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Protein
Submitted name:

Alpha-1B adrenergic receptor

Gene

Adra1b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
  • adult heart development Source: MGI
  • behavioral response to cocaine Source: MGI
  • blood vessel remodeling Source: MGI
  • cell-cell signaling Source: GO_Central
  • cell growth Source: MGI
  • glucose homeostasis Source: MGI
  • locomotory behavior Source: MGI
  • negative regulation of glycogen catabolic process Source: MGI
  • negative regulation of Rho protein signal transduction Source: MGI
  • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: GO_Central
  • organ growth Source: MGI
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • positive regulation of glycogen catabolic process Source: MGI
  • positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
  • positive regulation of MAPK cascade Source: MGI
  • positive regulation of smooth muscle contraction Source: GO_Central
  • positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
  • positive regulation of vasoconstriction Source: GO_Central
  • regulation of cardiac muscle contraction Source: InterPro
  • response to amphetamine Source: MGI
  • response to morphine Source: MGI
  • vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: MGI
  • visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_292251. Adrenoceptors.
REACT_299052. G alpha (12/13) signalling events.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-1B adrenergic receptorImported
Gene namesi
Name:Adra1bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104774. Adra1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiB1AU41.
ExpressionAtlasiB1AU41. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070200.

Structurei

3D structure databases

ProteinModelPortaliB1AU41.
SMRiB1AU41. Positions 43-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
OrthoDBiEOG7H4DTB.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1AU41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL
60 70 80 90 100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP
110 120 130 140 150
FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS
160 170 180 190 200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE
210 220 230 240 250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE
260 270 280 290 300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
310 320 330 340 350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC
360 370 380 390 400
SSKEFKRAFM RILGCQCRGG RRRRRRRRLG GCAYTYRPWT RGGSLERSQS
410 420 430 440 450
RKDSLDDSGS CMSGSQRTLP SASPSPGYLG RGTQPPVELC AFPEWKPGAL
460
LSLPEPPGRR GR
Length:462
Mass (Da):51,121
Last modified:April 8, 2008 - v1
Checksum:iADE09422A7D2EB44
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei462 – 4621Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669911 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000139906; ENSMUSP00000123435; ENSMUSG00000050541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669911 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AU41.
SMRiB1AU41. Positions 43-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070200.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000139906; ENSMUSP00000123435; ENSMUSG00000050541.

Organism-specific databases

MGIiMGI:104774. Adra1b.

Phylogenomic databases

GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
OrthoDBiEOG7H4DTB.

Enzyme and pathway databases

ReactomeiREACT_292251. Adrenoceptors.
REACT_299052. G alpha (12/13) signalling events.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi35545959.
SOURCEiSearch...

Gene expression databases

BgeeiB1AU41.
ExpressionAtlasiB1AU41. baseline and differential.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AU41_MOUSE
AccessioniPrimary (citable) accession number: B1AU41
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 24, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.