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Protein
Submitted name:

Alpha-1B adrenergic receptor

Gene

Adra1b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. alpha1-adrenergic receptor activity Source: MGI
  2. protein heterodimerization activity Source: MGI

GO - Biological processi

  1. adrenergic receptor signaling pathway Source: GOC
  2. adult heart development Source: MGI
  3. behavioral response to cocaine Source: MGI
  4. blood vessel remodeling Source: MGI
  5. cell growth Source: MGI
  6. glucose homeostasis Source: MGI
  7. locomotory behavior Source: MGI
  8. negative regulation of glycogen catabolic process Source: MGI
  9. negative regulation of Rho protein signal transduction Source: MGI
  10. organ growth Source: MGI
  11. positive regulation of glycogen catabolic process Source: MGI
  12. positive regulation of heart rate by epinephrine-norepinephrine Source: MGI
  13. positive regulation of MAPK cascade Source: MGI
  14. positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: MGI
  15. regulation of cardiac muscle contraction Source: InterPro
  16. regulation of vasoconstriction Source: InterPro
  17. response to amphetamine Source: MGI
  18. response to morphine Source: MGI
  19. vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure Source: MGI
  20. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_292251. Adrenoceptors.
REACT_299052. G alpha (12/13) signalling events.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Submitted name:
Alpha-1B adrenergic receptorImported
Gene namesi
Name:Adra1bImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104774. Adra1b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: MGI
  2. nuclear membrane Source: MGI
  3. nucleus Source: MGI
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiB1AU41.
ExpressionAtlasiB1AU41. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB1AU41.
SMRiB1AU41. Positions 43-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
OrthoDBiEOG7H4DTB.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1AU41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDLDTGHN TSAPAHWGEL KDANFTGPNQ TSSNSTLPQL DVTRAISVGL
60 70 80 90 100
VLGAFILFAI VGNILVILSV ACNRHLRTPT NYFIVNLAIA DLLLSFTVLP
110 120 130 140 150
FSATLEVLGY WVLGRIFCDI WAAVDVLCCT ASILSLCAIS IDRYIGVRYS
160 170 180 190 200
LQYPTLVTRR KAILALLSVW VLSTVISIGP LLGWKEPAPN DDKECGVTEE
210 220 230 240 250
PFYALFSSLG SFYIPLAVIL VMYCRVYIVA KRTTKNLEAG VMKEMSNSKE
260 270 280 290 300
LTLRIHSKNF HEDTLSSTKA KGHNPRSSIA VKLFKFSREK KAAKTLGIVV
310 320 330 340 350
GMFILCWLPF FIALPLGSLF STLKPPDAVF KVVFWLGYFN SCLNPIIYPC
360 370 380 390 400
SSKEFKRAFM RILGCQCRGG RRRRRRRRLG GCAYTYRPWT RGGSLERSQS
410 420 430 440 450
RKDSLDDSGS CMSGSQRTLP SASPSPGYLG RGTQPPVELC AFPEWKPGAL
460
LSLPEPPGRR GR
Length:462
Mass (Da):51,121
Last modified:April 8, 2008 - v1
Checksum:iADE09422A7D2EB44
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei462 – 4621Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669911 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000139906; ENSMUSP00000123435; ENSMUSG00000050541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669911 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AU41.
SMRiB1AU41. Positions 43-365.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000139906; ENSMUSP00000123435; ENSMUSG00000050541.

Organism-specific databases

MGIiMGI:104774. Adra1b.

Phylogenomic databases

GeneTreeiENSGT00760000118795.
HOGENOMiHOG000239244.
HOVERGENiHBG106962.
OrthoDBiEOG7H4DTB.

Enzyme and pathway databases

ReactomeiREACT_292251. Adrenoceptors.
REACT_299052. G alpha (12/13) signalling events.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

NextBioi35545959.
SOURCEiSearch...

Gene expression databases

BgeeiB1AU41.
ExpressionAtlasiB1AU41. baseline and differential.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR001115. ADRA1B_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24248:SF17. PTHR24248:SF17. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00556. ADRENRGCA1BR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AU41_MOUSE
AccessioniPrimary (citable) accession number: B1AU41
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 1, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.