Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Keratin, type I cuticular Ha6

Gene

Krt36

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei342 – 3421StutterSequence analysis

GO - Molecular functioni

  • structural constituent of epidermis Source: UniProtKB

GO - Biological processi

  • regulation of keratinocyte differentiation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha6By similarity
Alternative name(s):
Keratin-36Imported
Short name:
K36
Keratin-5Imported
MHRa-1Imported
Type I keratin 48 kDa1 Publication
Gene namesi
Name:Krt36Imported
Synonyms:Hra-1Imported, Krt1-22Imported, Krt1-5Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109364. Krt36.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • intermediate filament Source: UniProtKB-KW
  • intermediate filament cytoskeleton Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Keratin, type I cuticular Ha6PRO_0000363989Add
BLAST

Proteomic databases

EPDiB1AQ75.
MaxQBiB1AQ75.
PaxDbiB1AQ75.
PeptideAtlasiB1AQ75.
PRIDEiB1AQ75.

Expressioni

Tissue specificityi

In skin, only expressed in the suprabasal cells of tail scale epidermis. Suprabasally expressed in stratified squamous epithelia and also in the posterior unit of the complex filiform papillae of tongue. Expressed in rare anatomical sites in which an orthokeratinized stratum corneum would be too soft and a hard keratinized structure would be too rigid to meet the functional requirement of the respective epithelia.1 Publication

Inductioni

mRNA synthesis is suppressed during retinoic acid-mediated orthokeratotic conversion of tail scale epidermis.1 Publication

Gene expression databases

BgeeiB1AQ75.
GenevisibleiB1AQ75. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103039.

Structurei

3D structure databases

ProteinModelPortaliB1AQ75.
SMRiB1AQ75. Positions 143-241, 311-399.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9393HeadSequence analysisAdd
BLAST
Regioni94 – 400307RodSequence analysisAdd
BLAST
Regioni94 – 12835Coil 1ASequence analysisAdd
BLAST
Regioni129 – 13911Linker 1Sequence analysisAdd
BLAST
Regioni140 – 240101Coil 1BSequence analysisAdd
BLAST
Regioni241 – 25616Linker 12Sequence analysisAdd
BLAST
Regioni257 – 400144Coil 2Sequence analysisAdd
BLAST
Regioni401 – 47373TailSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiB1AQ75.
KOiK07604.
OMAiILEDMRC.
OrthoDBiEOG7FV3Q8.
PhylomeDBiB1AQ75.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B1AQ75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQICTPTF SAGSAKGLCG TSGSFSRISS IHSMGSCRAP SLVGTVGSVS
60 70 80 90 100
SFRTGFSGPG SCLPGSYLSS GCHSSGFAGS GGWFCEGAFN GNEKATMQIL
110 120 130 140 150
NDRLANYLEK VRQLEQENTQ LECRIREWYE CQIPYICPDY QSYFKTAEEL
160 170 180 190 200
QQKILLTKSE NARLILQIDN AKLAADDFRT KYETELSLRQ LVEADINGLR
210 220 230 240 250
RILDELTLCK ADLEAQVESL KEELLCLKRN HEEEVNALRS QLGDRLNVEV
260 270 280 290 300
DAAPPVDLNK ILDDMRCQYE TLVENNRRDV EAWFNTQTEE LNQQVVSSSE
310 320 330 340 350
QLQCCQTEII ELRRTVNSLE IELQAQQSMR NSLESTLAET EARYSSQLGQ
360 370 380 390 400
MQCLITNVES QLAEIRCDLE RQNHEYQVLL DVKARLESEI ATYRRLLDGE
410 420 430 440 450
DCKLPAHPCS TECKPAVRVP YIPSTTCTPA GPCTPAGPCT PAPQVSTQIR
460 470
TITEEIRDGR VISSREHVVP RAM
Length:473
Mass (Da):52,790
Last modified:April 8, 2008 - v1
Checksum:iA492B6686024FCA8
GO

Sequence cautioni

The sequence CAA46480.1 differs from that shown. Reason: Frameshift at position 418. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti285 – 2862NT → IA in CAA46480 (PubMed:1385239).Curated
Sequence conflicti316 – 3183VNS → SQL in CAA46480 (PubMed:1385239).Curated
Sequence conflicti326 – 3261Q → R in CAA46480 (PubMed:1385239).Curated
Sequence conflicti331 – 3311N → H in CAA46480 (PubMed:1385239).Curated
Sequence conflicti357 – 3571N → K in CAA46480 (PubMed:1385239).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590873, AL662808 Genomic DNA. Translation: CAM17771.1.
AL662808, AL590873 Genomic DNA. Translation: CAM15791.1.
X65506 mRNA. Translation: CAA46480.1. Frameshift.
CCDSiCCDS48929.1.
PIRiI48660. S21388.
RefSeqiNP_001167570.1. NM_001174099.1.
XP_006532395.1. XM_006532332.2.
XP_011247071.1. XM_011248769.1.
UniGeneiMm.306829.
Mm.401866.

Genome annotation databases

EnsembliENSMUST00000107416; ENSMUSP00000103039; ENSMUSG00000020916.
GeneIDi16673.
KEGGimmu:16673.
UCSCiuc011yey.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL590873, AL662808 Genomic DNA. Translation: CAM17771.1.
AL662808, AL590873 Genomic DNA. Translation: CAM15791.1.
X65506 mRNA. Translation: CAA46480.1. Frameshift.
CCDSiCCDS48929.1.
PIRiI48660. S21388.
RefSeqiNP_001167570.1. NM_001174099.1.
XP_006532395.1. XM_006532332.2.
XP_011247071.1. XM_011248769.1.
UniGeneiMm.306829.
Mm.401866.

3D structure databases

ProteinModelPortaliB1AQ75.
SMRiB1AQ75. Positions 143-241, 311-399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103039.

Proteomic databases

EPDiB1AQ75.
MaxQBiB1AQ75.
PaxDbiB1AQ75.
PeptideAtlasiB1AQ75.
PRIDEiB1AQ75.

Protocols and materials databases

DNASUi16673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000107416; ENSMUSP00000103039; ENSMUSG00000020916.
GeneIDi16673.
KEGGimmu:16673.
UCSCiuc011yey.1. mouse.

Organism-specific databases

CTDi8689.
MGIiMGI:109364. Krt36.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiB1AQ75.
KOiK07604.
OMAiILEDMRC.
OrthoDBiEOG7FV3Q8.
PhylomeDBiB1AQ75.
TreeFamiTF332742.

Miscellaneous databases

PROiB1AQ75.
SOURCEiSearch...

Gene expression databases

BgeeiB1AQ75.
GenevisibleiB1AQ75. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation."
    Tobiasch E., Winter H., Schweizer J.
    Differentiation 50:163-178(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 283-473, SUBUNIT, TISSUE SPECIFICITY, INDUCTION.
    Strain: NMRI.
    Tissue: Tail epidermis1 Publication.

Entry informationi

Entry nameiKRT36_MOUSE
AccessioniPrimary (citable) accession number: B1AQ75
Secondary accession number(s): Q61861
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.