PRKACB

Functionⁱ

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB-KW

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	B1APG3.

SignaLinkⁱ

B1APG3.

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: cAMP-dependent protein kinase catalytic subunit betaImported
Gene namesⁱ	Name:PRKACBImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9381. PRKACB.

HGNCⁱ

HGNC:9381. PRKACB.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytosol Source: HPA
intercellular bridge Source: HPA

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000142875.

OpenTargetsⁱ

ENSG00000142875.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B1APG3.
PaxDbⁱ	B1APG3.
PeptideAtlas More...PeptideAtlasⁱ	B1APG3.
PRIDEⁱ	B1APG3.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000142875.
ExpressionAtlasⁱ	B1APG3. baseline and differential.

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000359719.

STRINGⁱ

9606.ENSP00000359719.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B1APG3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	50 – 264	Protein kinaseInterPro annotationAdd BLAST		215

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0616. Eukaryota. ENOG410XPQQ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125385.
HOGENOMⁱ	HOG000233033.
HOVERGENⁱ	HBG108317.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B1APG3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSARKSSDAS ACSSSEISDS FVKEFLAKAK EDFLKKWENP TQNNAGLEDF 
        60         70         80         90        100
ERKKTLGTGS FGRVMLVKHK ATEQYYAMKI LDKQKVVKLK QIEHTLNEKR 
       110        120        130        140        150
ILQAVNFPFL VRLEYAFKDN SNLYMVMEYV PGGEMFSHLR RIGRFSEPHA 
       160        170        180        190        200
RFYAAQIVLT FEYLHSLDLI YRDLKPENLL IDHQGYIQVT DFGFAKRVKG 
       210        220        230        240        250
RTWTLCGTPE YLAPEIILSK GYNKAVDWWA LGVLIYEMAA GYPPFFADQP 
       260 
IQIYEKIVSG KQNF

Length:264

Mass (Da):30,498

Last modified:April 8, 2008 - v1

Checksum:ⁱ181CA0A6367836DB

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL359504 Genomic DNA. No translation available. AL450063 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001287844.1. NM_001300915.1.
UniGeneⁱ	Hs.487325.

Genome annotation databases

Ensemblⁱ	ENST00000370680; ENSP00000359714; ENSG00000142875.
GeneIDⁱ	5567.
UCSC genome browser More...UCSCⁱ	uc009wcf.3. human.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL359504 Genomic DNA. No translation available. AL450063 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	NP_001287844.1. NM_001300915.1.
UniGeneⁱ	Hs.487325.

3D structure databases

ProteinModelPortalⁱ	B1APG3.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000359719.

STRINGⁱ

9606.ENSP00000359719.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	B1APG3.
PaxDbⁱ	B1APG3.
PeptideAtlas More...PeptideAtlasⁱ	B1APG3.
PRIDEⁱ	B1APG3.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000370680; ENSP00000359714; ENSG00000142875.
GeneIDⁱ	5567.
UCSC genome browser More...UCSCⁱ	uc009wcf.3. human.

Organism-specific databases

CTDⁱ	5567.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9381. PRKACB.
Open Targets More...OpenTargetsⁱ	ENSG00000142875.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0616. Eukaryota. ENOG410XPQQ. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125385.
HOGENOMⁱ	HOG000233033.
HOVERGENⁱ	HBG108317.

Enzyme and pathway databases

SignaLinkⁱ	B1APG3.

SignaLinkⁱ

B1APG3.

Miscellaneous databases

ChiTaRSⁱ	PRKACB. human.
GenomeRNAiⁱ	5567.

Gene expression databases

Bgeeⁱ	ENSG00000142875.
ExpressionAtlasⁱ	B1APG3. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069. Pkinase. 1 hit.
SMARTⁱ	View protein in SMART SM00220. S_TKc. 1 hit.
SUPFAMⁱ	SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B1APG3_HUMAN
Accessionⁱ	B1APG3Primary (citable) accession number: B1APG3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 8, 2008
	Last sequence update:	April 8, 2008
	Last modified:	May 10, 2017
	This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B1APG3 (B1APG3_HUMAN)

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cAMP-dependent protein kinase catalytic subunit beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ