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Protein
Submitted name:

Metalloproteinase inhibitor 2

Gene

Timp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1592389. Activation of Matrix Metalloproteinases.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Submitted name:
Metalloproteinase inhibitor 2Imported
Gene namesi
Name:Timp2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98753. Timp2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiB1AQJ3.
PeptideAtlasiB1AQJ3.
PRIDEiB1AQJ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000017466.
ExpressionAtlasiB1AQJ3. baseline and differential.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB1AQJ3.
SMRiB1AQJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 75NTRInterPro annotationAdd BLAST75

Phylogenomic databases

eggNOGiKOG4745. Eukaryota.
ENOG41103NU. LUCA.
GeneTreeiENSGT00390000004555.
HOGENOMiHOG000285981.
HOVERGENiHBG068749.

Family and domain databases

Gene3Di3.90.370.10. 1 hit.
InterProiView protein in InterPro
IPR001134. Netrin_domain.
IPR001820. TIMP.
IPR008993. TIMP-like_OB-fold.
IPR015613. TIMP2.
IPR027465. TIMP_C.
PANTHERiPTHR11844. PTHR11844. 1 hit.
PTHR11844:SF24. PTHR11844:SF24. 1 hit.
PfamiView protein in Pfam
PF00965. TIMP. 1 hit.
SMARTiView protein in SMART
SM00206. NTR. 1 hit.
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiView protein in PROSITE
PS50189. NTR. 1 hit.

Sequencei

Sequence statusi: Fragment.

B1AQJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKGPDKDIE FIYTAPSSAV CGVSLDVGGK KEYLIAGKAE GDGKMHITLC
60 70 80 90 100
DFIVPWDTLS ITQKKSLNHR YQMGCECKIT RCPMIPCYIS SPDECLWMDW
110 120 130 140
VTEKSINGHQ AKFFACIKRS DGSCAWYRGA APPKQEFLDI EDP
Length:143
Mass (Da):16,053
Last modified:April 8, 2008 - v1
Checksum:i2F6782BBB12E0BAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei143Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591404 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000155707; ENSMUSP00000122642; ENSMUSG00000017466.

Similar proteinsi

Entry informationi

Entry nameiB1AQJ3_MOUSE
AccessioniPrimary (citable) accession number: B1AQJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported