXN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEPMGEEEI NPQTEEGSIK EIAITHHVKE GHEKADPSQF ELLKVLGQGS
60 70 80 90 100
FGKVFLVKKI SGSDARQLYA MKVLKKATLK VRDRVRTKME RDILVEVNHP
110 120 130 140 150
FIVKLHYAFQ TEGKLYLILD FLRGGDLFTR LSKEVMFTEE DVKFYLAELA
160 170 180 190 200
LALDHLHSLG IIYRDLKPEN ILLDEEGHIK LTDFGLSKES IDHEKKAYSF
210 220 230 240 250
CGTVEYMAPE VVNRRGHTQS ADWWSFGVLM FEMLTGTLPF QGKDRKETMT
260 270 280 290 300
MILKAKLGMP QFLSPEAQSL LRMLFKRNPA NRLGAGPDGV EEIKRHSFFS
310 320 330 340 350
TIDWNKLYRR EIHPPFKPAT GRPEDTFYFD PEFTAKTPKD SPGIPPSANA
360 370 380 390 400
HQLFRGFSFV AITSDDESQA MQTVGVHSIV QQLHRNSIQF TDGYEVKEDI
410 420 430 440 450
GVGSYSVCKR CIHKATNMEF AVKIIDKSKR DPTEEIEILL RYGQHPNIIT
460 470 480 490 500
LKDVYDDGKY VYVVTELMKG GELLDKILRQ KFFSEREASA VLFTITKTVE
510 520 530 540 550
YLHAQGVVHR DLKPSNILYV DESGNPESIR ICDFGFAKQL RAENGLLMTP
560 570 580 590 600
CYTANFVAPE VLKRQGYDAA CDIWSLGVLL YTMLTGYTPF ANGPDDTPEE
610 620 630 640 650
ILARIGSGKF SLSGGYWNSV SDTAKDLVSK MLHVDPHQRL TAALVLRHPW
660 670 680 690 700
IVHWDQLPQY QLNRQDAPHL VKGAMAATYS ALNRNQSPVL EPVGRSTLAQ
710
RRGIKKITST AL
Length:712
Mass (Da):80,670
Last modified:April 8, 2008 - v1
Checksum:i7156B8A0F3BECB3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671881 Genomic DNA. No translation available.
AL808146 Genomic DNA. No translation available.
RefSeqiXP_006528749.1. XM_006528686.1.
XP_006528750.1. XM_006528687.1.
UniGeneiMm.328476.
Mm.392829.

Genome annotation databases

EnsembliENSMUST00000112493; ENSMUSP00000108112; ENSMUSG00000031309.
GeneIDi110651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671881 Genomic DNA. No translation available.
AL808146 Genomic DNA. No translation available.
RefSeqiXP_006528749.1. XM_006528686.1.
XP_006528750.1. XM_006528687.1.
UniGeneiMm.328476.
Mm.392829.

3D structure databases

ProteinModelPortaliB1AXN9.
SMRiB1AXN9. Positions 23-686.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033671.

Chemistry

BindingDBiB1AXN9.

Proteomic databases

MaxQBiB1AXN9.
PaxDbiB1AXN9.
PRIDEiB1AXN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000112493; ENSMUSP00000108112; ENSMUSG00000031309.
GeneIDi110651.

Organism-specific databases

CTDi6197.
MGIiMGI:104557. Rps6ka3.

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00820000126961.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
OrthoDBiEOG7B8S38.

Miscellaneous databases

ChiTaRSiRps6ka3. mouse.
NextBioi35546240.
SOURCEiSearch...

Gene expression databases

BgeeiB1AXN9.
ExpressionAtlasiB1AXN9. baseline and differential.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016239. Ribosomal_S6_kinase_II.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000606. Ribsml_S6_kin_2. 1 hit.
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00108. PROTEIN_KINASE_ST. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AXN9_MOUSE
AccessioniPrimary (citable) accession number: B1AXN9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.