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B1AU41

- B1AU41_MOUSE

UniProt

B1AU41 - B1AU41_MOUSE

Protein
Submitted name:

Alpha-1B adrenergic receptor

Gene

Adra1b

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. alpha1-adrenergic receptor activity Source: MGI

    GO - Biological processi

    1. adrenergic receptor signaling pathway Source: GOC
    2. adult heart development Source: MGI
    3. behavioral response to cocaine Source: MGI
    4. blood vessel remodeling Source: MGI
    5. cell growth Source: MGI
    6. glucose homeostasis Source: MGI
    7. locomotory behavior Source: MGI
    8. negative regulation of glycogen catabolic process Source: MGI
    9. negative regulation of Rho protein signal transduction Source: MGI
    10. organ growth Source: MGI
    11. positive regulation of glycogen catabolic process Source: MGI
    12. positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
    13. positive regulation of MAPK cascade Source: Ensembl
    14. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
    15. regulation of cardiac muscle contraction Source: InterPro
    16. regulation of vasoconstriction Source: InterPro
    17. response to amphetamine Source: MGI
    18. response to morphine Source: MGI
    19. vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: MGI
    20. visual learning Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Alpha-1B adrenergic receptorImported
    Gene namesi
    Name:Adra1bImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:104774. Adra1b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: MGI
    2. nuclear membrane Source: Ensembl
    3. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membraneSAAS annotation, Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiB1AU41.

    Structurei

    3D structure databases

    ProteinModelPortaliB1AU41.
    SMRiB1AU41. Positions 43-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117429.
    HOGENOMiHOG000239244.
    HOVERGENiHBG106962.
    InParanoidiB1AU41.
    OrthoDBiEOG7H4DTB.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR002233. ADR_fam.
    IPR001115. ADRA1B_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01103. ADRENERGICR.
    PR00556. ADRENRGCA1BR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B1AU41-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL    50
    VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP 100
    FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS 150
    LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE 200
    PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE 250
    LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 300
    GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC 350
    SSKEFKRAFM RILGCQCRGG RRRRRRRRLG GCAYTYRPWT RGGSLERSQS 400
    RKDSLDDSGS CMSGSQRTLP SASPSPGYLG RGTQPPVELC AFPEWKPGAL 450
    LSLPEPPGRR GR 462
    Length:462
    Mass (Da):51,121
    Last modified:April 8, 2008 - v1
    Checksum:iADE09422A7D2EB44
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei462 – 4621Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL669911 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000139906; ENSMUSP00000123435; ENSMUSG00000050541.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL669911 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali B1AU41.
    SMRi B1AU41. Positions 43-365.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000139906 ; ENSMUSP00000123435 ; ENSMUSG00000050541 .

    Organism-specific databases

    MGIi MGI:104774. Adra1b.

    Phylogenomic databases

    GeneTreei ENSGT00750000117429.
    HOGENOMi HOG000239244.
    HOVERGENi HBG106962.
    InParanoidi B1AU41.
    OrthoDBi EOG7H4DTB.

    Enzyme and pathway databases

    Reactomei REACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 35545959.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B1AU41.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR002233. ADR_fam.
    IPR001115. ADRA1B_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24248:SF17. PTHR24248:SF17. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01103. ADRENERGICR.
    PR00556. ADRENRGCA1BR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB1AU41_MOUSE
    AccessioniPrimary (citable) accession number: B1AU41
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3