B1ANS9 (WDR64_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WD repeat-containing protein 64

Gene names

Name:

WDR64

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1081 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 12 WD repeats.
Sequence caution	The sequence AAP92796.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB71525.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: B1ANS9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: B1ANS9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     669-835: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1081	1081	WD repeat-containing protein 64		PRO_0000333256
Regions
	Repeat	129 – 161	33	WD 1
	Repeat	162 – 199	38	WD 2
	Repeat	321 – 360	40	WD 3
	Repeat	364 – 403	40	WD 4
	Repeat	411 – 448	38	WD 5
	Repeat	453 – 492	40	WD 6
	Repeat	498 – 539	42	WD 7
	Repeat	560 – 602	43	WD 8
	Repeat	643 – 684	42	WD 9
	Repeat	762 – 807	46	WD 10
	Repeat	811 – 852	42	WD 11
	Repeat	865 – 904	40	WD 12
Natural variations
	Alternative sequence	669 – 835	167	Missing in isoform 2.		VSP_033509
	Natural variant	647	1	R → Q. Corresponds to variant rs12095445 [ dbSNP | Ensembl ].		VAR_043138
	Natural variant	952	1	R → W. Corresponds to variant rs12074374 [ dbSNP | Ensembl ].		VAR_043139
Experimental info
	Sequence conflict	699	1	P → S in BAB71525. Ref.3
	Sequence conflict	1055 – 1056	2	AP → VT in AAP92796. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 2F497F01C44D3202	FASTA	1,081	123,631
	10 20 30 40 50 60 MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA IGYDKFYASV 70 80 90 100 110 120 QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE EDPIASQLDE ENLVFFVSRK 130 140 150 160 170 180 RRILISGSRR RDVIKSIVKI PHLDLLITAT QKGLITVFNN QDTSWITGCD YLLQLKRIVA 190 200 210 220 230 240 TTERTIIVWD YKAQGSSQEN YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF 250 260 270 280 290 300 TVNSDDFGIK QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN 310 320 330 340 350 360 HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW HPNISTKPVG 370 380 390 400 410 420 KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL LQVFHDSQGG PGDMQIYSMI 430 440 450 460 470 480 YDANHGMLIT GSSVMDMYPL TRMIQDTKQV PHTHEREINV MLYNKYFHQV LTICSESIIR 490 500 510 520 530 540 VWELETGLQV YQILEPHGFN TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE 550 560 570 580 590 600 GKDWKEDEHC LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF 610 620 630 640 650 660 LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC IDLLQVEGYN 670 680 690 700 710 720 LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK HFKINDILFL FRTPECARRS 730 740 750 760 770 780 SQDSICSSSQ CESSKGPQSS KGSKQSIHDS EVKGEQTDVM VGKQQPMDKK HPGIANLPEA 790 800 810 820 830 840 QPPILVTAHE DGHLRLWTLE GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI 850 860 870 880 890 900 LCNISSFLDP PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH 910 920 930 940 950 960 YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF DREKWRKMSS 970 980 990 1000 1010 1020 VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT ENREAGIVFG SLPIYSISSP 1030 1040 1050 1060 1070 1080 TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV QREKAPRRRS LKKNLVPQIN LASSFFPAIP K
	Isoform 2 [UniParc]. Checksum: C86101A9819B9E80	FASTA	914	105,020
	10 20 30 40 50 60 MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA IGYDKFYASV 70 80 90 100 110 120 QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE EDPIASQLDE ENLVFFVSRK 130 140 150 160 170 180 RRILISGSRR RDVIKSIVKI PHLDLLITAT QKGLITVFNN QDTSWITGCD YLLQLKRIVA 190 200 210 220 230 240 TTERTIIVWD YKAQGSSQEN YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF 250 260 270 280 290 300 TVNSDDFGIK QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN 310 320 330 340 350 360 HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW HPNISTKPVG 370 380 390 400 410 420 KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL LQVFHDSQGG PGDMQIYSMI 430 440 450 460 470 480 YDANHGMLIT GSSVMDMYPL TRMIQDTKQV PHTHEREINV MLYNKYFHQV LTICSESIIR 490 500 510 520 530 540 VWELETGLQV YQILEPHGFN TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE 550 560 570 580 590 600 GKDWKEDEHC LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF 610 620 630 640 650 660 LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC IDLLQVEGYN 670 680 690 700 710 720 LIAAGTLNEG HVILCNISSF LDPPHDEKKF KQLLSWRAHS LEIIQVIYVE EKQVVLTASI 730 740 750 760 770 780 DGSVRLWHAL NGHYCGYFGQ RRLFELSQTR DFILPCDVTE YPIEIKEESK FTEKQKYEYP 790 800 810 820 830 840 LIFDREKWRK MSSVSLLFKR TPPKAFEVEQ DFKFFKSLSS PKIRRYPLEG FVTENREAGI 850 860 870 880 890 900 VFGSLPIYSI SSPTSLRFLP LIGVEAQKDS SDGITGKKKG GHVQREKAPR RRSLKKNLVP 910 QINLASSFFP AIPK

References

[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Shan Y.X., Yu L. Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 230-1081 (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 555-1081 (ISOFORM 1). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248405 Genomic DNA. Translation: CAH71837.1. AL365366 Genomic DNA. Translation: CAI15650.1. BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1. AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1. AY327404 mRNA. Translation: AAP92796.1. Different initiation. AK057540 mRNA. Translation: BAB71525.1. Different initiation.
IPI	IPI00480208. IPI00641421.
RefSeq	NP_653226.4. NM_144625.4.
UniGene	Hs.97527.
3D structure databases
ProteinModelPortal	B1ANS9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000340960.
PTM databases
PhosphoSite	B1ANS9.
Proteomic databases
PaxDb	B1ANS9.
PRIDE	B1ANS9.
Protocols and materials databases
DNASU	128025.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000366552; ENSP00000355510; ENSG00000162843. ENST00000414635; ENSP00000406656; ENSG00000162843. ENST00000437684; ENSP00000402446; ENSG00000162843.
GeneID	128025.
KEGG	hsa:128025.
UCSC	uc001hzg.2. human. uc021plh.1. human.
Organism-specific databases
CTD	128025.
GeneCards	GC01P241815.
HGNC	HGNC:26570. WDR64.
HPA	HPA046186.
neXtProt	NX_B1ANS9.
PharmGKB	PA142670597.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG325408.
HOGENOM	HOG000068084.
HOVERGEN	HBG108670.
InParanoid	B1ANS9.
OMA	WNFVTST.
Gene expression databases
ArrayExpress	B1ANS9.
Bgee	B1ANS9.
CleanEx	HS_WDR64.
Genevestigator	B1ANS9.
Family and domain databases
Gene3D	2.130.10.10. 5 hits.
InterPro	IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF00400. WD40. 3 hits. [Graphical view]
SMART	SM00320. WD40. 8 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 2 hits.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	128025.
NextBio	82212.

Entry information

Entry name

WDR64_HUMAN

Accession

Primary (citable) accession number: B1ANS9
Secondary accession number(s): B1ANT0, Q7Z573, Q96LY9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.