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Protein

Glutamate receptor ionotropic, kainate 3

Gene

Grik3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei520GlutamateBy similarity1
Binding sitei525GlutamateBy similarity1
Binding sitei739GlutamateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.
R-MMU-500657. Presynaptic function of Kainate receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 3
Short name:
GluK3
Alternative name(s):
Glutamate receptor 7
Short name:
GluR-7
Short name:
GluR7
Gene namesi
Name:Grik3
Synonyms:Glur7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95816. Grik3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 563ExtracellularBy similarityAdd BLAST532
Transmembranei564 – 584HelicalSequence analysisAdd BLAST21
Topological domaini585 – 636CytoplasmicSequence analysisAdd BLAST52
Transmembranei637 – 657HelicalSequence analysisAdd BLAST21
Topological domaini658 – 820ExtracellularSequence analysisAdd BLAST163
Transmembranei821 – 841HelicalSequence analysisAdd BLAST21
Topological domaini842 – 919CytoplasmicSequence analysisAdd BLAST78

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000041679332 – 919Glutamate receptor ionotropic, kainate 3Add BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 350By similarity
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi415N-linked (GlcNAc...)Sequence analysis1
Glycosylationi426N-linked (GlcNAc...)Sequence analysis1
Glycosylationi548N-linked (GlcNAc...)Sequence analysis1
Modified residuei869PhosphoserineBy similarity1
Cross-linki887Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiB1AS29.
PaxDbiB1AS29.
PeptideAtlasiB1AS29.
PRIDEiB1AS29.

PTM databases

iPTMnetiB1AS29.
PhosphoSitePlusiB1AS29.

Expressioni

Tissue specificityi

Detected in whole brain, cerebellum, brain cortex and hippocampus.1 Publication

Gene expression databases

BgeeiENSMUSG00000001985.
GenevisibleiB1AS29. MM.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200065. 2 interactors.
STRINGi10090.ENSMUSP00000030676.

Structurei

3D structure databases

ProteinModelPortaliB1AS29.
SMRiB1AS29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni690 – 692Glutamate bindingBy similarity3

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiB1AS29.
KOiK05203.
OMAiHILKQAM.
OrthoDBiEOG091G02LN.
PhylomeDBiB1AS29.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1AS29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPWRRLRS LVWEYWAGFL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA
60 70 80 90 100
QVMNAEEHAF RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD
110 120 130 140 150
QLALGVVAIF GPSQGSCTNA VQSICNALEV PHIQLRWKHH PLDNKDTFYV
160 170 180 190 200
NLYPDYASLS HAILDLVQSL KWRSATVVYD DSTGLIRLQE LIMAPSRYNI
210 220 230 240 250
RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ ILKQAMAMGM
260 270 280 290 300
MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWA
310 320 330 340 350
MERLQAAPRA ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC
360 370 380 390 400
HRHKAWRFGG RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED
410 420 430 440 450
GLEKVGVWSP ADGLNITEVA KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR
460 470 480 490 500
KSDRTLYGND RFEGYCIDLL KELAHILGFS YEIRLVEDGK YGAQDDKGQW
510 520 530 540 550
NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV SILYRKPNGT
560 570 580 590 600
NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG
610 620 630 640 650
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII
660 670 680 690 700
SSYTANLAAF LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK
710 720 730 740 750
ISTFEKMWAF MSSKPSALVK NNEEGIQRTL TADYALLMES TTIEYITQRN
760 770 780 790 800
CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT IAILQLQEED KLHIMKEKWW
810 820 830 840 850
RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV GEFIYKLRKT
860 870 880 890 900
AEREQRSFCS TVADEIRFSL TCQRRLKHKP QPPMMVKTDA VINMHTFNDR
910
RLPGKDSMSC STSLAPVFP
Length:919
Mass (Da):104,051
Last modified:April 8, 2008 - v1
Checksum:iDD543E45951ACB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607090, AL627328 Genomic DNA. Translation: CAM19291.1.
AL627328, AL607090 Genomic DNA. Translation: CAM20078.1.
BC118004 mRNA. Translation: AAI18005.1.
AF245444 mRNA. Translation: AAF90049.1.
CCDSiCCDS38878.1.
RefSeqiNP_001074566.1. NM_001081097.2.
UniGeneiMm.40896.

Genome annotation databases

EnsembliENSMUST00000030676; ENSMUSP00000030676; ENSMUSG00000001985.
GeneIDi14807.
KEGGimmu:14807.
UCSCiuc008usa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607090, AL627328 Genomic DNA. Translation: CAM19291.1.
AL627328, AL607090 Genomic DNA. Translation: CAM20078.1.
BC118004 mRNA. Translation: AAI18005.1.
AF245444 mRNA. Translation: AAF90049.1.
CCDSiCCDS38878.1.
RefSeqiNP_001074566.1. NM_001081097.2.
UniGeneiMm.40896.

3D structure databases

ProteinModelPortaliB1AS29.
SMRiB1AS29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200065. 2 interactors.
STRINGi10090.ENSMUSP00000030676.

PTM databases

iPTMnetiB1AS29.
PhosphoSitePlusiB1AS29.

Proteomic databases

MaxQBiB1AS29.
PaxDbiB1AS29.
PeptideAtlasiB1AS29.
PRIDEiB1AS29.

Protocols and materials databases

DNASUi14807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030676; ENSMUSP00000030676; ENSMUSG00000001985.
GeneIDi14807.
KEGGimmu:14807.
UCSCiuc008usa.2. mouse.

Organism-specific databases

CTDi2899.
MGIiMGI:95816. Grik3.

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiB1AS29.
KOiK05203.
OMAiHILKQAM.
OrthoDBiEOG091G02LN.
PhylomeDBiB1AS29.
TreeFamiTF334668.

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.
R-MMU-500657. Presynaptic function of Kainate receptors.

Miscellaneous databases

ChiTaRSiGrik3. mouse.
PROiB1AS29.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001985.
GenevisibleiB1AS29. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRIK3_MOUSE
AccessioniPrimary (citable) accession number: B1AS29
Secondary accession number(s): Q17R20, Q9JIA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.