B1AQJ3 (B1AQJ3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Metalloproteinase inhibitor 2 Ensembl ENSMUSP00000122642

Gene names

Name:

Timp2 Ensembl ENSMUSP00000122642 MGI 98753

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000122642

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	143 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 1 NTR domain. SAAS SAAS008993
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000122642

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS008993
PTM	Disulfide bond SAAS SAAS008993
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aging Inferred from electronic annotation. Source: Compara cellular response to organic substance Inferred from direct assay PubMed 11869290. Source: MGI central nervous system development Inferred from electronic annotation. Source: Compara negative regulation of Ras protein signal transduction Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from direct assay PubMed 15901773. Source: MGI negative regulation of mitotic cell cycle Inferred from electronic annotation. Source: Compara negative regulation of proteolysis Inferred from electronic annotation. Source: Compara positive regulation of MAPK cascade Inferred from electronic annotation. Source: Compara positive regulation of adenylate cyclase activity Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara regulation of MAPK cascade Inferred from direct assay PubMed 15901773. Source: MGI regulation of Rap protein signal transduction Inferred from electronic annotation. Source: Compara regulation of cAMP metabolic process Inferred from direct assay PubMed 15901773. Source: MGI regulation of neuron differentiation Inferred from direct assay PubMed 15901773. Source: MGI response to cytokine stimulus Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara
Cellular_component	basement membrane Inferred from direct assay PubMed 12950084. Source: MGI cell surface Inferred from direct assay PubMed 15901773. Source: MGI extracellular space Inferred from electronic annotation. Source: Compara growth cone Inferred from electronic annotation. Source: Compara neuronal cell body Inferred from electronic annotation. Source: Compara
Molecular_function	enzyme activator activity Inferred from mutant phenotype PubMed 10827175PubMed 10827176. Source: MGI integrin binding Inferred from direct assay PubMed 15901773. Source: MGI metalloendopeptidase inhibitor activity Inferred from mutant phenotype PubMed 10827176. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	143	1	Ensembl ENSMUSP00000122642

Sequences

	Sequence		Length	Mass (Da)
	B1AQJ3 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 2F6782BBB12E0BAA	FASTA	143	16,053
	10 20 30 40 50 60 MFKGPDKDIE FIYTAPSSAV CGVSLDVGGK KEYLIAGKAE GDGKMHITLC DFIVPWDTLS 70 80 90 100 110 120 ITQKKSLNHR YQMGCECKIT RCPMIPCYIS SPDECLWMDW VTEKSINGHQ AKFFACIKRS 130 140 DGSCAWYRGA APPKQEFLDI EDP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000122642.
[2]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000122642.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591404 Genomic DNA. No translation available.
IPI	IPI00420951.
UniGene	Mm.206505. Mm.487859.
3D structure databases
ProteinModelPortal	B1AQJ3.
SMR	B1AQJ3. Positions 1-141.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000155707; ENSMUSP00000122642; ENSMUSG00000017466.
Organism-specific databases
MGI	MGI:98753. Timp2.
Phylogenomic databases
GeneTree	ENSGT00390000004555.
HOGENOM	HOG000285981.
HOVERGEN	HBG068749.
InParanoid	B1AQJ3.
Gene expression databases
ArrayExpress	B1AQJ3.
Family and domain databases
InterPro	IPR001134. Netrin_domain. IPR001820. Prot_inh_TIMP. IPR008993. TIMP-like_OB-fold. IPR015613. TIMP2. [Graphical view]
PANTHER	PTHR11844. PTHR11844. 1 hit. PTHR11844:SF7. PTHR11844:SF7. 1 hit.
Pfam	PF00965. TIMP. 1 hit. [Graphical view]
SMART	SM00206. NTR. 1 hit. [Graphical view]
SUPFAM	SSF50242. TIMP_like. 1 hit.
PROSITE	PS50189. NTR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35545653.
SOURCE	Search...

Entry information

Entry name

B1AQJ3_MOUSE

Accession

Primary (citable) accession number: B1AQJ3

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)