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B1ANS9

- WDR64_HUMAN

UniProt

B1ANS9 - WDR64_HUMAN

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Protein

WD repeat-containing protein 64

Gene
WDR64
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiB1ANS9.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 64
Gene namesi
Name:WDR64
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:26570. WDR64.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10811081WD repeat-containing protein 64PRO_0000333256Add
BLAST

Proteomic databases

PaxDbiB1ANS9.
PRIDEiB1ANS9.

PTM databases

PhosphoSiteiB1ANS9.

Expressioni

Gene expression databases

ArrayExpressiB1ANS9.
BgeeiB1ANS9.
CleanExiHS_WDR64.
GenevestigatoriB1ANS9.

Organism-specific databases

HPAiHPA046186.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340960.

Structurei

3D structure databases

ProteinModelPortaliB1ANS9.
SMRiB1ANS9. Positions 333-619.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati129 – 16133WD 1Add
BLAST
Repeati162 – 19938WD 2Add
BLAST
Repeati321 – 36040WD 3Add
BLAST
Repeati364 – 40340WD 4Add
BLAST
Repeati411 – 44838WD 5Add
BLAST
Repeati453 – 49240WD 6Add
BLAST
Repeati498 – 53942WD 7Add
BLAST
Repeati560 – 60243WD 8Add
BLAST
Repeati643 – 68442WD 9Add
BLAST
Repeati762 – 80746WD 10Add
BLAST
Repeati811 – 85242WD 11Add
BLAST
Repeati865 – 90440WD 12Add
BLAST

Sequence similaritiesi

Contains 12 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG325408.
HOGENOMiHOG000068084.
HOVERGENiHBG108670.
InParanoidiB1ANS9.
OMAiASADWCE.
OrthoDBiEOG7C5M7D.
PhylomeDBiB1ANS9.
TreeFamiTF324700.

Family and domain databases

Gene3Di2.130.10.10. 5 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 5 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: B1ANS9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA     50
IGYDKFYASV QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE 100
EDPIASQLDE ENLVFFVSRK RRILISGSRR RDVIKSIVKI PHLDLLITAT 150
QKGLITVFNN QDTSWITGCD YLLQLKRIVA TTERTIIVWD YKAQGSSQEN 200
YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF TVNSDDFGIK 250
QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN 300
HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW 350
HPNISTKPVG KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL 400
LQVFHDSQGG PGDMQIYSMI YDANHGMLIT GSSVMDMYPL TRMIQDTKQV 450
PHTHEREINV MLYNKYFHQV LTICSESIIR VWELETGLQV YQILEPHGFN 500
TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE GKDWKEDEHC 550
LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF 600
LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC 650
IDLLQVEGYN LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK 700
HFKINDILFL FRTPECARRS SQDSICSSSQ CESSKGPQSS KGSKQSIHDS 750
EVKGEQTDVM VGKQQPMDKK HPGIANLPEA QPPILVTAHE DGHLRLWTLE 800
GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI LCNISSFLDP 850
PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH 900
YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF 950
DREKWRKMSS VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT 1000
ENREAGIVFG SLPIYSISSP TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV 1050
QREKAPRRRS LKKNLVPQIN LASSFFPAIP K 1081
Length:1,081
Mass (Da):123,631
Last modified:April 8, 2008 - v1
Checksum:i2F497F01C44D3202
GO
Isoform 2 (identifier: B1ANS9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     669-835: Missing.

Show »
Length:914
Mass (Da):105,020
Checksum:iC86101A9819B9E80
GO

Sequence cautioni

The sequence AAP92796.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB71525.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti647 – 6471R → Q.
Corresponds to variant rs12095445 [ dbSNP | Ensembl ].
VAR_043138
Natural varianti952 – 9521R → W.
Corresponds to variant rs12074374 [ dbSNP | Ensembl ].
VAR_043139

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei669 – 835167Missing in isoform 2. VSP_033509Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti699 – 6991P → S in BAB71525. 1 Publication
Sequence conflicti1055 – 10562AP → VT in AAP92796. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248405 Genomic DNA. Translation: CAH71837.1.
AL365366 Genomic DNA. Translation: CAI15650.1.
BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1.
AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1.
AY327404 mRNA. Translation: AAP92796.1. Different initiation.
AK057540 mRNA. Translation: BAB71525.1. Different initiation.
RefSeqiNP_653226.4. NM_144625.4. [B1ANS9-1]
UniGeneiHs.97527.

Genome annotation databases

EnsembliENST00000366552; ENSP00000355510; ENSG00000162843. [B1ANS9-1]
ENST00000437684; ENSP00000402446; ENSG00000162843. [B1ANS9-2]
GeneIDi128025.
KEGGihsa:128025.
UCSCiuc001hzg.2. human. [B1ANS9-1]
uc021plh.1. human. [B1ANS9-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX248405 Genomic DNA. Translation: CAH71837.1 .
AL365366 Genomic DNA. Translation: CAI15650.1 .
BX248405 , AL365366 , BX322532 Genomic DNA. Translation: CAI95104.1 .
AL365366 , BX248405 , BX322532 Genomic DNA. Translation: CAI95314.1 .
AY327404 mRNA. Translation: AAP92796.1 . Different initiation.
AK057540 mRNA. Translation: BAB71525.1 . Different initiation.
RefSeqi NP_653226.4. NM_144625.4. [B1ANS9-1 ]
UniGenei Hs.97527.

3D structure databases

ProteinModelPortali B1ANS9.
SMRi B1ANS9. Positions 333-619.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000340960.

PTM databases

PhosphoSitei B1ANS9.

Proteomic databases

PaxDbi B1ANS9.
PRIDEi B1ANS9.

Protocols and materials databases

DNASUi 128025.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366552 ; ENSP00000355510 ; ENSG00000162843 . [B1ANS9-1 ]
ENST00000437684 ; ENSP00000402446 ; ENSG00000162843 . [B1ANS9-2 ]
GeneIDi 128025.
KEGGi hsa:128025.
UCSCi uc001hzg.2. human. [B1ANS9-1 ]
uc021plh.1. human. [B1ANS9-2 ]

Organism-specific databases

CTDi 128025.
GeneCardsi GC01P241815.
HGNCi HGNC:26570. WDR64.
HPAi HPA046186.
neXtProti NX_B1ANS9.
PharmGKBi PA142670597.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325408.
HOGENOMi HOG000068084.
HOVERGENi HBG108670.
InParanoidi B1ANS9.
OMAi ASADWCE.
OrthoDBi EOG7C5M7D.
PhylomeDBi B1ANS9.
TreeFami TF324700.

Enzyme and pathway databases

SignaLinki B1ANS9.

Miscellaneous databases

GenomeRNAii 128025.
NextBioi 82212.
PROi B1ANS9.

Gene expression databases

ArrayExpressi B1ANS9.
Bgeei B1ANS9.
CleanExi HS_WDR64.
Genevestigatori B1ANS9.

Family and domain databases

Gene3Di 2.130.10.10. 5 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 8 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 5 hits.
PROSITEi PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Shan Y.X., Yu L.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 230-1081 (ISOFORM 2).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 555-1081 (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiWDR64_HUMAN
AccessioniPrimary (citable) accession number: B1ANS9
Secondary accession number(s): B1ANT0, Q7Z573, Q96LY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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