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Protein
Submitted name:

Metalloproteinase inhibitor 2

Gene

Timp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. enzyme activator activity Source: MGI
  2. integrin binding Source: MGI
  3. metalloendopeptidase inhibitor activity Source: MGI
  4. protease binding Source: GO_Central

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to organic substance Source: MGI
  3. central nervous system development Source: Ensembl
  4. negative regulation of cell proliferation Source: MGI
  5. negative regulation of endopeptidase activity Source: GOC
  6. negative regulation of membrane protein ectodomain proteolysis Source: GO_Central
  7. negative regulation of metalloenzyme activity Source: GO_Central
  8. negative regulation of mitotic cell cycle Source: Ensembl
  9. negative regulation of Ras protein signal transduction Source: Ensembl
  10. positive regulation of adenylate cyclase activity Source: Ensembl
  11. positive regulation of MAPK cascade Source: Ensembl
  12. positive regulation of neuron differentiation Source: Ensembl
  13. regulation of cAMP metabolic process Source: MGI
  14. regulation of MAPK cascade Source: MGI
  15. regulation of neuron differentiation Source: MGI
  16. regulation of Rap protein signal transduction Source: Ensembl
  17. response to cytokine Source: GO_Central
  18. response to drug Source: Ensembl
  19. response to hormone Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_332323. Activation of Matrix Metalloproteinases.

Names & Taxonomyi

Protein namesi
Submitted name:
Metalloproteinase inhibitor 2Imported
Gene namesi
Name:Timp2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98753. Timp2.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. cell surface Source: MGI
  3. extracellular space Source: GO_Central
  4. extracellular vesicular exosome Source: MGI
  5. growth cone Source: Ensembl
  6. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiB1AQJ3.
ExpressionAtlasiB1AQJ3. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB1AQJ3.
SMRiB1AQJ3. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains NTR domain.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000004555.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiIPR001134. Netrin_domain.
IPR001820. Prot_inh_TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015613. TIMP2.
IPR027465. TIMP_C_dom.
[Graphical view]
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF7. PTHR11844:SF7. 1 hit.
PfamiPF00965. TIMP. 1 hit.
[Graphical view]
SMARTiSM00206. NTR. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1AQJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKGPDKDIE FIYTAPSSAV CGVSLDVGGK KEYLIAGKAE GDGKMHITLC
60 70 80 90 100
DFIVPWDTLS ITQKKSLNHR YQMGCECKIT RCPMIPCYIS SPDECLWMDW
110 120 130 140
VTEKSINGHQ AKFFACIKRS DGSCAWYRGA APPKQEFLDI EDP
Length:143
Mass (Da):16,053
Last modified:April 8, 2008 - v1
Checksum:i2F6782BBB12E0BAA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei143 – 1431Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591404 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000155707; ENSMUSP00000122642; ENSMUSG00000017466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591404 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliB1AQJ3.
SMRiB1AQJ3. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000155707; ENSMUSP00000122642; ENSMUSG00000017466.

Organism-specific databases

MGIiMGI:98753. Timp2.

Phylogenomic databases

GeneTreeiENSGT00390000004555.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.

Enzyme and pathway databases

ReactomeiREACT_332323. Activation of Matrix Metalloproteinases.

Miscellaneous databases

NextBioi35545653.
SOURCEiSearch...

Gene expression databases

BgeeiB1AQJ3.
ExpressionAtlasiB1AQJ3. baseline and differential.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiIPR001134. Netrin_domain.
IPR001820. Prot_inh_TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015613. TIMP2.
IPR027465. TIMP_C_dom.
[Graphical view]
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF7. PTHR11844:SF7. 1 hit.
PfamiPF00965. TIMP. 1 hit.
[Graphical view]
SMARTiSM00206. NTR. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AQJ3_MOUSE
AccessioniPrimary (citable) accession number: B1AQJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 1, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.