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B1AQJ2 (UBP36_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:Kiaa1453
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1098 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with PAF1 By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence caution

The sequence BAC98173.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentNucleus
   Molecular functionHydrolase
Protease
Thiol protease
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10981098Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378494

Regions

Domain122 – 423302USP

Sites

Active site1311Nucleophile By similarity
Active site3821Proton acceptor By similarity

Amino acid modifications

Modified residue4631Phosphoserine By similarity
Modified residue5781Phosphoserine By similarity
Modified residue6631Phosphoserine By similarity
Modified residue6781Phosphoserine By similarity
Modified residue7091Phosphoserine By similarity

Experimental info

Sequence conflict4521S → P in BAC98173. Ref.2
Sequence conflict4861V → I in BAC98173. Ref.2
Sequence conflict5411L → P in BAC98173. Ref.2

Sequences

Sequence LengthMass (Da)Tools
B1AQJ2 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 5853578D7BFD84DF

FASTA1,098119,913
        10         20         30         40         50         60 
MPIVDKLKEA LKPGRKDSAE DGDLGRLLAA SAKKVLLQRI EFEPASKSFS YQLESLKSKY 

        70         80         90        100        110        120 
VLLSARAEGA SRHRSGDELQ ARKPGTERVS GSGGDGVPAP QKVLFPVERL SLRWERVFRV 

       130        140        150        160        170        180 
GAGLHNLGNT CFLNSTIQCL TYTPPLANYL LSKEHARSCH QGGFCMLCLM QNHMVQAFAN 

       190        200        210        220        230        240 
SGNAIKPVSF IRDLKKIARH FRFGNQEDAH EFLRYTIDAM QKACLNGYAK LDRQTQATTL 

       250        260        270        280        290        300 
VHQIFGGYLR SRVKCSVCKS VSDTYDPYLD IALEIRQAAN IVRALELFVK SDVLSGENAY 

       310        320        330        340        350        360 
MCAKCKKKVP ASKRFTIHRT SNVLTLSLKR FANFSGGKIT KDVGYPEFLN IRPYMSQSSG 

       370        380        390        400        410        420 
DPVMYGLYAV LVHSGYSCHA GHYYCYVKAS NGQWYQMNDS LVHSSNVKVV LNQQAYVLFY 

       430        440        450        460        470        480 
LRIPGSKKSP EGPVSRVGAT LPSRPKVVPE HSKKSPGNGV VPSPLMAKRQ DSVMMRKLPA 

       490        500        510        520        530        540 
PEEVGVPVSR NGSLPGLKLQ NGCAPAKTPA GSPSPRLTPT PTHMPTILDE PGKKVKKSAP 

       550        560        570        580        590        600 
LQSLTTSPTT SQGSPGTGES RSQRPGSWAS RDTIFSTSPK LLARAITNGH RLKGEGSGVD 

       610        620        630        640        650        660 
LEKGDSSSSS PEHSASSDPA KAPQTAESRA AHACDSQGTN CPTAGHPKAL LNGVDAKMVK 

       670        680        690        700        710        720 
LKSPALSSTT TEPTSLMSPP PAKKLALSAK KASTLRRATG NDIGSPSPSA FCDLTSPMKA 

       730        740        750        760        770        780 
THPVVASTGP VSKTRTAAPA PRPSTHPHSA SLSSSSAKPL GTSEPQSCRP SAWTPLPQVN 

       790        800        810        820        830        840 
GHFTSHLHQL PEASEALHSP SKKRKKTPNG DPQRLGIDTL LPQCLRGAPA AARRKRKKRC 

       850        860        870        880        890        900 
SEGEGATAPK QEGQFQDQSW SSGSQKEEGT QPQVNGHQVS HILDSYHVSS RKRRKRKRSE 

       910        920        930        940        950        960 
GLSQEATPSQ DLIQHSCSPV DHSEPEARTE LQKKKKKKRR KRKPEPQQDE ESKHPGDQRS 

       970        980        990       1000       1010       1020 
PRPSVTPVPA LSVNGHLPSD CLGLGQAPLV TWNRDQEPDV VQALLQDSSD KAYGKKVLTW 

      1030       1040       1050       1060       1070       1080 
DGEPSAISQD AIKDSRLART QTVVDDWDEE FDRGKEKKIK KFKREKKRNF NAFQKLQSRR 

      1090 
NFWSVTHPAK VASLSYRR 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-937.
Tissue: Embryonic tail.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591404 Genomic DNA. Translation: CAM23104.1.
AK129363 mRNA. Translation: BAC98173.1. Different initiation.
CCDSCCDS48998.1.
RefSeqNP_001028700.1. NM_001033528.1.
XP_006534365.1. XM_006534302.1.
XP_006534366.1. XM_006534303.1.
XP_006534367.1. XM_006534304.1.
UniGeneMm.232293.

3D structure databases

ProteinModelPortalB1AQJ2.
SMRB1AQJ2. Positions 122-420.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.042.

Proteomic databases

PaxDbB1AQJ2.
PRIDEB1AQJ2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000092382; ENSMUSP00000090036; ENSMUSG00000033909.
ENSMUST00000106296; ENSMUSP00000101903; ENSMUSG00000033909.
GeneID72344.
KEGGmmu:72344.
UCSCuc007mot.2. mouse.

Organism-specific databases

CTD57602.
MGIMGI:1919594. Usp36.
RougeSearch...

Phylogenomic databases

eggNOGCOG5533.
GeneTreeENSGT00750000117288.
HOGENOMHOG000154759.
InParanoidB1AQJ2.
KOK11855.
OMAHQDPPWH.
OrthoDBEOG72VH5K.
PhylomeDBB1AQJ2.
TreeFamTF315281.

Gene expression databases

ArrayExpressB1AQJ2.
BgeeB1AQJ2.
GenevestigatorB1AQJ2.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUSP36. mouse.
NextBio336077.
PROB1AQJ2.
SOURCESearch...

Entry information

Entry nameUBP36_MOUSE
AccessionPrimary (citable) accession number: B1AQJ2
Secondary accession number(s): Q6ZPQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: April 8, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot