Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protein 8B

Gene

Tmem8b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Growth regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 8B
Alternative name(s):
Protein NGX6
Gene namesi
Name:Tmem8b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2441680. Tmem8b.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity
  • Cytoplasm By similarity
  • Nucleus By similarity
  • Mitochondrion By similarity
  • Endoplasmic reticulum By similarity

  • Note: Also detected in mitochondrion and endoplasmic reticulum.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 233233ExtracellularSequence analysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence analysisAdd
BLAST
Topological domaini255 – 2573CytoplasmicSequence analysis
Transmembranei258 – 27720HelicalSequence analysisAdd
BLAST
Topological domaini278 – 29215ExtracellularSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Topological domaini314 – 3152CytoplasmicSequence analysis
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Topological domaini337 – 3426ExtracellularSequence analysis
Transmembranei343 – 36321HelicalSequence analysisAdd
BLAST
Topological domaini364 – 37916CytoplasmicSequence analysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence analysisAdd
BLAST
Topological domaini401 – 4055ExtracellularSequence analysis
Transmembranei406 – 42621HelicalSequence analysisAdd
BLAST
Topological domaini427 – 47246CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Transmembrane protein 8BPRO_0000333040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi186 ↔ 196By similarity
Disulfide bondi190 ↔ 209By similarity
Disulfide bondi211 ↔ 220By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiB1AWJ5.
PRIDEiB1AWJ5.

PTM databases

iPTMnetiB1AWJ5.
PhosphoSiteiB1AWJ5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000078716.
ExpressionAtlasiB1AWJ5. baseline and differential.
GenevisibleiB1AWJ5. MM.

Interactioni

Subunit structurei

May interact with EZR.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103496.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini182 – 22140EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the TMEM8 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJ3. Eukaryota.
ENOG4111FA8. LUCA.
GeneTreeiENSGT00390000004668.
HOGENOMiHOG000049225.
InParanoidiB1AWJ5.
PhylomeDBiB1AWJ5.
TreeFamiTF331003.

Family and domain databases

InterProiIPR021910. DUF3522.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AWJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMPQSLGTQ PLPPEPPSLG TPIEGSGAIA PTEHCWPVRP TLRNELDTFS
60 70 80 90 100
VHFYIFFGPS VALPPERPAV FALRLLPVLD SGGVLSLELQ LNASSLRQEN
110 120 130 140 150
VTVFGCLTHE VPLSLGDAAV TCSKESLAGF LLSVSATSRV ARLRIPFPQT
160 170 180 190 200
GTWFLTLRSL CGVGPRFVRC RNATAEVRLR TFLSPCVDDC GPYGQCKLLR
210 220 230 240 250
THNYLYAACE CKAGWRGWGC TDSADALTYG FQLLSTLLLC LSNLMFLPPV
260 270 280 290 300
VLAIRSRYVL EAAVYTFTMF FSTFYHACDQ PGIVVFCIMD YDVLQFCDFL
310 320 330 340 350
GSLMSVWVTV IAMARLQPVI KQVLYLLGAM LLSMALQLDR HGLWNLLGPS
360 370 380 390 400
LFALGILATA WTVRSVRRRH CYPPTWRRWL FYLCPGSLIA GSAVLLYAFV
410 420 430 440 450
ETRDNYFYIH SIWHMLIAGS VGFLLPPRAK TDRRVPSGAR ARGCGYQLCI
460 470
NEQEELGLVG PGGTTVSSIC VS
Length:472
Mass (Da):52,114
Last modified:April 8, 2008 - v1
Checksum:i7CA09DD6D1676DDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732626 Genomic DNA. Translation: CAM17054.1.
BC147569 mRNA. Translation: AAI47570.1.
BC147574 mRNA. Translation: AAI47575.1.
BC151067 mRNA. Translation: AAI51068.1.
BC151070 mRNA. Translation: AAI51071.1.
CCDSiCCDS51168.1.
RefSeqiNP_001078977.1. NM_001085508.2.
XP_011248332.1. XM_011250030.1.
UniGeneiMm.171489.

Genome annotation databases

EnsembliENSMUST00000107864; ENSMUSP00000103496; ENSMUSG00000078716.
ENSMUST00000107865; ENSMUSP00000103497; ENSMUSG00000078716.
ENSMUST00000167153; ENSMUSP00000129760; ENSMUSG00000078716.
GeneIDi242409.
KEGGimmu:242409.
UCSCiuc008sqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL732626 Genomic DNA. Translation: CAM17054.1.
BC147569 mRNA. Translation: AAI47570.1.
BC147574 mRNA. Translation: AAI47575.1.
BC151067 mRNA. Translation: AAI51068.1.
BC151070 mRNA. Translation: AAI51071.1.
CCDSiCCDS51168.1.
RefSeqiNP_001078977.1. NM_001085508.2.
XP_011248332.1. XM_011250030.1.
UniGeneiMm.171489.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103496.

PTM databases

iPTMnetiB1AWJ5.
PhosphoSiteiB1AWJ5.

Proteomic databases

PaxDbiB1AWJ5.
PRIDEiB1AWJ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107864; ENSMUSP00000103496; ENSMUSG00000078716.
ENSMUST00000107865; ENSMUSP00000103497; ENSMUSG00000078716.
ENSMUST00000167153; ENSMUSP00000129760; ENSMUSG00000078716.
GeneIDi242409.
KEGGimmu:242409.
UCSCiuc008sqv.1. mouse.

Organism-specific databases

CTDi51754.
MGIiMGI:2441680. Tmem8b.

Phylogenomic databases

eggNOGiENOG410IHJ3. Eukaryota.
ENOG4111FA8. LUCA.
GeneTreeiENSGT00390000004668.
HOGENOMiHOG000049225.
InParanoidiB1AWJ5.
PhylomeDBiB1AWJ5.
TreeFamiTF331003.

Miscellaneous databases

PROiB1AWJ5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078716.
ExpressionAtlasiB1AWJ5. baseline and differential.
GenevisibleiB1AWJ5. MM.

Family and domain databases

InterProiIPR021910. DUF3522.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF12036. DUF3522. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM8B_MOUSE
AccessioniPrimary (citable) accession number: B1AWJ5
Secondary accession number(s): B9EJV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.