Alpha-1B adrenergic receptor - Mus musculus (Mouse)

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B1AU41 (B1AU41_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 45. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Submitted name:
Alpha-1B adrenergic receptor Ensembl ENSMUSP00000123435

Gene names

Name:

Adra1b Ensembl ENSMUSP00000123435 MGI 104774

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000123435

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	462 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000123435

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	adult heart development Inferred from genetic interaction PubMed 12782680. Source: MGI behavioral response to cocaine Inferred from mutant phenotype PubMed 11923452. Source: MGI blood vessel remodeling Inferred from mutant phenotype PubMed 15231500. Source: MGI cell growth Inferred from genetic interaction PubMed 12782680. Source: MGI glucose homeostasis Inferred from mutant phenotype PubMed 14581480. Source: MGI locomotory behavior Inferred from mutant phenotype PubMed 11222061. Source: MGI negative regulation of Rho protein signal transduction Inferred from sequence orthology PubMed 18332105. Source: MGI negative regulation of glycogen catabolic process Inferred from mutant phenotype PubMed 14581480. Source: MGI organ growth Inferred from genetic interaction PubMed 12782680. Source: MGI positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of glycogen catabolic process Inferred from mutant phenotype PubMed 14581480. Source: MGI positive regulation of heart rate by epinephrine-norepinephrine Inferred from genetic interaction PubMed 12782680. Source: MGI positive regulation of the force of heart contraction by epinephrine-norepinephrine Inferred from genetic interaction PubMed 12595294. Source: MGI response to amphetamine Inferred from mutant phenotype PubMed 11923452 PubMed 12871582. Source: MGI response to morphine Inferred from mutant phenotype PubMed 11923452. Source: MGI vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Inferred from mutant phenotype PubMed 9326654. Source: MGI visual learning Inferred from mutant phenotype PubMed 11222061. Source: MGI
Cellular_component	integral to membrane Inferred from direct assay PubMed 11923452. Source: MGI nuclear membrane Inferred from electronic annotation. Source: Compara
Molecular_function	alpha1-adrenergic receptor activity Inferred from direct assay PubMed 11923452 PubMed 7911220. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

462

Ensembl ENSMUSP00000123435

Sequences

Sequence

Length

Mass (Da)

Tools

B1AU41 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: ADE09422A7D2EB44
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FASTA

462

51,121

        10         20         30         40         50         60 
MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL VLGAFILFAI 

        70         80         90        100        110        120 
VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP FSATLEVLGY WVLGRIFCDI 

       130        140        150        160        170        180 
WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP 

       190        200        210        220        230        240 
LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG 

       250        260        270        280        290        300 
VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 

       310        320        330        340        350        360 
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFM 

       370        380        390        400        410        420 
RILGCQCRGG RRRRRRRRLG GCAYTYRPWT RGGSLERSQS RKDSLDDSGS CMSGSQRTLP 

       430        440        450        460 
SASPSPGYLG RGTQPPVELC AFPEWKPGAL LSLPEPPGRR GR

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000123435.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000123435.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL669911 Genomic DNA. No translation available.
IPI	IPI00648440.
UniGene	Mm.39086.
3D structure databases
ProteinModelPortal	B1AU41.
SMR	B1AU41. Positions 43-365.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000139906; ENSMUSP00000123435; ENSMUSG00000050541.
Organism-specific databases
MGI	MGI:104774. Adra1b.
Phylogenomic databases
GeneTree	ENSGT00700000104182.
HOGENOM	HOG000239244.
HOVERGEN	HBG106962.
InParanoid	B1AU41.
Gene expression databases
ArrayExpress	B1AU41.
Family and domain databases
InterPro	IPR001115. Adrene_rcpt_A1B. IPR002233. Adrnrgc_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR01103. ADRENERGICR. PR00556. ADRENRGCA1BR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35545959.
SOURCE	Search...

Entry information

Entry name

B1AU41_MOUSE

Accession

Primary (citable) accession number: B1AU41

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information