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Protein
Submitted name:

Myotubularin-related protein 3

Gene

Mtmr3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Source: MGI
  3. phosphatidylinositol-3-phosphatase activity Source: MGI
  4. protein serine/threonine phosphatase activity Source: MGI
  5. protein tyrosine phosphatase activity Source: MGI

GO - Biological processi

  1. peptidyl-tyrosine dephosphorylation Source: MGI
  2. phosphatidylinositol dephosphorylation Source: MGI
  3. protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Myotubularin-related protein 3Imported
Gene namesi
Name:Mtmr3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1921552. Mtmr3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extrinsic component of membrane Source: MGI
  3. membrane Source: MGI
  4. nucleus Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiB1ATD4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB1ATD4.
SMRiB1ATD4. Positions 34-579, 1074-1151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains myotubularin phosphatase domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
OrthoDBiEOG7PVWNJ.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1ATD4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DEEMRHSLEC IQANQIFPRK QLIREDENLQ VPFLELHGES TEYVGRAEEA
60 70 80 90 100
IIALSNYRLH IKFKESLVNV PLQLIESVEC RDIFQLHLTC KDCKVIRCQF
110 120 130 140 150
PTFEQCQDWL KRLNNAIRPP GKIEDLFSFA YHAWCMEVYA SEKEQHGDLC
160 170 180 190 200
RPGEHVTSRF KNEVERMGFD MNNAWRISNI NEKYKLCGSY PQELIVPAWI
210 220 230 240 250
TDKELESVAG FRSWKRIPAV IYRHQSNGAV IARCGQPEVS WWGWRNADDE
260 270 280 290 300
HLVQSVARAC ASDSQSSISK VSTRNSCRDF PNAGDLSDVE FDSSLSNTSG
310 320 330 340 350
AESLALQPQK LLILDARSYA AAVANRAKGG GCECPEYYPN CEVVFMGMAN
360 370 380 390 400
IHSIRRSFQS LRLLCTQMPD PGNWLSALES TKWLHHLSVL LKSALLVVHA
410 420 430 440 450
VDRDQRPVLV HCSDGWDRTP QIVALAKLLL DPYYRTIEGF QVLVEMEWLD
460 470 480 490 500
FGHKFADRCG HGEDSDDLNE RCPVFLQWLD CVHQLQRQFP CSFEFNEAFL
510 520 530 540 550
VKLVQHTYSC LFGTFLCNNA KERGEKQTQE RTCSVWSLLR AGNKAFKNLL
560 570 580 590 600
YSSQSEAVLY PVCHVRNLML WSAVYLPCPS PSTPTDDSCA PYPVPGTSPD
610 620 630 640 650
EPPLSRLPKT RSFDNLTTTC ENMVPLASRR SSDPSLNEKW QEHGRSLELS
660 670 680 690 700
SFASAGEEVP AMDSLRKPSR LLGGAELSVA AGVAEGQMEN ILQEATKEES
710 720 730 740 750
GVEEPTHRGH TEVPEVKEEA PLAKESSMAA EGPVVLYQEP QLDDATLRSH
760 770 780 790 800
QGPSLSLFSQ GIPEHQDGHN VLSSSLQAPL RGEDSQEVPV EQPQVENIAE
810 820 830 840 850
DRENVAPAVP VDAKVGLGIS QSSSLLPSQV PFETRGPHIN NSVHMLLEDK
860 870 880 890 900
VKSESGPQLH HRPCPASSGR FSGKDMLPVA PEPRSAERPQ WDSVLHRTSS
910 920 930 940 950
PGNTLSLLQA PCALPLDKCR QGIVCNGALE TENKASEQPA GFDTLQKYPT
960 970 980 990 1000
PNGHCANWEA GRSKDSLSHQ LSATSCSSAH LYSRNLHHKW LNSHSGRPST
1010 1020 1030 1040 1050
TSSPDQPSRS HLDDDGMPVY TDTIQQRLRQ IESGHQQEVE TLKKQVQELK
1060 1070 1080 1090 1100
SRLESQYLTS SLRFNGDFGD EVMTRWLPDH LAAHCYACDS AFWLASRKHH
1110 1120 1130 1140 1150
CRDTDCVDQT WNCGNVFCSS CCNQKVPVPS QQLFEPSRVC KSCYSSLHPT
1160
SSSIDLELDK PIAATSN
Length:1,167
Mass (Da):130,612
Last modified:April 8, 2008 - v1
Checksum:iF99FA5CDA9EAB04A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606521 Genomic DNA. No translation available.
AL645910 Genomic DNA. No translation available.
BX323081 Genomic DNA. No translation available.
UniGeneiMm.425669.

Genome annotation databases

EnsembliENSMUST00000128256; ENSMUSP00000116315; ENSMUSG00000034354.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606521 Genomic DNA. No translation available.
AL645910 Genomic DNA. No translation available.
BX323081 Genomic DNA. No translation available.
UniGeneiMm.425669.

3D structure databases

ProteinModelPortaliB1ATD4.
SMRiB1ATD4. Positions 34-579, 1074-1151.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000128256; ENSMUSP00000116315; ENSMUSG00000034354.

Organism-specific databases

MGIiMGI:1921552. Mtmr3.

Phylogenomic databases

GeneTreeiENSGT00760000118832.
HOGENOMiHOG000004861.
HOVERGENiHBG052526.
OrthoDBiEOG7PVWNJ.

Miscellaneous databases

NextBioi35545894.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiB1ATD4. baseline and differential.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR010569. Myotubularin-like_Pase_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (MAY-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1ATD4_MOUSE
AccessioniPrimary (citable) accession number: B1ATD4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: February 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.