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Protein

Monocarboxylate transporter 7

Gene

Slc16a6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 7
Short name:
MCT 7
Alternative name(s):
Monocarboxylate transporter 6
Short name:
MCT 6
Solute carrier family 16 member 6
Gene namesi
Name:Slc16a6
Synonyms:Mct7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144585. Slc16a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 105105CytoplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 14620ExtracellularSequence analysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence analysisAdd
BLAST
Topological domaini168 – 1758CytoplasmicSequence analysis
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Topological domaini197 – 2026ExtracellularSequence analysis
Transmembranei203 – 22321HelicalSequence analysisAdd
BLAST
Topological domaini224 – 23310CytoplasmicSequence analysis
Transmembranei234 – 25421HelicalSequence analysisAdd
BLAST
Topological domaini255 – 26814ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence analysisAdd
BLAST
Topological domaini290 – 38394CytoplasmicSequence analysisAdd
BLAST
Transmembranei384 – 40421HelicalSequence analysisAdd
BLAST
Topological domaini405 – 41410ExtracellularSequence analysis
Transmembranei415 – 43521HelicalSequence analysisAdd
BLAST
Topological domaini436 – 4427CytoplasmicSequence analysis
Transmembranei443 – 46321HelicalSequence analysisAdd
BLAST
Topological domaini464 – 4652ExtracellularSequence analysis
Transmembranei466 – 48621HelicalSequence analysisAdd
BLAST
Topological domaini487 – 50721CytoplasmicSequence analysisAdd
BLAST
Transmembranei508 – 52821HelicalSequence analysisAdd
BLAST
Topological domaini529 – 5368ExtracellularSequence analysis
Transmembranei537 – 55721HelicalSequence analysisAdd
BLAST
Topological domaini558 – 60750CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 607607Monocarboxylate transporter 7PRO_0000416126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei319 – 3191PhosphoserineCombined sources
Modified residuei322 – 3221PhosphoserineCombined sources
Modified residuei325 – 3251PhosphoserineCombined sources
Modified residuei332 – 3321PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiB1AT66.
MaxQBiB1AT66.
PaxDbiB1AT66.
PRIDEiB1AT66.

PTM databases

iPTMnetiB1AT66.
PhosphoSiteiB1AT66.

Expressioni

Gene expression databases

BgeeiB1AT66.
ExpressionAtlasiB1AT66. baseline and differential.
GenevisibleiB1AT66. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065628.

Structurei

3D structure databases

ProteinModelPortaliB1AT66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000220939.
HOVERGENiHBG006386.
InParanoidiB1AT66.
KOiK08183.
OMAiAFAPAIM.
OrthoDBiEOG7JQBN6.
PhylomeDBiB1AT66.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1AT66-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRASGQGPQR RRRGWATRDD SAVTFRDPQP RQPAGGARAL RGPDPRGPAR
60 70 80 90 100
AHQAGPLLAG ARRSQHMVGG APPRPAETGC SRSRMTQKNS KLCARANVYT
110 120 130 140 150
QVPDGGWGWA VAVSFFFVEV FTYGIIKSFG VFFNDLMDSF DESNSKISWI
160 170 180 190 200
ISICVFVLTF TAPLSTVLSN RFGHRLVVMA GGLLISLGMI TASFSQRVYH
210 220 230 240 250
MYISIGVISG LGYCFSFLPT VTILSQYFDK RRSVVTAVAS TGECFAVFAF
260 270 280 290 300
APAITALKEH IGWRYSLLFV GLLQLNIMVC GALLRPIIIQ GPGQSPKAVT
310 320 330 340 350
LEPRREVQYM LENEKTRTSI DSIDSGVELT TSPKNVPSEA KMEQETRAEQ
360 370 380 390 400
QQTLVTAPKH SQMKAPLLDF SVLKEKSFIC YALFGLFATL GFFAPSLYII
410 420 430 440 450
PLGISLGIDP DRAAFLLSTM AIAEVFGRIG AGFVLNREPI RKIYIELICV
460 470 480 490 500
ILLTASLFAF TFATEFWGLM LCSVFFGSMV GTIGGTHIPM LAEDDVVGIE
510 520 530 540 550
KMSSAAGVYV FIQSISGLAG PPLAGLLVDQ SKIYSRAFYS CAAGMCLAAV
560 570 580 590 600
CLALVRPCKK GLCQNSHSGE NQTDRQRGKA LQDIPEDFLE MDLGKCEHRA

HMKMDPV
Length:607
Mass (Da):66,236
Last modified:April 8, 2008 - v1
Checksum:iED0E45D224D7587B
GO
Isoform 2 (identifier: B1AT66-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:523
Mass (Da):57,296
Checksum:i7AEAB121D7BF4009
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371A → T in BAC27657 (PubMed:16141072).Curated
Sequence conflicti243 – 2431E → D in BAC27657 (PubMed:16141072).Curated
Sequence conflicti302 – 3021E → K in BAE41817 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 2. 2 PublicationsVSP_042512Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032026 mRNA. Translation: BAC27657.1.
AK170472 mRNA. Translation: BAE41817.1.
AL645791 Genomic DNA. Translation: CAM25213.1.
AL645791 Genomic DNA. Translation: CAM25214.1.
CH466558 Genomic DNA. Translation: EDL34359.1.
CH466558 Genomic DNA. Translation: EDL34361.1.
BC017129 mRNA. Translation: AAH17129.1.
CCDSiCCDS25580.1. [B1AT66-1]
CCDS36360.1. [B1AT66-2]
RefSeqiNP_001025013.1. NM_001029842.1. [B1AT66-1]
NP_598799.1. NM_134038.2. [B1AT66-2]
XP_006532010.1. XM_006531947.1. [B1AT66-2]
UniGeneiMm.265874.

Genome annotation databases

EnsembliENSMUST00000070152; ENSMUSP00000065628; ENSMUSG00000041920. [B1AT66-1]
ENSMUST00000070872; ENSMUSP00000067423; ENSMUSG00000041920. [B1AT66-2]
GeneIDi104681.
KEGGimmu:104681.
UCSCiuc007mcl.1. mouse. [B1AT66-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032026 mRNA. Translation: BAC27657.1.
AK170472 mRNA. Translation: BAE41817.1.
AL645791 Genomic DNA. Translation: CAM25213.1.
AL645791 Genomic DNA. Translation: CAM25214.1.
CH466558 Genomic DNA. Translation: EDL34359.1.
CH466558 Genomic DNA. Translation: EDL34361.1.
BC017129 mRNA. Translation: AAH17129.1.
CCDSiCCDS25580.1. [B1AT66-1]
CCDS36360.1. [B1AT66-2]
RefSeqiNP_001025013.1. NM_001029842.1. [B1AT66-1]
NP_598799.1. NM_134038.2. [B1AT66-2]
XP_006532010.1. XM_006531947.1. [B1AT66-2]
UniGeneiMm.265874.

3D structure databases

ProteinModelPortaliB1AT66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065628.

PTM databases

iPTMnetiB1AT66.
PhosphoSiteiB1AT66.

Proteomic databases

EPDiB1AT66.
MaxQBiB1AT66.
PaxDbiB1AT66.
PRIDEiB1AT66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070152; ENSMUSP00000065628; ENSMUSG00000041920. [B1AT66-1]
ENSMUST00000070872; ENSMUSP00000067423; ENSMUSG00000041920. [B1AT66-2]
GeneIDi104681.
KEGGimmu:104681.
UCSCiuc007mcl.1. mouse. [B1AT66-1]

Organism-specific databases

CTDi9120.
MGIiMGI:2144585. Slc16a6.

Phylogenomic databases

eggNOGiKOG2504. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000220939.
HOVERGENiHBG006386.
InParanoidiB1AT66.
KOiK08183.
OMAiAFAPAIM.
OrthoDBiEOG7JQBN6.
PhylomeDBiB1AT66.
TreeFamiTF313792.

Miscellaneous databases

PROiB1AT66.
SOURCEiSearch...

Gene expression databases

BgeeiB1AT66.
ExpressionAtlasiB1AT66. baseline and differential.
GenevisibleiB1AT66. MM.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Medulla oblongata.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Eye.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319; SER-322 AND SER-325, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT7_MOUSE
AccessioniPrimary (citable) accession number: B1AT66
Secondary accession number(s): D3Z3P6
, E9Q5J8, Q3TCY8, Q8C086, Q91W47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: April 8, 2008
Last modified: June 8, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.