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B1AQJ3

- B1AQJ3_MOUSE

UniProt

B1AQJ3 - B1AQJ3_MOUSE

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Protein
Submitted name:

Metalloproteinase inhibitor 2

Gene
Timp2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. enzyme activator activity Source: MGI
  2. integrin binding Source: MGI
  3. metalloendopeptidase inhibitor activity Source: MGI

GO - Biological processi

  1. aging Source: Ensembl
  2. cellular response to organic substance Source: MGI
  3. central nervous system development Source: Ensembl
  4. negative regulation of cell proliferation Source: MGI
  5. negative regulation of endopeptidase activity Source: GOC
  6. negative regulation of mitotic cell cycle Source: Ensembl
  7. negative regulation of proteolysis Source: Ensembl
  8. negative regulation of Ras protein signal transduction Source: Ensembl
  9. positive regulation of adenylate cyclase activity Source: Ensembl
  10. positive regulation of MAPK cascade Source: Ensembl
  11. positive regulation of neuron differentiation Source: Ensembl
  12. regulation of cAMP metabolic process Source: MGI
  13. regulation of MAPK cascade Source: MGI
  14. regulation of neuron differentiation Source: MGI
  15. regulation of Rap protein signal transduction Source: Ensembl
  16. response to cytokine Source: Ensembl
  17. response to drug Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

Names & Taxonomyi

Protein namesi
Submitted name:
Metalloproteinase inhibitor 2Imported
Gene namesi
Name:Timp2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:98753. Timp2.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: MGI
  2. cell surface Source: MGI
  3. extracellular space Source: Ensembl
  4. growth cone Source: Ensembl
  5. neuronal cell body Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiB1AQJ3.

Structurei

3D structure databases

ProteinModelPortaliB1AQJ3.
SMRiB1AQJ3. Positions 1-141.

Family & Domainsi

Sequence similaritiesi

Contains NTR domain.SAAS annotations

Phylogenomic databases

GeneTreeiENSGT00390000004555.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.
InParanoidiB1AQJ3.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiIPR001134. Netrin_domain.
IPR001820. Prot_inh_TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015613. TIMP2.
IPR027465. TIMP_C_dom.
[Graphical view]
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF7. PTHR11844:SF7. 1 hit.
PfamiPF00965. TIMP. 1 hit.
[Graphical view]
SMARTiSM00206. NTR. 1 hit.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS50189. NTR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

B1AQJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MFKGPDKDIE FIYTAPSSAV CGVSLDVGGK KEYLIAGKAE GDGKMHITLC    50
DFIVPWDTLS ITQKKSLNHR YQMGCECKIT RCPMIPCYIS SPDECLWMDW 100
VTEKSINGHQ AKFFACIKRS DGSCAWYRGA APPKQEFLDI EDP 143
Length:143
Mass (Da):16,053
Last modified:April 8, 2008 - v1
Checksum:i2F6782BBB12E0BAA
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei143 – 1431Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591404 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000155707; ENSMUSP00000122642; ENSMUSG00000017466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591404 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali B1AQJ3.
SMRi B1AQJ3. Positions 1-141.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000155707 ; ENSMUSP00000122642 ; ENSMUSG00000017466 .

Organism-specific databases

MGIi MGI:98753. Timp2.

Phylogenomic databases

GeneTreei ENSGT00390000004555.
HOGENOMi HOG000285981.
HOVERGENi HBG068749.
InParanoidi B1AQJ3.

Enzyme and pathway databases

Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

Miscellaneous databases

NextBioi 35545653.
SOURCEi Search...

Gene expression databases

ArrayExpressi B1AQJ3.

Family and domain databases

Gene3Di 3.90.370.10. 1 hit.
InterProi IPR001134. Netrin_domain.
IPR001820. Prot_inh_TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015613. TIMP2.
IPR027465. TIMP_C_dom.
[Graphical view ]
PANTHERi PTHR11844. PTHR11844. 1 hit.
PTHR11844:SF7. PTHR11844:SF7. 1 hit.
Pfami PF00965. TIMP. 1 hit.
[Graphical view ]
SMARTi SM00206. NTR. 1 hit.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
PROSITEi PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiB1AQJ3_MOUSE
AccessioniPrimary (citable) accession number: B1AQJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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