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Protein
Submitted name:

Metalloproteinase inhibitor 2

Gene

Timp2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-1592389 Activation of Matrix Metalloproteinases
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Metalloproteinase inhibitor 2Imported
Gene namesi
Name:Timp2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:98753 Timp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiB1AQJ3
PeptideAtlasiB1AQJ3
PRIDEiB1AQJ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000017466
ExpressionAtlasiB1AQJ3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliB1AQJ3
SMRiB1AQJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 75NTRInterPro annotationAdd BLAST75

Phylogenomic databases

eggNOGiKOG4745 Eukaryota
ENOG41103NU LUCA
GeneTreeiENSGT00390000004555
HOGENOMiHOG000285981
HOVERGENiHBG068749

Family and domain databases

Gene3Di3.90.370.10, 1 hit
InterProiView protein in InterPro
IPR001134 Netrin_domain
IPR001820 TIMP
IPR008993 TIMP-like_OB-fold
IPR015613 TIMP2
IPR027465 TIMP_C
PANTHERiPTHR11844 PTHR11844, 1 hit
PTHR11844:SF24 PTHR11844:SF24, 1 hit
PfamiView protein in Pfam
PF00965 TIMP, 1 hit
SMARTiView protein in SMART
SM00206 NTR, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Fragment.

B1AQJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKGPDKDIE FIYTAPSSAV CGVSLDVGGK KEYLIAGKAE GDGKMHITLC
60 70 80 90 100
DFIVPWDTLS ITQKKSLNHR YQMGCECKIT RCPMIPCYIS SPDECLWMDW
110 120 130 140
VTEKSINGHQ AKFFACIKRS DGSCAWYRGA APPKQEFLDI EDP
Length:143
Mass (Da):16,053
Last modified:April 8, 2008 - v1
Checksum:i2F6782BBB12E0BAA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei143Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591404 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000155707; ENSMUSP00000122642; ENSMUSG00000017466

Similar proteinsi

Entry informationi

Entry nameiB1AQJ3_MOUSE
AccessioniPrimary (citable) accession number: B1AQJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health