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B1AUH1

- PTPRU_MOUSE

UniProt

B1AUH1 - PTPRU_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase U

Gene

Ptpru

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1053 – 10531SubstrateSequence Analysis
Active sitei1085 – 10851Phosphocysteine intermediateBy similarity
Binding sitei1129 – 11291SubstrateBy similarity
Active sitei1380 – 13801Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. canonical Wnt signaling pathway Source: Ensembl
  2. cell differentiation Source: UniProtKB-KW
  3. homotypic cell-cell adhesion Source: MGI
  4. negative regulation of cell migration Source: Ensembl
  5. negative regulation of cell proliferation Source: Ensembl
  6. organ regeneration Source: Ensembl
  7. protein localization to cell surface Source: Ensembl
  8. response to glucocorticoid Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Keywords - Biological processi

Cell adhesion, Differentiation

Enzyme and pathway databases

ReactomeiREACT_188578. Signaling by SCF-KIT.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase U (EC:3.1.3.48)
Short name:
R-PTP-U
Alternative name(s):
Ftp-1
Pancreatic carcinoma phosphatase 2
Short name:
PCP-2
Protein-tyrosine phosphatase-lamda
Short name:
PTP-lambda
Short name:
PTPlambda
Receptor-type protein-tyrosine phosphatase psi
Short name:
R-PTP-psi
Gene namesi
Name:Ptpru
Synonyms:Pcp2, Ptpf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1321151. Ptpru.

Subcellular locationi

Cell junction By similarity. Cell membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. cell-cell junction Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 14461428Receptor-type tyrosine-protein phosphatase UPRO_0000371659Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi210 ↔ 264Sequence Analysis
Glycosylationi410 – 4101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi685 – 6851N-linked (GlcNAc...)Sequence Analysis
Modified residuei848 – 8481PhosphoserineBy similarity
Modified residuei853 – 8531PhosphoserineBy similarity

Post-translational modificationi

The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed (By similarity).By similarity
N-glycosylated.By similarity
Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiB1AUH1.

Expressioni

Tissue specificityi

Transcripts of different sizes are differentially expressed in a subset of tissues. Detected in brain, lung, skeletal muscle, heart, kidney and placenta. In brain; expressed in olfactory bulb, cerebral cortex, hippocampus and cerebellum.3 Publications

Developmental stagei

Expressed throughout embryonic development. First detected at E7.1 Publication

Gene expression databases

BgeeiB1AUH1.
ExpressionAtlasiB1AUH1. baseline and differential.
GenevestigatoriB1AUH1.

Interactioni

Subunit structurei

Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable). Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT (By similarity). May interact with AP3B1 (By similarity).By similarityCurated

Structurei

3D structure databases

ProteinModelPortaliB1AUH1.
SMRiB1AUH1. Positions 22-591, 871-1440.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 749731ExtracellularSequence AnalysisAdd
BLAST
Topological domaini771 – 1446676CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei750 – 77021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 188164MAMPROSITE-ProRule annotationAdd
BLAST
Domaini190 – 27586Ig-like C2-typeAdd
BLAST
Domaini288 – 38396Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini386 – 48499Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini485 – 591107Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini592 – 66877Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini888 – 1144257Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1176 – 1439264Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni771 – 887117Mediates interaction with CTNNB1Add
BLAST
Regioni1085 – 10917Substrate bindingBy similarity

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
InParanoidiB1AUH1.
KOiK16662.
OMAiLTDSYTR.
OrthoDBiEOG70KGNP.
PhylomeDBiB1AUH1.
TreeFamiTF312900.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B1AUH1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARAQALVLA LTFQFCAPET ETPAAGCTFE EASDPVVPCE FSQAQYDDFQ
60 70 80 90 100
WEQVRIHPGT RTPEDLPHGA YLMVNASQHA PGQRAHIIFQ TLSENDTHCV
110 120 130 140 150
QFSYFLYSRD GHSPGTLGVY VRVNGGPLGS AVWNMTGSHG RQWHQAELAV
160 170 180 190 200
STFWPNEYQV LFEALISPDH KGYIGLDDIL LFSYPCAKAP HFSRLGDVEV
210 220 230 240 250
NAGQNASFQC MAAGRAAEAE HFFLQRQSGV LVPAAGVRHI SHRRFLATFP
260 270 280 290 300
LASVGRSEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT
310 320 330 340 350
YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVNLQ TYKLWHLDPD
360 370 380 390 400
TEYEISVLLT RPGDGGTGRP GPPLISRTKC AEPTRAPKGL AFAEIQARQL
410 420 430 440 450
TLQWEPLGYN VTRCHTYAVS LCYRYTLGGS HNQTIRECVK MERGASRYTI
460 470 480 490 500
KNLLPFRNIH VRLILTNPEG RKEGKEVTFQ TDEDVPGGIA AESLTFTPLE
510 520 530 540 550
DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR RTISKLRNET
560 570 580 590 600
YHVFSNLHPG TTYLFSVRAR TSKGFGQAAL TEITTNISAP SFDYADMPSP
610 620 630 640 650
LGESENTITV LLRPAQGRGA PISVYQVVVE EERPRRLRRE PGAQDCFSVP
660 670 680 690 700
LTFETALARG LVHYFGAELA ASSLLEAMPF TVGDNQTYRG FWNPPLEPRK
710 720 730 740 750
AYLIYFQAAS HLKGETRLNC IRIARKAACK ESKRPLEVSQ RSEEMGLILG
760 770 780 790 800
ICAGGLAVLI LLLGAIIVII RKGRDRYAYS YYPKPVNMTK ATVNYRQEKT
810 820 830 840 850
HMMSAVDRSF TDQSTLQEDE RLGLSFMDAP GYSPRGDQRS GGVTEASSLL
860 870 880 890 900
GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES
910 920 930 940 950
FFEGWDATKK KDKLKGGRQE PVSAYDRHHV KLHPMLADPD ADYISANYID
960 970 980 990 1000
GYHRSNHFIA TQGPKPEMIY DFWRMVWQEQ CASIVMITKL VEVGRVKCSR
1010 1020 1030 1040 1050
YWPEDSDMYG DIKITLVKTE TLAEYVVRTF ALERRGYSAR HEVRQFHFTA
1060 1070 1080 1090 1100
WPEHGVPYHA TGLLAFIRRV KASTPPDAGP IVIHCSAGTG RTGCYIVLDV
1110 1120 1130 1140 1150
MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA ILEACLCGET
1160 1170 1180 1190 1200
TIPVNEFKAT YREMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL
1210 1220 1230 1240 1250
PRNRDKNRSM DVLPPDRCLP FLISSDGDPN NYINAALTDS YTRSAAFIVT
1260 1270 1280 1290 1300
LHPLQSTTPD FWRLVYDYGC TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY
1310 1320 1330 1340 1350
GLMEVEFVSG TANEDLVSRV FRVQNSSRLQ EGHLLVRHFQ FLRWSAYRDT
1360 1370 1380 1390 1400
PDSRKAFLHL LAEVDKWQAE SGDGRTVVHC LNGGGRSGTF CACATVLEMI
1410 1420 1430 1440
RCHSLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL EALELR
Length:1,446
Mass (Da):162,494
Last modified:April 8, 2008 - v1
Checksum:iCBF639D8150D0D0B
GO
Isoform 2 (identifier: B1AUH1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     774-783: Missing.

Show »
Length:1,436
Mass (Da):161,158
Checksum:i8D406DE4948643FF
GO

Sequence cautioni

The sequence AAH80736.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.
The sequence BAE43351.1 differs from that shown. Reason: Intron retention.
The sequence AAH80736.1 differs from that shown. Reason: Erroneous termination at position 618. Translated as Arg.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801A → T in AAB17895. (PubMed:9054423)Curated
Sequence conflicti158 – 1581Y → F in AAB17895. (PubMed:9054423)Curated
Sequence conflicti265 – 2651V → A in AAH80736. (PubMed:15489334)Curated
Sequence conflicti387 – 3871P → S in AAH80736. (PubMed:15489334)Curated
Sequence conflicti506 – 5061K → R in AAH80736. (PubMed:15489334)Curated
Sequence conflicti1158 – 11581K → R in AAB17895. (PubMed:9054423)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei774 – 78310Missing in isoform 2. 4 PublicationsVSP_037086

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88187 mRNA. Translation: BAA23475.1.
U55057 mRNA. Translation: AAB17895.1.
AL670959 Genomic DNA. Translation: CAM27391.1.
AL670959 Genomic DNA. Translation: CAM27392.1.
CH466552 Genomic DNA. Translation: EDL30128.1.
AK052720 mRNA. Translation: BAE43351.1. Sequence problems.
BC080736 mRNA. Translation: AAH80736.1. Sequence problems.
CCDSiCCDS18714.1. [B1AUH1-2]
CCDS38896.1. [B1AUH1-1]
RefSeqiNP_001076588.1. NM_001083119.2. [B1AUH1-1]
NP_035344.2. NM_011214.2. [B1AUH1-2]
UniGeneiMm.4860.

Genome annotation databases

EnsembliENSMUST00000030741; ENSMUSP00000030741; ENSMUSG00000028909. [B1AUH1-1]
ENSMUST00000105987; ENSMUSP00000101607; ENSMUSG00000028909. [B1AUH1-2]
GeneIDi19273.
KEGGimmu:19273.
UCSCiuc008vaa.1. mouse. [B1AUH1-1]
uc008vab.1. mouse. [B1AUH1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D88187 mRNA. Translation: BAA23475.1 .
U55057 mRNA. Translation: AAB17895.1 .
AL670959 Genomic DNA. Translation: CAM27391.1 .
AL670959 Genomic DNA. Translation: CAM27392.1 .
CH466552 Genomic DNA. Translation: EDL30128.1 .
AK052720 mRNA. Translation: BAE43351.1 . Sequence problems.
BC080736 mRNA. Translation: AAH80736.1 . Sequence problems.
CCDSi CCDS18714.1. [B1AUH1-2 ]
CCDS38896.1. [B1AUH1-1 ]
RefSeqi NP_001076588.1. NM_001083119.2. [B1AUH1-1 ]
NP_035344.2. NM_011214.2. [B1AUH1-2 ]
UniGenei Mm.4860.

3D structure databases

ProteinModelPortali B1AUH1.
SMRi B1AUH1. Positions 22-591, 871-1440.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B1AUH1.

Protocols and materials databases

DNASUi 19273.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000030741 ; ENSMUSP00000030741 ; ENSMUSG00000028909 . [B1AUH1-1 ]
ENSMUST00000105987 ; ENSMUSP00000101607 ; ENSMUSG00000028909 . [B1AUH1-2 ]
GeneIDi 19273.
KEGGi mmu:19273.
UCSCi uc008vaa.1. mouse. [B1AUH1-1 ]
uc008vab.1. mouse. [B1AUH1-2 ]

Organism-specific databases

CTDi 10076.
MGIi MGI:1321151. Ptpru.

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00760000118900.
HOGENOMi HOG000049029.
InParanoidi B1AUH1.
KOi K16662.
OMAi LTDSYTR.
OrthoDBi EOG70KGNP.
PhylomeDBi B1AUH1.
TreeFami TF312900.

Enzyme and pathway databases

Reactomei REACT_188578. Signaling by SCF-KIT.

Miscellaneous databases

NextBioi 296166.
PROi B1AUH1.
SOURCEi Search...

Gene expression databases

Bgeei B1AUH1.
ExpressionAtlasi B1AUH1. baseline and differential.
Genevestigatori B1AUH1.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR013320. ConA-like_dom.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 3 hits.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel receptor-type protein tyrosine phosphatase from murine fetal liver."
    Yoneya T., Yamada Y., Kakeda M., Osawa M., Arai E., Hayashi K., Nishi N., Inoue H., Nishikawa M.
    Gene 194:241-247(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Fetal liver.
  2. "A novel protein-tyrosine phosphatase related to the homotypically adhering kappa and mu receptors."
    Cheng J., Wu K., Armanini M., O'Rourke N., Dowbenko D., Lasky L.A.
    J. Biol. Chem. 272:7264-7277(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), HOMOOLIGOMERIZATION, INTERACTION WITH CTNNB1, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, PROTEOLYTIC PROCESSING.
    Tissue: Lung.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1286 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Kidney.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-911 (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Embryo.
  7. "Genomic structure and alternative splicing of murine R2B receptor protein tyrosine phosphatases (PTPkappa, mu, rho and PCP-2)."
    Besco J., Popesco M.C., Davuluri R.V., Frostholm A., Rotter A.
    BMC Genomics 5:14-14(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPTPRU_MOUSE
AccessioniPrimary (citable) accession number: B1AUH1
Secondary accession number(s): O35564
, P70125, Q3V312, Q66JV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3