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Protein
Submitted name:

Gamma-aminobutyric acid receptor subunit alpha-3

Gene

Gabra3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-aminobutyric acid receptor subunit alpha-3Imported
Gene namesi
Name:Gabra3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:95615 Gabra3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 66HelicalSequence analysisAdd BLAST19
Transmembranei316 – 340HelicalSequence analysisAdd BLAST25
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei378 – 403HelicalSequence analysisAdd BLAST26
Transmembranei502 – 521HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiB1AVY2
PeptideAtlasiB1AVY2
PRIDEiB1AVY2

Expressioni

Gene expression databases

BgeeiENSMUSG00000031343
ExpressionAtlasiB1AVY2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB1AVY2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 315Neur_chan_LBDInterPro annotationAdd BLAST207
Domaini323 – 407Neur_chan_membInterPro annotationAdd BLAST85

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
OMAiYNIVGTT
OrthoDBiEOG091G0805

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005433 GABBAa3_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01616 GABAARALPHA3
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

B1AVY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGREERKGG SSHFGPEERS KHLTAACTVD LTGLFKLLSK KMIITQMWHF
60 70 80 90 100
YVTRVVLLLL ISILPGTTSQ GESRRQEPGD FVKQDIGGLS PKHAPDIPDD
110 120 130 140 150
STDNITIFTR ILDRLLDGYD NRLRPGLGDA VTEVKTDIYV TSFGPVSDTD
160 170 180 190 200
MEYTIDVFFR QTWHDERLKF DGPMKILPLN NLLASKIWTP DTFFHNGKKS
210 220 230 240 250
VAHNMTTPNK LLRLVDNGTL LYTMRLTIHA ECPMHLEDFP MDVHACPLKF
260 270 280 290 300
GSYAYTKAEV IYSWTLGKNK SVEVAQDGSR LNQYDLLGHV VGTEIIRSST
310 320 330 340 350
GEYVVMTTHF HLKRKIGYFV IQTYLPCIMT VILSQVSFWL NRESVPARTV
360 370 380 390 400
FGVTTVLTMT TLSISARNSL PKVAYATAMD WFIAVCYAFV FSALIEFATV
410 420 430 440 450
NYFTKRSWAW EGKKVPEALE MKKKTPAAPT KKNTTFNIVG TTYPINLAKD
460 470 480 490 500
TEFSTISKSA AAPSASSTPT AIASPKATYV QDSPAETKTY NSVSKVDKIS
510 520 530
RIIFPVLFAI FNLVYWATYV NRESAIKGMI RKQ
Length:533
Mass (Da):59,912
Last modified:April 8, 2008 - v1
Checksum:i5B82129252D544CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731695 Genomic DNA No translation available.
BX119994 Genomic DNA No translation available.
BX813327 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000114554; ENSMUSP00000110201; ENSMUSG00000031343

Similar proteinsi

Entry informationi

Entry nameiB1AVY2_MOUSE
AccessioniPrimary (citable) accession number: B1AVY2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health