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Protein

Akirin-2

Gene

Akirin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Required for embryonic development and the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • embryo development Source: UniProtKB
  • innate immune response Source: UniProtKB-KW
  • negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of endopeptidase activity Source: Ensembl
  • positive regulation of interleukin-6 production Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • response to lipopolysaccharide Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Immunity, Innate immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Akirin-2
Gene namesi
Name:Akirin21 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1889364. Akirin2.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are embryonic lethal. Null mutant embryos could not be detected even on embryonic day 9.5.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Akirin-2PRO_0000355121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181PhosphoserineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei55 – 551PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiB1AXD8.
MaxQBiB1AXD8.
PaxDbiB1AXD8.
PRIDEiB1AXD8.

PTM databases

iPTMnetiB1AXD8.
PhosphoSiteiB1AXD8.

Expressioni

Gene expression databases

BgeeiB1AXD8.
GenevisibleiB1AXD8. MM.

Interactioni

Subunit structurei

Interacts with YWHAB.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NFKBIZQ9BYH83EBI-10107866,EBI-3939694From a different organism.
NfkbizQ9EST83EBI-10107866,EBI-10107924
Smarcd1Q614662EBI-10107866,EBI-371529

GO - Molecular functioni

Protein-protein interaction databases

IntActiB1AXD8. 6 interactions.
STRINGi10090.ENSMUSP00000081322.

Structurei

3D structure databases

ProteinModelPortaliB1AXD8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi23 – 286Nuclear localization signal

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 5427Ala-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the akirin family.Curated

Phylogenomic databases

eggNOGiKOG4330. Eukaryota.
ENOG4111J00. LUCA.
GeneTreeiENSGT00390000007905.
HOGENOMiHOG000231406.
HOVERGENiHBG055078.
InParanoidiB1AXD8.
OMAiRAQMGTI.
OrthoDBiEOG72ZCGW.
PhylomeDBiB1AXD8.
TreeFamiTF317123.

Family and domain databases

InterProiIPR024132. Akirin.
[Graphical view]
PANTHERiPTHR13293. PTHR13293. 1 hit.

Sequencei

Sequence statusi: Complete.

B1AXD8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACGATLKRT LDFDPLLSPA SPKRRRCAPL SAPASAAASP AAATAAAAAS
60 70 80 90 100
AAAASPQKYL RMEPSPFGDV SSRLTTEQIL YNIKQEYKRM QKRRHLEASF
110 120 130 140 150
QQADPGCTSD SQPHAFLISG PASPGTSSAT SSPLKKEQPL FTLRQVGMIC
160 170 180 190 200
ERLLKEREEK VREEYEEILN TKLAEQYDAF VKFTHDQIMR RYGEQPASYV

S
Length:201
Mass (Da):22,113
Last modified:April 8, 2008 - v1
Checksum:i8DB8235D12246DD1
GO

Sequence cautioni

The sequence BAB24265.1 differs from that shown. Reason: Frameshift at positions 130, 148 and 173. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481A → V in BAB24265 (PubMed:16141072).Curated
Sequence conflicti181 – 1811V → G in BAB24265 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005836 mRNA. Translation: BAB24265.1. Frameshift.
AL807397 Genomic DNA. Translation: CAM16479.1.
CCDSiCCDS18027.1.
RefSeqiNP_001007590.2. NM_001007589.3.
XP_011248361.1. XM_011250059.1.
XP_011248362.1. XM_011250060.1.
UniGeneiMm.389532.
Mm.399624.

Genome annotation databases

EnsembliENSMUST00000084299; ENSMUSP00000081322; ENSMUSG00000028291.
GeneIDi433693.
KEGGimmu:433693.
UCSCiuc008sga.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005836 mRNA. Translation: BAB24265.1. Frameshift.
AL807397 Genomic DNA. Translation: CAM16479.1.
CCDSiCCDS18027.1.
RefSeqiNP_001007590.2. NM_001007589.3.
XP_011248361.1. XM_011250059.1.
XP_011248362.1. XM_011250060.1.
UniGeneiMm.389532.
Mm.399624.

3D structure databases

ProteinModelPortaliB1AXD8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiB1AXD8. 6 interactions.
STRINGi10090.ENSMUSP00000081322.

PTM databases

iPTMnetiB1AXD8.
PhosphoSiteiB1AXD8.

Proteomic databases

EPDiB1AXD8.
MaxQBiB1AXD8.
PaxDbiB1AXD8.
PRIDEiB1AXD8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084299; ENSMUSP00000081322; ENSMUSG00000028291.
GeneIDi433693.
KEGGimmu:433693.
UCSCiuc008sga.1. mouse.

Organism-specific databases

CTDi55122.
MGIiMGI:1889364. Akirin2.

Phylogenomic databases

eggNOGiKOG4330. Eukaryota.
ENOG4111J00. LUCA.
GeneTreeiENSGT00390000007905.
HOGENOMiHOG000231406.
HOVERGENiHBG055078.
InParanoidiB1AXD8.
OMAiRAQMGTI.
OrthoDBiEOG72ZCGW.
PhylomeDBiB1AXD8.
TreeFamiTF317123.

Miscellaneous databases

ChiTaRSiAkirin2. mouse.
NextBioi408895.
PROiB1AXD8.
SOURCEiSearch...

Gene expression databases

BgeeiB1AXD8.
GenevisibleiB1AXD8. MM.

Family and domain databases

InterProiIPR024132. Akirin.
[Graphical view]
PANTHERiPTHR13293. PTHR13293. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: TestisImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-21, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in Drosophila and mice."
    Goto A., Matsushita K., Gesellchen V., El Chamy L., Kuttenkeuler D., Takeuchi O., Hoffmann J.A., Akira S., Boutros M., Reichhart J.-M.
    Nat. Immunol. 9:97-104(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-21 AND SER-55, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiAKIR2_MOUSE
AccessioniPrimary (citable) accession number: B1AXD8
Secondary accession number(s): Q641L8, Q9DAH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: March 16, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.