ID   NB5R5_MOUSE             Reviewed;         316 AA.
AC   B1AS42; B1AS41; Q571N5; Q80W48; Q99KB7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   07-JUL-2009, entry version 14.
DE   RecName: Full=NADH-cytochrome b5 reductase-like;
DE            EC=1.6.2.2;
GN   Name=Cyb5rl;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC   STRAIN=ICR; TISSUE=Embryonic tail;
RX   PubMed=15449545; DOI=10.1093/dnares/11.2.127;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of FLJ genes:
RT   the complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 11:127-135(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RG   The mouse genome sequencing consortium;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC   STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: NADH-cytochrome b5 reductases are involved in
CC       desaturation and elongation of fatty acids, cholesterol
CC       biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin
CC       reduction (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + 2 ferricytochrome b5 = NAD(+) + H(+) +
CC       2 ferrocytochrome b5.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=B1AS42-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B1AS42-2; Sequence=VSP_033851;
CC         Note=No experimental confirmation available;
CC       Name=3;
CC         IsoId=B1AS42-3; Sequence=VSP_033849, VSP_033850;
CC         Note=No experimental confirmation available;
CC       Name=4;
CC         IsoId=B1AS42-4; Sequence=VSP_033848, VSP_033852, VSP_033853;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the flavoprotein pyridine nucleotide
CC       cytochrome reductase family.
CC   -!- SIMILARITY: Contains 1 FAD-binding FR-type domain.
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DR   EMBL; AK220154; BAD90340.1; ALT_INIT; mRNA.
DR   EMBL; AL607132; CAM46300.2; -; Genomic_DNA.
DR   EMBL; AL607132; CAM46301.1; -; Genomic_DNA.
DR   EMBL; BC004750; AAH04750.1; ALT_INIT; mRNA.
DR   EMBL; BC043687; AAH43687.1; -; mRNA.
DR   IPI; IPI00320088; -.
DR   IPI; IPI00403588; -.
DR   IPI; IPI00895275; -.
DR   IPI; IPI00895324; -.
DR   RefSeq; NP_780680.1; -.
DR   UniGene; Mm.44608; -.
DR   Ensembl; ENSMUSG00000028621; Mus musculus.
DR   GeneID; 230582; -.
DR   KEGG; mmu:230582; -.
DR   MGI; MGI:1919657; Cyb5rl.
DR   OMA; B1AS42; ECERILQ.
DR   NextBio; 379943; -.
DR   Bgee; B1AS42; -.
DR   GO; GO:0004128; F:cytochrome-b5 reductase activity; IEA:EC.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR017927; Fd_Rdtase_FAD-bd.
DR   InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR   InterPro; IPR001834; NADH-Cyt_B5_reductase.
DR   InterPro; IPR008333; OxRdtase_FAD-bd.
DR   InterPro; IPR001433; OxRdtase_FAD/NAD_bd.
DR   Pfam; PF00970; FAD_binding_6; 1.
DR   Pfam; PF00175; NAD_binding_1; 1.
DR   PRINTS; PR00406; CYTB5RDTASE.
DR   PRINTS; PR00371; FPNCR.
DR   PROSITE; PS51384; FAD_FR; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; FAD; Flavoprotein; NAD; Oxidoreductase.
FT   CHAIN         1    316       NADH-cytochrome b5 reductase-like.
FT                                /FTId=PRO_0000337042.
FT   DOMAIN       76    178       FAD-binding FR-type.
FT   NP_BIND     158    173       FAD (By similarity).
FT   NP_BIND     183    215       FAD (By similarity).
FT   VAR_SEQ       1     85       Missing (in isoform 4).
FT                                /FTId=VSP_033848.
FT   VAR_SEQ       1     60       Missing (in isoform 3).
FT                                /FTId=VSP_033849.
FT   VAR_SEQ      61     67       KQPPESQ -> MNNKDLE (in isoform 3).
FT                                /FTId=VSP_033850.
FT   VAR_SEQ     146    180       Missing (in isoform 2).
FT                                /FTId=VSP_033851.
FT   VAR_SEQ     250    283       EVSPEQLPWSYRDKTHFGRLGQELVAELVACCRR -> ASP
FT                                SPSYRGGSRLTEVLDQGGARTGPVCLTLLSL (in
FT                                isoform 4).
FT                                /FTId=VSP_033852.
FT   VAR_SEQ     284    316       Missing (in isoform 4).
FT                                /FTId=VSP_033853.
SQ   SEQUENCE   316 AA;  35884 MW;  A5D49CF710DD7AFA CRC64;
     MAETEEEEDS EAWLRLKPVE PLPSQCCGSG CSPCVFDLYY RDLERWETAR ARNDRSLLSG
     KQPPESQSCS AKLSPETFLA FHISTMEKVT KDTYLVRFTL PGNSRLGLRP GQHLILRGVV
     DGLEIQRAYT PISPVTAEGY FDVLIKCYRT GLMSQYVESW RTGDTAFWRG PFGSFLYEPK
     KYGELLMLAA GTGLAPMVPI LQSITDDEDD ETFVTLVGCF KTFEGIYLKT FFQEQARFWN
     VQTFFVLSQE VSPEQLPWSY RDKTHFGRLG QELVAELVAC CRRKPFTLVC GSPAFNEDMA
     RCLLSAGLTE DSYFLF
//