B1AUH1 (PTPRU_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase U
Short name=R-PTP-U
EC=3.1.3.48

Alternative name(s):
Ftp-1
Pancreatic carcinoma phosphatase 2
Short name=PCP-2
Protein-tyrosine phosphatase-lamda
Short name=PTP-lambda
Short name=PTPlambda
Receptor-type protein-tyrosine phosphatase psi
Short name=R-PTP-psi

Gene names

Name:	Ptpru
Synonyms:	Pcp2, Ptpf

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1446 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Forms homooligomeric complexes which mediate cell homotypic adhesion Probable. Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT By similarity. May interact with AP3B1 By similarity. Ref.2
Subcellular location	Cell junction By similarity. Cell membrane; Single-pass type I membrane protein By similarity.
Tissue specificity	Transcripts of different sizes are differentially expressed in a subset of tissues. Detected in brain, lung, skeletal muscle, heart, kidney and placenta. In brain; expressed in olfactory bulb, cerebral cortex, hippocampus and cerebellum. Ref.1 Ref.2 Ref.7
Developmental stage	Expressed throughout embryonic development. First detected at E7. Ref.2
Post-translational modification	The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. Beside the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed By similarity. N-glycosylated By similarity. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 MAM domain. Contains 2 tyrosine-protein phosphatase domains.
Sequence caution	The sequence AAH80736.1 differs from that shown. Reason: Erroneous termination at position 618. Translated as Arg. The sequence AAH80736.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. The sequence BAE43351.1 differs from that shown. Reason: Intron retention.

Ontologies

Keywords
Biological process	Cell adhesion Differentiation
Cellular component	Cell junction Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW homotypic cell-cell adhesion Inferred from direct assay Ref.2. Source: MGI negative regulation of cell migration Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara protein localization to cell surface Inferred from electronic annotation. Source: Compara
Cellular_component	cell-cell junction Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: B1AUH1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: B1AUH1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     774-783: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 1446	1428	Receptor-type tyrosine-protein phosphatase U		PRO_0000371659
Regions
	Topological domain	19 – 749	731	Extracellular Potential
	Transmembrane	750 – 770	21	Helical; Potential
	Topological domain	771 – 1446	676	Cytoplasmic Potential
	Domain	25 – 188	164	MAM
	Domain	190 – 275	86	Ig-like C2-type
	Domain	285 – 377	93	Fibronectin type-III 1
	Domain	383 – 481	99	Fibronectin type-III 2
	Domain	482 – 585	104	Fibronectin type-III 3
	Domain	587 – 668	82	Fibronectin type-III 4
	Domain	888 – 1144	257	Tyrosine-protein phosphatase 1
	Domain	1176 – 1439	264	Tyrosine-protein phosphatase 2
	Region	771 – 887	117	Mediates interaction with CTNNB1
	Region	1085 – 1091	7	Substrate binding By similarity
Sites
	Active site	1085	1	Phosphocysteine intermediate By similarity
	Active site	1380	1	Phosphocysteine intermediate By similarity
	Binding site	1053	1	Substrate Potential
	Binding site	1129	1	Substrate By similarity
Amino acid modifications
	Modified residue	848	1	Phosphoserine By similarity
	Modified residue	853	1	Phosphoserine By similarity
	Glycosylation	75	1	N-linked (GlcNAc...) Potential
	Glycosylation	410	1	N-linked (GlcNAc...) Potential
	Glycosylation	685	1	N-linked (GlcNAc...) Potential
	Disulfide bond	210 ↔ 264		Potential
Natural variations
	Alternative sequence	774 – 783	10	Missing in isoform 2.		VSP_037086
Experimental info
	Sequence conflict	80	1	A → T in AAB17895. Ref.2
	Sequence conflict	158	1	Y → F in AAB17895. Ref.2
	Sequence conflict	265	1	V → A in AAH80736. Ref.6
	Sequence conflict	387	1	P → S in AAH80736. Ref.6
	Sequence conflict	506	1	K → R in AAH80736. Ref.6
	Sequence conflict	1158	1	K → R in AAB17895. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: CBF639D8150D0D0B	FASTA	1,446	162,494
	10 20 30 40 50 60 MARAQALVLA LTFQFCAPET ETPAAGCTFE EASDPVVPCE FSQAQYDDFQ WEQVRIHPGT 70 80 90 100 110 120 RTPEDLPHGA YLMVNASQHA PGQRAHIIFQ TLSENDTHCV QFSYFLYSRD GHSPGTLGVY 130 140 150 160 170 180 VRVNGGPLGS AVWNMTGSHG RQWHQAELAV STFWPNEYQV LFEALISPDH KGYIGLDDIL 190 200 210 220 230 240 LFSYPCAKAP HFSRLGDVEV NAGQNASFQC MAAGRAAEAE HFFLQRQSGV LVPAAGVRHI 250 260 270 280 290 300 SHRRFLATFP LASVGRSEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT 310 320 330 340 350 360 YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVNLQ TYKLWHLDPD TEYEISVLLT 370 380 390 400 410 420 RPGDGGTGRP GPPLISRTKC AEPTRAPKGL AFAEIQARQL TLQWEPLGYN VTRCHTYAVS 430 440 450 460 470 480 LCYRYTLGGS HNQTIRECVK MERGASRYTI KNLLPFRNIH VRLILTNPEG RKEGKEVTFQ 490 500 510 520 530 540 TDEDVPGGIA AESLTFTPLE DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR 550 560 570 580 590 600 RTISKLRNET YHVFSNLHPG TTYLFSVRAR TSKGFGQAAL TEITTNISAP SFDYADMPSP 610 620 630 640 650 660 LGESENTITV LLRPAQGRGA PISVYQVVVE EERPRRLRRE PGAQDCFSVP LTFETALARG 670 680 690 700 710 720 LVHYFGAELA ASSLLEAMPF TVGDNQTYRG FWNPPLEPRK AYLIYFQAAS HLKGETRLNC 730 740 750 760 770 780 IRIARKAACK ESKRPLEVSQ RSEEMGLILG ICAGGLAVLI LLLGAIIVII RKGRDRYAYS 790 800 810 820 830 840 YYPKPVNMTK ATVNYRQEKT HMMSAVDRSF TDQSTLQEDE RLGLSFMDAP GYSPRGDQRS 850 860 870 880 890 900 GGVTEASSLL GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES 910 920 930 940 950 960 FFEGWDATKK KDKLKGGRQE PVSAYDRHHV KLHPMLADPD ADYISANYID GYHRSNHFIA 970 980 990 1000 1010 1020 TQGPKPEMIY DFWRMVWQEQ CASIVMITKL VEVGRVKCSR YWPEDSDMYG DIKITLVKTE 1030 1040 1050 1060 1070 1080 TLAEYVVRTF ALERRGYSAR HEVRQFHFTA WPEHGVPYHA TGLLAFIRRV KASTPPDAGP 1090 1100 1110 1120 1130 1140 IVIHCSAGTG RTGCYIVLDV MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA 1150 1160 1170 1180 1190 1200 ILEACLCGET TIPVNEFKAT YREMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL 1210 1220 1230 1240 1250 1260 PRNRDKNRSM DVLPPDRCLP FLISSDGDPN NYINAALTDS YTRSAAFIVT LHPLQSTTPD 1270 1280 1290 1300 1310 1320 FWRLVYDYGC TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY GLMEVEFVSG TANEDLVSRV 1330 1340 1350 1360 1370 1380 FRVQNSSRLQ EGHLLVRHFQ FLRWSAYRDT PDSRKAFLHL LAEVDKWQAE SGDGRTVVHC 1390 1400 1410 1420 1430 1440 LNGGGRSGTF CACATVLEMI RCHSLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL EALELR
	Isoform 2 [UniParc]. Checksum: 8D406DE4948643FF	FASTA	1,436	161,158
	10 20 30 40 50 60 MARAQALVLA LTFQFCAPET ETPAAGCTFE EASDPVVPCE FSQAQYDDFQ WEQVRIHPGT 70 80 90 100 110 120 RTPEDLPHGA YLMVNASQHA PGQRAHIIFQ TLSENDTHCV QFSYFLYSRD GHSPGTLGVY 130 140 150 160 170 180 VRVNGGPLGS AVWNMTGSHG RQWHQAELAV STFWPNEYQV LFEALISPDH KGYIGLDDIL 190 200 210 220 230 240 LFSYPCAKAP HFSRLGDVEV NAGQNASFQC MAAGRAAEAE HFFLQRQSGV LVPAAGVRHI 250 260 270 280 290 300 SHRRFLATFP LASVGRSEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT 310 320 330 340 350 360 YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVNLQ TYKLWHLDPD TEYEISVLLT 370 380 390 400 410 420 RPGDGGTGRP GPPLISRTKC AEPTRAPKGL AFAEIQARQL TLQWEPLGYN VTRCHTYAVS 430 440 450 460 470 480 LCYRYTLGGS HNQTIRECVK MERGASRYTI KNLLPFRNIH VRLILTNPEG RKEGKEVTFQ 490 500 510 520 530 540 TDEDVPGGIA AESLTFTPLE DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR 550 560 570 580 590 600 RTISKLRNET YHVFSNLHPG TTYLFSVRAR TSKGFGQAAL TEITTNISAP SFDYADMPSP 610 620 630 640 650 660 LGESENTITV LLRPAQGRGA PISVYQVVVE EERPRRLRRE PGAQDCFSVP LTFETALARG 670 680 690 700 710 720 LVHYFGAELA ASSLLEAMPF TVGDNQTYRG FWNPPLEPRK AYLIYFQAAS HLKGETRLNC 730 740 750 760 770 780 IRIARKAACK ESKRPLEVSQ RSEEMGLILG ICAGGLAVLI LLLGAIIVII RKGKPVNMTK 790 800 810 820 830 840 ATVNYRQEKT HMMSAVDRSF TDQSTLQEDE RLGLSFMDAP GYSPRGDQRS GGVTEASSLL 850 860 870 880 890 900 GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES FFEGWDATKK 910 920 930 940 950 960 KDKLKGGRQE PVSAYDRHHV KLHPMLADPD ADYISANYID GYHRSNHFIA TQGPKPEMIY 970 980 990 1000 1010 1020 DFWRMVWQEQ CASIVMITKL VEVGRVKCSR YWPEDSDMYG DIKITLVKTE TLAEYVVRTF 1030 1040 1050 1060 1070 1080 ALERRGYSAR HEVRQFHFTA WPEHGVPYHA TGLLAFIRRV KASTPPDAGP IVIHCSAGTG 1090 1100 1110 1120 1130 1140 RTGCYIVLDV MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA ILEACLCGET 1150 1160 1170 1180 1190 1200 TIPVNEFKAT YREMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL PRNRDKNRSM 1210 1220 1230 1240 1250 1260 DVLPPDRCLP FLISSDGDPN NYINAALTDS YTRSAAFIVT LHPLQSTTPD FWRLVYDYGC 1270 1280 1290 1300 1310 1320 TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY GLMEVEFVSG TANEDLVSRV FRVQNSSRLQ 1330 1340 1350 1360 1370 1380 EGHLLVRHFQ FLRWSAYRDT PDSRKAFLHL LAEVDKWQAE SGDGRTVVHC LNGGGRSGTF 1390 1400 1410 1420 1430 CACATVLEMI RCHSLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL EALELR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel receptor-type protein tyrosine phosphatase from murine fetal liver." Yoneya T., Yamada Y., Kakeda M., Osawa M., Arai E., Hayashi K., Nishi N., Inoue H., Nishikawa M. Gene 194:241-247(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Fetal liver.
[2]	"A novel protein-tyrosine phosphatase related to the homotypically adhering kappa and mu receptors." Cheng J., Wu K., Armanini M., O'Rourke N., Dowbenko D., Lasky L.A. J. Biol. Chem. 272:7264-7277(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), HOMOOLIGOMERIZATION, INTERACTION WITH CTNNB1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PROTEOLYTIC PROCESSING. Tissue: Lung.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[4]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1286 (ISOFORM 2). Strain: C57BL/6J. Tissue: Kidney.
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-911 (ISOFORM 2). Strain: C57BL/6J. Tissue: Embryo.
[7]	"Genomic structure and alternative splicing of murine R2B receptor protein tyrosine phosphatases (PTPkappa, mu, rho and PCP-2)." Besco J., Popesco M.C., Davuluri R.V., Frostholm A., Rotter A. BMC Genomics 5:14-14(2004) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D88187 mRNA. Translation: BAA23475.1. U55057 mRNA. Translation: AAB17895.1. AL670959 Genomic DNA. Translation: CAM27391.1. AL670959 Genomic DNA. Translation: CAM27392.1. CH466552 Genomic DNA. Translation: EDL30128.1. AK052720 mRNA. Translation: BAE43351.1. Sequence problems. BC080736 mRNA. Translation: AAH80736.1. Sequence problems.
IPI	IPI00121326. IPI00649924.
RefSeq	NP_001076588.1. NM_001083119.2. NP_035344.2. NM_011214.2.
UniGene	Mm.4860.
3D structure databases
ProteinModelPortal	B1AUH1.
SMR	B1AUH1. Positions 22-591, 871-1440.
ModBase	Search...
Proteomic databases
PRIDE	B1AUH1.
Protocols and materials databases
DNASU	19273.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030741; ENSMUSP00000030741; ENSMUSG00000028909. ENSMUST00000105987; ENSMUSP00000101607; ENSMUSG00000028909.
GeneID	19273.
KEGG	mmu:19273.
UCSC	uc008vaa.1. mouse. uc008vab.1. mouse.
Organism-specific databases
CTD	10076.
MGI	MGI:1321151. Ptpru.
Phylogenomic databases
eggNOG	COG5599.
GeneTree	ENSGT00640000091300.
HOGENOM	HOG000049029.
InParanoid	Q66JV9.
KO	K16662.
OMA	SAPSFDY.
OrthoDB	EOG4868BM.
Gene expression databases
ArrayExpress	B1AUH1.
Bgee	B1AUH1.
Genevestigator	B1AUH1.
Family and domain databases
Gene3D	2.60.40.10. 4 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR003961. Fibronectin_type3. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR000998. MAM_dom. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. IPR000242. Tyr_Pase_rcpt/non-rcpt. [Graphical view]
Pfam	PF00041. fn3. 2 hits. PF00629. MAM. 1 hit. PF00102. Y_phosphatase. 2 hits. [Graphical view]
PRINTS	PR00020. MAMDOMAIN. PR00700. PRTYPHPHTASE.
SMART	SM00060. FN3. 3 hits. SM00409. IG. 1 hit. SM00137. MAM. 1 hit. SM00194. PTPc. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit. SSF49265. FN_III-like. 3 hits.
PROSITE	PS50853. FN3. 3 hits. PS50835. IG_LIKE. False negative. PS00740. MAM_1. False negative. PS50060. MAM_2. 1 hit. PS00383. TYR_PHOSPHATASE_1. 2 hits. PS50056. TYR_PHOSPHATASE_2. 2 hits. PS50055. TYR_PHOSPHATASE_PTP. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	296166.
SOURCE	Search...

Entry information

Entry name

PTPRU_MOUSE

Accession

Primary (citable) accession number: B1AUH1
Secondary accession number(s): O35564 , P70125, Q3V312, Q66JV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program