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B1AUR6

- MMS22_MOUSE

UniProt

B1AUR6 - MMS22_MOUSE

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Protein
Protein MMS22-like
Gene
Mms22l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA By similarity.

GO - Biological processi

  1. double-strand break repair via homologous recombination Source: UniProtKB
  2. replication fork processing Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MMS22-like
Alternative name(s):
Methyl methanesulfonate-sensitivity protein 22-like
Gene namesi
Name:Mms22l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2684980. Mms22l.

Subcellular locationi

Nucleus By similarity
Note: Localizes to DNA damage sites, accumulates at stressed replication forks By similarity.

GO - Cellular componenti

  1. FACT complex Source: Ensembl
  2. MCM complex Source: Ensembl
  3. nuclear replication fork Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12381238Protein MMS22-like
PRO_0000403772Add
BLAST

Proteomic databases

PaxDbiB1AUR6.
PRIDEiB1AUR6.

Expressioni

Gene expression databases

ArrayExpressiB1AUR6.
BgeeiB1AUR6.
GenevestigatoriB1AUR6.

Interactioni

Subunit structurei

Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2 By similarity.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG27315.
GeneTreeiENSGT00390000011769.
HOGENOMiHOG000049190.
HOVERGENiHBG058755.
InParanoidiB1AUR6.
OMAiEVGLQNF.
OrthoDBiEOG7K0ZBB.
PhylomeDBiB1AUR6.
TreeFamiTF353832.

Family and domain databases

InterProiIPR029424. MMS22L_C.
IPR029425. MMS22L_N.
[Graphical view]
PfamiPF14911. MMS22L_C. 1 hit.
PF14910. MMS22L_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B1AUR6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDGCSAASTF LTDSLELELG TEWCKPPCFS CAFDNREGKF SGESYLASGA     50
LKRLILNLDP LPTNFEEDTV ELFGFQWVTE TALVYSCREL FHLFRQQIFN 100
LESLVQVSCD FGKIATLHAK ADSIRQQCVV FLHYIKVFIF RCLKVQEAES 150
HSRPAHPYEA LEAQLPSMLV DELRGLLLYI GHLAALPSVT VGAFVNQNQM 200
KLFPPSWHLL HLYLDTHWLV LEILHILGEK LKQVVYGRQF IGQAGDNLTN 250
VSLFEEHCEH LFCDLICLSL NRFDKVMPSE ALLISHCPCS CVKELWVLLI 300
HLLDHRRKWS VADSFWNWLN KLLRTLFEKS SDQRRSSVSL TQAKDPLGFS 350
WWISVHVASL YQIDRHGVSD KMKQMESNWS FIEELLKRSV TVQDSILEEQ 400
LRMHLHCCLT LCDFWEPNIS VVTILWEYYS KNLNSSFSIS WLPLKGLTNI 450
IKSPLSMLTL VRNCCSDKQD PDLYKSSSSY IIFLCILAKV VKKAMRTSGP 500
HPWKQVKGRI YSKFHQKRME ELTEVGLQNF FSLFLLLAAV AEIEDVASHV 550
LDLLRFLRPA SMSSHGALVW KGQMAFLLMY AQKNLDIGVW AEKLSCEFQE 600
KAKEFLVSKN DEMVQRHALW TLLCIYIDGV QEVFETSSCL YPSHEHLLND 650
GFSMLLPACR ESELRTVLNF LQAVLARIRS VHQQLCQELQ RENVDLTVQS 700
SLSAKERPLA AVAGALWRHF FSFLKSQRMT QVVPLSQLAD AAADFTLLAV 750
DMPNTAPPDL QPQPVISIIQ LFGWDDIIWP QVVARYLSHL LQNSTVYEAL 800
SQSSCVSSQS LTIRSWVRCV LQMHIKHLSD PDLLIDVNPE QAVEKEYMEQ 850
LAEMTRLLFT LSEVKSVFSK AQIEQLPSPD DPKQALIQFL EAVGVTYRTL 900
QTFSDKSAMV TKSLEYLGEV LKYIKPYLGK KVSSAGLQLT YGIMGILVKS 950
WAHIFATSKA QKLLFRIIDC LLLPHTVLQQ DKELPGPMLT AIQKTLPLYL 1000
QGICIVCCQS QNPNAYLNQL LRNVIEQYIG RFLPTSPCVS DLGQHPVLLA 1050
LRNPASVPSM TPLRKHTVHA IRKSYLEFKG SSPPPRLASV LAFVLQLFKD 1100
TEMGACDLEL LLPGILKCLV LVNEPQVKKL ATENLQCMVQ TCQVGSEGGP 1150
ATQLTSLFRQ FIQDYGMQYS YQVYSILETV ATLNQHVVIQ LIPTLTQSLK 1200
DSELKWGLGR NIAQREAYSR LLSGLGQVGQ GEKQRLEK 1238
Length:1,238
Mass (Da):140,582
Last modified:April 8, 2008 - v1
Checksum:i9C2733D598CF2F2D
GO
Isoform 2 (identifier: B1AUR6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.
     793-793: N → NS

Note: No experimental confirmation available.

Show »
Length:963
Mass (Da):109,242
Checksum:i91CE2C35CABA608A
GO

Sequence cautioni

The sequence AAI37911.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAI45029.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 276276Missing in isoform 2.
VSP_040445Add
BLAST
Alternative sequencei793 – 7931N → NS in isoform 2.
VSP_040446

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY512923 mRNA. Translation: AAR87794.1.
BX296536, AL671913 Genomic DNA. Translation: CAM23327.1.
BC051674 mRNA. Translation: AAH51674.1.
BC137910 mRNA. Translation: AAI37911.1. Different initiation.
BC145028 mRNA. Translation: AAI45029.1. Different initiation.
CCDSiCCDS18006.2. [B1AUR6-1]
RefSeqiNP_955761.2. NM_199467.2. [B1AUR6-1]
UniGeneiMm.120919.

Genome annotation databases

EnsembliENSMUST00000108222; ENSMUSP00000103857; ENSMUSG00000045751. [B1AUR6-1]
GeneIDi212377.
KEGGimmu:212377.
UCSCiuc008sdv.2. mouse. [B1AUR6-1]
uc008sdy.1. mouse. [B1AUR6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY512923 mRNA. Translation: AAR87794.1 .
BX296536 , AL671913 Genomic DNA. Translation: CAM23327.1 .
BC051674 mRNA. Translation: AAH51674.1 .
BC137910 mRNA. Translation: AAI37911.1 . Different initiation.
BC145028 mRNA. Translation: AAI45029.1 . Different initiation.
CCDSi CCDS18006.2. [B1AUR6-1 ]
RefSeqi NP_955761.2. NM_199467.2. [B1AUR6-1 ]
UniGenei Mm.120919.

3D structure databases

ModBasei Search...

Proteomic databases

PaxDbi B1AUR6.
PRIDEi B1AUR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000108222 ; ENSMUSP00000103857 ; ENSMUSG00000045751 . [B1AUR6-1 ]
GeneIDi 212377.
KEGGi mmu:212377.
UCSCi uc008sdv.2. mouse. [B1AUR6-1 ]
uc008sdy.1. mouse. [B1AUR6-2 ]

Organism-specific databases

CTDi 253714.
MGIi MGI:2684980. Mms22l.

Phylogenomic databases

eggNOGi NOG27315.
GeneTreei ENSGT00390000011769.
HOGENOMi HOG000049190.
HOVERGENi HBG058755.
InParanoidi B1AUR6.
OMAi EVGLQNF.
OrthoDBi EOG7K0ZBB.
PhylomeDBi B1AUR6.
TreeFami TF353832.

Miscellaneous databases

ChiTaRSi MMS22L. mouse.
NextBioi 373541.
PROi B1AUR6.
SOURCEi Search...

Gene expression databases

ArrayExpressi B1AUR6.
Bgeei B1AUR6.
Genevestigatori B1AUR6.

Family and domain databases

InterProi IPR029424. MMS22L_C.
IPR029425. MMS22L_N.
[Graphical view ]
Pfami PF14911. MMS22L_C. 1 hit.
PF14910. MMS22L_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: CD-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1238.
    Strain: 129.
    Tissue: Brain and Mammary tumor.

Entry informationi

Entry nameiMMS22_MOUSE
AccessioniPrimary (citable) accession number: B1AUR6
Secondary accession number(s): B7ZN61
, D3YXA0, Q6R5F9, Q80UT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: April 8, 2008
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi