UniProtKB - B1ATE0 (B1ATE0_MOUSE)
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Protein
Submitted name:
N-sulfoglucosamine sulfohydrolase (sulfamidase)
Gene
Sgsh
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- N-sulfoglucosamine sulfohydrolase activity Source: MGI
- sulfuric ester hydrolase activity Source: MGI
GO - Biological processi
- glycosaminoglycan catabolic process Source: MGI
- heparan sulfate proteoglycan catabolic process Source: MGI
- heparan sulfate proteoglycan metabolic process Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-2024096. HS-GAG degradation. |
Names & Taxonomyi
Protein namesi | Submitted name: N-sulfoglucosamine sulfohydrolase (sulfamidase)Imported |
Gene namesi | Name:SgshImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1350341. Sgsh. |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_5002761932 | 23 – 422 | Sequence analysisAdd BLAST | 400 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 70 | 3-oxoalanine (Cys)UniRule annotation | 1 |
Post-translational modificationi
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.UniRule annotation
Proteomic databases
MaxQBi | B1ATE0. |
PeptideAtlasi | B1ATE0. |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000005043. |
ExpressionAtlasi | B1ATE0. baseline and differential. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 248 | SulfataseInterPro annotationAdd BLAST | 226 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3867. Eukaryota. COG3119. LUCA. |
GeneTreei | ENSGT00390000013080. |
HOGENOMi | HOG000207959. |
HOVERGENi | HBG064229. |
Family and domain databases
Gene3Di | 3.40.720.10. 1 hit. |
InterProi | View protein in InterPro IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core_sf. IPR024607. Sulfatase_CS. IPR000917. Sulfatase_N. |
Pfami | View protein in Pfam PF00884. Sulfatase. 1 hit. |
SUPFAMi | SSF53649. SSF53649. 2 hits. |
PROSITEi | View protein in PROSITE PS00523. SULFATASE_1. 1 hit. PS00149. SULFATASE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
B1ATE0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHCPGLACCT ILLVLGLCGA HSRNVLLIVA DDGGFESGVY NNTAIATPHL
60 70 80 90 100
DALSRHSLIF RNAFTSVSSC SPSRASLLTG LPQHQNGMYG LHQDVHHFNS
110 120 130 140 150
FDKVQSLPLL LNQAGVRTGI IGKKHVGPET VYPFDFAFTE ENSSVMQVGR
160 170 180 190 200
NITRIKQLVQ KFLQTQDDRP FFLYVAFHDP HRCGHSQPQY GTFCEKFGNG
210 220 230 240 250
ESGMGYIPDW TPQIYDPQDV MVPYFVPDTP AARADLAAQY TTIGRMDQER
260 270 280 290 300
QDQPVLARYS RAFAGVISRA PTALGPGQRR LREPSRPHPY HPGLVLHPVP
310 320 330 340 350
QLCHLWLKDD PAHRPIPPAG AGGRAPLGHC LQQPEPPRGH HVLPDALGVP
360 370 380 390 400
PELPPHSQPE LQDAISHRPR FLCLADLPGP PEPNHHRPAH GLVQGPPPLL
410 420
LPGTLGTLRH QPGPSRDTEP GR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL645911 Genomic DNA. No translation available. |
Genome annotation databases
Ensembli | ENSMUST00000100172; ENSMUSP00000097748; ENSMUSG00000005043. |
Similar proteinsi
Entry informationi
Entry namei | B1ATE0_MOUSE | |
Accessioni | B1ATE0Primary (citable) accession number: B1ATE0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | March 28, 2018 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |