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B1AUR6 (MMS22_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein MMS22-like
Alternative name(s):
Methyl methanesulfonate-sensitivity protein 22-like
Gene names
Name:Mms22l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1238 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA By similarity.

Subunit structure

Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2 By similarity.

Subcellular location

Nucleus By similarity. Note: Localizes to DNA damage sites, accumulates at stressed replication forks By similarity.

Sequence similarities

Belongs to the MMS22 family. MMS22L subfamily.

Sequence caution

The sequence AAI37911.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI45029.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B1AUR6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B1AUR6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.
     793-793: N → NS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12381238Protein MMS22-like
PRO_0000403772

Natural variations

Alternative sequence1 – 276276Missing in isoform 2.
VSP_040445
Alternative sequence7931N → NS in isoform 2.
VSP_040446

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 9C2733D598CF2F2D

FASTA1,238140,582
        10         20         30         40         50         60 
MDGCSAASTF LTDSLELELG TEWCKPPCFS CAFDNREGKF SGESYLASGA LKRLILNLDP 

        70         80         90        100        110        120 
LPTNFEEDTV ELFGFQWVTE TALVYSCREL FHLFRQQIFN LESLVQVSCD FGKIATLHAK 

       130        140        150        160        170        180 
ADSIRQQCVV FLHYIKVFIF RCLKVQEAES HSRPAHPYEA LEAQLPSMLV DELRGLLLYI 

       190        200        210        220        230        240 
GHLAALPSVT VGAFVNQNQM KLFPPSWHLL HLYLDTHWLV LEILHILGEK LKQVVYGRQF 

       250        260        270        280        290        300 
IGQAGDNLTN VSLFEEHCEH LFCDLICLSL NRFDKVMPSE ALLISHCPCS CVKELWVLLI 

       310        320        330        340        350        360 
HLLDHRRKWS VADSFWNWLN KLLRTLFEKS SDQRRSSVSL TQAKDPLGFS WWISVHVASL 

       370        380        390        400        410        420 
YQIDRHGVSD KMKQMESNWS FIEELLKRSV TVQDSILEEQ LRMHLHCCLT LCDFWEPNIS 

       430        440        450        460        470        480 
VVTILWEYYS KNLNSSFSIS WLPLKGLTNI IKSPLSMLTL VRNCCSDKQD PDLYKSSSSY 

       490        500        510        520        530        540 
IIFLCILAKV VKKAMRTSGP HPWKQVKGRI YSKFHQKRME ELTEVGLQNF FSLFLLLAAV 

       550        560        570        580        590        600 
AEIEDVASHV LDLLRFLRPA SMSSHGALVW KGQMAFLLMY AQKNLDIGVW AEKLSCEFQE 

       610        620        630        640        650        660 
KAKEFLVSKN DEMVQRHALW TLLCIYIDGV QEVFETSSCL YPSHEHLLND GFSMLLPACR 

       670        680        690        700        710        720 
ESELRTVLNF LQAVLARIRS VHQQLCQELQ RENVDLTVQS SLSAKERPLA AVAGALWRHF 

       730        740        750        760        770        780 
FSFLKSQRMT QVVPLSQLAD AAADFTLLAV DMPNTAPPDL QPQPVISIIQ LFGWDDIIWP 

       790        800        810        820        830        840 
QVVARYLSHL LQNSTVYEAL SQSSCVSSQS LTIRSWVRCV LQMHIKHLSD PDLLIDVNPE 

       850        860        870        880        890        900 
QAVEKEYMEQ LAEMTRLLFT LSEVKSVFSK AQIEQLPSPD DPKQALIQFL EAVGVTYRTL 

       910        920        930        940        950        960 
QTFSDKSAMV TKSLEYLGEV LKYIKPYLGK KVSSAGLQLT YGIMGILVKS WAHIFATSKA 

       970        980        990       1000       1010       1020 
QKLLFRIIDC LLLPHTVLQQ DKELPGPMLT AIQKTLPLYL QGICIVCCQS QNPNAYLNQL 

      1030       1040       1050       1060       1070       1080 
LRNVIEQYIG RFLPTSPCVS DLGQHPVLLA LRNPASVPSM TPLRKHTVHA IRKSYLEFKG 

      1090       1100       1110       1120       1130       1140 
SSPPPRLASV LAFVLQLFKD TEMGACDLEL LLPGILKCLV LVNEPQVKKL ATENLQCMVQ 

      1150       1160       1170       1180       1190       1200 
TCQVGSEGGP ATQLTSLFRQ FIQDYGMQYS YQVYSILETV ATLNQHVVIQ LIPTLTQSLK 

      1210       1220       1230 
DSELKWGLGR NIAQREAYSR LLSGLGQVGQ GEKQRLEK 

« Hide

Isoform 2 [UniParc].

Checksum: 91CE2C35CABA608A
Show »

FASTA963109,242

References

[1]"Transcriptome analysis of mouse stem cells and early embryos."
Sharov A.A., Piao Y., Matoba R., Dudekula D.B., Qian Y., VanBuren V., Falco G., Martin P.R., Stagg C.A., Bassey U.C., Wang Y., Carter M.G., Hamatani T., Aiba K., Akutsu H., Sharova L., Tanaka T.S., Kimber W.L. expand/collapse author list , Yoshikawa T., Jaradat S.A., Pantano S., Nagaraja R., Boheler K.R., Taub D., Hodes R.J., Longo D.L., Schlessinger D., Keller J., Klotz E., Kelsoe G., Umezawa A., Vescovi A.L., Rossant J., Kunath T., Hogan B.L.M., Curci A., D'Urso M., Kelso J., Hide W., Ko M.S.H.
PLoS Biol. 1:410-419(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: CD-1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1238.
Strain: 129.
Tissue: Brain and Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY512923 mRNA. Translation: AAR87794.1.
BX296536, AL671913 Genomic DNA. Translation: CAM23327.1.
BC051674 mRNA. Translation: AAH51674.1.
BC137910 mRNA. Translation: AAI37911.1. Different initiation.
BC145028 mRNA. Translation: AAI45029.1. Different initiation.
CCDSCCDS18006.2. [B1AUR6-1]
RefSeqNP_955761.2. NM_199467.2. [B1AUR6-1]
UniGeneMm.120919.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbB1AUR6.
PRIDEB1AUR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108222; ENSMUSP00000103857; ENSMUSG00000045751. [B1AUR6-1]
GeneID212377.
KEGGmmu:212377.
UCSCuc008sdv.2. mouse. [B1AUR6-1]
uc008sdy.1. mouse. [B1AUR6-2]

Organism-specific databases

CTD253714.
MGIMGI:2684980. Mms22l.

Phylogenomic databases

eggNOGNOG27315.
GeneTreeENSGT00390000011769.
HOGENOMHOG000049190.
HOVERGENHBG058755.
InParanoidB1AUR6.
OMAEVGLQNF.
OrthoDBEOG7K0ZBB.
PhylomeDBB1AUR6.
TreeFamTF353832.

Gene expression databases

ArrayExpressB1AUR6.
BgeeB1AUR6.
GenevestigatorB1AUR6.

Family and domain databases

InterProIPR029424. MMS22L_C.
IPR029425. MMS22L_N.
[Graphical view]
PfamPF14911. MMS22L_C. 1 hit.
PF14910. MMS22L_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMMS22L. mouse.
NextBio373541.
PROB1AUR6.
SOURCESearch...

Entry information

Entry nameMMS22_MOUSE
AccessionPrimary (citable) accession number: B1AUR6
Secondary accession number(s): B7ZN61 expand/collapse secondary AC list , D3YXA0, Q6R5F9, Q80UT0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 8, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot