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Protein

Monocarboxylate transporter 7

Gene

Slc16a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 7
Short name:
MCT 7
Alternative name(s):
Monocarboxylate transporter 6
Short name:
MCT 6
Solute carrier family 16 member 6
Gene namesi
Name:Slc16a6
Synonyms:Mct7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144585. Slc16a6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 105CytoplasmicSequence analysisAdd BLAST105
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 146ExtracellularSequence analysisAdd BLAST20
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 175CytoplasmicSequence analysis8
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 202ExtracellularSequence analysis6
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 233CytoplasmicSequence analysis10
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 268ExtracellularSequence analysisAdd BLAST14
Transmembranei269 – 289HelicalSequence analysisAdd BLAST21
Topological domaini290 – 383CytoplasmicSequence analysisAdd BLAST94
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Topological domaini405 – 414ExtracellularSequence analysis10
Transmembranei415 – 435HelicalSequence analysisAdd BLAST21
Topological domaini436 – 442CytoplasmicSequence analysis7
Transmembranei443 – 463HelicalSequence analysisAdd BLAST21
Topological domaini464 – 465ExtracellularSequence analysis2
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
Topological domaini487 – 507CytoplasmicSequence analysisAdd BLAST21
Transmembranei508 – 528HelicalSequence analysisAdd BLAST21
Topological domaini529 – 536ExtracellularSequence analysis8
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Topological domaini558 – 607CytoplasmicSequence analysisAdd BLAST50

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004161261 – 607Monocarboxylate transporter 7Add BLAST607

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei319PhosphoserineCombined sources1
Modified residuei322PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei332PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiB1AT66.
PaxDbiB1AT66.
PeptideAtlasiB1AT66.
PRIDEiB1AT66.

PTM databases

iPTMnetiB1AT66.
PhosphoSitePlusiB1AT66.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041920.
ExpressionAtlasiB1AT66. baseline and differential.
GenevisibleiB1AT66. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065628.

Structurei

3D structure databases

ProteinModelPortaliB1AT66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000220939.
HOVERGENiHBG006386.
InParanoidiB1AT66.
KOiK08183.
OMAiAFAPAIM.
OrthoDBiEOG091G04FE.
PhylomeDBiB1AT66.
TreeFamiTF313792.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1AT66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRASGQGPQR RRRGWATRDD SAVTFRDPQP RQPAGGARAL RGPDPRGPAR
60 70 80 90 100
AHQAGPLLAG ARRSQHMVGG APPRPAETGC SRSRMTQKNS KLCARANVYT
110 120 130 140 150
QVPDGGWGWA VAVSFFFVEV FTYGIIKSFG VFFNDLMDSF DESNSKISWI
160 170 180 190 200
ISICVFVLTF TAPLSTVLSN RFGHRLVVMA GGLLISLGMI TASFSQRVYH
210 220 230 240 250
MYISIGVISG LGYCFSFLPT VTILSQYFDK RRSVVTAVAS TGECFAVFAF
260 270 280 290 300
APAITALKEH IGWRYSLLFV GLLQLNIMVC GALLRPIIIQ GPGQSPKAVT
310 320 330 340 350
LEPRREVQYM LENEKTRTSI DSIDSGVELT TSPKNVPSEA KMEQETRAEQ
360 370 380 390 400
QQTLVTAPKH SQMKAPLLDF SVLKEKSFIC YALFGLFATL GFFAPSLYII
410 420 430 440 450
PLGISLGIDP DRAAFLLSTM AIAEVFGRIG AGFVLNREPI RKIYIELICV
460 470 480 490 500
ILLTASLFAF TFATEFWGLM LCSVFFGSMV GTIGGTHIPM LAEDDVVGIE
510 520 530 540 550
KMSSAAGVYV FIQSISGLAG PPLAGLLVDQ SKIYSRAFYS CAAGMCLAAV
560 570 580 590 600
CLALVRPCKK GLCQNSHSGE NQTDRQRGKA LQDIPEDFLE MDLGKCEHRA

HMKMDPV
Length:607
Mass (Da):66,236
Last modified:April 8, 2008 - v1
Checksum:iED0E45D224D7587B
GO
Isoform 2 (identifier: B1AT66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:523
Mass (Da):57,296
Checksum:i7AEAB121D7BF4009
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37A → T in BAC27657 (PubMed:16141072).Curated1
Sequence conflicti243E → D in BAC27657 (PubMed:16141072).Curated1
Sequence conflicti302E → K in BAE41817 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0425121 – 84Missing in isoform 2. 2 PublicationsAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032026 mRNA. Translation: BAC27657.1.
AK170472 mRNA. Translation: BAE41817.1.
AL645791 Genomic DNA. Translation: CAM25213.1.
AL645791 Genomic DNA. Translation: CAM25214.1.
CH466558 Genomic DNA. Translation: EDL34359.1.
CH466558 Genomic DNA. Translation: EDL34361.1.
BC017129 mRNA. Translation: AAH17129.1.
CCDSiCCDS25580.1. [B1AT66-1]
CCDS36360.1. [B1AT66-2]
RefSeqiNP_001025013.1. NM_001029842.1. [B1AT66-1]
NP_598799.1. NM_134038.2. [B1AT66-2]
XP_006532010.1. XM_006531947.2. [B1AT66-2]
UniGeneiMm.265874.

Genome annotation databases

EnsembliENSMUST00000070152; ENSMUSP00000065628; ENSMUSG00000041920. [B1AT66-1]
ENSMUST00000070872; ENSMUSP00000067423; ENSMUSG00000041920. [B1AT66-2]
GeneIDi104681.
KEGGimmu:104681.
UCSCiuc007mcl.1. mouse. [B1AT66-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032026 mRNA. Translation: BAC27657.1.
AK170472 mRNA. Translation: BAE41817.1.
AL645791 Genomic DNA. Translation: CAM25213.1.
AL645791 Genomic DNA. Translation: CAM25214.1.
CH466558 Genomic DNA. Translation: EDL34359.1.
CH466558 Genomic DNA. Translation: EDL34361.1.
BC017129 mRNA. Translation: AAH17129.1.
CCDSiCCDS25580.1. [B1AT66-1]
CCDS36360.1. [B1AT66-2]
RefSeqiNP_001025013.1. NM_001029842.1. [B1AT66-1]
NP_598799.1. NM_134038.2. [B1AT66-2]
XP_006532010.1. XM_006531947.2. [B1AT66-2]
UniGeneiMm.265874.

3D structure databases

ProteinModelPortaliB1AT66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065628.

PTM databases

iPTMnetiB1AT66.
PhosphoSitePlusiB1AT66.

Proteomic databases

MaxQBiB1AT66.
PaxDbiB1AT66.
PeptideAtlasiB1AT66.
PRIDEiB1AT66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070152; ENSMUSP00000065628; ENSMUSG00000041920. [B1AT66-1]
ENSMUST00000070872; ENSMUSP00000067423; ENSMUSG00000041920. [B1AT66-2]
GeneIDi104681.
KEGGimmu:104681.
UCSCiuc007mcl.1. mouse. [B1AT66-1]

Organism-specific databases

CTDi9120.
MGIiMGI:2144585. Slc16a6.

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000220939.
HOVERGENiHBG006386.
InParanoidiB1AT66.
KOiK08183.
OMAiAFAPAIM.
OrthoDBiEOG091G04FE.
PhylomeDBiB1AT66.
TreeFamiTF313792.

Miscellaneous databases

PROiB1AT66.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041920.
ExpressionAtlasiB1AT66. baseline and differential.
GenevisibleiB1AT66. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMOT7_MOUSE
AccessioniPrimary (citable) accession number: B1AT66
Secondary accession number(s): D3Z3P6
, E9Q5J8, Q3TCY8, Q8C086, Q91W47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.