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Protein
Submitted name:

Dual-specificity protein kinase CLK2

Gene

CLK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB1AVT0.

Names & Taxonomyi

Protein namesi
Submitted name:
Dual-specificity protein kinase CLK2Imported
Gene namesi
Name:CLK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000176444.18.
HGNCiHGNC:2069. CLK2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176444.

PTM / Processingi

Proteomic databases

MaxQBiB1AVT0.

Expressioni

Gene expression databases

BgeeiENSG00000176444.
ExpressionAtlasiB1AVT0. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiB1AVT0. 3 interactors.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 477Protein kinaseInterPro annotationAdd BLAST317

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0671. Eukaryota.
ENOG410XQF2. LUCA.
GeneTreeiENSGT00580000081366.
HOGENOMiHOG000203417.
HOVERGENiHBG107720.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

B1AVT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHPRRYHSS ERGSRGSYRE HYRSRKHKRR RSRSWSSSSD RTRRRRREDS
60 70 80 90 100
YHVRSRSYDD RSSDRRVYDR RYCGSYRRND YSRDRGDAYY DTDYRHSYEY
110 120 130 140 150
QRENSSYRSQ RSSRRKHRRR RRRSRTFSRS SSHSSRRAKS VEDDAEGHLI
160 170 180 190 200
YHVGDWLQER YEIVSTLGEG TFGRVVQCVD HRRGGARVAL KIIKNVEKYK
210 220 230 240 250
EAARLEINVL EKINEKDPDN KNLCVQMFDW FDYHGHMCIS FELLGLSTFD
260 270 280 290 300
FLKDNNYLPY PIHQVRHMAF QLCQAVKFLH DNKLTHTDLK PENILFVNSD
310 320 330 340 350
YELTYNLEKK RDERSVKSTA VRVVDFGSAT FDHEHHSTIV STRHYRAPEV
360 370 380 390 400
ILELGWSQPC DVWSIGCIIF EYYVGFTLFQ THDNREHLAM MERILGPIPS
410 420 430 440 450
RMIRKTRKQK YFYRGRLDWD ENTSAGRYVR ENCKPLRRYL TSEAEEHHQL
460 470 480 490
FDLIESMLEY EPAKRLTLGE ALQHPFFARL RAEPPNKLWD SSRDISR
Length:497
Mass (Da):59,875
Last modified:April 8, 2008 - v1
Checksum:iFE795567A19BD514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713999 Genomic DNA. No translation available.
RefSeqiXP_005244935.1. XM_005244878.1.
UniGeneiHs.73986.

Genome annotation databases

EnsembliENST00000355560; ENSP00000347759; ENSG00000176444.
ENST00000576584; ENSP00000458788; ENSG00000261893.
GeneIDi1196.
UCSCiuc057loz.1. human.

Similar proteinsi

Entry informationi

Entry nameiB1AVT0_HUMAN
AccessioniPrimary (citable) accession number: B1AVT0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 27, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported