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Protein

Putative zinc finger protein 487

Gene

ZNF487

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri286 – 308C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 378C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 487
Alternative name(s):
KRAB domain only protein 1
Gene namesi
Name:ZNF487
Synonyms:KRBO1, ZNF487P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000243660.9.
HGNCiHGNC:23488. ZNF487.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000243660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003449761 – 448Putative zinc finger protein 487Add BLAST448

Proteomic databases

PaxDbiB1APH4.
PRIDEiB1APH4.

Expressioni

Gene expression databases

BgeeiENSG00000243660.
CleanExiHS_ZNF487.
ExpressionAtlasiB1APH4. baseline and differential.

Organism-specific databases

HPAiHPA037820.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000388421.

Structurei

3D structure databases

ProteinModelPortaliB1APH4.
SMRiB1APH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 108KRAB 1PROSITE-ProRule annotationAdd BLAST72
Domaini433 – 447KRAB 2PROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri286 – 308C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 378C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00900000141000.
HOGENOMiHOG000200059.
HOVERGENiHBG018163.
InParanoidiB1APH4.
OMAiGKFLLCM.
OrthoDBiEOG091G0J7Z.
PhylomeDBiB1APH4.
TreeFamiTF337898.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 2 hits.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 2 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1APH4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASRPRPRTP SRGPSDLRFR GEAGLRRVFL KKAGGSVSFS DVAVGFTQEE
60 70 80 90 100
WQHLDSAQRT PYRDMMLENY SLLLSVGYCI TKPEVVCKLE HGQVLWILEE
110 120 130 140 150
ESPSQSHLDC CIDDDLMEKR QENQDQHLQK VDFVNNKTLT MDRNGVLGKT
160 170 180 190 200
FSLDTNPILS RKIRGNCDSS GMNLNNISEL IISNRSSFVR NPAECNVRGK
210 220 230 240 250
FLLCMKRENP YARGKPLEYD GNGKAVSQNE DLFRHQYIQT LKQCFEYNHR
260 270 280 290 300
GYTEERNPMN ALNVGKLLDI GHALQYIKEH TRDKTYECNE CGKNFCEKSN
310 320 330 340 350
LHVHQRTHTG EKPYGCNECQ KAFGDRSALK VHQRIHTGEK PYELHQRTHT
360 370 380 390 400
GEKPYACSEC GKTFYQKSSL TTHQRTHTRE QPYEYNESFY QNPNFTKCQR
410 420 430 440
DNIEETLVNI LKAQKPSPSW TRSIAETTQV GGSVSLKDVT VDFTQEEW
Length:448
Mass (Da):51,624
Last modified:July 22, 2008 - v3
Checksum:i589DBBF3A2E1CCC4
GO
Isoform 2 (identifier: B1APH4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-64: Missing.
     249-272: HRGYTEERNPMNALNVGKLLDIGH → QCGKAFHEEAACSTHKRVCSWETL
     273-448: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):23,904
Checksum:i1E66AE44912FD5AE
GO

Sequence cautioni

B1APH4: The sequence CAI15018 differs from that shown. Reason: Erroneous gene model prediction.Curated
B1APH4: The sequence CAO03512 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04563561P → R. Corresponds to variant dbSNP:rs11816311Ensembl.1
Natural variantiVAR_045636120R → S. Corresponds to variant dbSNP:rs11598660Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559581 – 64Missing in isoform 2. 1 PublicationAdd BLAST64
Alternative sequenceiVSP_055959249 – 272HRGYT…LDIGH → QCGKAFHEEAACSTHKRVCS WETL in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_055960273 – 448Missing in isoform 2. 1 PublicationAdd BLAST176

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK302442 mRNA. Translation: BAH13711.1.
AL450326 Genomic DNA. Translation: CAI15018.3. Sequence problems.
AL450326 Genomic DNA. Translation: CAO03512.1. Sequence problems.
UniGeneiHs.719657.

Genome annotation databases

EnsembliENST00000437590; ENSP00000392335; ENSG00000243660. [B1APH4-2]
UCSCiuc010qfb.2. human. [B1APH4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Entry informationi

Entry nameiZN487_HUMAN
AccessioniPrimary (citable) accession number: B1APH4
Secondary accession number(s): B1APH5, B7Z7S5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: October 25, 2017
This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families