ID   WDR64_HUMAN             Reviewed;        1081 AA.
AC   B1ANS9; B1ANT0; Q7Z573; Q96LY9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   RecName: Full=WD repeat-containing protein 64;
GN   Name=WDR64;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 230-1081 (ISOFORM 2).
RA   Shan Y.X., Yu L.;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 555-1081 (ISOFORM 1).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=B1ANS9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=B1ANS9-2; Sequence=VSP_033509;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAP92796.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB71525.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL365366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX248405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX322532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY327404; AAP92796.1; ALT_INIT; mRNA.
DR   EMBL; AK057540; BAB71525.1; ALT_INIT; mRNA.
DR   RefSeq; NP_653226.4; NM_144625.4.
DR   AlphaFoldDB; B1ANS9; -.
DR   BioGRID; 126090; 3.
DR   IntAct; B1ANS9; 1.
DR   STRING; 9606.ENSP00000355510; -.
DR   iPTMnet; B1ANS9; -.
DR   PhosphoSitePlus; B1ANS9; -.
DR   BioMuta; WDR64; -.
DR   EPD; B1ANS9; -.
DR   MassIVE; B1ANS9; -.
DR   PaxDb; 9606-ENSP00000355510; -.
DR   PeptideAtlas; B1ANS9; -.
DR   ProteomicsDB; 3269; -. [B1ANS9-1]
DR   ProteomicsDB; 3270; -. [B1ANS9-2]
DR   Antibodypedia; 52507; 44 antibodies from 12 providers.
DR   DNASU; 128025; -.
DR   Ensembl; ENST00000366552.6; ENSP00000355510.2; ENSG00000162843.18. [B1ANS9-1]
DR   UCSC; uc001hzg.3; human. [B1ANS9-1]
DR   AGR; HGNC:26570; -.
DR   GeneCards; WDR64; -.
DR   HGNC; HGNC:26570; WDR64.
DR   HPA; ENSG00000162843; Tissue enriched (testis).
DR   neXtProt; NX_B1ANS9; -.
DR   OpenTargets; ENSG00000162843; -.
DR   PharmGKB; PA142670597; -.
DR   VEuPathDB; HostDB:ENSG00000162843; -.
DR   eggNOG; KOG0281; Eukaryota.
DR   eggNOG; KOG0642; Eukaryota.
DR   GeneTree; ENSGT00940000160037; -.
DR   HOGENOM; CLU_011653_2_0_1; -.
DR   InParanoid; B1ANS9; -.
DR   OMA; MDWCEIF; -.
DR   PhylomeDB; B1ANS9; -.
DR   TreeFam; TF324700; -.
DR   PathwayCommons; B1ANS9; -.
DR   SignaLink; B1ANS9; -.
DR   BioGRID-ORCS; 128025; 5 hits in 249 CRISPR screens.
DR   ChiTaRS; WDR64; human.
DR   GenomeRNAi; 128025; -.
DR   Pharos; B1ANS9; Tdark.
DR   PRO; PR:B1ANS9; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; B1ANS9; Protein.
DR   Bgee; ENSG00000162843; Expressed in buccal mucosa cell and 85 other cell types or tissues.
DR   ExpressionAtlas; B1ANS9; baseline and differential.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR44324:SF2; WD REPEAT-CONTAINING PROTEIN 64; 1.
DR   PANTHER; PTHR44324; WD40 REPEAT DOMAIN 95; 1.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
DR   Genevisible; B1ANS9; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..1081
FT                   /note="WD repeat-containing protein 64"
FT                   /id="PRO_0000333256"
FT   REPEAT          102..152
FT                   /note="WD 1"
FT   REPEAT          153..198
FT                   /note="WD 2"
FT   REPEAT          199..265
FT                   /note="WD 3"
FT   REPEAT          266..314
FT                   /note="WD 4"
FT   REPEAT          315..356
FT                   /note="WD 5"
FT   REPEAT          357..400
FT                   /note="WD 6"
FT   REPEAT          401..444
FT                   /note="WD 7"
FT   REPEAT          445..488
FT                   /note="WD 8"
FT   REPEAT          489..532
FT                   /note="WD 9"
FT   REPEAT          533..631
FT                   /note="WD 10"
FT   REPEAT          632..740
FT                   /note="WD 11"
FT   REPEAT          741..803
FT                   /note="WD 12"
FT   REPEAT          804..857
FT                   /note="WD 13"
FT   REPEAT          858..895
FT                   /note="WD 14"
FT   REGION          726..757
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1036..1060
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        726..745
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         669..835
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_033509"
FT   VARIANT         647
FT                   /note="R -> Q (in dbSNP:rs12095445)"
FT                   /id="VAR_043138"
FT   VARIANT         952
FT                   /note="R -> W (in dbSNP:rs12074374)"
FT                   /id="VAR_043139"
FT   CONFLICT        699
FT                   /note="P -> S (in Ref. 3; BAB71525)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1055..1056
FT                   /note="AP -> VT (in Ref. 2; AAP92796)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1081 AA;  123631 MW;  2F497F01C44D3202 CRC64;
     MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA IGYDKFYASV
     QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE EDPIASQLDE ENLVFFVSRK
     RRILISGSRR RDVIKSIVKI PHLDLLITAT QKGLITVFNN QDTSWITGCD YLLQLKRIVA
     TTERTIIVWD YKAQGSSQEN YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF
     TVNSDDFGIK QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN
     HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW HPNISTKPVG
     KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL LQVFHDSQGG PGDMQIYSMI
     YDANHGMLIT GSSVMDMYPL TRMIQDTKQV PHTHEREINV MLYNKYFHQV LTICSESIIR
     VWELETGLQV YQILEPHGFN TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE
     GKDWKEDEHC LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF
     LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC IDLLQVEGYN
     LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK HFKINDILFL FRTPECARRS
     SQDSICSSSQ CESSKGPQSS KGSKQSIHDS EVKGEQTDVM VGKQQPMDKK HPGIANLPEA
     QPPILVTAHE DGHLRLWTLE GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI
     LCNISSFLDP PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH
     YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF DREKWRKMSS
     VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT ENREAGIVFG SLPIYSISSP
     TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV QREKAPRRRS LKKNLVPQIN LASSFFPAIP
     K
//