Sgsh

Functionⁱ

GO - Molecular functionⁱ

N-sulfoglucosamine sulfohydrolase activity Source: MGI
sulfuric ester hydrolase activity
Source: MGI
Inferred from direct assayⁱ
- 15962010

Complete GO annotation...

GO - Biological processⁱ

glycosaminoglycan catabolic process Source: MGI
heparan sulfate proteoglycan catabolic process Source: MGI
heparan sulfate proteoglycan metabolic process
Source: MGI
Traceable author statementⁱ
- 10818207

Complete GO annotation...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2024096. HS-GAG degradation.

Reactomeⁱ

R-MMU-2024096. HS-GAG degradation.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: N-sulfoglucosamine sulfohydrolase (sulfamidase)Imported
Gene namesⁱ	Name:SgshImported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1350341. Sgsh.

Subcellular locationⁱ

GO - Cellular componentⁱ

extracellular exosome Source: MGI
lysosome Source: MGI

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_5002761932	23 – 422	Sequence analysisAdd BLAST		400

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	70	3-oxoalanine (Cys)UniRule annotation		1

Post-translational modificationⁱ

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.UniRule annotation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B1ATE0.
PaxDbⁱ	B1ATE0.
PeptideAtlas More...PeptideAtlasⁱ	B1ATE0.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000005043.
ExpressionAtlasⁱ	B1ATE0. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1ATE0.
SMRⁱ	B1ATE0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	23 – 248	SulfataseInterPro annotationAdd BLAST		226

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	KOG3867. Eukaryota. COG3119. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013080.
HOGENOMⁱ	HOG000207959.
HOVERGENⁱ	HBG064229.

Family and domain databases

Gene3Dⁱ	3.40.720.10. 1 hit.
InterProⁱ	View protein in InterPro IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR024607. Sulfatase_CS. IPR000917. Sulfatase_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00884. Sulfatase. 1 hit.
SUPFAMⁱ	SSF53649. SSF53649. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00523. SULFATASE_1. 1 hit. PS00149. SULFATASE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B1ATE0-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHCPGLACCT ILLVLGLCGA HSRNVLLIVA DDGGFESGVY NNTAIATPHL 
        60         70         80         90        100
DALSRHSLIF RNAFTSVSSC SPSRASLLTG LPQHQNGMYG LHQDVHHFNS 
       110        120        130        140        150
FDKVQSLPLL LNQAGVRTGI IGKKHVGPET VYPFDFAFTE ENSSVMQVGR 
       160        170        180        190        200
NITRIKQLVQ KFLQTQDDRP FFLYVAFHDP HRCGHSQPQY GTFCEKFGNG 
       210        220        230        240        250
ESGMGYIPDW TPQIYDPQDV MVPYFVPDTP AARADLAAQY TTIGRMDQER 
       260        270        280        290        300
QDQPVLARYS RAFAGVISRA PTALGPGQRR LREPSRPHPY HPGLVLHPVP 
       310        320        330        340        350
QLCHLWLKDD PAHRPIPPAG AGGRAPLGHC LQQPEPPRGH HVLPDALGVP 
       360        370        380        390        400
PELPPHSQPE LQDAISHRPR FLCLADLPGP PEPNHHRPAH GLVQGPPPLL 
       410        420 
LPGTLGTLRH QPGPSRDTEP GR

Length:422

Mass (Da):46,311

Last modified:April 8, 2008 - v1

Checksum:ⁱE01F5706346C16B0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645911 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL645911 Genomic DNA. No translation available.

Genome annotation databases

Ensemblⁱ	ENSMUST00000100172; ENSMUSP00000097748; ENSMUSG00000005043.

Ensemblⁱ

ENSMUST00000100172; ENSMUSP00000097748; ENSMUSG00000005043.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL645911 Genomic DNA. No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL645911 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalⁱ	B1ATE0.
SMRⁱ	B1ATE0.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B1ATE0.
PaxDbⁱ	B1ATE0.
PeptideAtlas More...PeptideAtlasⁱ	B1ATE0.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000100172; ENSMUSP00000097748; ENSMUSG00000005043.

Ensemblⁱ

ENSMUST00000100172; ENSMUSP00000097748; ENSMUSG00000005043.

Organism-specific databases

MGIⁱ	MGI:1350341. Sgsh.

Phylogenomic databases

eggNOGⁱ	KOG3867. Eukaryota. COG3119. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013080.
HOGENOMⁱ	HOG000207959.
HOVERGENⁱ	HBG064229.

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2024096. HS-GAG degradation.

Reactomeⁱ

R-MMU-2024096. HS-GAG degradation.

Miscellaneous databases

SOURCEⁱ	Search...

SOURCEⁱ

Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005043.
ExpressionAtlasⁱ	B1ATE0. baseline and differential.

Family and domain databases

Gene3Dⁱ	3.40.720.10. 1 hit.
InterProⁱ	View protein in InterPro IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR024607. Sulfatase_CS. IPR000917. Sulfatase_N.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00884. Sulfatase. 1 hit.
SUPFAMⁱ	SSF53649. SSF53649. 2 hits.
PROSITEⁱ	View protein in PROSITE PS00523. SULFATASE_1. 1 hit. PS00149. SULFATASE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B1ATE0_MOUSE
Accessionⁱ	B1ATE0Primary (citable) accession number: B1ATE0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 8, 2008
	Last sequence update:	April 8, 2008
	Last modified:	July 5, 2017
	This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1ATE0 (B1ATE0_MOUSE)

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N-sulfoglucosamine sulfohydrolase (sulfamidase)

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ