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B1ANS9 (WDR64_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WD repeat-containing protein 64
Gene names
Name:WDR64
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1081 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 12 WD repeats.

Sequence caution

The sequence AAP92796.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB71525.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: B1ANS9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: B1ANS9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     669-835: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10811081WD repeat-containing protein 64
PRO_0000333256

Regions

Repeat129 – 16133WD 1
Repeat162 – 19938WD 2
Repeat321 – 36040WD 3
Repeat364 – 40340WD 4
Repeat411 – 44838WD 5
Repeat453 – 49240WD 6
Repeat498 – 53942WD 7
Repeat560 – 60243WD 8
Repeat643 – 68442WD 9
Repeat762 – 80746WD 10
Repeat811 – 85242WD 11
Repeat865 – 90440WD 12

Natural variations

Alternative sequence669 – 835167Missing in isoform 2.
VSP_033509
Natural variant6471R → Q.
Corresponds to variant rs12095445 [ dbSNP | Ensembl ].
VAR_043138
Natural variant9521R → W.
Corresponds to variant rs12074374 [ dbSNP | Ensembl ].
VAR_043139

Experimental info

Sequence conflict6991P → S in BAB71525. Ref.3
Sequence conflict1055 – 10562AP → VT in AAP92796. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 2F497F01C44D3202

FASTA1,081123,631
        10         20         30         40         50         60 
MDIRKEKRLN MALQMSNFKK ALNRFEKLVE QTAAQKRDER AGLFIHKEDA IGYDKFYASV 

        70         80         90        100        110        120 
QKLFGPDVKN QDVKRFYRKL CNNTDASADW CEIFGYFSSE EDPIASQLDE ENLVFFVSRK 

       130        140        150        160        170        180 
RRILISGSRR RDVIKSIVKI PHLDLLITAT QKGLITVFNN QDTSWITGCD YLLQLKRIVA 

       190        200        210        220        230        240 
TTERTIIVWD YKAQGSSQEN YFVIKPMDHC LLCVCVVPLP DHLCRDDILL GDDGGFVNRF 

       250        260        270        280        290        300 
TVNSDDFGIK QAKSKRKLQN QVLDSKNFKS VKRKLHNDWV MKIRYISALN CFGSCSLDSN 

       310        320        330        340        350        360 
HSLVLESLKR LEDNLPVREF SMPRGANTFC YCVKANVIVT GGDDKVIRLW HPNISTKPVG 

       370        380        390        400        410        420 
KLVGHMFSIA EIVTNEKDQH VVSLSSAKVF RVWDIQTLSL LQVFHDSQGG PGDMQIYSMI 

       430        440        450        460        470        480 
YDANHGMLIT GSSVMDMYPL TRMIQDTKQV PHTHEREINV MLYNKYFHQV LTICSESIIR 

       490        500        510        520        530        540 
VWELETGLQV YQILEPHGFN TEVTSAAVDE SGFLFATGAY NGTVRIWDFG SGQEMKVLPE 

       550        560        570        580        590        600 
GKDWKEDEHC LRRLIFLKAQ EKHQQLVLAL ERNGTIKMIQ GKEDDIYLMV IWELPDVVPF 

       610        620        630        640        650        660 
LQDGKHAVHL RMSTRDRNMA IPFPDVELIV ERNFSQPTDN PTMDLLRVNC IDLLQVEGYN 

       670        680        690        700        710        720 
LIAAGTLNGV IILWNFVTST VKKVYRPEDC FTVNPDLHPK HFKINDILFL FRTPECARRS 

       730        740        750        760        770        780 
SQDSICSSSQ CESSKGPQSS KGSKQSIHDS EVKGEQTDVM VGKQQPMDKK HPGIANLPEA 

       790        800        810        820        830        840 
QPPILVTAHE DGHLRLWTLE GRLLKDMLPF TKHSAISLTS LYTDSCTRIL LAGNVEGHVI 

       850        860        870        880        890        900 
LCNISSFLDP PHDEKKFKQL LSWRAHSLEI IQVIYVEEKQ VVLTASIDGS VRLWHALNGH 

       910        920        930        940        950        960 
YCGYFGQRRL FELSQTRDFI LPCDVTEYPI EIKEESKFTE KQKYEYPLIF DREKWRKMSS 

       970        980        990       1000       1010       1020 
VSLLFKRTPP KAFEVEQDFK FFKSLSSPKI RRYPLEGFVT ENREAGIVFG SLPIYSISSP 

      1030       1040       1050       1060       1070       1080 
TSLRFLPLIG VEAQKDSSDG ITGKKKGGHV QREKAPRRRS LKKNLVPQIN LASSFFPAIP 


K 

« Hide

Isoform 2 [UniParc].

Checksum: C86101A9819B9E80
Show »

FASTA914105,020

References

[1]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Shan Y.X., Yu L.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 230-1081 (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 555-1081 (ISOFORM 1).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248405 Genomic DNA. Translation: CAH71837.1.
AL365366 Genomic DNA. Translation: CAI15650.1.
BX248405, AL365366, BX322532 Genomic DNA. Translation: CAI95104.1.
AL365366, BX248405, BX322532 Genomic DNA. Translation: CAI95314.1.
AY327404 mRNA. Translation: AAP92796.1. Different initiation.
AK057540 mRNA. Translation: BAB71525.1. Different initiation.
RefSeqNP_653226.4. NM_144625.4. [B1ANS9-1]
UniGeneHs.97527.

3D structure databases

ProteinModelPortalB1ANS9.
SMRB1ANS9. Positions 333-619.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000340960.

PTM databases

PhosphoSiteB1ANS9.

Proteomic databases

PaxDbB1ANS9.
PRIDEB1ANS9.

Protocols and materials databases

DNASU128025.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000366552; ENSP00000355510; ENSG00000162843. [B1ANS9-1]
ENST00000437684; ENSP00000402446; ENSG00000162843. [B1ANS9-2]
GeneID128025.
KEGGhsa:128025.
UCSCuc001hzg.2. human. [B1ANS9-1]
uc021plh.1. human. [B1ANS9-2]

Organism-specific databases

CTD128025.
GeneCardsGC01P241815.
HGNCHGNC:26570. WDR64.
HPAHPA046186.
neXtProtNX_B1ANS9.
PharmGKBPA142670597.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325408.
HOGENOMHOG000068084.
HOVERGENHBG108670.
InParanoidB1ANS9.
OMAASADWCE.
OrthoDBEOG7C5M7D.
PhylomeDBB1ANS9.
TreeFamTF324700.

Enzyme and pathway databases

SignaLinkB1ANS9.

Gene expression databases

ArrayExpressB1ANS9.
BgeeB1ANS9.
CleanExHS_WDR64.
GenevestigatorB1ANS9.

Family and domain databases

Gene3D2.130.10.10. 5 hits.
InterProIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00400. WD40. 3 hits.
[Graphical view]
SMARTSM00320. WD40. 8 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 5 hits.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi128025.
NextBio82212.
PROB1ANS9.

Entry information

Entry nameWDR64_HUMAN
AccessionPrimary (citable) accession number: B1ANS9
Secondary accession number(s): B1ANT0, Q7Z573, Q96LY9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM