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Protein

TBC1 domain family member 2A

Gene

Tbc1d2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 2A
Gene namesi
Name:Tbc1d2
Synonyms:Tbc1d2a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2652885. Tbc1d2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 922922TBC1 domain family member 2APRO_0000395194Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei914 – 9141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiB1AVH7.
MaxQBiB1AVH7.
PaxDbiB1AVH7.
PRIDEiB1AVH7.

Expressioni

Gene expression databases

BgeeiB1AVH7.
GenevisibleiB1AVH7. MM.

Interactioni

Subunit structurei

Interacts with activated RAC1 and CDH1.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081670.

Structurei

3D structure databases

ProteinModelPortaliB1AVH7.
SMRiB1AVH7. Positions 44-145, 576-862.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 14199PHPROSITE-ProRule annotationAdd
BLAST
Domaini619 – 811193Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 168168Interaction with CADH1By similarityAdd
BLAST
Regioni298 – 435138Interaction with RAC1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili302 – 33332Sequence analysisAdd
BLAST
Coiled coili362 – 41756Sequence analysisAdd
BLAST
Coiled coili443 – 47634Sequence analysisAdd
BLAST
Coiled coili869 – 90436Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi192 – 1954Poly-Ala

Sequence similaritiesi

Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000049204.
HOVERGENiHBG059233.
InParanoidiB1AVH7.
OMAiVDQRVLQ.
OrthoDBiEOG7PK8XW.
PhylomeDBiB1AVH7.
TreeFamiTF317336.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1AVH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDAPERTPS SSESTQPPGL AREPEVVSPG DSEGCARPLD TVPKKLCGYL
60 70 80 90 100
SKFGGKGPIK GWKCRWFFYD ERKCHLYYSR TAQDANPLDS IDLSSAVFDC
110 120 130 140 150
KADAEEEGTF EIKTPSRVIT LKAATKQAML YWLQQLQMKR WEFHNSPPAL
160 170 180 190 200
PATPAAALAE NGPTLHLKLE QEEAELEEFL CPVKTPTGLV GAAAALQPVP
210 220 230 240 250
AVPSALQNIS LKHLGTEIQN TMHNIRGNKQ AQAAAHGPLV EDSPQGGEPQ
260 270 280 290 300
SGEQPSISDP SLPEKEPEDP AKSAPRSSVP SGPTQKPKRQ SNTFPFFSDG
310 320 330 340 350
LARSRTAQEK VAALEQQVLM LTKELKSQKE LVIILHKALE AAQQEKRASS
360 370 380 390 400
AYLAATEDRD RLELVRHKVR QIAELNQRVE ALEQGRERLA HEAGLREQQV
410 420 430 440 450
QALQQHVQLL MDKNHAKQQV ICKLTQKLTE DLAQPADATN GDFLSQQERM
460 470 480 490 500
EHLKDDMEAY RTQNRFLNSE IHQVTKIWRK VAEKEKALLT KCAYLQARNC
510 520 530 540 550
QVESKYLAGL RRLQEAAGAE AGDFPELLQQ LIQEALQWEA GEADSVGLSP
560 570 580 590 600
VSEYDDYGFL TVPDYEMEDL KLLAKIQALE VRSHHLLAHE AVERPLRDRW
610 620 630 640 650
ATLTELTPSA ELKQLLRAGV PREHRPRVWR WLVHRRVRHL QAPGCYQELL
660 670 680 690 700
ARGRACEHPA ARQIELDLNR TFPTNKHFTC PTSSFPDKLR RVLLAFSWQN
710 720 730 740 750
PTIGYCQGLN RLAAIALLVL EDEESAFWCL VAIVETILPA EYYSKTLTAS
760 770 780 790 800
QVDQRVLQDL LSEKLPRLTA HLGQHRVDLS LITFNWFLVV FADSLISDIL
810 820 830 840 850
LRVWDAFLYE GTKVVFRYAL AIFKYNEEAI LQLQDSLEIY QYLRFFTKTI
860 870 880 890 900
CDSRKLMSIA FNDMNPFPMK QLRQLRAAHR ERLEAELREL ELLKVEYLQR
910 920
RASLGRAPPE GCVSEDEGEG DS
Length:922
Mass (Da):104,260
Last modified:April 8, 2008 - v1
Checksum:i729C466D976B8C8E
GO
Isoform 2 (identifier: B1AVH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-922: NTMHNIRGNK...VSEDEGEGDS → AVGVVTSTGAGVQETWSNTFHPM

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):26,338
Checksum:i659ED76EC923EC17
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271V → A in BAE28440 (PubMed:16141072).Curated
Sequence conflicti157 – 1571A → T in BAE28440 (PubMed:16141072).Curated
Sequence conflicti165 – 1651L → P in BAE28440 (PubMed:16141072).Curated
Sequence conflicti202 – 2021V → M in BAE28440 (PubMed:16141072).Curated
Sequence conflicti243 – 2431S → L in BAE28440 (PubMed:16141072).Curated
Sequence conflicti415 – 4151H → Q in BAE28440 (PubMed:16141072).Curated
Sequence conflicti430 – 4301E → G in BAE28440 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei220 – 922703NTMHN…GEGDS → AVGVVTSTGAGVQETWSNTF HPM in isoform 2. 1 PublicationVSP_039384Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041359 mRNA. Translation: BAC30918.1.
AK148254 mRNA. Translation: BAE28440.1.
BX682536, BX571848 Genomic DNA. Translation: CAM17021.1.
BX571848, BX682536 Genomic DNA. Translation: CAM27677.1.
AL683884, BX571848, BX682536 Genomic DNA. Translation: CAM13787.1.
BX682536, AL683884, BX571848 Genomic DNA. Translation: CAM17022.1.
BX571848, AL683884, BX682536 Genomic DNA. Translation: CAM27678.1.
CCDSiCCDS18155.1. [B1AVH7-1]
RefSeqiNP_941066.3. NM_198664.3. [B1AVH7-1]
UniGeneiMm.331595.

Genome annotation databases

EnsembliENSMUST00000084621; ENSMUSP00000081670; ENSMUSG00000039813. [B1AVH7-1]
ENSMUST00000107750; ENSMUSP00000103379; ENSMUSG00000039813. [B1AVH7-2]
GeneIDi381605.
KEGGimmu:381605.
UCSCiuc008suf.1. mouse. [B1AVH7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK041359 mRNA. Translation: BAC30918.1.
AK148254 mRNA. Translation: BAE28440.1.
BX682536, BX571848 Genomic DNA. Translation: CAM17021.1.
BX571848, BX682536 Genomic DNA. Translation: CAM27677.1.
AL683884, BX571848, BX682536 Genomic DNA. Translation: CAM13787.1.
BX682536, AL683884, BX571848 Genomic DNA. Translation: CAM17022.1.
BX571848, AL683884, BX682536 Genomic DNA. Translation: CAM27678.1.
CCDSiCCDS18155.1. [B1AVH7-1]
RefSeqiNP_941066.3. NM_198664.3. [B1AVH7-1]
UniGeneiMm.331595.

3D structure databases

ProteinModelPortaliB1AVH7.
SMRiB1AVH7. Positions 44-145, 576-862.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081670.

Proteomic databases

EPDiB1AVH7.
MaxQBiB1AVH7.
PaxDbiB1AVH7.
PRIDEiB1AVH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084621; ENSMUSP00000081670; ENSMUSG00000039813. [B1AVH7-1]
ENSMUST00000107750; ENSMUSP00000103379; ENSMUSG00000039813. [B1AVH7-2]
GeneIDi381605.
KEGGimmu:381605.
UCSCiuc008suf.1. mouse. [B1AVH7-1]

Organism-specific databases

CTDi55357.
MGIiMGI:2652885. Tbc1d2.

Phylogenomic databases

eggNOGiKOG2058. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000049204.
HOVERGENiHBG059233.
InParanoidiB1AVH7.
OMAiVDQRVLQ.
OrthoDBiEOG7PK8XW.
PhylomeDBiB1AVH7.
TreeFamiTF317336.

Miscellaneous databases

ChiTaRSiTbc1d2. mouse.
NextBioi402304.
PROiB1AVH7.
SOURCEiSearch...

Gene expression databases

BgeeiB1AVH7.
GenevisibleiB1AVH7. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000195. Rab-GTPase-TBC_dom.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00566. RabGAP-TBC. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-773 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Thymus.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiTBD2A_MOUSE
AccessioniPrimary (citable) accession number: B1AVH7
Secondary accession number(s): Q3UFW9, Q8BYB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: April 8, 2008
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.