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Protein

Glutamate receptor ionotropic, kainate 3

Gene

Grik3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei520 – 5201GlutamateBy similarity
Binding sitei525 – 5251GlutamateBy similarity
Binding sitei739 – 7391GlutamateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.
R-MMU-500657. Presynaptic function of Kainate receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, kainate 3
Short name:
GluK3
Alternative name(s):
Glutamate receptor 7
Short name:
GluR-7
Short name:
GluR7
Gene namesi
Name:Grik3
Synonyms:Glur7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:95816. Grik3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 563532ExtracellularBy similarityAdd
BLAST
Transmembranei564 – 58421HelicalSequence analysisAdd
BLAST
Topological domaini585 – 63652CytoplasmicSequence analysisAdd
BLAST
Transmembranei637 – 65721HelicalSequence analysisAdd
BLAST
Topological domaini658 – 820163ExtracellularSequence analysisAdd
BLAST
Transmembranei821 – 84121HelicalSequence analysisAdd
BLAST
Topological domaini842 – 91978CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131By similarityAdd
BLAST
Chaini32 – 919888Glutamate receptor ionotropic, kainate 3PRO_0000416793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 350By similarity
Glycosylationi278 – 2781N-linked (GlcNAc...)Sequence analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence analysis
Glycosylationi415 – 4151N-linked (GlcNAc...)Sequence analysis
Glycosylationi426 – 4261N-linked (GlcNAc...)Sequence analysis
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence analysis
Modified residuei869 – 8691PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiB1AS29.
PaxDbiB1AS29.
PRIDEiB1AS29.

PTM databases

iPTMnetiB1AS29.

Expressioni

Tissue specificityi

Detected in whole brain, cerebellum, brain cortex and hippocampus.1 Publication

Gene expression databases

BgeeiB1AS29.
GenevisibleiB1AS29. MM.

Interactioni

Subunit structurei

Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Interacts with PRKCABP (By similarity). Interacts with NETO2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200065. 2 interactions.
STRINGi10090.ENSMUSP00000030676.

Structurei

3D structure databases

ProteinModelPortaliB1AS29.
SMRiB1AS29. Positions 34-851.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni690 – 6923Glutamate bindingBy similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiB1AS29.
KOiK05203.
OMAiCSHLMAA.
OrthoDBiEOG71G9W6.
PhylomeDBiB1AS29.
TreeFamiTF334668.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B1AS29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPWRRLRS LVWEYWAGFL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA
60 70 80 90 100
QVMNAEEHAF RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD
110 120 130 140 150
QLALGVVAIF GPSQGSCTNA VQSICNALEV PHIQLRWKHH PLDNKDTFYV
160 170 180 190 200
NLYPDYASLS HAILDLVQSL KWRSATVVYD DSTGLIRLQE LIMAPSRYNI
210 220 230 240 250
RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ ILKQAMAMGM
260 270 280 290 300
MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWA
310 320 330 340 350
MERLQAAPRA ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC
360 370 380 390 400
HRHKAWRFGG RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED
410 420 430 440 450
GLEKVGVWSP ADGLNITEVA KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR
460 470 480 490 500
KSDRTLYGND RFEGYCIDLL KELAHILGFS YEIRLVEDGK YGAQDDKGQW
510 520 530 540 550
NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV SILYRKPNGT
560 570 580 590 600
NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG
610 620 630 640 650
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII
660 670 680 690 700
SSYTANLAAF LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK
710 720 730 740 750
ISTFEKMWAF MSSKPSALVK NNEEGIQRTL TADYALLMES TTIEYITQRN
760 770 780 790 800
CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT IAILQLQEED KLHIMKEKWW
810 820 830 840 850
RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV GEFIYKLRKT
860 870 880 890 900
AEREQRSFCS TVADEIRFSL TCQRRLKHKP QPPMMVKTDA VINMHTFNDR
910
RLPGKDSMSC STSLAPVFP
Length:919
Mass (Da):104,051
Last modified:April 8, 2008 - v1
Checksum:iDD543E45951ACB87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607090, AL627328 Genomic DNA. Translation: CAM19291.1.
AL627328, AL607090 Genomic DNA. Translation: CAM20078.1.
BC118004 mRNA. Translation: AAI18005.1.
AF245444 mRNA. Translation: AAF90049.1.
CCDSiCCDS38878.1.
RefSeqiNP_001074566.1. NM_001081097.2.
UniGeneiMm.40896.

Genome annotation databases

EnsembliENSMUST00000030676; ENSMUSP00000030676; ENSMUSG00000001985.
GeneIDi14807.
KEGGimmu:14807.
UCSCiuc008usa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL607090, AL627328 Genomic DNA. Translation: CAM19291.1.
AL627328, AL607090 Genomic DNA. Translation: CAM20078.1.
BC118004 mRNA. Translation: AAI18005.1.
AF245444 mRNA. Translation: AAF90049.1.
CCDSiCCDS38878.1.
RefSeqiNP_001074566.1. NM_001081097.2.
UniGeneiMm.40896.

3D structure databases

ProteinModelPortaliB1AS29.
SMRiB1AS29. Positions 34-851.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200065. 2 interactions.
STRINGi10090.ENSMUSP00000030676.

PTM databases

iPTMnetiB1AS29.

Proteomic databases

MaxQBiB1AS29.
PaxDbiB1AS29.
PRIDEiB1AS29.

Protocols and materials databases

DNASUi14807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030676; ENSMUSP00000030676; ENSMUSG00000001985.
GeneIDi14807.
KEGGimmu:14807.
UCSCiuc008usa.2. mouse.

Organism-specific databases

CTDi2899.
MGIiMGI:95816. Grik3.

Phylogenomic databases

eggNOGiKOG1054. Eukaryota.
ENOG410XPSH. LUCA.
GeneTreeiENSGT00760000118920.
HOGENOMiHOG000234371.
HOVERGENiHBG051839.
InParanoidiB1AS29.
KOiK05203.
OMAiCSHLMAA.
OrthoDBiEOG71G9W6.
PhylomeDBiB1AS29.
TreeFamiTF334668.

Enzyme and pathway databases

ReactomeiR-MMU-451308. Activation of Ca-permeable Kainate Receptor.
R-MMU-500657. Presynaptic function of Kainate receptors.

Miscellaneous databases

ChiTaRSiGrik3. mouse.
NextBioi286987.
PROiB1AS29.
SOURCEiSearch...

Gene expression databases

BgeeiB1AS29.
GenevisibleiB1AS29. MM.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-897.
  3. "Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains."
    Schiffer H.H., Swanson G.T., Masliah E., Heinemann S.F.
    J. Neurosci. 20:9025-9033(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 403-919, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiGRIK3_MOUSE
AccessioniPrimary (citable) accession number: B1AS29
Secondary accession number(s): Q17R20, Q9JIA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 8, 2008
Last modified: February 17, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.