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Protein

WD repeat-containing protein 64

Gene

WDR64

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiB1ANS9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 64
Gene namesi
Name:WDR64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26570. WDR64.

Pathology & Biotechi

Organism-specific databases

DisGeNETi128025.
OpenTargetsiENSG00000162843.
PharmGKBiPA142670597.

Polymorphism and mutation databases

BioMutaiWDR64.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332561 – 1081WD repeat-containing protein 64Add BLAST1081

Proteomic databases

EPDiB1ANS9.
PaxDbiB1ANS9.
PRIDEiB1ANS9.

PTM databases

iPTMnetiB1ANS9.
PhosphoSitePlusiB1ANS9.

Expressioni

Gene expression databases

BgeeiENSG00000162843.
CleanExiHS_WDR64.
ExpressionAtlasiB1ANS9. baseline and differential.
GenevisibleiB1ANS9. HS.

Organism-specific databases

HPAiHPA046186.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355510.

Structurei

3D structure databases

ProteinModelPortaliB1ANS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati102 – 152WD 1Add BLAST51
Repeati153 – 198WD 2Add BLAST46
Repeati199 – 265WD 3Add BLAST67
Repeati266 – 314WD 4Add BLAST49
Repeati315 – 356WD 5Add BLAST42
Repeati357 – 400WD 6Add BLAST44
Repeati401 – 444WD 7Add BLAST44
Repeati445 – 488WD 8Add BLAST44
Repeati489 – 532WD 9Add BLAST44
Repeati533 – 631WD 10Add BLAST99
Repeati632 – 740WD 11Add BLAST109
Repeati741 – 803WD 12Add BLAST63
Repeati804 – 857WD 13Add BLAST54
Repeati858 – 895WD 14Add BLAST38

Sequence similaritiesi

Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
KOG0642. Eukaryota.
ENOG410XRKM. LUCA.
GeneTreeiENSGT00530000063510.
HOGENOMiHOG000068084.
HOVERGENiHBG108670.
InParanoidiB1ANS9.
OMAiASADWCE.
OrthoDBiEOG091G036J.
PhylomeDBiB1ANS9.
TreeFamiTF324700.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1ANS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA
60 70 80 90 100
IGYDKFYASV QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE
110 120 130 140 150
EDPIASQLDE ENLVFFVSRK RRILISGSRR RDVIKSIVKI PHLDLLITAT
160 170 180 190 200
QKGLITVFNN QDTSWITGCD YLLQLKRIVA TTERTIIVWD YKAQGSSQEN
210 220 230 240 250
YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF TVNSDDFGIK
260 270 280 290 300
QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN
310 320 330 340 350
HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW
360 370 380 390 400
HPNISTKPVG KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL
410 420 430 440 450
LQVFHDSQGG PGDMQIYSMI YDANHGMLIT GSSVMDMYPL TRMIQDTKQV
460 470 480 490 500
PHTHEREINV MLYNKYFHQV LTICSESIIR VWELETGLQV YQILEPHGFN
510 520 530 540 550
TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE GKDWKEDEHC
560 570 580 590 600
LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF
610 620 630 640 650
LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC
660 670 680 690 700
IDLLQVEGYN LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK
710 720 730 740 750
HFKINDILFL FRTPECARRS SQDSICSSSQ CESSKGPQSS KGSKQSIHDS
760 770 780 790 800
EVKGEQTDVM VGKQQPMDKK HPGIANLPEA QPPILVTAHE DGHLRLWTLE
810 820 830 840 850
GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI LCNISSFLDP
860 870 880 890 900
PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH
910 920 930 940 950
YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF
960 970 980 990 1000
DREKWRKMSS VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT
1010 1020 1030 1040 1050
ENREAGIVFG SLPIYSISSP TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV
1060 1070 1080
QREKAPRRRS LKKNLVPQIN LASSFFPAIP K
Length:1,081
Mass (Da):123,631
Last modified:April 8, 2008 - v1
Checksum:i2F497F01C44D3202
GO
Isoform 2 (identifier: B1ANS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     669-835: Missing.

Show »
Length:914
Mass (Da):105,020
Checksum:iC86101A9819B9E80
GO

Sequence cautioni

The sequence AAP92796 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71525 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti699P → S in BAB71525 (PubMed:14702039).Curated1
Sequence conflicti1055 – 1056AP → VT in AAP92796 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043138647R → Q.Corresponds to variant rs12095445dbSNPEnsembl.1
Natural variantiVAR_043139952R → W.Corresponds to variant rs12074374dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033509669 – 835Missing in isoform 2. 1 PublicationAdd BLAST167

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248405 Genomic DNA. Translation: CAH71837.1.
AL365366 Genomic DNA. Translation: CAI15650.1.
BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1.
AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1.
AY327404 mRNA. Translation: AAP92796.1. Different initiation.
AK057540 mRNA. Translation: BAB71525.1. Different initiation.
RefSeqiNP_653226.4. NM_144625.4. [B1ANS9-1]
UniGeneiHs.97527.

Genome annotation databases

EnsembliENST00000366552; ENSP00000355510; ENSG00000162843. [B1ANS9-1]
GeneIDi128025.
KEGGihsa:128025.
UCSCiuc001hzg.3. human. [B1ANS9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248405 Genomic DNA. Translation: CAH71837.1.
AL365366 Genomic DNA. Translation: CAI15650.1.
BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1.
AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1.
AY327404 mRNA. Translation: AAP92796.1. Different initiation.
AK057540 mRNA. Translation: BAB71525.1. Different initiation.
RefSeqiNP_653226.4. NM_144625.4. [B1ANS9-1]
UniGeneiHs.97527.

3D structure databases

ProteinModelPortaliB1ANS9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355510.

PTM databases

iPTMnetiB1ANS9.
PhosphoSitePlusiB1ANS9.

Polymorphism and mutation databases

BioMutaiWDR64.

Proteomic databases

EPDiB1ANS9.
PaxDbiB1ANS9.
PRIDEiB1ANS9.

Protocols and materials databases

DNASUi128025.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366552; ENSP00000355510; ENSG00000162843. [B1ANS9-1]
GeneIDi128025.
KEGGihsa:128025.
UCSCiuc001hzg.3. human. [B1ANS9-1]

Organism-specific databases

CTDi128025.
DisGeNETi128025.
GeneCardsiWDR64.
HGNCiHGNC:26570. WDR64.
HPAiHPA046186.
neXtProtiNX_B1ANS9.
OpenTargetsiENSG00000162843.
PharmGKBiPA142670597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0281. Eukaryota.
KOG0642. Eukaryota.
ENOG410XRKM. LUCA.
GeneTreeiENSGT00530000063510.
HOGENOMiHOG000068084.
HOVERGENiHBG108670.
InParanoidiB1ANS9.
OMAiASADWCE.
OrthoDBiEOG091G036J.
PhylomeDBiB1ANS9.
TreeFamiTF324700.

Enzyme and pathway databases

SignaLinkiB1ANS9.

Miscellaneous databases

GenomeRNAii128025.
PROiB1ANS9.

Gene expression databases

BgeeiENSG00000162843.
CleanExiHS_WDR64.
ExpressionAtlasiB1ANS9. baseline and differential.
GenevisibleiB1ANS9. HS.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR64_HUMAN
AccessioniPrimary (citable) accession number: B1ANS9
Secondary accession number(s): B1ANT0, Q7Z573, Q96LY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.