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Protein
Submitted name:

Voltage-dependent N-type calcium channel subunit alpha-1B

Gene

CACNA1B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Submitted name:
Voltage-dependent N-type calcium channel subunit alpha-1BImported
Gene namesi
Name:CACNA1BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:1389. CACNA1B.

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei97 – 11418HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15622HelicalSequence analysisAdd
BLAST
Transmembranei168 – 18821HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24523HelicalSequence analysisAdd
BLAST
Transmembranei300 – 32122HelicalSequence analysisAdd
BLAST
Transmembranei333 – 35523HelicalSequence analysisAdd
BLAST
Transmembranei485 – 50521HelicalSequence analysisAdd
BLAST
Transmembranei511 – 52818HelicalSequence analysisAdd
BLAST
Transmembranei610 – 63223HelicalSequence analysisAdd
BLAST
Transmembranei688 – 71023HelicalSequence analysisAdd
BLAST
Transmembranei1152 – 117019HelicalSequence analysisAdd
BLAST
Transmembranei1190 – 121021HelicalSequence analysisAdd
BLAST
Transmembranei1222 – 124019HelicalSequence analysisAdd
BLAST
Transmembranei1283 – 130523HelicalSequence analysisAdd
BLAST
Transmembranei1395 – 142026HelicalSequence analysisAdd
BLAST
Transmembranei1476 – 149419HelicalSequence analysisAdd
BLAST
Transmembranei1506 – 152924HelicalSequence analysisAdd
BLAST
Transmembranei1541 – 156525HelicalSequence analysisAdd
BLAST
Transmembranei1586 – 161530HelicalSequence analysisAdd
BLAST
Transmembranei1684 – 170724HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiB1AQK7.
PeptideAtlasiB1AQK7.
PRIDEiB1AQK7.

Expressioni

Gene expression databases

BgeeiB1AQK7.
ExpressionAtlasiB1AQK7. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360406.

Structurei

3D structure databases

ProteinModelPortaliB1AQK7.
SMRiB1AQK7. Positions 363-407, 1243-1270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1723 – 175836EF-handInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili713 – 73927Sequence analysisAdd
BLAST
Coiled coili993 – 102028Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AQK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA
60 70 80 90 100
QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM
110 120 130 140 150
ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII
160 170 180 190 200
ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL
210 220 230 240 250
KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH
260 270 280 290 300
KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI
310 320 330 340 350
LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL
360 370 380 390 400
VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML
410 420 430 440 450
AEEDRNAEEK SPLDAVLKRA ATKKSRNDLI HAEEGEDRFA DLCAVGSPFA
460 470 480 490 500
RASLKSGKTE SSSYFRRKEK MFRFFIRRMV KAQSFYWVVL CVVALNTLCV
510 520 530 540 550
AMVHYNQPRR LTTTLYFAEF VFLGLFLTEM SLKMYGLGPR SYFRSSFNCF
560 570 580 590 600
DFGVIVGSVF EVVWAAIKPG SSFGISVLRA LRLLRIFKVT KYWSSLRNLV
610 620 630 640 650
VSLLNSMKSI ISLLFLLFLF IVVFALLGMQ LFGGQFNFQD ETPTTNFDTF
660 670 680 690 700
PAAILTVFQI LTGEDWNAVM YHGIESQGGV SKGMFSSFYF IVLTLFGNYT
710 720 730 740 750
LLNVFLAIAV DNLANAQELT KDEEEMEEAA NQKLALQKAK EVAEVSPMSA
760 770 780 790 800
ANISIAARQQ NSAKARSVWE QRASQLRLQN LRASCEALYS EMDPEERLRF
810 820 830 840 850
ATTRHLRPDM KTHLDRPLVV ELGRDGARGP VGGKARPEAA EAPEGVDPPR
860 870 880 890 900
RHHRHRDKDK TPAAGDQDRA EAPKAESGEP GAREERPRPH RSHSKEAAGP
910 920 930 940 950
PEARSERGRG PGPEGGRRHH RRGSPEEAAE REPRRHRAHR HQDPSKECAG
960 970 980 990 1000
AKGERRARHR GGPRAGPREA ESGEEPARRH RARHKAQPAH EAVEKETTEK
1010 1020 1030 1040 1050
EATEKEAEIV EADKEKELRN HQPREPHCDL ETSGTVTVGP MHTLPSTCLQ
1060 1070 1080 1090 1100
KVEEQPEDAD NQRNVTRMGS QPPDPNTIVH IPVMLTGPLG EATVVPSGNV
1110 1120 1130 1140 1150
DLESQAEGKK EVEADDVMRS GPRPIVPYSS MFCLSPTNLL RRFCHYIVTM
1160 1170 1180 1190 1200
RYFEVVILVV IALSSIALAA EDPVRTDSPR NNALKYLDYI FTGVFTFEMV
1210 1220 1230 1240 1250
IKMIDLGLLL HPGAYFRDLW NILDFIVVSG ALVAFAFSGS KGKDINTIKS
1260 1270 1280 1290 1300
LRVLRVLRPL KTIKRLPKLK AVFDCVVNSL KNVLNILIVY MLFMFIFAVI
1310 1320 1330 1340 1350
AVQLFKGKFF YCTDESKELE RDCRGQYLDY EKEEVEAQPR QWKKYDFHYD
1360 1370 1380 1390 1400
NVLWALLTLF TVSTGEGWPM VLKHSVDATY EEQGPSPGYR MELSIFYVVY
1410 1420 1430 1440 1450
FVVFPFFFVN IFVALIIITF QEQGDKVMSE CSLEKNERAC IDFAISAKPL
1460 1470 1480 1490 1500
TRYMPQNRQS FQYKTWTFVV SPPFEYFIMA MIALNTVVLM MKFYDAPYEY
1510 1520 1530 1540 1550
ELMLKCLNIV FTSMFSMECV LKIIAFGVLN YFRDAWNVFD FVTVLGSITD
1560 1570 1580 1590 1600
ILVTEIANNF INLSFLRLFR AARLIKLLRQ GYTIRILLWT FVQSFKALPY
1610 1620 1630 1640 1650
VCLLIAMLFF IYAIIGMQVF GNIALDDDTS INRHNNFRTF LQALMLLFRS
1660 1670 1680 1690 1700
ATGEAWHEIM LSCLSNQACD EQANATECGS DFAYFYFVSF IFLCSFLMLN
1710 1720 1730 1740 1750
LFVAVIMDNF EYLTRDSSIL GPHHLDEFIR VWAEYDPAAC GRISYNDMFE
1760 1770 1780 1790 1800
MLKHMSPPLG LGKKCPARVA YKRLVRMNMP ISNEDMTVHF TSTLMALIRT
1810 1820 1830 1840 1850
ALEIKLAPAG TKQHQCDAEL RKEISVVWAN LPQKTLDLLV PPHKPDEMTV
1860 1870 1880 1890 1900
GKVYAALMIF DFYKQNKTTR DQMQQAPGGL SQMGPVSLFH PLKATLEQTQ
1910 1920 1930 1940 1950
PAVLRGARVF LRQKSSTSLS NGGAIQNQES GIKESVSWGT QRTQDAPHEA
1960 1970 1980 1990 2000
RPPLERGHST EIPVGRSGAL AVDVQMQSIT RRGPDGEPQP GLESQGRAAS
2010 2020 2030 2040 2050
MPRLAAETQP VTDASPMKRS ISTLAQRPRG THLCSTTPDR PPPSQASSHH
2060 2070 2080 2090 2100
HHHRCHRRRD RKQRSLEKGP SLSADMDGAP SSAVGPGLPP GEGPTGCRRE
2110 2120 2130 2140 2150
RERRQERGRS QERRQPSSSS SEKQRFYSCD RFGGREPPKP KPSLSSHPTS
2160 2170 2180 2190 2200
PTAGQEPGPH PQGSGSVNGS PLLSTSGAST PGRGGRRQLP QTPLTPRPSI
2210 2220 2230 2240 2250
TYKTANSSPI HFAGAQTSLP AFSPGRLSRG LSEHNALLQR DPLSQPLAPG
2260 2270 2280 2290 2300
SRIGSDPYLG QRLDSEASVH ALPEDTLTFE EAVATNSGRS SRTSYVSSLT
2310 2320 2330
SQSHPLRRVP NGYHCTLGLS SGGRARHSYH HPDQDHWC
Length:2,338
Mass (Da):262,337
Last modified:April 8, 2008 - v1
Checksum:i787A1D6153ED7276
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591424 Genomic DNA. No translation available.
AL772363 Genomic DNA. No translation available.
RefSeqiXP_011517296.1. XM_011518994.1.
UniGeneiHs.495522.

Genome annotation databases

EnsembliENST00000371357; ENSP00000360408; ENSG00000148408.
GeneIDi774.
UCSCiuc064xob.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591424 Genomic DNA. No translation available.
AL772363 Genomic DNA. No translation available.
RefSeqiXP_011517296.1. XM_011518994.1.
UniGeneiHs.495522.

3D structure databases

ProteinModelPortaliB1AQK7.
SMRiB1AQK7. Positions 363-407, 1243-1270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360406.

Proteomic databases

PaxDbiB1AQK7.
PeptideAtlasiB1AQK7.
PRIDEiB1AQK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371357; ENSP00000360408; ENSG00000148408.
GeneIDi774.
UCSCiuc064xob.1. human.

Organism-specific databases

CTDi774.
HGNCiHGNC:1389. CACNA1B.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
GeneTreeiENSGT00830000128247.
HOGENOMiHOG000231530.
HOVERGENiHBG050763.

Miscellaneous databases

ChiTaRSiCACNA1B. human.
GenomeRNAii774.

Gene expression databases

BgeeiB1AQK7.
ExpressionAtlasiB1AQK7. baseline and differential.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR002048. EF_hand_dom.
IPR031649. GPHH_dom.
IPR005821. Ion_trans_dom.
IPR014873. VDCC_a1su_IQ.
IPR005447. VDCC_N_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF161. PTHR10037:SF161. 3 hits.
PfamiPF08763. Ca_chan_IQ. 1 hit.
PF16905. GPHH. 1 hit.
PF00520. Ion_trans. 4 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01631. NVDCCALPHA1.
SMARTiSM01062. Ca_chan_IQ. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiB1AQK7_HUMAN
AccessioniPrimary (citable) accession number: B1AQK7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.