B1APZ0 (B1APZ0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Guanine nucleotide-binding protein subunit gamma RuleBase RU004973

Gene names

Name:	GNG4 EMBL EAW70030.1
ORF Names:	hCG_23460 EMBL EAW70030.1

Organism

Homo sapiens (Human) EMBL BAG34724.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	75 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction By similarity. RuleBase RU004973
Subunit structure	G proteins are composed of 3 units; alpha, beta and gamma By similarity. RuleBase RU004973
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side By similarity RuleBase RU004973.
Sequence similarities	Belongs to the G protein gamma family. RuleBase RU004973

Ontologies

Keywords
Cellular component	Cell membrane RuleBase RU004973 Membrane
Molecular function	Transducer SAAS SAAS015898 RuleBase RU004973
PTM	Lipoprotein RuleBase RU004973
Gene Ontology (GO)
Biological_process	G-protein coupled receptor signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	heterotrimeric G-protein complex Inferred from electronic annotation. Source: InterPro
Molecular_function	signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B1APZ0 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 42FAEF4728F83FF5	FASTA	75	8,389
	10 20 30 40 50 60 MKEGMSNNST TSISQARKAV EQLKMEACMD RVKVSQAAAD LLAYCEAHVR EDPLIIPVPA 70 SENPFREKKF FCTIL

References

[1]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"NEDO functional analysis of protein and research application project." Wakamatsu A., Yamamoto J., Kimura K., Kaida T., Tsuchiya K., Iida Y., Takayama Y., Murakawa K., Kanehori K., Andoh T., Kagawa N., Sato R., Kawamura Y., Tanaka S., Kisu Y., Sugano S., Goshima N., Nomura N., Isogai T. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK311781 mRNA. Translation: BAG34724.1. CH471098 Genomic DNA. Translation: EAW70030.1.
IPI	IPI00030058.
RefSeq	NP_001092191.1. NM_001098721.1. NP_001092192.1. NM_001098722.1. NP_004476.1. NM_004485.3.
UniGene	Hs.159711.
3D structure databases
ModBase	Search...
Protocols and materials databases
DNASU	2786.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2786.
KEGG	hsa:2786.
Organism-specific databases
CTD	2786.
PharmGKB	PA28786.
Phylogenomic databases
HOVERGEN	HBG014983.
KO	K04541.
OMA	EVMSNNS.
Family and domain databases
Gene3D	4.10.260.10. 1 hit.
InterPro	IPR015898. G-protein_gamma-like_dom. IPR001770. Gprotein-gamma. [Graphical view]
PANTHER	PTHR13809. PTHR13809. 1 hit.
Pfam	PF00631. G-gamma. 1 hit. [Graphical view]
PRINTS	PR00321. GPROTEING.
SMART	SM00224. GGL. 1 hit. [Graphical view]
SUPFAM	SSF48670. G-protein_gamma-like. 1 hit.
PROSITE	PS50058. G_PROTEIN_GAMMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	GNG4. human.
GenomeRNAi	2786.
NextBio	10975.

Entry information

Entry name

B1APZ0_HUMAN

Accession

Primary (citable) accession number: B1APZ0

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.