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Protein
Submitted name:

cAMP-dependent protein kinase catalytic subunit beta

Gene

PRKACB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiB1APF9.

Names & Taxonomyi

Protein namesi
Submitted name:
cAMP-dependent protein kinase catalytic subunit betaImported
Gene namesi
Name:PRKACBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000142875.19.
HGNCiHGNC:9381. PRKACB.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142875.

PTM / Processingi

Proteomic databases

MaxQBiB1APF9.
PaxDbiB1APF9.
PeptideAtlasiB1APF9.
PRIDEiB1APF9.

Expressioni

Gene expression databases

BgeeiENSG00000142875.
ExpressionAtlasiB1APF9. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliB1APF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 245Protein kinaseInterPro annotationAdd BLAST214

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0616. Eukaryota.
ENOG410XPQQ. LUCA.
GeneTreeiENSGT00810000125385.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

B1APF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLKEFLAK AKEDFLKKWE NPTQNNAGLE DFERKKTLGT GSFGRVMLVK
60 70 80 90 100
HKATEQYYAM KILDKQKVVK LKQIEHTLNE KRILQAVNFP FLVRLEYAFK
110 120 130 140 150
DNSNLYMVME YVPGGEMFSH LRRIGRFSEP HARFYAAQIV LTFEYLHSLD
160 170 180 190 200
LIYRDLKPEN LLIDHQGYIQ VTDFGFAKRV KGRTWTLCGT PEYLAPEIIL
210 220 230 240
SKGYNKAVDW WALGVLIYEM AAGYPPFFAD QPIQIYEKIV SGKNF
Length:245
Mass (Da):28,550
Last modified:April 8, 2008 - v1
Checksum:i72ABC48F946516DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL359504 Genomic DNA. No translation available.
AL450063 Genomic DNA. No translation available.
RefSeqiNP_001287846.1. NM_001300917.1.
UniGeneiHs.487325.

Genome annotation databases

EnsembliENST00000370684; ENSP00000359718; ENSG00000142875.
GeneIDi5567.
UCSCiuc057hyn.1. human.

Similar proteinsi

Entry informationi

Entry nameiB1APF9_HUMAN
AccessioniPrimary (citable) accession number: B1APF9
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: November 22, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported