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Protein
Submitted name:

Disks large homolog 4

Gene

Dlg4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. guanylate kinase activity Source: GO_Central
  2. kinase binding Source: MGI
  3. protein C-terminus binding Source: MGI

GO - Biological processi

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering Source: GO_Central
  2. establishment of protein localization Source: MGI
  3. nucleotide phosphorylation Source: GOC
  4. protein complex assembly Source: MGI
  5. protein localization to synapse Source: MGI
  6. receptor localization to synapse Source: GO_Central
  7. regulation of long-term neuronal synaptic plasticity Source: MGI
  8. signal transduction Source: GO_Central
  9. synaptic vesicle maturation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Disks large homolog 4Imported
Gene namesi
Name:Dlg4Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1277959. Dlg4.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
  2. cell junction Source: MGI
  3. cerebellar mossy fiber Source: MGI
  4. cortical cytoskeleton Source: MGI
  5. cytoplasm Source: MGI
  6. dendrite Source: MGI
  7. endoplasmic reticulum Source: MGI
  8. excitatory synapse Source: MGI
  9. extrinsic component of cytoplasmic side of plasma membrane Source: MGI
  10. juxtaparanode region of axon Source: MGI
  11. membrane Source: MGI
  12. neuronal postsynaptic density Source: MGI
  13. neuron projection terminus Source: MGI
  14. neuron spine Source: MGI
  15. plasma membrane Source: MGI
  16. postsynaptic density Source: MGI
  17. postsynaptic membrane Source: MGI
  18. synapse Source: MGI
  19. synaptic membrane Source: MGI
  20. synaptic vesicle Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiB1AR31.
PRIDEiB1AR31.

Expressioni

Gene expression databases

BgeeiB1AR31.
ExpressionAtlasiB1AR31. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB1AR31.
SMRiB1AR31. Positions 40-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118866.
HOVERGENiHBG104157.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. MAGUK_PEST_N.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 2 hits.
PF10600. PDZ_assoc. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1AR31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQDLEQMYA KANSPPVIVN TDTLEAPGYE LQVNGTEGEM EYEEITLERG
60 70 80 90 100
NSGLGFSIAG GTDNPHIGDD PSIFITKIIP GGAAAQDGRL RVNDSILFVN
110 120 130 140 150
EVDVREVTHS AAVEALKEAG SIVRLYVMRR KPPAEKIIEI KLIKGPKGLG
160 170 180 190 200
FSIAGGVGNQ HIPGDNSIYV TKIIEGGAAH KDGRLQIGDK ILAVNSVGLE
210 220 230 240
DVMHEDAVAA LKNTYDVVYL KVAKPSNAYL SDSYAPPDIT TSYSQHLD
Length:248
Mass (Da):26,559
Last modified:April 8, 2008 - v1
Checksum:iA5A2E3783526D13E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei248 – 2481Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596185 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000132597; ENSMUSP00000114165; ENSMUSG00000020886.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596185 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AR31.
SMRiB1AR31. Positions 40-228.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiB1AR31.
PRIDEiB1AR31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000132597; ENSMUSP00000114165; ENSMUSG00000020886.

Organism-specific databases

MGIiMGI:1277959. Dlg4.

Phylogenomic databases

GeneTreeiENSGT00760000118866.
HOVERGENiHBG104157.

Miscellaneous databases

ChiTaRSiDlg4. mouse.
NextBioi35545684.
SOURCEiSearch...

Gene expression databases

BgeeiB1AR31.
ExpressionAtlasiB1AR31. baseline and differential.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR016313. DLG1.
IPR019590. MAGUK_PEST_N.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 2 hits.
PF10600. PDZ_assoc. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AR31_MOUSE
AccessioniPrimary (citable) accession number: B1AR31
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 1, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.