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B1ANS9

- WDR64_HUMAN

UniProt

B1ANS9 - WDR64_HUMAN

Protein

WD repeat-containing protein 64

Gene

WDR64

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    SignaLinkiB1ANS9.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    WD repeat-containing protein 64
    Gene namesi
    Name:WDR64
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:26570. WDR64.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670597.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10811081WD repeat-containing protein 64PRO_0000333256Add
    BLAST

    Proteomic databases

    PaxDbiB1ANS9.
    PRIDEiB1ANS9.

    PTM databases

    PhosphoSiteiB1ANS9.

    Expressioni

    Gene expression databases

    ArrayExpressiB1ANS9.
    BgeeiB1ANS9.
    CleanExiHS_WDR64.
    GenevestigatoriB1ANS9.

    Organism-specific databases

    HPAiHPA046186.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000340960.

    Structurei

    3D structure databases

    ProteinModelPortaliB1ANS9.
    SMRiB1ANS9. Positions 333-619.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati129 – 16133WD 1Add
    BLAST
    Repeati162 – 19938WD 2Add
    BLAST
    Repeati321 – 36040WD 3Add
    BLAST
    Repeati364 – 40340WD 4Add
    BLAST
    Repeati411 – 44838WD 5Add
    BLAST
    Repeati453 – 49240WD 6Add
    BLAST
    Repeati498 – 53942WD 7Add
    BLAST
    Repeati560 – 60243WD 8Add
    BLAST
    Repeati643 – 68442WD 9Add
    BLAST
    Repeati762 – 80746WD 10Add
    BLAST
    Repeati811 – 85242WD 11Add
    BLAST
    Repeati865 – 90440WD 12Add
    BLAST

    Sequence similaritiesi

    Contains 12 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG325408.
    HOGENOMiHOG000068084.
    HOVERGENiHBG108670.
    InParanoidiB1ANS9.
    OMAiASADWCE.
    OrthoDBiEOG7C5M7D.
    PhylomeDBiB1ANS9.
    TreeFamiTF324700.

    Family and domain databases

    Gene3Di2.130.10.10. 5 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 3 hits.
    [Graphical view]
    SMARTiSM00320. WD40. 8 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 5 hits.
    PROSITEiPS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: B1ANS9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA     50
    IGYDKFYASV QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE 100
    EDPIASQLDE ENLVFFVSRK RRILISGSRR RDVIKSIVKI PHLDLLITAT 150
    QKGLITVFNN QDTSWITGCD YLLQLKRIVA TTERTIIVWD YKAQGSSQEN 200
    YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF TVNSDDFGIK 250
    QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN 300
    HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW 350
    HPNISTKPVG KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL 400
    LQVFHDSQGG PGDMQIYSMI YDANHGMLIT GSSVMDMYPL TRMIQDTKQV 450
    PHTHEREINV MLYNKYFHQV LTICSESIIR VWELETGLQV YQILEPHGFN 500
    TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE GKDWKEDEHC 550
    LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF 600
    LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC 650
    IDLLQVEGYN LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK 700
    HFKINDILFL FRTPECARRS SQDSICSSSQ CESSKGPQSS KGSKQSIHDS 750
    EVKGEQTDVM VGKQQPMDKK HPGIANLPEA QPPILVTAHE DGHLRLWTLE 800
    GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI LCNISSFLDP 850
    PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH 900
    YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF 950
    DREKWRKMSS VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT 1000
    ENREAGIVFG SLPIYSISSP TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV 1050
    QREKAPRRRS LKKNLVPQIN LASSFFPAIP K 1081
    Length:1,081
    Mass (Da):123,631
    Last modified:April 8, 2008 - v1
    Checksum:i2F497F01C44D3202
    GO
    Isoform 2 (identifier: B1ANS9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         669-835: Missing.

    Show »
    Length:914
    Mass (Da):105,020
    Checksum:iC86101A9819B9E80
    GO

    Sequence cautioni

    The sequence AAP92796.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB71525.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti699 – 6991P → S in BAB71525. (PubMed:14702039)Curated
    Sequence conflicti1055 – 10562AP → VT in AAP92796. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti647 – 6471R → Q.
    Corresponds to variant rs12095445 [ dbSNP | Ensembl ].
    VAR_043138
    Natural varianti952 – 9521R → W.
    Corresponds to variant rs12074374 [ dbSNP | Ensembl ].
    VAR_043139

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei669 – 835167Missing in isoform 2. 1 PublicationVSP_033509Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248405 Genomic DNA. Translation: CAH71837.1.
    AL365366 Genomic DNA. Translation: CAI15650.1.
    BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1.
    AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1.
    AY327404 mRNA. Translation: AAP92796.1. Different initiation.
    AK057540 mRNA. Translation: BAB71525.1. Different initiation.
    RefSeqiNP_653226.4. NM_144625.4. [B1ANS9-1]
    UniGeneiHs.97527.

    Genome annotation databases

    EnsembliENST00000366552; ENSP00000355510; ENSG00000162843. [B1ANS9-1]
    ENST00000437684; ENSP00000402446; ENSG00000162843. [B1ANS9-2]
    GeneIDi128025.
    KEGGihsa:128025.
    UCSCiuc001hzg.2. human. [B1ANS9-1]
    uc021plh.1. human. [B1ANS9-2]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX248405 Genomic DNA. Translation: CAH71837.1 .
    AL365366 Genomic DNA. Translation: CAI15650.1 .
    BX248405 , AL365366 , BX322532 Genomic DNA. Translation: CAI95104.1 .
    AL365366 , BX248405 , BX322532 Genomic DNA. Translation: CAI95314.1 .
    AY327404 mRNA. Translation: AAP92796.1 . Different initiation.
    AK057540 mRNA. Translation: BAB71525.1 . Different initiation.
    RefSeqi NP_653226.4. NM_144625.4. [B1ANS9-1 ]
    UniGenei Hs.97527.

    3D structure databases

    ProteinModelPortali B1ANS9.
    SMRi B1ANS9. Positions 333-619.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000340960.

    PTM databases

    PhosphoSitei B1ANS9.

    Proteomic databases

    PaxDbi B1ANS9.
    PRIDEi B1ANS9.

    Protocols and materials databases

    DNASUi 128025.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366552 ; ENSP00000355510 ; ENSG00000162843 . [B1ANS9-1 ]
    ENST00000437684 ; ENSP00000402446 ; ENSG00000162843 . [B1ANS9-2 ]
    GeneIDi 128025.
    KEGGi hsa:128025.
    UCSCi uc001hzg.2. human. [B1ANS9-1 ]
    uc021plh.1. human. [B1ANS9-2 ]

    Organism-specific databases

    CTDi 128025.
    GeneCardsi GC01P241815.
    HGNCi HGNC:26570. WDR64.
    HPAi HPA046186.
    neXtProti NX_B1ANS9.
    PharmGKBi PA142670597.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG325408.
    HOGENOMi HOG000068084.
    HOVERGENi HBG108670.
    InParanoidi B1ANS9.
    OMAi ASADWCE.
    OrthoDBi EOG7C5M7D.
    PhylomeDBi B1ANS9.
    TreeFami TF324700.

    Enzyme and pathway databases

    SignaLinki B1ANS9.

    Miscellaneous databases

    GenomeRNAii 128025.
    NextBioi 82212.
    PROi B1ANS9.

    Gene expression databases

    ArrayExpressi B1ANS9.
    Bgeei B1ANS9.
    CleanExi HS_WDR64.
    Genevestigatori B1ANS9.

    Family and domain databases

    Gene3Di 2.130.10.10. 5 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 3 hits.
    [Graphical view ]
    SMARTi SM00320. WD40. 8 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 5 hits.
    PROSITEi PS00678. WD_REPEATS_1. 1 hit.
    PS50082. WD_REPEATS_2. 3 hits.
    PS50294. WD_REPEATS_REGION. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Shan Y.X., Yu L.
      Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 230-1081 (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 555-1081 (ISOFORM 1).
      Tissue: Testis.

    Entry informationi

    Entry nameiWDR64_HUMAN
    AccessioniPrimary (citable) accession number: B1ANS9
    Secondary accession number(s): B1ANT0, Q7Z573, Q96LY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3