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B1AUR6

- MMS22_MOUSE

UniProt

B1AUR6 - MMS22_MOUSE

Protein

Protein MMS22-like

Gene

Mms22l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA By similarity.By similarity

    GO - Biological processi

    1. double-strand break repair via homologous recombination Source: UniProtKB
    2. replication fork processing Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein MMS22-like
    Alternative name(s):
    Methyl methanesulfonate-sensitivity protein 22-like
    Gene namesi
    Name:Mms22l
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2684980. Mms22l.

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes to DNA damage sites, accumulates at stressed replication forks.By similarity

    GO - Cellular componenti

    1. FACT complex Source: Ensembl
    2. MCM complex Source: Ensembl
    3. nuclear replication fork Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12381238Protein MMS22-likePRO_0000403772Add
    BLAST

    Proteomic databases

    PaxDbiB1AUR6.
    PRIDEiB1AUR6.

    Expressioni

    Gene expression databases

    ArrayExpressiB1AUR6.
    BgeeiB1AUR6.
    GenevestigatoriB1AUR6.

    Interactioni

    Subunit structurei

    Component of the MMS22L-TONSL complex, a complex at least composed of MMS22L and TONSL/NFKBIL2.By similarity

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MMS22 family. MMS22L subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG27315.
    GeneTreeiENSGT00390000011769.
    HOGENOMiHOG000049190.
    HOVERGENiHBG058755.
    InParanoidiB1AUR6.
    OMAiEVGLQNF.
    OrthoDBiEOG7K0ZBB.
    PhylomeDBiB1AUR6.
    TreeFamiTF353832.

    Family and domain databases

    InterProiIPR029424. MMS22L_C.
    IPR029425. MMS22L_N.
    [Graphical view]
    PfamiPF14911. MMS22L_C. 1 hit.
    PF14910. MMS22L_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B1AUR6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDGCSAASTF LTDSLELELG TEWCKPPCFS CAFDNREGKF SGESYLASGA     50
    LKRLILNLDP LPTNFEEDTV ELFGFQWVTE TALVYSCREL FHLFRQQIFN 100
    LESLVQVSCD FGKIATLHAK ADSIRQQCVV FLHYIKVFIF RCLKVQEAES 150
    HSRPAHPYEA LEAQLPSMLV DELRGLLLYI GHLAALPSVT VGAFVNQNQM 200
    KLFPPSWHLL HLYLDTHWLV LEILHILGEK LKQVVYGRQF IGQAGDNLTN 250
    VSLFEEHCEH LFCDLICLSL NRFDKVMPSE ALLISHCPCS CVKELWVLLI 300
    HLLDHRRKWS VADSFWNWLN KLLRTLFEKS SDQRRSSVSL TQAKDPLGFS 350
    WWISVHVASL YQIDRHGVSD KMKQMESNWS FIEELLKRSV TVQDSILEEQ 400
    LRMHLHCCLT LCDFWEPNIS VVTILWEYYS KNLNSSFSIS WLPLKGLTNI 450
    IKSPLSMLTL VRNCCSDKQD PDLYKSSSSY IIFLCILAKV VKKAMRTSGP 500
    HPWKQVKGRI YSKFHQKRME ELTEVGLQNF FSLFLLLAAV AEIEDVASHV 550
    LDLLRFLRPA SMSSHGALVW KGQMAFLLMY AQKNLDIGVW AEKLSCEFQE 600
    KAKEFLVSKN DEMVQRHALW TLLCIYIDGV QEVFETSSCL YPSHEHLLND 650
    GFSMLLPACR ESELRTVLNF LQAVLARIRS VHQQLCQELQ RENVDLTVQS 700
    SLSAKERPLA AVAGALWRHF FSFLKSQRMT QVVPLSQLAD AAADFTLLAV 750
    DMPNTAPPDL QPQPVISIIQ LFGWDDIIWP QVVARYLSHL LQNSTVYEAL 800
    SQSSCVSSQS LTIRSWVRCV LQMHIKHLSD PDLLIDVNPE QAVEKEYMEQ 850
    LAEMTRLLFT LSEVKSVFSK AQIEQLPSPD DPKQALIQFL EAVGVTYRTL 900
    QTFSDKSAMV TKSLEYLGEV LKYIKPYLGK KVSSAGLQLT YGIMGILVKS 950
    WAHIFATSKA QKLLFRIIDC LLLPHTVLQQ DKELPGPMLT AIQKTLPLYL 1000
    QGICIVCCQS QNPNAYLNQL LRNVIEQYIG RFLPTSPCVS DLGQHPVLLA 1050
    LRNPASVPSM TPLRKHTVHA IRKSYLEFKG SSPPPRLASV LAFVLQLFKD 1100
    TEMGACDLEL LLPGILKCLV LVNEPQVKKL ATENLQCMVQ TCQVGSEGGP 1150
    ATQLTSLFRQ FIQDYGMQYS YQVYSILETV ATLNQHVVIQ LIPTLTQSLK 1200
    DSELKWGLGR NIAQREAYSR LLSGLGQVGQ GEKQRLEK 1238
    Length:1,238
    Mass (Da):140,582
    Last modified:April 8, 2008 - v1
    Checksum:i9C2733D598CF2F2D
    GO
    Isoform 2 (identifier: B1AUR6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-276: Missing.
         793-793: N → NS

    Note: No experimental confirmation available.

    Show »
    Length:963
    Mass (Da):109,242
    Checksum:i91CE2C35CABA608A
    GO

    Sequence cautioni

    The sequence AAI37911.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI45029.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 276276Missing in isoform 2. 1 PublicationVSP_040445Add
    BLAST
    Alternative sequencei793 – 7931N → NS in isoform 2. 1 PublicationVSP_040446

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY512923 mRNA. Translation: AAR87794.1.
    BX296536, AL671913 Genomic DNA. Translation: CAM23327.1.
    BC051674 mRNA. Translation: AAH51674.1.
    BC137910 mRNA. Translation: AAI37911.1. Different initiation.
    BC145028 mRNA. Translation: AAI45029.1. Different initiation.
    CCDSiCCDS18006.2. [B1AUR6-1]
    RefSeqiNP_955761.2. NM_199467.2. [B1AUR6-1]
    UniGeneiMm.120919.

    Genome annotation databases

    EnsembliENSMUST00000108222; ENSMUSP00000103857; ENSMUSG00000045751. [B1AUR6-1]
    GeneIDi212377.
    KEGGimmu:212377.
    UCSCiuc008sdv.2. mouse. [B1AUR6-1]
    uc008sdy.1. mouse. [B1AUR6-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY512923 mRNA. Translation: AAR87794.1 .
    BX296536 , AL671913 Genomic DNA. Translation: CAM23327.1 .
    BC051674 mRNA. Translation: AAH51674.1 .
    BC137910 mRNA. Translation: AAI37911.1 . Different initiation.
    BC145028 mRNA. Translation: AAI45029.1 . Different initiation.
    CCDSi CCDS18006.2. [B1AUR6-1 ]
    RefSeqi NP_955761.2. NM_199467.2. [B1AUR6-1 ]
    UniGenei Mm.120919.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi B1AUR6.
    PRIDEi B1AUR6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108222 ; ENSMUSP00000103857 ; ENSMUSG00000045751 . [B1AUR6-1 ]
    GeneIDi 212377.
    KEGGi mmu:212377.
    UCSCi uc008sdv.2. mouse. [B1AUR6-1 ]
    uc008sdy.1. mouse. [B1AUR6-2 ]

    Organism-specific databases

    CTDi 253714.
    MGIi MGI:2684980. Mms22l.

    Phylogenomic databases

    eggNOGi NOG27315.
    GeneTreei ENSGT00390000011769.
    HOGENOMi HOG000049190.
    HOVERGENi HBG058755.
    InParanoidi B1AUR6.
    OMAi EVGLQNF.
    OrthoDBi EOG7K0ZBB.
    PhylomeDBi B1AUR6.
    TreeFami TF353832.

    Miscellaneous databases

    ChiTaRSi MMS22L. mouse.
    NextBioi 373541.
    PROi B1AUR6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B1AUR6.
    Bgeei B1AUR6.
    Genevestigatori B1AUR6.

    Family and domain databases

    InterProi IPR029424. MMS22L_C.
    IPR029425. MMS22L_N.
    [Graphical view ]
    Pfami PF14911. MMS22L_C. 1 hit.
    PF14910. MMS22L_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: CD-1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 216-1238.
      Strain: 129.
      Tissue: Brain and Mammary tumor.

    Entry informationi

    Entry nameiMMS22_MOUSE
    AccessioniPrimary (citable) accession number: B1AUR6
    Secondary accession number(s): B7ZN61
    , D3YXA0, Q6R5F9, Q80UT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3