Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sodium channel protein

Gene

Scn2a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent sodium ion permeability of excitable membranes.UniRule annotation

GO - Molecular functioni

  • voltage-gated sodium channel activity Source: MGI

GO - Biological processi

  • intrinsic apoptotic signaling pathway in response to osmotic stress Source: MGI
  • membrane depolarization during action potential Source: GO_Central
  • nervous system development Source: MGI
  • neuronal action potential Source: GO_Central
  • neuron apoptotic process Source: MGI
  • sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channelUniRule annotation, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel proteinUniRule annotation
Gene namesi
Name:Scn2a1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98248. Scn2a1.

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei125 – 14824HelicalUniRule annotationAdd
BLAST
Transmembranei193 – 21220HelicalUniRule annotationAdd
BLAST
Transmembranei224 – 24522HelicalUniRule annotationAdd
BLAST
Transmembranei251 – 27121HelicalUniRule annotationAdd
BLAST
Transmembranei401 – 42828HelicalUniRule annotationAdd
BLAST
Transmembranei752 – 77625HelicalUniRule annotationAdd
BLAST
Transmembranei788 – 80922HelicalUniRule annotationAdd
BLAST
Transmembranei871 – 89929HelicalUniRule annotationAdd
BLAST
Transmembranei961 – 98424HelicalUniRule annotationAdd
BLAST
Transmembranei1210 – 122819HelicalUniRule annotationAdd
BLAST
Transmembranei1249 – 127123HelicalUniRule annotationAdd
BLAST
Transmembranei1277 – 129721HelicalUniRule annotationAdd
BLAST
Transmembranei1326 – 135227HelicalUniRule annotationAdd
BLAST
Transmembranei1450 – 147425HelicalUniRule annotationAdd
BLAST
Transmembranei1533 – 155119HelicalUniRule annotationAdd
BLAST
Transmembranei1563 – 158119HelicalUniRule annotationAdd
BLAST
Transmembranei1593 – 161321HelicalUniRule annotationAdd
BLAST
Transmembranei1650 – 167829HelicalUniRule annotationAdd
BLAST
Transmembranei1754 – 177724HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  • axon Source: MGI
  • intercalated disc Source: MGI
  • intracellular Source: GOC
  • membrane Source: MGI
  • paranode region of axon Source: MGI
  • T-tubule Source: MGI
  • voltage-gated sodium channel complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

PTM databases

PhosphoSiteiB1AWN6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000075318.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028377.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 435308Ion_transInterPro annotationAdd
BLAST
Domaini507 – 710204Na_trans_cytoplInterPro annotationAdd
BLAST
Domaini761 – 989229Ion_transInterPro annotationAdd
BLAST
Domaini998 – 1204207Na_trans_assocInterPro annotationAdd
BLAST
Domaini1208 – 1482275Ion_transInterPro annotationAdd
BLAST
Domaini1532 – 1787256Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili425 – 47046Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the sodium channel (TC 1.A.1.10) family. [View classification]UniRule annotation
Contains 1 IQ domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04834.
OMAiDQTKEMD.
OrthoDBiEOG091G00FK.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AWN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP
60 70 80 90 100
KPNSDLEAGK SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI
110 120 130 140 150
SRFSATSALY ILTPFNPIRK LAIKILVHSL FNVLIMCTIL TNCVFMTMSN
160 170 180 190 200
PPDWTKNVEY TFTGIYTFES LIKILARGFC LEDFTFLRDP WNWLDFTVIT
210 220 230 240 250
FAYVTEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD
260 270 280 290 300
VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSTFEI NITSFFNNSL
310 320 330 340 350
DWNGTAFNRT MNMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG
360 370 380 390 400
YICVKAGRNP NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT
410 420 430 440 450
YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATLEEAE QKEAEFQQML
460 470 480 490 500
EQLKKQQEEA QAAAAAASAE SRDFSGAGGI GVFSESSSVA SKLSSKSEKE
510 520 530 540 550
LKNRRKKKKQ KEQAGEEEKE DAVRKSASED SIRKKGFRFS LEGSRLTYEK
560 570 580 590 600
RFSSPHQSLL SIRGSLFSPR RNSRASLFSF KGRVKDIGSE NDFADDEHST
610 620 630 640 650
FEDNDSRRDS LFVPHRHGER RPSNVSQASR ASRGIPTLPM NGKMHSAVDC
660 670 680 690 700
NGVVSLVGGP SALTSPVGQL LPEGTTTETE IRKRRSSSYH VSMDLLEDPT
710 720 730 740 750
SRQRAMSMAS ILTNTMEELE ESRQKCPPCW YKFANMCLIW DCCKPWLKVK
760 770 780 790 800
HVVNLVVMDP FVDLAITICI VLNTLFMAME HYPMTEQFSS VLSVGNLVFT
810 820 830 840 850
GIFTAEMFLK IIAMDPYYYF QEGWNIFDGF IVSLSLMELG LANVEGLSVL
860 870 880 890 900
RSFRLLRVFK LAKSWPTLNM LIKIIGNSVG ALGNLTLVLA IIVFIFAVVG
910 920 930 940 950
MQLFGKSYKE CVCKISNDCE LPRWHMHDFF HSFLIVFRVL CGEWIETMWD
960 970 980 990 1000
CMEVAGQTMC LTVFMMVMVI GNLVVLNLFL ALLLSSFSSD NLAATDDDNE
1010 1020 1030 1040 1050
MNNLQIAVGR MQKGIDFVKR KIREFIQKAF VRKQKALDEI KPLEDLNNKK
1060 1070 1080 1090 1100
DSCISNHTTI EIGKDLNYLK DGNGTTSGIG SSVEKYVVDE SDYMSFINNP
1110 1120 1130 1140 1150
SLTVTVPIAV GESDFENLNT EEFSSESDME ESKEKLNATS SSEGSTVDIG
1160 1170 1180 1190 1200
APAEGEQPEA EPEESLEPEA CFTEDCVRKF KCCQISIEEG KGKLWWNLRK
1210 1220 1230 1240 1250
TCYKIVEHNW FETFIVFMIL LSSGALAFED IYIEQRKTIK TMLEYADKVF
1260 1270 1280 1290 1300
TYIFILEMLL KWVAYGFQMY FTNAWCWLDF LIVDVSLVSL TANALGYSEL
1310 1320 1330 1340 1350
GAIKSLRTLR ALRPLRALSR FEGMRVVVNA LLGAIPSIMN VLLVCLIFWL
1360 1370 1380 1390 1400
IFSIMGVNLF AGKFYHCINY TTGEMFDVSV VNNYSECQAL IESNQTARWK
1410 1420 1430 1440 1450
NVKVNFDNVG LGYLSLLQVA TFKGWMDIMY AAVDSRNVEL QPKYEDNLYM
1460 1470 1480 1490 1500
YLYFVIFIIF GSFFTLNLFI GVIIDNFNQQ KKKFGGQDIF MTEEQKKYYN
1510 1520 1530 1540 1550
AMKKLGSKKP QKPIPRPANK FQGMVFDFVT KQVFDISIMI LICLNMVTMM
1560 1570 1580 1590 1600
VETDDQSQEM TNILYWINLV FIVLFTGECV LKLISLRHYY FTIGWNIFDF
1610 1620 1630 1640 1650
VVVILSIVGM FLAELIEKYF VSPTLFRVIR LARIGRILRL IKGAKGIRTL
1660 1670 1680 1690 1700
LFALMMSLPA LFNIGLLLFL VMFIYAIFGM SNFAYVKREV GIDDMFNFET
1710 1720 1730 1740 1750
FGNSMICLFQ ITTSAGWDGL LAPILNSGPP DCDPEKDHPG SSVKGDCGNP
1760 1770 1780 1790 1800
SVGIFFFVSY IIISFLVVVN MYIAVILENF SVATEESAEP LSEDDFEMFY
1810 1820 1830 1840 1850
EVWEKFDPDA TQFIEFCKLS DFAAALDPPL LIAKPNKVQL IAMDLPMVSG
1860 1870 1880 1890 1900
DRIHCLDILF AFTKRVLGES GEMDALRIQM EERFMASNPS KVSYEPITTT
1910 1920 1930 1940 1950
LKRKQEEVSA IVIQRAYRRY LLKQKVKKVS SIYKKDKGKE DEGTPIKEDI
1960 1970 1980 1990 2000
ITDKLNENST PEKTDVTPST TSPPSYDSVT KPEKEKFEKD KSEKEDKGKD

IRESKK
Length:2,006
Mass (Da):227,945
Last modified:April 8, 2008 - v1
Checksum:i8A607C83C4E97F0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772235 Genomic DNA. No translation available.
BX284648 Genomic DNA. No translation available.
RefSeqiNP_001092768.1. NM_001099298.2.
XP_006498645.1. XM_006498582.2.
UniGeneiMm.220329.
Mm.433692.

Genome annotation databases

EnsembliENSMUST00000028377; ENSMUSP00000028377; ENSMUSG00000075318.
ENSMUST00000100067; ENSMUSP00000097645; ENSMUSG00000075318.
GeneIDi110876.
KEGGimmu:110876.
UCSCiuc008jwo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL772235 Genomic DNA. No translation available.
BX284648 Genomic DNA. No translation available.
RefSeqiNP_001092768.1. NM_001099298.2.
XP_006498645.1. XM_006498582.2.
UniGeneiMm.220329.
Mm.433692.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028377.

PTM databases

PhosphoSiteiB1AWN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028377; ENSMUSP00000028377; ENSMUSG00000075318.
ENSMUST00000100067; ENSMUSP00000097645; ENSMUSG00000075318.
GeneIDi110876.
KEGGimmu:110876.
UCSCiuc008jwo.2. mouse.

Organism-specific databases

CTDi110876.
MGIiMGI:98248. Scn2a1.

Phylogenomic databases

eggNOGiENOG410INF8. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00830000128242.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
KOiK04834.
OMAiDQTKEMD.
OrthoDBiEOG091G00FK.
TreeFamiTF323985.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075318.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
IPR024583. Na_trans_cytopl.
[Graphical view]
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
PF11933. Na_trans_cytopl. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB1AWN6_MOUSE
AccessioniPrimary (citable) accession number: B1AWN6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.