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B1AQJ2

- UBP36_MOUSE

UniProt

B1AQJ2 - UBP36_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311NucleophilePROSITE-ProRule annotation
    Active sitei382 – 3821Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:Kiaa1453
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1919594. Usp36.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10981098Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei463 – 4631PhosphoserineBy similarity
    Modified residuei578 – 5781PhosphoserineBy similarity
    Modified residuei663 – 6631PhosphoserineBy similarity
    Modified residuei678 – 6781PhosphoserineBy similarity
    Modified residuei709 – 7091PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiB1AQJ2.
    PRIDEiB1AQJ2.

    Expressioni

    Gene expression databases

    ArrayExpressiB1AQJ2.
    BgeeiB1AQJ2.
    GenevestigatoriB1AQJ2.

    Interactioni

    Subunit structurei

    Interacts with PAF1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB1AQJ2.
    SMRiB1AQJ2. Positions 122-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini122 – 423302USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    GeneTreeiENSGT00750000117288.
    HOGENOMiHOG000154759.
    InParanoidiB1AQJ2.
    KOiK11855.
    OMAiHQDPPWH.
    OrthoDBiEOG72VH5K.
    PhylomeDBiB1AQJ2.
    TreeFamiTF315281.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B1AQJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIVDKLKEA LKPGRKDSAE DGDLGRLLAA SAKKVLLQRI EFEPASKSFS     50
    YQLESLKSKY VLLSARAEGA SRHRSGDELQ ARKPGTERVS GSGGDGVPAP 100
    QKVLFPVERL SLRWERVFRV GAGLHNLGNT CFLNSTIQCL TYTPPLANYL 150
    LSKEHARSCH QGGFCMLCLM QNHMVQAFAN SGNAIKPVSF IRDLKKIARH 200
    FRFGNQEDAH EFLRYTIDAM QKACLNGYAK LDRQTQATTL VHQIFGGYLR 250
    SRVKCSVCKS VSDTYDPYLD IALEIRQAAN IVRALELFVK SDVLSGENAY 300
    MCAKCKKKVP ASKRFTIHRT SNVLTLSLKR FANFSGGKIT KDVGYPEFLN 350
    IRPYMSQSSG DPVMYGLYAV LVHSGYSCHA GHYYCYVKAS NGQWYQMNDS 400
    LVHSSNVKVV LNQQAYVLFY LRIPGSKKSP EGPVSRVGAT LPSRPKVVPE 450
    HSKKSPGNGV VPSPLMAKRQ DSVMMRKLPA PEEVGVPVSR NGSLPGLKLQ 500
    NGCAPAKTPA GSPSPRLTPT PTHMPTILDE PGKKVKKSAP LQSLTTSPTT 550
    SQGSPGTGES RSQRPGSWAS RDTIFSTSPK LLARAITNGH RLKGEGSGVD 600
    LEKGDSSSSS PEHSASSDPA KAPQTAESRA AHACDSQGTN CPTAGHPKAL 650
    LNGVDAKMVK LKSPALSSTT TEPTSLMSPP PAKKLALSAK KASTLRRATG 700
    NDIGSPSPSA FCDLTSPMKA THPVVASTGP VSKTRTAAPA PRPSTHPHSA 750
    SLSSSSAKPL GTSEPQSCRP SAWTPLPQVN GHFTSHLHQL PEASEALHSP 800
    SKKRKKTPNG DPQRLGIDTL LPQCLRGAPA AARRKRKKRC SEGEGATAPK 850
    QEGQFQDQSW SSGSQKEEGT QPQVNGHQVS HILDSYHVSS RKRRKRKRSE 900
    GLSQEATPSQ DLIQHSCSPV DHSEPEARTE LQKKKKKKRR KRKPEPQQDE 950
    ESKHPGDQRS PRPSVTPVPA LSVNGHLPSD CLGLGQAPLV TWNRDQEPDV 1000
    VQALLQDSSD KAYGKKVLTW DGEPSAISQD AIKDSRLART QTVVDDWDEE 1050
    FDRGKEKKIK KFKREKKRNF NAFQKLQSRR NFWSVTHPAK VASLSYRR 1098
    Length:1,098
    Mass (Da):119,913
    Last modified:April 8, 2008 - v1
    Checksum:i5853578D7BFD84DF
    GO

    Sequence cautioni

    The sequence BAC98173.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti452 – 4521S → P in BAC98173. (PubMed:14621295)Curated
    Sequence conflicti486 – 4861V → I in BAC98173. (PubMed:14621295)Curated
    Sequence conflicti541 – 5411L → P in BAC98173. (PubMed:14621295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591404 Genomic DNA. Translation: CAM23104.1.
    AK129363 mRNA. Translation: BAC98173.1. Different initiation.
    CCDSiCCDS48998.1.
    RefSeqiNP_001028700.1. NM_001033528.1.
    XP_006534365.1. XM_006534302.1.
    XP_006534366.1. XM_006534303.1.
    XP_006534367.1. XM_006534304.1.
    UniGeneiMm.232293.

    Genome annotation databases

    EnsembliENSMUST00000092382; ENSMUSP00000090036; ENSMUSG00000033909.
    ENSMUST00000106296; ENSMUSP00000101903; ENSMUSG00000033909.
    GeneIDi72344.
    KEGGimmu:72344.
    UCSCiuc007mot.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591404 Genomic DNA. Translation: CAM23104.1 .
    AK129363 mRNA. Translation: BAC98173.1 . Different initiation.
    CCDSi CCDS48998.1.
    RefSeqi NP_001028700.1. NM_001033528.1.
    XP_006534365.1. XM_006534302.1.
    XP_006534366.1. XM_006534303.1.
    XP_006534367.1. XM_006534304.1.
    UniGenei Mm.232293.

    3D structure databases

    ProteinModelPortali B1AQJ2.
    SMRi B1AQJ2. Positions 122-420.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.042.

    Proteomic databases

    PaxDbi B1AQJ2.
    PRIDEi B1AQJ2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092382 ; ENSMUSP00000090036 ; ENSMUSG00000033909 .
    ENSMUST00000106296 ; ENSMUSP00000101903 ; ENSMUSG00000033909 .
    GeneIDi 72344.
    KEGGi mmu:72344.
    UCSCi uc007mot.2. mouse.

    Organism-specific databases

    CTDi 57602.
    MGIi MGI:1919594. Usp36.
    Rougei Search...

    Phylogenomic databases

    eggNOGi COG5533.
    GeneTreei ENSGT00750000117288.
    HOGENOMi HOG000154759.
    InParanoidi B1AQJ2.
    KOi K11855.
    OMAi HQDPPWH.
    OrthoDBi EOG72VH5K.
    PhylomeDBi B1AQJ2.
    TreeFami TF315281.

    Miscellaneous databases

    ChiTaRSi USP36. mouse.
    NextBioi 336077.
    PROi B1AQJ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi B1AQJ2.
    Bgeei B1AQJ2.
    Genevestigatori B1AQJ2.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-937.
      Tissue: Embryonic tail.

    Entry informationi

    Entry nameiUBP36_MOUSE
    AccessioniPrimary (citable) accession number: B1AQJ2
    Secondary accession number(s): Q6ZPQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3