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B1AQJ3

- B1AQJ3_MOUSE

UniProt

B1AQJ3 - B1AQJ3_MOUSE

Protein
Submitted name:

Metalloproteinase inhibitor 2

Gene

Timp2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. enzyme activator activity Source: MGI
    2. integrin binding Source: MGI
    3. metalloendopeptidase inhibitor activity Source: MGI

    GO - Biological processi

    1. aging Source: Ensembl
    2. cellular response to organic substance Source: MGI
    3. central nervous system development Source: Ensembl
    4. negative regulation of cell proliferation Source: MGI
    5. negative regulation of endopeptidase activity Source: GOC
    6. negative regulation of mitotic cell cycle Source: Ensembl
    7. negative regulation of proteolysis Source: Ensembl
    8. negative regulation of Ras protein signal transduction Source: Ensembl
    9. positive regulation of adenylate cyclase activity Source: Ensembl
    10. positive regulation of MAPK cascade Source: Ensembl
    11. positive regulation of neuron differentiation Source: Ensembl
    12. regulation of cAMP metabolic process Source: MGI
    13. regulation of MAPK cascade Source: MGI
    14. regulation of neuron differentiation Source: MGI
    15. regulation of Rap protein signal transduction Source: Ensembl
    16. response to cytokine Source: Ensembl
    17. response to drug Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_199000. Activation of Matrix Metalloproteinases.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Metalloproteinase inhibitor 2Imported
    Gene namesi
    Name:Timp2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:98753. Timp2.

    Subcellular locationi

    GO - Cellular componenti

    1. basement membrane Source: MGI
    2. cell surface Source: MGI
    3. extracellular space Source: Ensembl
    4. growth cone Source: Ensembl
    5. neuronal cell body Source: Ensembl

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiB1AQJ3.

    Structurei

    3D structure databases

    ProteinModelPortaliB1AQJ3.
    SMRiB1AQJ3. Positions 1-141.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains NTR domain.SAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000004555.
    HOGENOMiHOG000285981.
    HOVERGENiHBG068749.
    InParanoidiB1AQJ3.

    Family and domain databases

    Gene3Di3.90.370.10. 1 hit.
    InterProiIPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR015613. TIMP2.
    IPR027465. TIMP_C_dom.
    [Graphical view]
    PANTHERiPTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF7. PTHR11844:SF7. 1 hit.
    PfamiPF00965. TIMP. 1 hit.
    [Graphical view]
    SMARTiSM00206. NTR. 1 hit.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    PROSITEiPS50189. NTR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    B1AQJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFKGPDKDIE FIYTAPSSAV CGVSLDVGGK KEYLIAGKAE GDGKMHITLC    50
    DFIVPWDTLS ITQKKSLNHR YQMGCECKIT RCPMIPCYIS SPDECLWMDW 100
    VTEKSINGHQ AKFFACIKRS DGSCAWYRGA APPKQEFLDI EDP 143
    Length:143
    Mass (Da):16,053
    Last modified:April 8, 2008 - v1
    Checksum:i2F6782BBB12E0BAA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei143 – 1431Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591404 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000155707; ENSMUSP00000122642; ENSMUSG00000017466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591404 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali B1AQJ3.
    SMRi B1AQJ3. Positions 1-141.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000155707 ; ENSMUSP00000122642 ; ENSMUSG00000017466 .

    Organism-specific databases

    MGIi MGI:98753. Timp2.

    Phylogenomic databases

    GeneTreei ENSGT00390000004555.
    HOGENOMi HOG000285981.
    HOVERGENi HBG068749.
    InParanoidi B1AQJ3.

    Enzyme and pathway databases

    Reactomei REACT_199000. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 35545653.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B1AQJ3.

    Family and domain databases

    Gene3Di 3.90.370.10. 1 hit.
    InterProi IPR001134. Netrin_domain.
    IPR001820. Prot_inh_TIMP.
    IPR008993. TIMP-like_OB-fold.
    IPR015613. TIMP2.
    IPR027465. TIMP_C_dom.
    [Graphical view ]
    PANTHERi PTHR11844. PTHR11844. 1 hit.
    PTHR11844:SF7. PTHR11844:SF7. 1 hit.
    Pfami PF00965. TIMP. 1 hit.
    [Graphical view ]
    SMARTi SM00206. NTR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    PROSITEi PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiB1AQJ3_MOUSE
    AccessioniPrimary (citable) accession number: B1AQJ3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 8, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3