SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B1AQJ2

- UBP36_MOUSE

UniProt

B1AQJ2 - UBP36_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ubiquitin carboxyl-terminal hydrolase 36
Gene
Usp36, Kiaa1453
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Nucleophile By similarity
Active sitei382 – 3821Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.042.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:Kiaa1453
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1919594. Usp36.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10981098Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378494Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei463 – 4631Phosphoserine By similarity
Modified residuei578 – 5781Phosphoserine By similarity
Modified residuei663 – 6631Phosphoserine By similarity
Modified residuei678 – 6781Phosphoserine By similarity
Modified residuei709 – 7091Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB1AQJ2.
PRIDEiB1AQJ2.

Expressioni

Gene expression databases

ArrayExpressiB1AQJ2.
BgeeiB1AQJ2.
GenevestigatoriB1AQJ2.

Interactioni

Subunit structurei

Interacts with PAF1 By similarity.

Structurei

3D structure databases

ProteinModelPortaliB1AQJ2.
SMRiB1AQJ2. Positions 122-420.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini122 – 423302USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
GeneTreeiENSGT00750000117288.
HOGENOMiHOG000154759.
InParanoidiB1AQJ2.
KOiK11855.
OMAiHQDPPWH.
OrthoDBiEOG72VH5K.
PhylomeDBiB1AQJ2.
TreeFamiTF315281.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AQJ2-1 [UniParc]FASTAAdd to Basket

« Hide

MPIVDKLKEA LKPGRKDSAE DGDLGRLLAA SAKKVLLQRI EFEPASKSFS     50
YQLESLKSKY VLLSARAEGA SRHRSGDELQ ARKPGTERVS GSGGDGVPAP 100
QKVLFPVERL SLRWERVFRV GAGLHNLGNT CFLNSTIQCL TYTPPLANYL 150
LSKEHARSCH QGGFCMLCLM QNHMVQAFAN SGNAIKPVSF IRDLKKIARH 200
FRFGNQEDAH EFLRYTIDAM QKACLNGYAK LDRQTQATTL VHQIFGGYLR 250
SRVKCSVCKS VSDTYDPYLD IALEIRQAAN IVRALELFVK SDVLSGENAY 300
MCAKCKKKVP ASKRFTIHRT SNVLTLSLKR FANFSGGKIT KDVGYPEFLN 350
IRPYMSQSSG DPVMYGLYAV LVHSGYSCHA GHYYCYVKAS NGQWYQMNDS 400
LVHSSNVKVV LNQQAYVLFY LRIPGSKKSP EGPVSRVGAT LPSRPKVVPE 450
HSKKSPGNGV VPSPLMAKRQ DSVMMRKLPA PEEVGVPVSR NGSLPGLKLQ 500
NGCAPAKTPA GSPSPRLTPT PTHMPTILDE PGKKVKKSAP LQSLTTSPTT 550
SQGSPGTGES RSQRPGSWAS RDTIFSTSPK LLARAITNGH RLKGEGSGVD 600
LEKGDSSSSS PEHSASSDPA KAPQTAESRA AHACDSQGTN CPTAGHPKAL 650
LNGVDAKMVK LKSPALSSTT TEPTSLMSPP PAKKLALSAK KASTLRRATG 700
NDIGSPSPSA FCDLTSPMKA THPVVASTGP VSKTRTAAPA PRPSTHPHSA 750
SLSSSSAKPL GTSEPQSCRP SAWTPLPQVN GHFTSHLHQL PEASEALHSP 800
SKKRKKTPNG DPQRLGIDTL LPQCLRGAPA AARRKRKKRC SEGEGATAPK 850
QEGQFQDQSW SSGSQKEEGT QPQVNGHQVS HILDSYHVSS RKRRKRKRSE 900
GLSQEATPSQ DLIQHSCSPV DHSEPEARTE LQKKKKKKRR KRKPEPQQDE 950
ESKHPGDQRS PRPSVTPVPA LSVNGHLPSD CLGLGQAPLV TWNRDQEPDV 1000
VQALLQDSSD KAYGKKVLTW DGEPSAISQD AIKDSRLART QTVVDDWDEE 1050
FDRGKEKKIK KFKREKKRNF NAFQKLQSRR NFWSVTHPAK VASLSYRR 1098
Length:1,098
Mass (Da):119,913
Last modified:April 8, 2008 - v1
Checksum:i5853578D7BFD84DF
GO

Sequence cautioni

The sequence BAC98173.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti452 – 4521S → P in BAC98173. 1 Publication
Sequence conflicti486 – 4861V → I in BAC98173. 1 Publication
Sequence conflicti541 – 5411L → P in BAC98173. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591404 Genomic DNA. Translation: CAM23104.1.
AK129363 mRNA. Translation: BAC98173.1. Different initiation.
CCDSiCCDS48998.1.
RefSeqiNP_001028700.1. NM_001033528.1.
XP_006534365.1. XM_006534302.1.
XP_006534366.1. XM_006534303.1.
XP_006534367.1. XM_006534304.1.
UniGeneiMm.232293.

Genome annotation databases

EnsembliENSMUST00000092382; ENSMUSP00000090036; ENSMUSG00000033909.
ENSMUST00000106296; ENSMUSP00000101903; ENSMUSG00000033909.
GeneIDi72344.
KEGGimmu:72344.
UCSCiuc007mot.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591404 Genomic DNA. Translation: CAM23104.1 .
AK129363 mRNA. Translation: BAC98173.1 . Different initiation.
CCDSi CCDS48998.1.
RefSeqi NP_001028700.1. NM_001033528.1.
XP_006534365.1. XM_006534302.1.
XP_006534366.1. XM_006534303.1.
XP_006534367.1. XM_006534304.1.
UniGenei Mm.232293.

3D structure databases

ProteinModelPortali B1AQJ2.
SMRi B1AQJ2. Positions 122-420.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.042.

Proteomic databases

PaxDbi B1AQJ2.
PRIDEi B1AQJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092382 ; ENSMUSP00000090036 ; ENSMUSG00000033909 .
ENSMUST00000106296 ; ENSMUSP00000101903 ; ENSMUSG00000033909 .
GeneIDi 72344.
KEGGi mmu:72344.
UCSCi uc007mot.2. mouse.

Organism-specific databases

CTDi 57602.
MGIi MGI:1919594. Usp36.
Rougei Search...

Phylogenomic databases

eggNOGi COG5533.
GeneTreei ENSGT00750000117288.
HOGENOMi HOG000154759.
InParanoidi B1AQJ2.
KOi K11855.
OMAi HQDPPWH.
OrthoDBi EOG72VH5K.
PhylomeDBi B1AQJ2.
TreeFami TF315281.

Miscellaneous databases

ChiTaRSi USP36. mouse.
NextBioi 336077.
PROi B1AQJ2.
SOURCEi Search...

Gene expression databases

ArrayExpressi B1AQJ2.
Bgeei B1AQJ2.
Genevestigatori B1AQJ2.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-937.
    Tissue: Embryonic tail.

Entry informationi

Entry nameiUBP36_MOUSE
AccessioniPrimary (citable) accession number: B1AQJ2
Secondary accession number(s): Q6ZPQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi