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Protein

Guanine nucleotide-binding protein subunit gamma

Gene

GNG4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducerUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit gammaUniRule annotation
Gene namesi
Name:GNG4Imported
ORF Names:hCG_23460Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000168243.10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28786

PTM / Processingi

Keywords - PTMi

LipoproteinUniRule annotation

Expressioni

Gene expression databases

BgeeiENSG00000168243
ExpressionAtlasiB1APZ0 baseline and differential

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma.UniRule annotation

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiB1APZ0, 2 interactors

Structurei

3D structure databases

SMRiB1APZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 75G protein gammaInterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the G protein gamma family.UniRule annotation

Phylogenomic databases

eggNOGiKOG4119 Eukaryota
ENOG41122JF LUCA
HOVERGENiHBG014983
KOiK04541
OMAiAHTREDP
OrthoDBiEOG091G17J0

Family and domain databases

CDDicd00068 GGL, 1 hit
Gene3Di4.10.260.10, 1 hit
InterProiView protein in InterPro
IPR015898 G-protein_gamma-like_dom
IPR036284 GGL_sf
IPR001770 Gprotein-gamma
PANTHERiPTHR13809 PTHR13809, 1 hit
PfamiView protein in Pfam
PF00631 G-gamma, 1 hit
PRINTSiPR00321 GPROTEING
SMARTiView protein in SMART
SM00224 GGL, 1 hit
SUPFAMiSSF48670 SSF48670, 1 hit
PROSITEiView protein in PROSITE
PS50058 G_PROTEIN_GAMMA, 1 hit

Sequencei

Sequence statusi: Complete.

B1APZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR
60 70
EDPLIIPVPA SENPFREKKF FCTIL
Length:75
Mass (Da):8,389
Last modified:April 8, 2008 - v1
Checksum:i42FAEF4728F83FF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK311781 mRNA Translation: BAG34724.1
CH471098 Genomic DNA Translation: EAW70030.1
CH471098 Genomic DNA Translation: EAW70031.1
RefSeqiNP_001092191.1, NM_001098721.1
NP_001092192.1, NM_001098722.1
NP_004476.1, NM_004485.3
XP_006711824.1, XM_006711761.2
XP_011542469.1, XM_011544167.2
UniGeneiHs.159711

Genome annotation databases

GeneIDi2786
KEGGihsa:2786

Similar proteinsi

Entry informationi

Entry nameiB1APZ0_HUMAN
AccessioniPrimary (citable) accession number: B1APZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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