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B1AU41 (B1AU41_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length462 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. RuleBase RU000688

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000123435

Ontologies

Keywords
   Cellular componentCell membrane SAAS SAAS002233
Membrane
   DomainTransmembrane
Transmembrane helix SAAS SAAS002233
   Molecular functionG-protein coupled receptor SAAS SAAS002233 RuleBase RU000688
Receptor
Transducer
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadrenergic receptor signaling pathway

Inferred from direct assay PubMed 11923452PubMed 7911220. Source: GOC

adult heart development

Inferred from genetic interaction PubMed 12782680. Source: MGI

behavioral response to cocaine

Inferred from mutant phenotype PubMed 11923452. Source: MGI

blood vessel remodeling

Inferred from mutant phenotype PubMed 15231500. Source: MGI

cell growth

Inferred from genetic interaction PubMed 12782680. Source: MGI

glucose homeostasis

Inferred from mutant phenotype PubMed 14581480. Source: MGI

locomotory behavior

Inferred from mutant phenotype PubMed 11222061. Source: MGI

negative regulation of Rho protein signal transduction

Inferred from sequence orthology PubMed 18332105. Source: MGI

negative regulation of glycogen catabolic process

Inferred from mutant phenotype PubMed 14581480. Source: MGI

organ growth

Inferred from genetic interaction PubMed 12782680. Source: MGI

positive regulation of MAPK cascade

Inferred from electronic annotation. Source: Ensembl

positive regulation of glycogen catabolic process

Inferred from mutant phenotype PubMed 14581480. Source: MGI

positive regulation of heart rate by epinephrine-norepinephrine

Inferred from genetic interaction PubMed 12782680. Source: MGI

positive regulation of the force of heart contraction by epinephrine-norepinephrine

Inferred from genetic interaction PubMed 12595294. Source: MGI

regulation of cardiac muscle contraction

Inferred from electronic annotation. Source: InterPro

regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

response to amphetamine

Inferred from mutant phenotype PubMed 11923452PubMed 12871582. Source: MGI

response to morphine

Inferred from mutant phenotype PubMed 11923452. Source: MGI

vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure

Inferred from mutant phenotype PubMed 9326654. Source: MGI

visual learning

Inferred from mutant phenotype PubMed 11222061. Source: MGI

   Cellular_componentintegral component of membrane

Inferred from direct assay PubMed 11923452. Source: MGI

nuclear membrane

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionalpha1-adrenergic receptor activity

Inferred from direct assay PubMed 11923452PubMed 7911220. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue4621 Ensembl ENSMUSP00000123435

Sequences

Sequence LengthMass (Da)Tools
B1AU41 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: ADE09422A7D2EB44

FASTA46251,121
        10         20         30         40         50         60 
MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL VLGAFILFAI 

        70         80         90        100        110        120 
VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP FSATLEVLGY WVLGRIFCDI 

       130        140        150        160        170        180 
WAAVDVLCCT ASILSLCAIS IDRYIGVRYS LQYPTLVTRR KAILALLSVW VLSTVISIGP 

       190        200        210        220        230        240 
LLGWKEPAPN DDKECGVTEE PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG 

       250        260        270        280        290        300 
VMKEMSNSKE LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV 

       310        320        330        340        350        360 
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC SSKEFKRAFM 

       370        380        390        400        410        420 
RILGCQCRGG RRRRRRRRLG GCAYTYRPWT RGGSLERSQS RKDSLDDSGS CMSGSQRTLP 

       430        440        450        460 
SASPSPGYLG RGTQPPVELC AFPEWKPGAL LSLPEPPGRR GR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL669911 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalB1AU41.
SMRB1AU41. Positions 43-365.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000139906; ENSMUSP00000123435; ENSMUSG00000050541.

Organism-specific databases

MGIMGI:104774. Adra1b.

Phylogenomic databases

GeneTreeENSGT00750000117429.
HOGENOMHOG000239244.
HOVERGENHBG106962.
InParanoidB1AU41.
OrthoDBEOG7H4DTB.

Gene expression databases

ArrayExpressB1AU41.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24248. PTHR24248. 1 hit.
PTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35545959.
SOURCESearch...

Entry information

Entry nameB1AU41_MOUSE
AccessionPrimary (citable) accession number: B1AU41
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)