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Protein
Submitted name:

Dual-specificity protein kinase CLK2

Gene

CLK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB1AVT0

Names & Taxonomyi

Protein namesi
Submitted name:
Dual-specificity protein kinase CLK2Imported
Gene namesi
Name:CLK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000176444.18
HGNCiHGNC:2069 CLK2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176444

PTM / Processingi

Proteomic databases

MaxQBiB1AVT0

Expressioni

Gene expression databases

BgeeiENSG00000176444

Interactioni

Protein-protein interaction databases

IntActiB1AVT0, 3 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini161 – 477Protein kinaseInterPro annotationAdd BLAST317

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili193 – 213Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0671 Eukaryota
ENOG410XQF2 LUCA
GeneTreeiENSGT00580000081366
HOGENOMiHOG000203417
HOVERGENiHBG107720

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

B1AVT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHPRRYHSS ERGSRGSYRE HYRSRKHKRR RSRSWSSSSD RTRRRRREDS
60 70 80 90 100
YHVRSRSYDD RSSDRRVYDR RYCGSYRRND YSRDRGDAYY DTDYRHSYEY
110 120 130 140 150
QRENSSYRSQ RSSRRKHRRR RRRSRTFSRS SSHSSRRAKS VEDDAEGHLI
160 170 180 190 200
YHVGDWLQER YEIVSTLGEG TFGRVVQCVD HRRGGARVAL KIIKNVEKYK
210 220 230 240 250
EAARLEINVL EKINEKDPDN KNLCVQMFDW FDYHGHMCIS FELLGLSTFD
260 270 280 290 300
FLKDNNYLPY PIHQVRHMAF QLCQAVKFLH DNKLTHTDLK PENILFVNSD
310 320 330 340 350
YELTYNLEKK RDERSVKSTA VRVVDFGSAT FDHEHHSTIV STRHYRAPEV
360 370 380 390 400
ILELGWSQPC DVWSIGCIIF EYYVGFTLFQ THDNREHLAM MERILGPIPS
410 420 430 440 450
RMIRKTRKQK YFYRGRLDWD ENTSAGRYVR ENCKPLRRYL TSEAEEHHQL
460 470 480 490
FDLIESMLEY EPAKRLTLGE ALQHPFFARL RAEPPNKLWD SSRDISR
Length:497
Mass (Da):59,875
Last modified:April 8, 2008 - v1
Checksum:iFE795567A19BD514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713999 Genomic DNA No translation available.
RefSeqiXP_005244935.1, XM_005244878.1
UniGeneiHs.73986

Genome annotation databases

EnsembliENST00000355560; ENSP00000347759; ENSG00000176444
ENST00000576584; ENSP00000458788; ENSG00000261893
GeneIDi1196
UCSCiuc057loz.1 human

Similar proteinsi

Entry informationi

Entry nameiB1AVT0_HUMAN
AccessioniPrimary (citable) accession number: B1AVT0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health