B1AVY2 (B1AVY2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Gamma-aminobutyric acid receptor subunit alpha-3 Ensembl ENSMUSP00000110201

Gene names

Name:

Gabra3 Ensembl ENSMUSP00000110201 MGI 95615

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000110201

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification] RuleBase RU000687
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000110201

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell junction Cell membrane SAAS SAAS006028 Membrane Postsynaptic cell membrane SAAS SAAS006202 Synapse
Domain	Transmembrane Transmembrane helix SAAS SAAS006028
Molecular function	Ion channel RuleBase RU000687 SAAS SAAS006028
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chloride transport Inferred from electronic annotation. Source: InterPro gamma-aminobutyric acid signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	GABA-A receptor activity Inferred from electronic annotation. Source: InterPro extracellular ligand-gated ion channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1AVY2 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 5B82129252D544CF	FASTA	533	59,912
	10 20 30 40 50 60 MEGREERKGG SSHFGPEERS KHLTAACTVD LTGLFKLLSK KMIITQMWHF YVTRVVLLLL 70 80 90 100 110 120 ISILPGTTSQ GESRRQEPGD FVKQDIGGLS PKHAPDIPDD STDNITIFTR ILDRLLDGYD 130 140 150 160 170 180 NRLRPGLGDA VTEVKTDIYV TSFGPVSDTD MEYTIDVFFR QTWHDERLKF DGPMKILPLN 190 200 210 220 230 240 NLLASKIWTP DTFFHNGKKS VAHNMTTPNK LLRLVDNGTL LYTMRLTIHA ECPMHLEDFP 250 260 270 280 290 300 MDVHACPLKF GSYAYTKAEV IYSWTLGKNK SVEVAQDGSR LNQYDLLGHV VGTEIIRSST 310 320 330 340 350 360 GEYVVMTTHF HLKRKIGYFV IQTYLPCIMT VILSQVSFWL NRESVPARTV FGVTTVLTMT 370 380 390 400 410 420 TLSISARNSL PKVAYATAMD WFIAVCYAFV FSALIEFATV NYFTKRSWAW EGKKVPEALE 430 440 450 460 470 480 MKKKTPAAPT KKNTTFNIVG TTYPINLAKD TEFSTISKSA AAPSASSTPT AIASPKATYV 490 500 510 520 530 QDSPAETKTY NSVSKVDKIS RIIFPVLFAI FNLVYWATYV NRESAIKGMI RKQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000110201.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000110201.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL731695 Genomic DNA. No translation available. BX119994 Genomic DNA. No translation available. BX813327 Genomic DNA. No translation available.
IPI	IPI00776142.
UniGene	Mm.102286. Mm.447666.
3D structure databases
ProteinModelPortal	B1AVY2.
SMR	B1AVY2. Positions 109-405.
ModBase	Search...
Proteomic databases
PRIDE	B1AVY2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000114554; ENSMUSP00000110201; ENSMUSG00000031343.
Organism-specific databases
MGI	MGI:95615. Gabra3.
Phylogenomic databases
GeneTree	ENSGT00550000074441.
HOGENOM	HOG000231337.
HOVERGEN	HBG051707.
InParanoid	B1AVY2.
Gene expression databases
ArrayExpress	B1AVY2.
Family and domain databases
Gene3D	2.70.170.10. 1 hit.
InterPro	IPR006028. GABAA_rcpt. IPR001390. GABAAa_rcpt. IPR005433. GABBAa3_rcpt. IPR006202. Neur_chan_lig-bd. IPR006201. Neur_channel. IPR006029. Neurotrans-gated_channel_TM. IPR018000. Neurotransmitter_ion_chnl_CS. [Graphical view]
PANTHER	PTHR18945. PTHR18945. 1 hit.
Pfam	PF02931. Neur_chan_LBD. 1 hit. PF02932. Neur_chan_memb. 2 hits. [Graphical view]
PRINTS	PR01079. GABAARALPHA. PR01616. GABAARALPHA3. PR00253. GABAARECEPTR. PR00252. NRIONCHANNEL.
SUPFAM	SSF90112. Neu_channel_TM. 1 hit. SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMs	TIGR00860. LIC. 1 hit.
PROSITE	PS00236. NEUROTR_ION_CHANNEL. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35546107.
SOURCE	Search...

Entry information

Entry name

B1AVY2_MOUSE

Accession

Primary (citable) accession number: B1AVY2

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)