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Protein
Submitted name:

Voltage-dependent L-type calcium channel subunit alpha-1F

Gene

Cacna1f

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent L-type calcium channel subunit alpha-1FImported
Gene namesi
Name:Cacna1fImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859639. Cacna1f.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei52 – 7019HelicalSequence analysisAdd
BLAST
Transmembranei144 – 16724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiB1AVA5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031142.
ExpressionAtlasiB1AVA5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111391.

Structurei

3D structure databases

ProteinModelPortaliB1AVA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 177161Ion_transInterPro annotationAdd
BLAST
Domaini179 – 23052GPHHInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.

Family and domain databases

InterProiIPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR030157. VDCC_L_a1F.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF184. PTHR10037:SF184. 1 hit.
PfamiPF16905. GPHH. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.

Sequencei

Sequence statusi: Fragment.

B1AVA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGGHLGESS EDSSRISITF FRLFRVMRLV KLLSKGEGIR TLLWTFIKSF
60 70 80 90 100
QALPYVALLI AMIFFIYAVI GMQMFGKVAL QDGTQINRNN NFQTFPQAVL
110 120 130 140 150
LLFRCATGEA WQEIMLASLP GNRCDPESDF GPGEEFTCGS SFAIVYFISF
160 170 180 190 200
FMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPGAK
210 220 230
GRIKHLDVVA LLRRIQPPLG FGKLCPHRVA
Length:230
Mass (Da):26,147
Last modified:February 17, 2016 - v7
Checksum:i6479A1D759582AD7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei230 – 2301Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672231 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000128628; ENSMUSP00000119207; ENSMUSG00000031142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672231 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AVA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000111391.

Proteomic databases

PaxDbiB1AVA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128628; ENSMUSP00000119207; ENSMUSG00000031142.

Organism-specific databases

MGIiMGI:1859639. Cacna1f.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.
R-MMU-5576893. Phase 2 - plateau phase.
R-MMU-5576894. Phase 1 - inactivation of fast Na+ channels.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031142.
ExpressionAtlasiB1AVA5. baseline and differential.

Family and domain databases

InterProiIPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR030157. VDCC_L_a1F.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF184. PTHR10037:SF184. 1 hit.
PfamiPF16905. GPHH. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiB1AVA5_MOUSE
AccessioniPrimary (citable) accession number: B1AVA5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: February 17, 2016
Last modified: September 7, 2016
This is version 67 of the entry and version 7 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.