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Protein

WD repeat-containing protein 64

Gene

WDR64

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiB1ANS9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 64
Gene namesi
Name:WDR64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:26570. WDR64.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670597.

Polymorphism and mutation databases

BioMutaiWDR64.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10811081WD repeat-containing protein 64PRO_0000333256Add
BLAST

Proteomic databases

PaxDbiB1ANS9.
PRIDEiB1ANS9.

PTM databases

PhosphoSiteiB1ANS9.

Expressioni

Gene expression databases

BgeeiB1ANS9.
CleanExiHS_WDR64.
ExpressionAtlasiB1ANS9. baseline.
GenevisibleiB1ANS9. HS.

Organism-specific databases

HPAiHPA046186.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355510.

Structurei

3D structure databases

ProteinModelPortaliB1ANS9.
SMRiB1ANS9. Positions 333-619, 654-685.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati102 – 15251WD 1Add
BLAST
Repeati153 – 19846WD 2Add
BLAST
Repeati199 – 26567WD 3Add
BLAST
Repeati266 – 31449WD 4Add
BLAST
Repeati315 – 35642WD 5Add
BLAST
Repeati357 – 40044WD 6Add
BLAST
Repeati401 – 44444WD 7Add
BLAST
Repeati445 – 48844WD 8Add
BLAST
Repeati489 – 53244WD 9Add
BLAST
Repeati533 – 63199WD 10Add
BLAST
Repeati632 – 740109WD 11Add
BLAST
Repeati741 – 80363WD 12Add
BLAST
Repeati804 – 85754WD 13Add
BLAST
Repeati858 – 89538WD 14Add
BLAST

Sequence similaritiesi

Contains 14 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG325408.
GeneTreeiENSGT00530000063510.
HOGENOMiHOG000068084.
HOVERGENiHBG108670.
InParanoidiB1ANS9.
OMAiASADWCE.
OrthoDBiEOG7C5M7D.
PhylomeDBiB1ANS9.
TreeFamiTF324700.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: B1ANS9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA
60 70 80 90 100
IGYDKFYASV QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE
110 120 130 140 150
EDPIASQLDE ENLVFFVSRK RRILISGSRR RDVIKSIVKI PHLDLLITAT
160 170 180 190 200
QKGLITVFNN QDTSWITGCD YLLQLKRIVA TTERTIIVWD YKAQGSSQEN
210 220 230 240 250
YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF TVNSDDFGIK
260 270 280 290 300
QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN
310 320 330 340 350
HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW
360 370 380 390 400
HPNISTKPVG KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL
410 420 430 440 450
LQVFHDSQGG PGDMQIYSMI YDANHGMLIT GSSVMDMYPL TRMIQDTKQV
460 470 480 490 500
PHTHEREINV MLYNKYFHQV LTICSESIIR VWELETGLQV YQILEPHGFN
510 520 530 540 550
TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE GKDWKEDEHC
560 570 580 590 600
LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF
610 620 630 640 650
LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC
660 670 680 690 700
IDLLQVEGYN LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK
710 720 730 740 750
HFKINDILFL FRTPECARRS SQDSICSSSQ CESSKGPQSS KGSKQSIHDS
760 770 780 790 800
EVKGEQTDVM VGKQQPMDKK HPGIANLPEA QPPILVTAHE DGHLRLWTLE
810 820 830 840 850
GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI LCNISSFLDP
860 870 880 890 900
PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH
910 920 930 940 950
YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF
960 970 980 990 1000
DREKWRKMSS VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT
1010 1020 1030 1040 1050
ENREAGIVFG SLPIYSISSP TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV
1060 1070 1080
QREKAPRRRS LKKNLVPQIN LASSFFPAIP K
Length:1,081
Mass (Da):123,631
Last modified:April 8, 2008 - v1
Checksum:i2F497F01C44D3202
GO
Isoform 2 (identifier: B1ANS9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     669-835: Missing.

Show »
Length:914
Mass (Da):105,020
Checksum:iC86101A9819B9E80
GO

Sequence cautioni

The sequence AAP92796.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB71525.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti699 – 6991P → S in BAB71525 (PubMed:14702039).Curated
Sequence conflicti1055 – 10562AP → VT in AAP92796 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti647 – 6471R → Q.
Corresponds to variant rs12095445 [ dbSNP | Ensembl ].
VAR_043138
Natural varianti952 – 9521R → W.
Corresponds to variant rs12074374 [ dbSNP | Ensembl ].
VAR_043139

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei669 – 835167Missing in isoform 2. 1 PublicationVSP_033509Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248405 Genomic DNA. Translation: CAH71837.1.
AL365366 Genomic DNA. Translation: CAI15650.1.
BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1.
AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1.
AY327404 mRNA. Translation: AAP92796.1. Different initiation.
AK057540 mRNA. Translation: BAB71525.1. Different initiation.
RefSeqiNP_653226.4. NM_144625.4. [B1ANS9-1]
UniGeneiHs.97527.

Genome annotation databases

EnsembliENST00000366552; ENSP00000355510; ENSG00000162843.
GeneIDi128025.
KEGGihsa:128025.
UCSCiuc001hzg.2. human. [B1ANS9-1]
uc021plh.1. human. [B1ANS9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248405 Genomic DNA. Translation: CAH71837.1.
AL365366 Genomic DNA. Translation: CAI15650.1.
BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1.
AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1.
AY327404 mRNA. Translation: AAP92796.1. Different initiation.
AK057540 mRNA. Translation: BAB71525.1. Different initiation.
RefSeqiNP_653226.4. NM_144625.4. [B1ANS9-1]
UniGeneiHs.97527.

3D structure databases

ProteinModelPortaliB1ANS9.
SMRiB1ANS9. Positions 333-619, 654-685.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355510.

PTM databases

PhosphoSiteiB1ANS9.

Polymorphism and mutation databases

BioMutaiWDR64.

Proteomic databases

PaxDbiB1ANS9.
PRIDEiB1ANS9.

Protocols and materials databases

DNASUi128025.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366552; ENSP00000355510; ENSG00000162843.
GeneIDi128025.
KEGGihsa:128025.
UCSCiuc001hzg.2. human. [B1ANS9-1]
uc021plh.1. human. [B1ANS9-2]

Organism-specific databases

CTDi128025.
GeneCardsiGC01P241815.
HGNCiHGNC:26570. WDR64.
HPAiHPA046186.
neXtProtiNX_B1ANS9.
PharmGKBiPA142670597.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG325408.
GeneTreeiENSGT00530000063510.
HOGENOMiHOG000068084.
HOVERGENiHBG108670.
InParanoidiB1ANS9.
OMAiASADWCE.
OrthoDBiEOG7C5M7D.
PhylomeDBiB1ANS9.
TreeFamiTF324700.

Enzyme and pathway databases

SignaLinkiB1ANS9.

Miscellaneous databases

GenomeRNAii128025.
NextBioi82212.
PROiB1ANS9.

Gene expression databases

BgeeiB1ANS9.
CleanExiHS_WDR64.
ExpressionAtlasiB1ANS9. baseline.
GenevisibleiB1ANS9. HS.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Shan Y.X., Yu L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 230-1081 (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 555-1081 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiWDR64_HUMAN
AccessioniPrimary (citable) accession number: B1ANS9
Secondary accession number(s): B1ANT0, Q7Z573, Q96LY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: July 22, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.